Clinical trials: Cardiometabolic Conditions
Healthy
Effect of Herbs and Spices on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study is to investigate how herbs and spices affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective appetite…
- Trial name
- AFC-SPICES (NCT02035241)
- Testing
- Spices 1, Spices 2, Spices 3
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lund University
Obesity
Outcomes of Circuit Training and Low Carbohydrates Diet in the Young Obese Male in KSA
Obesity is one of the common public problems that its prevalence increase incredibly in the last three decades in KSA. Thirty obese males aged 20 to 39 years will participate in the study.
- Trial name
- NCT04794309
- Testing
- Circuit training exercise, Healthy high Fiber diet
- Where
- Saudi Arabia
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Majmaah University
Resistant Hypertension, Primary Aldosteronism
Prospective Study on Primary Aldosteronism in Resistant Hypertension
Prevalence of primary aldosteronism (PA) in resistant hypertension is not clear. In addition, emerging evidence supports the role of elevated serum aldosterone in promoting cardiovascular disease, independently from high blood…
- Conditions
- Resistant Hypertension, Primary Aldosteronism, Refractory Hypertension, Hypertensive End-Organ Damage
- Trial name
- PrePARe (NCT04213963)
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Turin, Italy
Overweight and Obesity
Intermittent Fasting Compared to Continuous Energy Restriction on Body Weight Loss
Obesity remains a major public health challenge. Intermittent fasting continues to gain popularity compared to continuous energy restriction as a weight-loss approach for cardiometabolic health.
- Trial name
- NCT04526847
- Testing
- Intermittent energy restriction (IER) : 5:2 diet pattern, Continuous energy restricted (CER) group
- Where
- Nepal
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Armed Police Force Hospital, Nepal
Obesity and Overweight, Pre-diabetic
Targeted Precision Nutrition Strategy To Prevent Chronic Metabolic Diseases
Nutrition is very important to keep blood sugar levels balanced. If blood sugar levels are too high, it can lead to diseases such as cardiovascular disease and type 2 diabetes (T2DM).
- Conditions
- Obesity and Overweight, Pre-diabetic, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- PRECINUT (NCT06923644)
- Testing
- Optimal Metabotype-specific diet, Sub-optimal diet
- Where
- 2 sites in Netherlands
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obesity, Central Obesity
The Effects of Low Glycemic Index (GI) Diet on Cardiometabolic Outcomes Among Obese Chinese Adults
The aim of this study is to investigate the effects and the acceptability of low GI diet versus a conventional healthy diet on the BMI and other cardiometabolic risk factors of obese Chinese adults in Hong Kong.
- Trial name
- NCT04152213
- Testing
- Low GI diet
- Where
- Hong Kong
- Volunteers
- 166 people
- Sponsor
- Chinese University of Hong Kong
Obesity
The Effect of Methylsulfonylmethane (MSM) on Cardiometabolic Health
Obesity- related diseases are linked to elevated levels of inflammation, oxidative stress, and metabolic dysfunction. Methylsulfonylmethane (MSM) is a naturally occurring compound that demonstrates antioxidant and…
- Trial name
- NCT03716791
- Testing
- methylsulfonylmethane
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Lindsey Miller
Cardiometabolic Risk, Weight Loss
Effects of Caloric Restriction and Exercise on Body Weight, Immune Function, and Intestinal Flora
The purpose of this study is to estimate the effects of caloric restriction and exercise on body weight, cardiovascular metabolic markers, immune function, and intestinal flora among college students, as well as the underlying…
- Conditions
- Cardiometabolic Risk, Weight Loss, Immune System, Intestinal Microbiome
- Trial name
- NCT04275440
- Testing
- Exercise, Caloric restriction
- Where
- China
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction
Personalized GI Motility Responses to Diet
The goal of this randomized, crossover, clinical trial is to link: 1) gastrointestinal motility patterns induced by acute consumption of whole and refined grains, 2) enteric microbial production of bioactive metabolites, and 3)…
- Conditions
- Nutritional and Metabolic Diseases, Gastrointestinal Dysfunction, Cardiovascular Diseases, Dysbiosis
- Trial name
- NCT06386471
- Testing
- Whole grain rye bread, Refined grain rye bread
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Urbana-Champaign
Polyps, Cardiovascular Diseases
Lifestyle and Dietary Pattern in Relation to Precursor Lesions of Colorectal Cancer and Cardiometabolic Diseases
The association between lifestyle and dietary patterns with precursor lesions of colorectal cancer and cardiometabolic diseases is still unclear.
- Trial name
- NCT03708952
- Where
- 2 sites in China
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Overweight and Obesity, Vitamin D Deficiency
Magnesium and Vitamin D Supplementation and Cardiometabolic Outcomes
The purpose of this study is to investigate the effects of a combined vitamin D and magnesium supplementation on parathyroid hormone and cardiometabolic health in persons living with obesity.
- Conditions
- Overweight and Obesity, Vitamin D Deficiency, Magnesium Deficiency, Cardiovascular Risk Factor
- Trial name
- NCT03134417
- Testing
- Vitamin D and magnesium, Vitamin D
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Drexel University
Sarcopenia, Collagen Degeneration
Effects of Whey Protein Supplementation Collagen Associated to Resistance Training in Older Woman
The main purpose of the present study was to investigate the effects of whey protein with collagen hydrolyzed following resistance training on body composition, muscular strength, functional capacity, and plasma-metabolism…
- Trial name
- NCT04621383
- Testing
- Whey protein plus collagen, Whey protein plus maltodextrin
- Where
- Brazil
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Overweight (BMI > 25), Obesity &Amp; Overweight
Effects of Three Dietary Strategies on Body Composition and Metabolic Health in Adults With Overweight or Obesity
This study aims to compare the effects of three dietary interventions-a traditional Mediterranean diet, a Mediterranean low-carbohydrate diet, and a high-protein diet-on body composition, metabolic health markers, and metabolic…
- Conditions
- Overweight (BMI > 25), Obesity &Amp; Overweight, Metabolic Syndrome (MetS), Cardiometabolic Risk Factors
- Trial name
- NCT07314177
- Testing
- Mediterranean Diet, Mediterranean Low-Carbohydrate Diet, High-Protein Diet
- Where
- Spain
- Volunteers
- 45 people
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Obesity & Overweight, Perimenopausal Women
Prebiotic Inulin for Late-Reproductive Individuals
This study aims to evaluate the effects of 2 weeks of inulin supplementation in perimenopausal women with overweight or obesity. The primary questions this study seeks to answer are: 1.
- Conditions
- Obesity & Overweight, Perimenopausal Women, Prebiotics, Inulin
- Trial name
- PILI (NCT07724522)
- Testing
- Inulin
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- George Washington University
Food Insecurity, Dietary Quality
Enjoying Affordable and Tasty Food Together
The goal of this pilot study is to examine the feasibility of a novel meal kit and nutrition education intervention among adults aged 40 years and older, who are lower income, and to evaluate the preliminary impact of the meal…
- Conditions
- Food Insecurity, Dietary Quality, Quality of Life, Cooking Self-efficacy
- Trial name
- PROJECT EATT (NCT07036757)
- Testing
- Meal Kit and Nutrition Education
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Massachusetts, Lowell
Obesity, Polycystic Ovary Syndrome
Heat Therapy and Cardiometabolic Health in Obese Women
Traditional medical treatments are often based on research done exclusively in males, and recent research efforts in the physiology community have highlighted critical sex differences in disease presentation and progression.
- Conditions
- Obesity, Polycystic Ovary Syndrome, Prehypertension, PreDiabetes
- Trial name
- CMH (NCT03644524)
- Testing
- Heat therapy
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Oregon
Obesity, Dyslipidemia
Reduction of Sweetened Beverages and Intrahepatic Fat
The study will enroll 68 overweight male and female subjects with a high (> 2 3dl-can soda/day) consumption of sweetened beverage per day.
- Conditions
- Obesity, Dyslipidemia, Metabolic Syndrome
- Trial name
- REDUCS (NCT01394380)
- Testing
- artificially sweetened sodas
- Where
- Switzerland
- Volunteers
- 29 people
- Sponsor
- University of Lausanne
Overweight and Obesity
Paleo Diet 8wk Feasibility in Overweight Adults
Overweight, physically inactive but otherwise healthy adults habitually eating a traditional Western diet will follow an ad libitum self-administered Paleo diet for 8-weeks.
- Trial name
- NCT03814473
- Testing
- Diet
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Houston
Overweight and Obesity, Dyslipidemias
Reducing Circulating Sphingolipid Levels to Optimise Cardiometabolic Health - The SphingoFIT Trial
The purpose of this study is to assess the effects of an 8-week supervised high-intensity interval training (HIIT) program (vs. physical activity recommendations according to current guidelines) on a comprehensive panel of…
- Conditions
- Overweight and Obesity, Dyslipidemias, Blood Pressure, Cardiovascular Diseases
- Trial name
- SphingoFIT (NCT06024291)
- Testing
- 8-week HIIT programme, Physical activity recommendation
- Where
- Switzerland
- Volunteers
- 88 people
- Sponsor
- University of Basel
Hypertension, Gut Dysbiosis
The Effects of a Commercially Available Synbiotic on the Gut Microbiome and Cardiometabolic Health
The purpose of this study is to see the effect of 30 days of synbiotic vs. probiotic supplementation (usingJuice+ nutrition products) on body weight, metabolism, cardiovascular health, and gut health.
- Conditions
- Hypertension, Gut Dysbiosis, Overweight , Obesity
- Trial name
- NCT07515443
- Testing
- Synbiotic
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Southern Utah University