Clinical trials: Cardiogenic Shock, ECMO
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Support
Early LA Venting During Venoaterial ECMO Support
The EVOLVE-ECMO(Early Left Atrial Venting Versus Conventional Treatment For Left VEntricular Decompression During Venoarterial ExtraCorporeal Membrane Oxygenation Support) study is a randomized controlled trial to evaluate the…
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation Support, Refractory Pulmonary Edema
- Trial name
- NCT03740711
- Testing
- Left atrial venting
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Asan Medical Center
Acute Myocardial Infarction, Cardiogenic Shock
Assessment of ECMO in Acute Myocardial Infarction Cardiogenic Shock
Data from case series and large retrospective trials suggest that the early treatment of cardiogenic shock AMI patients with the association of VA-ECMO and IABP may significantly decrease mortality, which is still unacceptably…
- Trial name
- ANCHOR (NCT04184635)
- Testing
- VA-ECMO
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Acute Respiratory Distress Syndrome, Cardiogenic Shock
Study of Immunity Dysfunction Induced by Extracorporeal Assistance (ECMO / ECLS)
Study of immunosuppression biomarkers in patients with ARDS or cardiogenic shock with ECMO / ECLS, compared to patients with ARDS or cardiogenic shock without ECMO / ECLS
- Trial name
- IMPEC (NCT03262155)
- Testing
- Blood test
- Where
- France
- Volunteers
- 18 people
- Sponsor
- Rennes University Hospital
Cardiogenic Shock
A Study on the Effects of Left Ventricular Unloading in the Setting of VA ECMO Support
REMAP ECMO is a registry based platform in which multiple response adaptive randomized clinical trials (trial domains) will be embedded.
- Trial name
- REMAP ECMO (NCT05913622)
- Testing
- Intra-aortic balloon pump
- Where
- 14 sites in Belgium, Netherlands
- Volunteers
- 430 people
- Sponsor
- Erasmus Medical Center
Severe Aortic Stenosis, Cardiogenic Shock
Pre-Emptive LAVA-ECMO for Complex High-Risk TAVR
The goal of this clinical trial is to evaluate the feasibility, effectiveness, and safety of pre-emptive left atrial veno-arterial extracorporeal membrane oxygenation (LAVA-ECMO) in patients undergoing complex and high-risk…
- Conditions
- Severe Aortic Stenosis, Cardiogenic Shock, Cardiogenic Shock, ECMO, Trans-catheter Aortic Valve Implantation
- Trial name
- PROTECT-TAVR (NCT07309029)
- Testing
- Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Atlantic Health System
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
LEVOSIMENDAN to Facilitate Weaning From ECMO in Severe Cardiogenic Shock Patients
In the last decade, venoarterial extracorporeal membrane oxygenation (VA-ECMO) has become the first-line therapy in patients with refractory cardiogenic shock.
- Trial name
- LEVOECMO (NCT04728932)
- Testing
- Levosimendan
- Where
- 3 sites in France
- Volunteers
- 206 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiogenic Shock
Levosimendan Efficacy for Veno-arterial ECMO Weaning: a Retrospective Study
Failure of Weaning from ECMO is a serious complication, reaching an incidence between 29 and 58%. Inotrops are frequently used to help separating patient from ECMO.
- Trial name
- LEVO-ECMO (NCT03346824)
- Where
- France
- Volunteers
- 65 people
- Sponsor
- University Hospital, Strasbourg, France
EMCO-VA
Vaso-inotropic Score and ECMO-VA Support in Post-cardiotomy Cardiogenic Shock.
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is a well-established lifesaving treatment for refractory cardiogenic shock, with or without concomitant respiratory failure.
- Trial name
- ECMOVIS (NCT05412303)
- Testing
- data collection
- Where
- France
- Volunteers
- 2,769 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cardiac Rhythm Disorder
Incidence and Morbidity of Cardiac Rhythm Disorders in Patients Assisted by ECMO-VA for Refractory Cardiogenic Shock
Brief Summary : Rhythm disorders are a frequent and potentially serious complication of critical patients in the ICU and postoperative cardiac surgery.
- Trial name
- CAVA-ECMO (NCT05788120)
- Testing
- Follow up by phone call
- Where
- 20 sites in France
- Volunteers
- 600 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiogenic Shock
Evaluation of Oxiris Membrane as a Treatment for Ischemia-reperfusion Syndrome in Cardiogenic Shock Treated With Extracorporeal Life Support (ECMO/ECLS): A Randomized Pilot Study ECMORIX
The Oxiris membrane is an AN-69 membrane whose surface is treated with polyethyleneimine (PEI) grafted with heparin. This property allows the removal of lipopolysaccharide and cytokines from the blood.
- Trial name
- ECMORIX (NCT04886180)
- Testing
- Oxiris membrane, Prismaflex membrane, Blood tests
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Cardiogenic Shock
Optimal ECMO Flow in the Critical Phase of Cardiogenic Shock to Optimize Peripheral Organ Perfusion and Myocardial Stress
Veno-arterial ECMO (VA ECMO) is considered the ultimate lifesaving technique in refractory cardiogenic shock (CS). However, VA ECMO is associated with potentially serious adverse effects and complications.
- Trial name
- ECMO-FLOW (NCT06936839)
- Testing
- Obversation
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Extracorporeal Membrane Oxygenation Complication
Distal Perfusion Timing, Early or Conservative, to Prevent Limb Ischemia During Peripheral VA-ECMO
Peripheral VA-ECMO is widely used in refractory cardiogenic shock patients as a salvage therapy. In most cases, the femoral artery and vein are used for the vascular approach.
- Trial name
- DECIDE-ECMO (NCT05698628)
- Testing
- Distal perfusion catheterization
- Where
- South Korea
- Volunteers
- 400 people
- Sponsor
- Min-Seok Kim
Extracorporeal Membrane Oxygenation, Septic Shock
ExtraCorporeal Membrane Oxygenation in the Therapy for REfractory Septic Shock With Cardiac Function Under Estimated
The ECMO-RESCUE study is a prospective, multicenter, non-randomized, cohort study. In this study, we aimed to assessed whether VA-ECMO treatment can improve the 30-day survival rate of patients with sepsis-induced refractory…
- Conditions
- Extracorporeal Membrane Oxygenation, Septic Shock, Septic Cardiomyopathy, Cardiogenic Shock
- Trial name
- ECMO-RESCUE (NCT05184296)
- Testing
- Extracorporeal Membrane Oxygenation (ECMO)
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Second Affiliated Hospital of Guangzhou Medical University
Cardiogenic Shock
Venous Oxygen Saturation During ECMO Support
Extracorporeal veno-arterial membrane oxygenation" (ECMO-VA), are used to manage refractory cardiogenic shocks by replacing the failed "heart-lung" block.
- Trial name
- ECMOxygen (NCT04934566)
- Testing
- ECMO flow
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Lille
Acute Respiratory Distress Syndrome, Cardiogenic Shock
Closed Loop Mechanical Ventilation and ECMO
Mechanical ventilation and ECMO are both technologies interacting on gas exchange. Nevertheless, besides a consensus paper, no evidence-based guidelines regarding protective lung ventilation on ECMO exist to date.
- Trial name
- NCT04925518
- Testing
- Closed Loop Mechanical Ventilation, Conventional Mechanical Ventilation
- Volunteers
- 62 people
- Sponsor
- University of Zurich
Cardiogenic Shock
Management of Acute Cardiogenic Shock at the New Brunswick Heart Centre
In Atlantic Canada, acute myocardial infarction occurs at a rate of 2.9 % of the population and is the most common cause of cardiogenic shock (CS).
- Trial name
- Team-Shock (NCT05414643)
- Testing
- Standard care
- Where
- Canada
- Volunteers
- 1,416 people
- Sponsor
- New Brunswick Heart Centre
ECMO, Cardiogenic Shock
The ECMOCYP (cytochromes P450 Activity) Study
Prospective open label observational study including patients requiring a tMCS (VA-ECMO or Impella® CP) or in in cardiogenic shock according to the SCAI (Society for Cardiovascular Angiography and Interventions) ESC (European…
- Conditions
- ECMO, Cardiogenic Shock, Temporary Mechanical Circulatory Support
- Trial name
- NCT06662084
- Testing
- phenotype
- Where
- Switzerland
- Volunteers
- 46 people
- Sponsor
- University Hospital, Geneva
Cardiogenic Shock
PRecision Ecmo in CardIogenic Shock Evaluation
Venoarterial (VA) ECMO is a form of life support for patients with severe cardiogenic shock and cardiac arrest. Although it can be lifesaving, currently many patients still die or have long term disability, such as weakness…
- Trial name
- PRECISE (NCT05748860)
- Volunteers
- 236 people
- Sponsor
- Australian and New Zealand Intensive Care Research Centre
Residual Cardiac Output During PVA-ECMO
Use of Exhaled Carbon Dioxyde for Monitoring the Native Cardiac Function During Mechanical Circulatory Support With Venoarterial By-pass in Intensive Care Unit
Cardiogenic shock, the most severe form of acute heart failure, is a critical situation where the body cells lack of oxygen because of cardiac dysfunction.
- Trial name
- CAPNOECMO (NCT03323268)
- Testing
- PetCO2 monitoring
- Where
- France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Montpellier
Cardiogenic Shock
ExtraCorporeal Membrane Oxygenation in the Therapy of Cardiogenic Shock
Eligible patients with severe cardiogenic shock will be randomized to one of the two arms: immediate ECMO therapy or early conservative therapy.
- Trial name
- ECMO-CS (NCT02301819)
- Testing
- Veno-arterial extracorporeal membrane oxygenation (ECMO), Early conservative therapy according to standard practice
- Where
- 4 sites in Czechia
- Volunteers
- 122 people
- Sponsor
- Na Homolce Hospital