Clinical trials: Cardiometabolic Conditions
Overweight and Obesity
Circadian Timing, Information Processing and Energy Balance Study
This study design will test biological and behavioral mechanisms in the cross-sectional analyses and determine the prospective effects of circadian alignment and sleep on changes in cardiometabolic risk factors.
- Trial name
- TIME (NCT04759755)
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Utah
Obesity
NMES Plus Hypocaloric Diet: Body Composition, Cardiometabolic Markers, Irisin and Betatrophin in Women With Obesity
This randomized controlled trial evaluated whether adding localized neuromuscular electrical stimulation (NMES) to an individualized hypocaloric diet changes serum irisin and betatrophin (ANGPTL8) concentrations, body composition…
- Trial name
- NCT07675382
- Testing
- Hypocaloric Diet, Neuromuscular Electrical Stimulation (NMES)
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Firat University
Paraplegia
High-intensity Interval Training for Cardiometabolic Health in Persons With Spinal Cord Injury
Persons with chronic paraplegia at an increased risk of developing cardiovascular disease and type-2 diabetes compared to the able-bodied population.
- Trial name
- NCT04397250
- Testing
- High-intensity interval training
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Bath
Overweight, Obesity
Meta-analyses of the Effect of Liquid Meal Replacements on Cardiometabolic Risk
Obesity is a major risk factor for cardiovascular disease and diabetes. Weight loss is an important therapeutic goal for overweight and obese patients to reduce their risk of developing cardiovascular disease and diabetes.
- Conditions
- Overweight, Obesity, Type 2 Diabetes
- Trial name
- NCT02779790
- Testing
- Liquid Meal Replacements
- Where
- Canada
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- John Sievenpiper
Inflammation, Obesity
Inflammatory Resolution in Cardiometabolic Health and Disease
The specific aim of this study is to determine molecular pathways that differentiate metabolically healthy vs unhealthy human phenotypes, and to investigate the therapeutic potential of pro-resolving lipids.
- Conditions
- Inflammation, Obesity, Cardiovascular Diseases
- Trial name
- RESOLVE AU (NCT06390189)
- Where
- Denmark
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Obesity and Overweight, Hypertriglyceridaemia
Comparison of Cardiometabolic Markers in Individuals With Hypertriglyceridemia With Low and High Weight Loss Responses to an Energy-restricted Diet
Total RNA is extracted from isolated white blood cells, and cDNA is synthesized from these samples. Subsequently, the expression levels of the SIRT1 and leptin receptor genes are determined through quantitative PCR.
- Trial name
- NCT07012226
- Testing
- Low-calorie diet
- Where
- Iran
- Volunteers
- 60 people
- Sponsor
- Shahid Beheshti University of Medical Sciences
Overweight and Obesity, Metabolic Syndrome
Effects of Concurrent HIIT and WB-EMS Exercise on the Cardiometabolic Risk Profile in Obese Individuals
The main purpose of this study is to compare the impact of concurrent high-intensity interval training (HIIT) and whole-body electromyostimulation exercise (WB-EMS) or low-volume conventional strength training (CST) on the…
- Trial name
- NCT03710447
- Testing
- HIIT + WB-EMS, WB-EMS + HIIT, HIIT + CST
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Bipolar Youth Treated With Second-generation Antipsychotics
SGA-induced Metabolic Syndrome in Bipolar Youth
The investigators tested the hypothesis that long-chain omega-3 (LCn-3) fatty acid supplementation will attenuate the adverse cardiometabolic effects of second-generation antipsychotics exposure in first-episode adolescent manic…
- Trial name
- NCT01858948
- Testing
- Omega, Quetiapine fumarate
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Cincinnati
Type 2 Diabetic Patients
The Effect of DASH Diet on the Cardiometabolic Risks and Hepatic Function Among Type 2 Diabetic Patients
The investigators are not aware of any study regarding the effect of DASH eating pattern on different cardiovascular risks among type 2 diabetic patients.
- Trial name
- NCT01049321
- Testing
- DASH diet, a usual diabetic diet
- Where
- Iran
- Volunteers
- 36 people
- Sponsor
- Isfahan University of Medical Sciences
Prediabetes, Obesity / Overweight
Very-Low-Carbohydrate Diet for Prediabetes and Obesity
Prediabetes is a condition where blood sugar is higher than normal but not yet high enough to be called type 2 diabetes. It is common in adults who are overweight or obese, and without treatment it often progresses to diabetes…
- Conditions
- Prediabetes, Obesity / Overweight, VERY LOW CARBOHYDRATE DIET
- Trial name
- VLCBD (NCT07830121)
- Testing
- Standard Dietary Advice, Very-Low-Carbohydrate Diet (VLCBD)
- Where
- Malaysia
- Volunteers
- 33 people
- Sponsor
- Universiti Teknologi Mara
Coronary Artery Disease, Type 2 Diabetes Mellitus (T2DM)
Effects of Fecal Microbiota Transplantation in Patients With Type 2 Diabetes and Coronary Artery Disease (CAD-Microbiome) - A Pilot Study
This pilot study investigates whether fecal microbiota transplantation (FMT) can modify the gut microbiome in patients with type 2 diabetes mellitus and stable coronary artery disease (CAD).
- Trial name
- CAD-Microbiome (NCT07421947)
- Testing
- Fecal Microbiota Transplantation
- Where
- Switzerland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Zurich
Cognitive Impairment, Mild, Memory Impairment
Effect of Nordic Berries on Cognitive Function, Cardiometabolic Risk Markers and Gut Microbiota in Adults With Mild Cognitive Impairment
The aim of the current study is to investigate whether daily intake of Nordic berries for 12 weeks can improve cognitive abilities of adults with mild cognitive impairment, and whether the effect can be linked to changes in…
- Trial name
- MINDBERRY (NCT04317612)
- Testing
- Active berry product, Reference product
- Where
- 2 sites in Sweden
- Volunteers
- 96 people
- Sponsor
- Region Skane
Osteopenia, Cardiometabolic Conditions
Effects of Resistance Exercise Compared to Whole-body Electromyostimulation in Young Female Dentists.
Due to their high workload and unfavorable working position, young female dentists are particularly at risk of cardiometabolic diseases and an early reduction in bone mineral density (BMD).
- Trial name
- FeDeBoMa (NCT06813092)
- Testing
- Whole-Body Electromyostimulation, Resistance exercise
- Where
- 2 sites in Germany
- Volunteers
- 16 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Diabetes Mellitus, Cardiovascular Disease
Links Between Inflammation and Cardiometabolic Diseases
Background: Cardiometabolic diseases are a combination of medical disorders that, when they occur together, increase the risk of heart disease and diabetes.
- Conditions
- Diabetes Mellitus, Cardiovascular Disease, Healthy Volunteer, Inflammation
- Trial name
- NCT01934660
- Testing
- 13N-amonia, Fludeoxyglucose F18
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Cardiometabolic Risk Factors, Inflammation
FILIP: Fat Intake, Inflammation and LIPids
Low-grade inflammation is involved in the pathogenesis of type 2 diabetes and cardiovascular disease. Increasing evidence suggests that dietary intake may be involved in the inflammatory process.
- Conditions
- Cardiometabolic Risk Factors, Inflammation, Microbiota
- Trial name
- FILIP (NCT06640036)
- Testing
- Rapeseed oil, Butter, Coconut oil
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Morbid Obesity
Dairy Lipids and Cardiometabolic Risk
It is a randomized parallel arm intervention study in adults with severe obesity. The objective is to demonstrate that within a dietary handling for weight loss, the daily ingestion during 3 months of whole dairy products…
- Trial name
- DAILICATE (NCT05783466)
- Testing
- Low-fat dairy products, Whole-fat dairy products, Milk polar lipid enriched whole-fat dairy products
- Where
- 2 sites in France
- Volunteers
- 75 people
- Sponsor
- Hospices Civils de Lyon
Obesity, Time Restricted Feeding
Time Restricted Feeding on Weight Loss and Cardio-protection (TREATY Trial)
Time restricted feeding (TRF) is a novel type of intermittent calorie restriction diet that involves eating a daily period of 8 hours or less.
- Conditions
- Obesity, Time Restricted Feeding, Weight Loss, Calorie Restriction
- Trial name
- TREATY (NCT03745612)
- Testing
- Time restricted feeding, Continuous Energy Restriction
- Where
- China
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Overweight and Obesity, Cognitive Change
Acute Effects of Exercise Combined With Ketone Ester Supplement
To examine the acute changes in cardiometabolic and neurocognitive outcomes in response to exercise combined with ketone ester supplement in overweight/obese adults.
- Conditions
- Overweight and Obesity, Cognitive Change, Ketoses, Metabolic
- Trial name
- NCT06365957
- Testing
- Ketone monoester supplementation, High-intensity interval exercise, Moderate-intensity continuous exercise
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Macau
Overweight or Obesity, Metabolic Syndrome
Fermented Dairy Products and The Metabolic Syndrome
The study will be conducted as a randomized controlled trial with four parallel arms including four dairy products. We will investigate the health effects of including yogurt in the diet through a 16-weeks intervention period…
- Trial name
- FerMetS (NCT04755530)
- Testing
- Regular whole milk, Yogurt with live bacteria, Yogurt with inactivated bacteria
- Where
- Denmark
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Faidon Magkos
Obesity, Metabolic Syndrome
Noninvasive Biomarkers for Monitoring Cardiometabolic Risk in Children
The purpose of this study is to identify salivary biomarkers for monitoring cardiometabolic risk in children. The study hypothesis is that a combination of salivary biomarkers will predict the presence of risk factors including…
- Trial name
- NCT01465789
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- West Virginia School of Osteopathic Medicine