Clinical trials: Cardiology, open to volunteers
Symptom Tracking, Cardiology
AI-CLINIC: A Prospective Multisite Feasibility and Safety Study of AI-Assisted Pre-Consultation History-Taking in Outpatient Cardiology
An accurate medical diagnosis depends on the doctor getting a complete picture of the patient's health story, but clinic visits are short.
- Conditions
- Symptom Tracking, Cardiology, Medical History Taking
- Trial name
- AI-CLINIC (NCT07883304)
- Testing
- AI Interview
- Volunteers
- 60 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Coronary Artery Disease, High Risk Percutaneous Coronary Intervention
Pivotal Study of the SUpira System in Patients Undergoing High-Risk Percutaneous COronaRy InTervention (HRPCI)
The objective of this study is to assess the safety and efficacy of the Supira System in providing temporary cardiovascular hemodynamic support in patients undergoing HRPCI.
- Conditions
- Coronary Artery Disease, High Risk Percutaneous Coronary Intervention, Interventional Cardiology, Mechanical Circulatory Support
- Trial name
- SUPPORT II (NCT07296744)
- Testing
- The Supira System, Impella
- Where
- 25 sites in United States
- Volunteers
- 358 people
- Sponsor
- Supira Medical
Paroxysmal Atrial Fibrillation, Pulsed Field Ablation
Pulsed Field Ablation for Paroxysmal Atrial Fibrillation: Clinical Efficacy and Left Atrial Function Protection
This is a prospective clinical study aiming to evaluate the clinical efficacy and safety of a novel domestic pulsed field ablation (PFA) system in the treatment of paroxysmal atrial fibrillation (PAF), and to specifically assess…
- Conditions
- Paroxysmal Atrial Fibrillation, Pulsed Field Ablation, Catheter Ablation, Left Atrial Function
- Trial name
- NCT07865221
- Testing
- Novel Pulsed Field Ablation System, Radiofrequency Ablation Catheter
- Where
- China
- Volunteers
- 220 people
- Sponsor
- Tianjin Medical University General Hospital
Cardiology, Pediatric Cardiac Surgery
PULSE - Patient Understanding and Learning Through Structured Education - Effectiveness and Implementation of Patient Education Videos in a New Pediatric Cardiology Clinic
This study is looking at whether short educational videos shown during pediatric cardiology visits can help families better understand their child's condition while also making clinic visits run more efficiently.
- Conditions
- Cardiology, Pediatric Cardiac Surgery, Education, Patient Education
- Trial name
- PULSE (NCT07594041)
- Testing
- Room-based educational video: Murmur, Chest Pain, Room-based educational video: Syncope, Palpitations, Room-based educational video: Sports Clearance, Kawasaki, General
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Driscoll Children's Hospital
Preventive Cardiology, Respiration Disorders
"ADEN Platform: Pilot Clinical Validation for Chronic Disease Risk Stratification in Colombia"
This protocol describes a 90-day prospective pilot study designed to validate the capacity of the ADEN clinical intelligence platform to stratify early chronic disease risk across six priority public health profiles in Colombia.
- Conditions
- Preventive Cardiology, Respiration Disorders, Oncologic Disease, Autoimmune
- Trial name
- VALIDATES (NCT07727915)
- Testing
- Molecular Target
- Where
- Colombia
- Volunteers
- 120 people
- Sponsor
- Unidad de Investigación Genética Molecular
VSD, Pediatric Cardiology
Follow-up After Percutaneous Device Closure of Ventricular Septal Defects
Ventricular septal defects (VSDs) are the most common congenital heart defects, accounting for 30-40% of congenital cardiac anomalies.
- Trial name
- NCT07715032
- Testing
- • Amplatzer™ Ductal Occluder (ADO) • Amplatzer™ Muscular VSD Occluder • Amplatzer™ Membranous VSD Occluder
- Volunteers
- 85 people
- Sponsor
- Assiut University
Quality of Life, Cardiology
Implementation of a System to Measure the Quality of Life of Patients and Caregivers: a First Experiment in Cardiology at the Clermont-Ferrand University Hospital
Objectives: Measure the quality of life score in the post-interventional care pathway for patients with cardiology, using the EQ-5D-5L; measure caregivers' feelings about their work using the SAPHORA-Job; testing the feasibility…
- Trial name
- QALY-SATIS (NCT07680270)
- Testing
- quality of life questionnaire
- Where
- France
- Volunteers
- 1,124 people
- Sponsor
- University Hospital, Clermont-Ferrand
Artifical Inteligence, Cardiology
Safe and Explainable AI
While current AI technology is suitable for automating some repetitive clinical tasks, technical challenges remain in solving critical and gainful problems in the domains of patient and disease management.
- Conditions
- Artifical Inteligence, Cardiology, Breast Cancer, Sepsis
- Trial name
- NCT06694181
- Testing
- AI-PERSONALIZED CLINICAL DECISION SUPPORT
- Where
- United States
- Volunteers
- 300,000 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Tricuspid Regurgitation, Heart Failure
Biventricular Remodeling in Transcatheter Tricuspid Valve Replacement - Acute Hemodynamic Instability Study
TTVR-AHI is a multicenter, retrospective registry including heart failure patients displaying a severe and symptomatic tricuspid regurgitation (TR), deemed non-eligible to cardiac surgery and therefore treated with transcatheter…
- Conditions
- Tricuspid Regurgitation, Heart Failure, Structural Heart Disease, Interventional Cardiology
- Trial name
- TTVR-AHI (NCT06954792)
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Columbia University
Heart Failure, Structural Heart Disease
Pressure-Volume Loop Assessment in Valvular Heart Disease
The VHD PV loop study intends to assess invasive right ventricular to pulmonary artery (RV-PA) coupling in patients with valvular heart disease (VHD).
- Conditions
- Heart Failure, Structural Heart Disease, Interventional Cardiology
- Trial name
- VHD-PV-loop (NCT07112391)
- Testing
- Observational Invasive Hemodynamic Assessment
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Nantes University Hospital
High Bleeding Risk Patients, Cardiology
Dual Anti-Platelet Optimized Stent for High Bleeding Risk Patient
High risk of bleeding (HBR) is a determining factor for the duration of dual antiplatelet therapy (DAPT). Recent studies have shown that the use of one-month DAPT is beneficial in terms of ischemic as well as hemorrhagic events…
- Conditions
- High Bleeding Risk Patients, Cardiology, Stent Implantation, DAPT(Dual Antiplatelet Therapy)
- Trial name
- DIOHR (NCT07140133)
- Where
- France
- Volunteers
- 1,200 people
- Sponsor
- University Hospital, Grenoble
Emergency Medical Services, Nursing Care
High-Sensitivity Troponin I in Addition to Guideline-Based Care in EMS
The TIGER study is a study investigating the utlility of a point-of-care blood analyse of Troponin I to help identify patients with heart attacks in the prehospital emergency care.
- Conditions
- Emergency Medical Services, Nursing Care, Cardiology, Myocardial Infarction
- Trial name
- TIGER (NCT07008391)
- Testing
- high sensitivity Troponin I
- Where
- Sweden
- Volunteers
- 1,419 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Hypertrophic Cardiomyopathy (HCM), Cardiomyopathy
Large Language Models To Improve the Quality of Care of Cardiology Patients
This study evaluates the impact of large language models (LLMs) versus traditional decision support tools on clinical decision-making in cardiology.
- Conditions
- Hypertrophic Cardiomyopathy (HCM), Cardiomyopathy, Genetic Disease, Cardiology
- Trial name
- NCT06935253
- Testing
- Large Language Model
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Stanford University
Genetic Disease, Cardiac Disease
Utility of Gene Test Analysis for Diagnosis, Prognosis and Treatment of Patients With Genetic Arrhythmic Heart Disease: the ARRHYTHMIC GENE-HEART
The goal of this observational study is to enroll all patients evaluated at the specialized Cardiogenetic Center within the Cardiology Department of the University of Ferrara, Italy.
- Conditions
- Genetic Disease, Cardiac Disease, Cardiac Arrhythmias, Genetic Disorder
- Trial name
- NCT06898307
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- University Hospital of Ferrara
Hypertension, Essential, Cardiovascular Diseases
Efficacy and Safety of SPC1001 in Patients With Essential Hypertension
Objective: This study aims to evaluate the safety and efficacy of the fixed-dose triple combination therapy (SPC1001) of candesartan, amlodipine, and indapamide in adult patients with essential hypertension compared to…
- Conditions
- Hypertension, Essential, Cardiovascular Diseases, Cardiology
- Trial name
- NCT06826872
- Testing
- SPC 1001 Mid2, SPC 2002, SPC 2003
- Where
- South Korea
- Volunteers
- 252 people
- Sponsor
- Shin Poong Pharmaceutical Co. Ltd.
Acute Coronary Syndrome, Interventional Cardiology
Ticagrelor With Low-dose Versus Regular Aspirin in Patients With Acute Coronary Syndrome (ACS) at High-Risk for Ischemia After Percutaneous Coronary Intervention
The present study is aimed to compare the safety and efficacy of Ticagrelor with low-dose Aspirin versus standard dual anti-platelet therapy (DAPT) in patients with acute coronary syndrome (ACS) at high risk for ischemic events…
- Trial name
- LD-ASPIRIN (NCT04240834)
- Testing
- Aspirin, Ticagrelor
- Where
- China
- Volunteers
- 1,220 people
- Sponsor
- Fu Wai Hospital, Beijing, China
Sports Cardiology, Preventive Cardiology
Deep Learning ECG Evaluation and Clinical Assessment for Competitive Sport Eligibility
The goal of this observationl study is to evaluate the possibility of building a Deep Learning (DL) model capable of analyzing electrocardiographic traces of athletes and providing information in the form of a probability…
- Conditions
- Sports Cardiology, Preventive Cardiology, Electrocardiogram, Artificial Intelligence
- Trial name
- VALETUDO (NCT06285084)
- Where
- Italy
- Volunteers
- 531 people, healthy volunteers welcome
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Cardiology, Coronary Artery Disease
Screening Of CoRonary ArTEry diSease
This study is a randomized trial with the objective of comparing the cost-effectiveness of the 2 recommended strategies: CCTA vs functional tests, allowing the evaluation of the quality of life of these patients in relation to…
- Trial name
- SOCRATES (NCT05369728)
- Testing
- Coronary CT in 1st line compared to the strategy with functional test in 1st line in patient at Intermediate Risk of Developing Stable Coronary Disease:
- Volunteers
- 800 people
- Sponsor
- University Hospital, Grenoble
Interventional, Cardiology
France PCI Registry : National Observatory of Interventional Cardiology
Rigorous clinical practice assessment is a key factor to improve patient's care and prognosis in interventional cardiology (IC).
- Conditions
- Interventional, Cardiology, Angioplasty, Coronary
- Trial name
- NCT02778724
- Where
- 15 sites in France
- Volunteers
- 40,000 people
- Sponsor
- Club Régional des Angioplasticiens de la région Centre