Clinical trials: Cardiogenic Shock
Cardiogenic Shock, Pulmonary Artery Catheter Waveform Interpretation
The Role of Swan-Ganz Catheter in Hemodynamic Resuscitation for Patients With Cardiogenic Shock
This clinical trial examines whether the use of the Swan-Ganz catheter, a specialized pulmonary artery catheter, can improve hemodynamic management and treatment outcomes in patients experiencing cardiogenic shock due to acute…
- Conditions
- Cardiogenic Shock, Pulmonary Artery Catheter Waveform Interpretation, Hemodynamic Management, Hemodynamic Optimization
- Trial name
- NCT07062744
- Testing
- Swan-Ganz IQ Pulmonary Arterial catheter, Swan-Ganz IQ catheter
- Where
- Vietnam
- Volunteers
- 108 people
- Sponsor
- Bach Mai Hospital
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Normoxemic Versus Hyperoxemic Extracorporeal Oxygenation in Patients Supported by Veino-arterial ECMO for Cardiogenic Shock
Because of dual oxygenation and oxygenator performance (PO2 postoxygenator up to 500 mmHg), hyperoxemia (PaO2 > 150 mmHg) is frequent in veino-arterial ECMO, especially in the lower part of the body, which is mainly oxygenated by…
- Trial name
- ECMOxy (NCT04990349)
- Testing
- Oxygen gas
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Right Heart Catheterization
The Nanowear Wearable System SimpleSense Validation Trial for Cardiac Output
The Nanowear SimpleSense study is a single center, prospective, non-randomized, feasibility, non- significant risk study The study will be done in 2 phases.
- Trial name
- NCT05629533
- Testing
- SimpleSense
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Nanowear Inc.
Cardiogenic Shock
Effect of Early Empagliflozin Initiation in Cardiogenic Shock.
Cardiogenic shock represents a severe condition of heart pump dysfunction. Despite advances in medical management, the mortality rate for this condition remains high.
- Trial name
- EMPASHOCKRETRO (NCT07450417)
- Testing
- Patient in cardiogenic shock treated or not early with SGLT2 inhibitors.
- Where
- France
- Volunteers
- 418 people
- Sponsor
- Central Hospital, Nancy, France
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Effect of Reduced Vasopressors on Mortality in ECMO-supported Cardiogenic Shock Patients
The goal of this observational study is to learn about the association between vasopressor exposure levels and outcomes in adults with cardiogenic shock receiving VA-ECMO.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Vasopressors, Hemodynamic Management
- Trial name
- VREM-CS (NCT06862700)
- Testing
- Vasopressor Exposure Levels
- Where
- China
- Volunteers
- 534 people
- Sponsor
- Xiaotong Hou
Cardiogenic Shock, End-stage Heart Failure
ECLS Versus IMPELLA™ as Bridge to LVAD (ECI-BLAD)
In this retrospective observational multicenter study the authors tested the hypothesis that the use of IMPELLA™ pump as bridge to bridge, by giving the opportunity of active rehabilitation, should improve patient's outcomes…
- Trial name
- ECI-BLAD (NCT04480151)
- Testing
- standard of care
- Where
- 5 sites in France
- Volunteers
- 92 people
- Sponsor
- University Hospital, Bordeaux
Cardiogenic Shock, Volume Responsiveness
Volume Responsiveness By Ultrasound Of Carotid Blood Flow In Patients With Cardiogenic Shock
Resuscitation of critically ill patients has changed since the advent of goal directed therapy. Today, practitioners providing fluid resuscitation are attentive of the danger associated with volume depletion while being aware of…
- Conditions
- Cardiogenic Shock, Volume Responsiveness, Ultrasound
- Trial name
- NCT05271227
- Testing
- Transthoracic echocardiography and Carotid artery doppler (PHILIPS HD11 XE ultrasound device) before and after PLR test.
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Alexandria University
Cardiogenic Shock, Cardiac Arrest
Lower Limb Surveillance During VA-ECLS
Temporary cardiac support by VA-ECLS can lead to lower limb ischemia. The aim of this study is to evaluate a multi-modal strategy (physical examination, NIRS monitoring and angiography through the reperfusion canula) of lower…
- Conditions
- Cardiogenic Shock, Cardiac Arrest, Lower Limb Ischemia
- Trial name
- NCT03910062
- Testing
- Lower limb angiography via the reperfusion cannula and NIRS monitoring
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France
Acute Myocardial Infarction
Cyclosporine in Acute Myocardial Infarction Complicated by Cardiogenic Shock
The size of the acute myocardial infarction (AMI) is related to ischemia and injury induced by tissue reperfusion. These reperfusion's injuries can be reduced by injection of cyclosporin A (CsA) at the time of reperfusion.
- Trial name
- CLOTILDE (NCT01901471)
- Testing
- Single bolus of cyclosporine A (CicloMulsion®, Neurovive)
- Where
- 18 sites in France
- Sponsor
- Hospices Civils de Lyon
Acute Coronary Syndrome, Cardiogenic Shock
Left Ventricular Physiological Effects of Veno-Arterial Extracorporeal Membrane Oxygenation Support During Cardiogenic Shock
A Clinical Events Committee (CEC) will include Cardiac Surgery Professor and chief of cardiac surgery Rose Kelly MD, Professor of Medicine Ganesh Raveendran MD at the University of Minnesota who is the direction of Interventional…
- Trial name
- NCT05426083
- Testing
- Physiological Assessment
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Minnesota
Acute Heart Failure (AHF), Cardiogenic Shock
Prolonged Nasogastric Administration of Ketones in Decompensated Heart Failure
This study will evaluate the feasibility and safety of achieving therapeutic concentrations of beta-hydroxybutyrate using continuous infusion of D-beta-hydroxybutyrate monoester administered via a nasogastric tube in patients…
- Conditions
- Acute Heart Failure (AHF), Cardiogenic Shock, Heart Failure, Ketones
- Trial name
- KADHEF-2 (NCT07527156)
- Testing
- Ketone Monoester (KE)
- Where
- Czechia
- Volunteers
- 12 people
- Sponsor
- Institute for Clinical and Experimental Medicine
Severe Aortic Stenosis, Cardiogenic Shock
Pre-Emptive LAVA-ECMO for Complex High-Risk TAVR
The goal of this clinical trial is to evaluate the feasibility, effectiveness, and safety of pre-emptive left atrial veno-arterial extracorporeal membrane oxygenation (LAVA-ECMO) in patients undergoing complex and high-risk…
- Conditions
- Severe Aortic Stenosis, Cardiogenic Shock, Cardiogenic Shock, ECMO, Trans-catheter Aortic Valve Implantation
- Trial name
- PROTECT-TAVR (NCT07309029)
- Testing
- Left Atrial Veno-Arterial Extracorporeal Membrane Oxygenation (LAVA-ECMO)
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Atlantic Health System
Cardiogenic Shock, Bradycardia
Augmented Pacing for Shock in the Cardiac Intensive Care Unit
The goal of this clinical trial is to learn if backup pacing at an increased rate improves hemodynamics in adults with relative bradycardia, a permanent pacemaker, and cardiogenic shock.
- Conditions
- Cardiogenic Shock, Bradycardia, Shock
- Trial name
- NCT06713668
- Testing
- Backup Pacing Rate Change
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Vanderbilt University Medical Center
Acute Myocardial Infarction Complicated With Cardiogenic Shock, Mild Therapeutic Hypothermia
Evaluation of MTH in PCI Under VA-ECMO for AMICS
This study is a randomized controlled trial conducted at Beijing Anzhen Hospital, Capital Medical University. The primary objective is to assess the efficacy of mild therapeutic hypothermia in reducing infarct size and improving…
- Conditions
- Acute Myocardial Infarction Complicated With Cardiogenic Shock, Mild Therapeutic Hypothermia, Venous-arterial Extracorporeal Membrane Oxygenation
- Trial name
- HOPE-CS (NCT07186972)
- Testing
- Mild therapeutic hypothermia
- Volunteers
- 44 people
- Sponsor
- Beijing Anzhen Hospital
VA-ECMO for Postcardiotomy Cardiogenic Shock
Timing of VA-ECMO Support During or After Cardiac Surgery
Some patients develop severe heart failure during or after cardiac surgery and require temporary support for circulation and oxygenation.
- Trial name
- NCT07873034
- Where
- Slovakia
- Volunteers
- 128 people
- Sponsor
- National Institute of Cardiovascular Diseases, Slovakia
Takotsubo Syndrome
Italian Multicenter Observational Registry on Takostubo Syndrome
Takotsubo syndrome (TTS) has recently been described as an acquired form of cardiomyopathy whose pathophysiology is not yet well understood and mainly affects postmenopausal women.
- Trial name
- TIN (NCT06643949)
- Testing
- Echocardiography
- Volunteers
- 1,500 people
- Sponsor
- University of Molise
Cardiogenic Shock
The Safety and Efficacy of Istaroxime for Pre-Cardiogenic Shock
This is a pilot, multinational, randomized, double-blind, placebo-controlled, 2-part safety and efficacy study. Subjects will consist of patients hospitalized for acute decompensated heart failure with persistent hypotension.
- Trial name
- SEISMiC (NCT04325035)
- Testing
- Istaroxime
- Where
- 13 sites in United States, Argentina and 2 more
- Volunteers
- 90 people
- Sponsor
- Windtree Therapeutics
Cardiogenic Shock
Effects of Induced Moderate HYPOthermia on Mortality in Cardiogenic Shock Patients Rescued by Veno-arterial ExtraCorporeal Membrane Oxygenation (ECMO)
A multicenter, prospective, controlled, randomized (moderate hypothermia 33°C≤ T°C ≤34°C) during 24 hours ± 1h versus normothermia (36°C≤ T°C ≤37°C), comparative open trial will be conducted on two parallel groups of patients…
- Trial name
- HYPO-ECMO (NCT02754193)
- Testing
- moderate hypothermia
- Where
- 20 sites in France
- Volunteers
- 334 people
- Sponsor
- Central Hospital, Nancy, France
Aortic Stenosis, Cardiogenic Shock
Transcatheter AortiC Valve Implantation in aorTic stenosIs CardiogenIc Shock
The goal of this clinical trial is to learn if acute transcatheter aortic valve implantation (TAVI) is superior to standard treatment (stabilization in an intensive care unit and TAVI subsequently) to treat cardiogenic shock in…
- Trial name
- TACTICS (NCT06638268)
- Testing
- Acute TAVI, Stabilization and subacute TAVI
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Cardiogenic Shock
Norepinephrine vs Norepinephrine and Dobutamine in Cardiogenic Shock
Cardiogenic shock is a frequent cause of admission and death in the intensive care unit. Mortality is about 50%. Once the etiologic treatment has been done, for instance coronary revascularization, management of the shock state…
- Trial name
- SHOCK-NORDOB (NCT03340779)
- Testing
- Norepinephrine
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Central Hospital, Nancy, France