Clinical trials: Cardiogenic Shock, ECMO
Extracorporeal Membrane Oxygenation, Nitric Oxide
Nitric Oxide in Venoarterial Extracorporeal Membrane Oxygenation (VA ECMO)
This pilot study is designed to investigate the effect of inhaled nitric oxide on cardiac, pulmonary artery, and systemic hemodynamics at various time points during venoarterial extracorporeal membrane oxygenation (VA-ECMO)…
- Conditions
- Extracorporeal Membrane Oxygenation, Nitric Oxide, Shock, Cardiogenic
- Trial name
- NOVICE (NCT04224103)
- Testing
- Inhaled nitric oxide
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Filio Billia
ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome)
Ciprofol's Impact on Oxygenator Function in Extracorporeal Membrane Oxygenation (ECMO) Patients
This study evaluates the safety and effectiveness of Ciprofol, a new sedative, in critically ill patients receiving Extracorporeal Membrane Oxygenation (ECMO), a life-support system for heart or lung failure.
- Conditions
- ECMO Treatment, ARDS (Acute Respiratory Distress Syndrome), ECMO and Acute MI, Respiratory Failure Patients Treated With ECMO
- Trial name
- CIP-OXY (NCT06934811)
- Testing
- Ciprofol, Midazolam
- Volunteers
- 30 people
- Sponsor
- First Affiliated Hospital of Wannan Medical College
Cardiogenic Shock, Extracorporeal Life Support
Post-Surgery Extracorporeal Life Support
Extracorporeal Life Support (ECLS) may provide pulmonary and circulatory support for patients with acute heart failure refractory to conventional medical therapy.
- Conditions
- Cardiogenic Shock, Extracorporeal Life Support, Extracorporeal Membrane Oxygenation Complication, Post Cardiac Arrest Syndrome
- Trial name
- PC-ECLS (NCT04330651)
- Testing
- ECLS
- Where
- Italy
- Volunteers
- 500 people
- Sponsor
- University of Florence
Cardiac Arrest, Cardiopulmonary Arrest
ECMELLA vs. ECMO on 30-day Mortality
This international, multicenter cohort study aims to investigate outcomes after treatment with extracorporeal cardiopulmonary resuscitation (eCPR) during cardiac arrest.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest, Extracorporeal Membrane Oxygenation Complication, Cardiogenic Shock
- Trial name
- NCT05175898
- Testing
- VA-ECMO, ECMELLA
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Charite University, Berlin, Germany
Cardiogenic Shock
Establishing Physiologic Outcomes for Ventricular Unloading on VA ECMO
Aim 1: Prospective, observational analysis of the association between echocardiographic measures of cardiac function and left ventricular unloading on VA ECMO.
- Trial name
- NCT05658276
- Where
- 2 sites in United States, Canada
- Sponsor
- University of Utah
Cardiogenic Shock
Optimal ECMO Flow in the Critical Phase of Cardiogenic Shock to Optimize Peripheral Organ Perfusion and Myocardial Stress
Veno-arterial ECMO (VA ECMO) is considered the ultimate lifesaving technique in refractory cardiogenic shock (CS). However, VA ECMO is associated with potentially serious adverse effects and complications.
- Trial name
- ECMO-FLOW (NCT06936839)
- Testing
- Obversation
- Where
- France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Montpellier
Cardiogenic Shock, Post-cardiac Surgery
Pharmacokinetics and Modelling of Beta-Lactam in ECMO-VA Patients
The use of antibiotic therapy is common in intensive care units and primarily involves beta-lactams. Its optimal implementation is made difficult by the pharmacokinetic changes inherent in critically ill patients.
- Conditions
- Cardiogenic Shock, Post-cardiac Surgery, Cardiac Arrest, Extracorporeal Membrane Oxygenation Complication
- Trial name
- KAMELOT (NCT06338345)
- Testing
- Therapeutic drug monitoring of beta-lactam
- Where
- 5 sites in France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Grenoble
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
LEVOSIMENDAN to Facilitate Weaning From ECMO in Severe Cardiogenic Shock Patients
In the last decade, venoarterial extracorporeal membrane oxygenation (VA-ECMO) has become the first-line therapy in patients with refractory cardiogenic shock.
- Trial name
- LEVOECMO (NCT04728932)
- Testing
- Levosimendan
- Where
- 3 sites in France
- Volunteers
- 206 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Normoxemic Versus Hyperoxemic Extracorporeal Oxygenation in Patients Supported by Veino-arterial ECMO for Cardiogenic Shock
Because of dual oxygenation and oxygenator performance (PO2 postoxygenator up to 500 mmHg), hyperoxemia (PaO2 > 150 mmHg) is frequent in veino-arterial ECMO, especially in the lower part of the body, which is mainly oxygenated by…
- Trial name
- ECMOxy (NCT04990349)
- Testing
- Oxygen gas
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Efficacy and Safety of Synchronized Cardiac Support in Cardiogenic Shock Patients
The study aims to investigate the safety and efficacy of the Synchronized Cardiac Support treatment wit the icor kit and the Xenios console with modified sensor box ECG and Software Version 3.2.4
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, ECLS, VA ECMO
- Trial name
- PulseSE (NCT05106491)
- Testing
- Synchronized Cardiac Support with the icor kit
- Where
- 2 sites in Germany
- Volunteers
- 21 people
- Sponsor
- Xenios AG
Cardiogenic Shock, Cardiac Arrest
Outcome of Patients Treated With ECLS
Extracorporeal life support (ECLS), also called extracorporeal membrane oxygenation (ECMO), is an extracorporeal technique of providing effective circulatory and (or) respiratory failure, with a growing number of critically ill…
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Heart Failure, Acute Respiratory Failure
- Trial name
- NCT04405817
- Testing
- ECMO
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Nanjing Medical University
Cardiogenic Shock
CARDSUP - SWISS Circulatory Support Registry
The project's main goal is to collect baseline clinical and procedural data as well as to assess clinical outcomes for all patients undergoing ECMO or Impella implantation at all included sites.
- Trial name
- CARDSUP (NCT04117230)
- Where
- 5 sites in Switzerland
- Volunteers
- 1,500 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Cardiogenic Shock
Venous Oxygen Saturation During ECMO Support
Extracorporeal veno-arterial membrane oxygenation" (ECMO-VA), are used to manage refractory cardiogenic shocks by replacing the failed "heart-lung" block.
- Trial name
- ECMOxygen (NCT04934566)
- Testing
- ECMO flow
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Lille
Cardiogenic Shock, Peripartum Cardiomyopathy
"Treatment Use of ECMO In Pregnancy or Peripartum Patient."
The goal of this study is to describe the use of ECMO (Extracorporeal Membrane Oxygenation) in the pregnant or peripartum patient.
- Conditions
- Cardiogenic Shock, Peripartum Cardiomyopathy, Complication, Pregnancy
- Trial name
- NCT04144660
- Testing
- Extracorporeal Membrane Oxygenation
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Sarah Thordsen
Cardiac Arrest (CA), Cardiogenic Shock
On Scene ECPR in Ostrava
On-scene extracorporeal pulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) seems to speed up the start of extracorporeal membrane oxygenation (ECMO) and shorten low flow during cardiopulmonary resuscitation…
- Trial name
- NCT07374289
- Testing
- Prehospital ECMO cannulation on scene of cardiac arrest, Transfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation
- Where
- 2 sites in Czechia
- Volunteers
- 90 people
- Sponsor
- University Hospital Ostrava
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Effect of Reduced Vasopressors on Mortality in ECMO-supported Cardiogenic Shock Patients
The goal of this observational study is to learn about the association between vasopressor exposure levels and outcomes in adults with cardiogenic shock receiving VA-ECMO.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Vasopressors, Hemodynamic Management
- Trial name
- VREM-CS (NCT06862700)
- Testing
- Vasopressor Exposure Levels
- Where
- China
- Volunteers
- 534 people
- Sponsor
- Xiaotong Hou
Echocardiography, Mechanical Circulatory Support
The Usefulness of Myocardial Work IndeX in ExtraCorporeal Membrane Oxygenation Patients
Investigation of the potential prognostic role of non-invasive myocardial work in patients receiving veno-arterial extracorporeal membrane oxygenation therapy.
- Conditions
- Echocardiography, Mechanical Circulatory Support, Myocardial Failure, Cardiogenic Shock
- Trial name
- MIX-ECMO (NCT05838937)
- Where
- Hungary
- Volunteers
- 100 people
- Sponsor
- Semmelweis University Heart and Vascular Center
Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication
Impact of ECMO Cannula Chlorhexidine-impregnated Dressings to Decrease Extracorporeal Membrane Oxygenation-cannula Related Infection Rate
The Dressing-ECMO trial is a prospective, open-label, multicenter, controlled trial randomizing patients who received percutaneous ECMO to cannula chlorhexidine-impregnated dressing vs standard dressing.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation Complication, Acute Respiratory Distress Syndrome, Infections
- Trial name
- DRESSING-ECMO (NCT05750576)
- Testing
- Chlorhexidine-impregnated dressings, Non impregnated dressings
- Where
- 6 sites in France
- Volunteers
- 270 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cardiogenic Shock
Evaluation of Speckle Tracking Parameters as Predictors of Successful VA SPECKLE ECMO
Purpose of this study is to assess whether measurements obtained through speckle tracking (LV longitudinal and circumferential strain, RV longitudinal strain) can give additional information in identifying patients who develop…
- Trial name
- SPECKLE-ECMO (NCT03532529)
- Testing
- not applicable, it is an observational study
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Acute Kidney Injury, Cardiogenic Shock
Acute Kidney Injury in Adult Patients Supported by VA-ECMO
Post-cardiotomy cardiogenic shock (PCCS) occurs in 2-6% of patients undergoing cardiac surgery, and 1% of cardiac surgery patients will require mechanical circulatory support using Veno-Arterial ExtraCorporeal Membrane…
- Trial name
- AKI-ECMO (NCT04082312)
- Testing
- No intervention
- Where
- France
- Volunteers
- 347 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere