Clinical trials: Cardio Pulmonary Bypass
Brain Natriuretic Peptide, Coronary Artery Bypass Graft Surgery
Desflurane,Brain Natriuretic Peptide and Cardiac Surgery
During coronary artery bypass grafting (CABG) operations with cardiopulmonary bypass (CPB), the use of desflurane continuously or intermittently may have effects on serum brain natriuretic peptide (BNP) levels.
- Conditions
- Brain Natriuretic Peptide, Coronary Artery Bypass Graft Surgery, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT04238806
- Testing
- Desflurane Inhalational agent
- Volunteers
- 151 people
- Sponsor
- Kartal Kosuyolu Yuksek Ihtisas Education and Research Hospital
Acute Kidney Injury, Renal Resistive Index
Association Between Renal Resistive Index(RRI) and AKI(Acute Kidney Injury) in Cardiac Surgery Patients With Cardiopulmonary Bypass (CPB)
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity. The conventiional marker for detecting AKI is serum creatinine, however, which has many limits.
- Trial name
- NCT06464666
- Testing
- Renal interlobar artery US, Renal inter-lobular artery US
- Volunteers
- 250 people
- Sponsor
- Yonsei University
Coronary Artery Disease, Heart Failure
Study to Determine if Using Ventilation During Open Heart Surgery Improves Lung Outcomes
To demonstrate that using continuous mechanical lung ventilatory support in combination with Positive End Expiratory Pressure (PEEP)during open heart surgery will improve lung function and decrease lung complications after…
- Trial name
- PEEP (NCT01522222)
- Testing
- continuous, mechanical ventilatory support
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Aurora BayCare Medical Center
Congenital Heart Disease
Fresh Frozen Plasma and Plasmalyte ® for Priming Cardiopulmonary Bypass in Infants and Children
Coagulation abnormalities after pediatric open-heart surgery are complex and very often multifactorial. Besides the cardiopulmonary bypass (CPB), the congenital pathology and the coagulation tests during CPB, the younger age has…
- Trial name
- NCT02567786
- Testing
- Surgery with CPB, Fresh Frozen Plasma, Plasmalyte
- Where
- Belgium
- Volunteers
- 60 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Cardiac Surgery
Monitoring of Glycocalyx for Prediction of Complications After Cardiac Surgery
This is a prospective observational study of the evolution of the microcirculation and the sublingual glycocalyx in perioperative cardiac surgery under cardiopulmonary bypass.
- Trial name
- MOGLYCC (NCT06136637)
- Where
- France
- Volunteers
- 77 people
- Sponsor
- University Hospital, Rouen
Vasoplegia, Endothelial Dysfunction
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery patients have many risk factors for endothelial dysfunction (hypertension, atherosclerosis, dyslipidemia, chronic renal failure ...).
- Trial name
- DYVA (NCT02965339)
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Bypass Complications, Disorder of Blood Gas
Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy
Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.
- Trial name
- NCT01698853
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Cardiopulmonary Bypass, Congenital Heart Defects
SPY Imaging System: Its Role in Pediatric Cardiac Surgery
The current method of evaluating the surgical repair during surgery is limited to echocardiography (a noninvasive diagnostic procedure that uses ultrasound to study the structure and motions of the heart) or an invasive procedure…
- Trial name
- NCT00446927
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Emory University
Thoracoabdominal Aortic Aneurysm, Cardiopulmonary Bypass
CompaRison of FEmorofemoral Bypass and Left-Heart ByPass Techniques in Open Thoracoabdominal AortIc Aneurysm Repair
The study is a multicenter, two-arm, open-label, randomized, parallel-controlled trial, which plans to enroll 236 participants diagnosed with TAAA from 4 hospitals in China.
- Conditions
- Thoracoabdominal Aortic Aneurysm, Cardiopulmonary Bypass, Open Repair
- Trial name
- REPAIR (NCT07518251)
- Testing
- Thoracoabdominal aortic aneurysm repair under fCPB, Thoracoabdominal aortic aneurysm repair under LHB
- Where
- China
- Volunteers
- 236 people
- Sponsor
- Beijing Anzhen Hospital
Aortic Valve Stenosis, Cardiopulmonary Bypass
The Effect of Remote Ischemic Preconditioning in Aortic Valve Replacement Surgery
The study objective is to verify if a non-invasive remote ischemic preconditioning procedure (blood pressure cuff on the arm) is cardioprotective when applied before an aortic valve replacement surgery.
- Trial name
- NCT03305094
- Testing
- Blood pressure cuff inflation
- Where
- Canada
- Volunteers
- 140 people
- Sponsor
- Laval University
Coagulopathy, Cardiac Surgery, Cardiopulmonary Bypass
Coagulopathy in Cardiac Surgery
Coagulopathy in cardiac surgery; a quaternary-care academic center experience Objectives: Primary: To determine incidence of coagulopathy after cardiac surgery in Thai people To determine incidence of resternotomy for stop…
- Trial name
- NCT03475940
- Where
- 2 sites in Thailand
- Volunteers
- 398 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Minimally Invasive Coronary Revascularization Surgery, Elective Surgery
Impact of Total Coronary Revascularization Via Left Anterior Thoracotomy (TCRAT) vs. Robotic-Assisted Harvesting of LIMA (ITcrats)
The two types of total coronary revascularization via left anterior thoracotomy (TCRAT) might have their potential benefits and disadvantages.
- Trial name
- ITcrats (NCT06988735)
- Testing
- Nonrobotic TCRAT, Robotic TCRAT
- Where
- Saudi Arabia
- Volunteers
- 182 people
- Sponsor
- Mohamed R El Tahan
Bleeding, Surgical Blood Loss
Decreasing Postoperative Blood Loss and Seizures by Timing of Intravenous Tranexamic Acid 2 Pilot Trial
The goal of this clinical trial is to establish the feasibility of conducting a large trial to determine the optimal timing of intravenous tranexamic acid administration in cardiac surgery.
- Conditions
- Bleeding, Surgical Blood Loss, Seizures
- Trial name
- DEPOSITION-2 (NCT06622564)
- Testing
- Before CPB Tranexamic Acid, After CPB Tranexamic Acid
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Hamilton Health Sciences Corporation
Diabetes Mellitus, Cardiac Surgical Procedures
Cerebrovascular Effects of the Use of Alpha-stat or pH-stat Management of Cardiopulmonary Bypass
Type 2 diabetes mellitus (T2DM) poses a significant burden on the patients and the health care system. The increasing number of surgery performed in elderly population results in an increased number of perioperative T2DM-related…
- Trial name
- NCT03816280
- Testing
- Elective cardiopulmonary bypass (CPB), Alpha-stat acid-base management, pH-stat acid-base management
- Where
- Hungary
- Volunteers
- 200 people
- Sponsor
- Szeged University
Hemostatic Disorders
Blood Products Transfusion in Cardiac Surgery After the Implementation of a Coagulation Monitoring System at Patient Bedside: Thromboelastometry Versus Standard Transfusion Protocol
Main objective: Determine whether by introducing thromboelastograph, the investigators reduced the number of packed red cells received by each patient (median) compared to the usual protocol, in which the indication for…
- Trial name
- ROTEM-2010 (NCT01919840)
- Testing
- Group ROTEM, Group C
- Volunteers
- 49 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Cardiac Surgery, Cardiopulmonary Bypass
Mri characterIzation of Troponin Elevation After Cardiac Surgery
Cardiac surgery under cardiopulmonary bypass (CPB) induces myocardial ischemia-reperfusion injury. This myocardial attack is a well-identified independent prognostic factor of postoperative morbidity and mortality.
- Trial name
- MITEC (NCT04490785)
- Testing
- MRI, Postoperative dosage of released troponin
- Where
- France
- Volunteers
- 38 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injury, Cardiac Surgery
Transcutaneous Auricular Vagus Nerve Stimulation for Preventing Acute Kidney Injury in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
Acute kidney injury (AKI) is a common complication after cardiac surgery using cardiopulmonary bypass, leading to longer hospital stays and worse outcomes. Effective preventive therapies are lacking.
- Conditions
- Acute Kidney Injury, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07549243
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Sir Run Run Shaw Hospital
Acute Kidney Injury
Hematologic Ratios in Postoperative Acute Kidney Injury
Acute kidney injury (AKI) is a common complication after surgery for congenital heart disease and is associated with significant morbidity and mortality.
- Trial name
- NCT03658148
- Testing
- Cardiac Surgery with Cardiopulmonary Bypass
- Where
- United States
- Sponsor
- Children's Hospital Medical Center, Cincinnati
ICU Stay
Assessment of OHIR Score to Predict a Prolonged Intensive Care Unit Stay
A prolonged stay in intensive care unit (ICU) after cardiac surgery with cardiopulmonary bypass increases not only cost of patient care but also morbidity and mortality of patients.
- Trial name
- NCT02945358
- Testing
- adult cardiac surgery with cardiopulmonary pump
- Where
- 2 sites in Thailand
- Volunteers
- 120 people
- Sponsor
- Khon Kaen University
Delirium
Cerebral Blood Flow During CPB During Cardiac Surgery and the Presence of Post op Delirium
Cardiac surgery is associated with multiple events and issues that increase risk for adverse postoperative neurological outcomes including postoperative cognitive dysfunction.
- Trial name
- NCT02084394
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Johns Hopkins University