Clinical trials: Cardio-pulmonary Function
Congenital Heart Defect, Blood Coagulation Disorder
Bedside Evaluation of Coagulation in Children With Congenital Heart Disease
The purpose of this study is to assess coagulation and platelet function in children with congenital heart disease, measured with a bedside device (thromboelastometry and impedance aggregometry).
- Trial name
- POCHEMO (NCT02387944)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Acute Kidney Failure
BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery.
Use of BNP (nesiritide) vs placebo to help protect kidney function in patients undergoing heart bypass surgery.
- Trial name
- NCT00252200
- Testing
- Neseritide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Congenital Heart Disease, Heart Valve Disease
Myocardial Protection Effect of Simvastatin Undergoing Cardiac Surgery
Statins have been used to low cholesterol to prevent and treat coronary artery diseases. It was also reported that statins could protect endothelial function and cardiac function during coronary artery bypass graft.
- Trial name
- NCT01653223
- Testing
- simvastatin
- Where
- China
- Volunteers
- 369 people
- Sponsor
- Sun Yat-sen University
Post Cardiac Surgery Systemic Inflammatory Response
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery
Protocol Summary STUDY DESIGN A pilot, prospective, double blind, randomized, placebo controlled study. STUDY POPULATION Patients assigned to elective CABG with cardiopulmonary bypass (CPB) at the Department of Cardiothoracic…
- Trial name
- NCT02191839
- Testing
- Alpha 1-Antitrypsin
- Volunteers
- 20 people
- Sponsor
- Soroka University Medical Center
Spinal Fusion, Cardiopulmonary Bypass
Point of Care Testing in Pediatric Patients Undergoing Major Surgery
The current study proposes to investigate Point of Care Testing (POCT) (Coagcheck®) and compare obtained results versus standard laboratory coagulation parameters prothrombin time (PT) and partial thromboplastin time (PTT).
- Trial name
- NCT01742936
- Testing
- CoaguChek, Hospital Laboratory
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Nationwide Children's Hospital
Stable Coronary Heart Disease
Clinical Study on the Effect of Zhenyuan Capsule on Cardiopulmonary Function in Patients With SCAD
A randomized, double-blind, placebo trial was adopted, and cardiopulmonary exercise load test (CPET) was used to detect peak oxygen uptake (PeakVO2) and exercise metabolic equivalent (METs) to confirm the clinical effect of…
- Trial name
- NCT04421287
- Testing
- Zhenyuan capsule
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xiyuan Hospital of China Academy of Chinese Medical Sciences
Pulmonary Arterial Hypertension
Effects of Adding Yoga Respiratory Training to Osteopathic Manipulative Treatment in Pulmonary Arterial Hypertension
The investigators planned a randomized controlled study to investigate the effects of adding yoga respiratory training to osteopathic manipulative treatment (OMT), and OMT alone on exhaled nitric oxide level and cardiopulmonary…
- Trial name
- NCT04076241
- Testing
- Osteopathic manipulative treatment, Yoga respiratory training
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Istanbul University - Cerrahpasa
Stroke, Gait, Hemiplegic
The Effect of a Ankle Assist Robot on Gait Function and Cardiopulmonary Metabolic Efficiency in Stroke Patients
The aim of this study was to identify the assistance effect of Ankle Assist Robot v1 developed by Samsung Advanced Institute of Technology (Samsung Electronics Co, Ltd., Korea) by comparing 1.
- Trial name
- NCT03767205
- Testing
- Ankle Assist Robot
- Where
- South Korea
- Volunteers
- 45 people
- Sponsor
- Samsung Medical Center
Coronary Artery Disease, Heart Valve Diseases
Nitric Oxide in Cardiopulmonary Bypass for Renal Protection in Cardiac Surgery
This prospective randomized study evaluates the nephroprotective effects of exogenous nitric oxide delivered to the extracorporeal circulation circuit during cardiac surgery with cardiopulmonary bypass.
- Conditions
- Coronary Artery Disease, Heart Valve Diseases, Cardiomyopathies, Acute Kidney Injury
- Trial name
- NephroNO (NCT03527381)
- Testing
- Nitric Oxide, Standard CPB
- Volunteers
- 96 people
- Sponsor
- Nikolay Kamenshchikov
Out-of-Hospital Cardiac Arrest, Extracorporeal Cardiopulmonary Resuscitation
Left Ventricular Ejection Fraction in Cardiac Arrest Survivors Treated With Extracorporeal Cardiopulmonary Resuscitation
Extra-hospital cardiac arrest is a major public health problem, with approximately 46,000 cases per year. Nearly 71% of the patients for whom resuscitation was initiated did not present a return of spontaneous circulation on…
- Trial name
- FEVGECMO (NCT06046339)
- Testing
- Collection of data from the patient's medical file
- Where
- France
- Volunteers
- 116 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiopulmonary Bypass Surgery, Left Ventricular Dysfunction
Assement of Left Ventricular Function Before Decannulation in Cardiac Surgery :Visual Estimation vs TEE
This study aims to evaluate the diagnostic performance of the cardiovascular surgeon's visual estimation of LV function before decannulation following cardiopulmonary bypass, using TEE results as the reference standard.
- Trial name
- LVFuncTee (NCT07286227)
- Testing
- Intraoperative Left Ventricular Function Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people
- Sponsor
- Ataturk University
Coronary Heart Disease
Effect of HIIT on Cardiopulmonary Function After PCI in Patients With Coronary Heart Disease
Both the gut microbiome and exercise are closely related to human health, but the understanding of the effect of high-intensity interval training (HIIT) on cardiopulmonary function and human intestinal flora is still further…
- Trial name
- NCT06575569
- Testing
- high-intensity interval training, Moderate-intensity continuous training
- Where
- China
- Volunteers
- 67 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Pulmonary Arterial Hypertension
The Combination Ambrisentan Plus Spironolactone in Pulmonary Arterial Hypertension Study
The purpose of this study is to find out if spironolactone added to ambrisentan for Pulmonary Arterial Hypertension (PAH) will increase exercise capacity.
- Trial name
- NCT02253394
- Testing
- Ambrisentan plus Spironolactone
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Brigham and Women's Hospital
Abnormality, Respiratory System, Autonomic Nervous System
Effects of Deployment Exposures on Cardiopulmonary and Autonomic Function
Following deployment to Operations Enduring and Iraqi Freedom and Operation New Dawn (OEF/OIF/OND), Veterans report breathing problems, difficulty exercising and other symptoms.
- Trial name
- AirHzds (NCT01754922)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Right Heart Failure, Open-heart Surgery
Levosimendan in Patients With Impaired Right Ventricular Function Undergoing Cardiac Surgery
Perioperative right ventricular (RV) function is an important determinant of postoperative outcomes after cardiac surgery. Perioperative RV dysfunction increases the need for perioperative inotropic support, prolongs intensive…
- Trial name
- NCT05063370
- Testing
- Levosimendan, Standard Care
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Fluid Overload, Organ Edema
"The Effect of Reduced Fluid Load After Cardiac Surgery"
The purpose of this study is to verify that an infusion of hypertonic saline/colloids during cardio-pulmonary-bypass will reduce fluid overload and organ edema for cardiac patients with expected long-CPB-time.
- Conditions
- Fluid Overload, Organ Edema, Organ Function
- Trial name
- NCT01438502
- Testing
- HyperHAES® (hypertonic saline/HES)
- Sponsor
- Haukeland University Hospital
Obese College Students, Aerobic Exercise Combined with Resistance Exercise
Impact of Combined Aerobic and Resistance Exercise on Autonomic Function and Cardiopulmonary Endurance in Obese College Students
This study explores the potential link between aerobic exercise combined with resistance training and improvements in cardiopulmonary function in obese individuals, focusing particularly on the influence of autonomic nerve…
- Trial name
- NCT06848985
- Testing
- Aerobic combined with Resistance exercise
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Capital University of Physical Education and Sports, China
Coronary Artery Disease
Vascular Function on the First Day After Cardiac Surgery
This study examines the flow mediated dilation (FMD) of the brachial artery before and after cardiac surgery. FMD is measured with ultrasound technique.
- Trial name
- NCT02001090
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Norwegian University of Science and Technology
Covid19, Physical Disability
Physical Rehabilitation of COVID-19 Survivors by Heat Therapy
Older adults and people with underlying medical conditions are at higher risk for developing serious complications related to SARS-CoV-2 resulting in prolonged sequelae.
- Trial name
- NCT04673318
- Testing
- heat therapy, exercise training
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Amherst
Coronary Artery Disease, Cardiac Surgical Procedures
Does Modified Ultrafiltration Improves Inflammatory Response and Cardiopulmonary Function After CABG Procedures?
The inflammatory response after cardiac surgery increases mortality and morbidity. Modified ultrafiltration (MUF) has been shown to decrease the post-cardiac surgery inflammatory response, to improve respiratory function, and…
- Trial name
- NCT01140113
- Testing
- Modified Ultrafiltration
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Campinas, Brazil