Clinical trials: Cardiometabolic Diseases
Cardiometabolic Disease
Single and Multiple Ascending Dose Study of AMG 513 in Participants With Obesity
The primary objective of this study is to assess the safety and tolerability of AMG 513 after single and multiple doses.
- Trial name
- NCT06585462
- Testing
- AMG 513
- Where
- 13 sites in United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Amgen
Overweight and Obesity, Dyslipoproteinemia
Effect of Weight Management Programs on Cardiometabolic Risk Profile in Overweight Women
Aim of this prospective randomized study was to evaluate whether a diet with meal replacements can be as effective as a conventional energy-restricted modified diet on weight loss, body composition and cardiometabolic risk…
- Trial name
- FM-01 (NCT03109834)
- Testing
- Meal replacement (MR), Control (C), Verum
- Volunteers
- 105 people
- Sponsor
- Bonn Education Association for Dietetics r.A., Cologne, Germany
Healthy Volunteers, Cardiometabolic Diseases
A Study to See How Safe a New Medicine (NNC0705-0002) is in Healthy People
This study is testing NNC0705-0002, a new medicine that is being developed for conditions where inflammation may contribute to heart and metabolic health problems.
- Trial name
- NCT07797855
- Testing
- NNC0705-0002
- Where
- Netherlands
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Hypertension, Pre Diabetes
MegaNatural BP® GSE on Blood Pressure and Cardiometabolic Risk Factors
Inflammation and stressors can interfere with the function of the lining of blood vessels and insulin activity, therefore, investigators are aiming to see how the Grape seed Extract (GSE) called MegaNatural BP can help with…
- Trial name
- GSEBP (NCT06555952)
- Testing
- MegaNatural-BP SR 150Mg Tablet
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Clinical Nutrition Research Center, Illinois Institute of Technology
Obesity
Safety Evaluation of a Lifestyle Modification Program In.Form 1.1
The study evaluated and compared the safety, tolerance and acceptability of a lifestyle modification program with or without nutritional supplementation in generally healthy overweight subjects with cardiometabolic risk factors.
- Trial name
- NCT03097965
- Testing
- PROGRAM, DIET
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Nature's Sunshine Products, Inc.
Hypertension
Changes in Endothelial Function and Biomarkers in African Americans (AA) With Metabolic Syndrome
The purpose of the study is to compare the effects of Azor (a combination of amlodipine and olmesartan) with Hyzaar ( a combination of losartan and hydrochlorothiazide) on the thin lining on the inside of blood vessels.
- Trial name
- AMORE (NCT01271374)
- Testing
- amlodipine and olmesartan, losartan and HCTZ
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- InVasc Therapeutics, Inc.
Pre-diabetes, Diabetes Mellitus
Artificial Intelligence to Improve Cardiometabolic Risk Evaluation Using CT Scans
To validate the ability of the FatHealth algorithm to identify individuals with pre-diabetes and with type 2 diabetes mellitus
- Trial name
- ACRE-CT (NCT05058690)
- Testing
- Oral Glucose Tolerance Test
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Caristo Diagnostics Limited
Cardiometabolic Diseases
Video Vitals and Biomarkers
The investigators are doing this research to study the ability of mobile devices to measure vital signs and biomarkers from video as compared to standard-of-care clinical office tools.
- Trial name
- NCT06136156
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- Maiv Health Inc.
Heart Failure
Phase 1, Single Ascending Dose Study to Evaluate the Safety, Tolerability, PK, PD, and Comparative Bioavailability of THRV-1268 in Obese Adult Participants
A research study that involves the use of an investigational drug called THRV-1268. The main purpose is to measure the safety (whether it causes any side effects) and tolerability (if it does cause any side effects, how well your…
- Trial name
- NCT07186946
- Testing
- THRV-1268
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Thryv Therapeutics, Inc.
Obesity
Safety and Tolerance of a Nutritional Intervention Program- In.Form 1.2
The study evaluated and the safety, tolerance and acceptability of a lifestyle modification program with nutritional supplementation in generally healthy overweight subjects with cardiometabolic risk factors.
- Trial name
- NCT03098056
- Testing
- PROG2
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nature's Sunshine Products, Inc.
Acute Myocardial Infarction, Heart Failure
Dapagliflozin Effects on Cardiometabolic Outcomes in Patients With an Acute Heart Attack.
This study will evaluate the effect of dapagliflozin versus placebo, given once daily in addition to Standard of Care (SoC) therapies for patients with myocardial infarction (MI), for hospitalisation for heart failure (HHF)…
- Trial name
- DAPA-MI (NCT04564742)
- Testing
- Dapagliflozin
- Where
- 103 sites in Sweden, United Kingdom
- Volunteers
- 4,017 people
- Sponsor
- AstraZeneca
Obesity, Gastric Bypass
Impact of a Specific Micronutrient-probiotic-supplement on Fatty Liver of Patients After Mini-Gastric Bypass Surgery
Aim of this prospective randomized intervention study is to evaluate the effect of a dietary intervention with a specific micronutrient-probiotic-combination for 12 weeks on fatty liver and cardiometabolic status in obese…
- Conditions
- Obesity, Gastric Bypass, NAFLD
- Trial name
- FMG-01 (NCT03585413)
- Testing
- Micronutrient-probiotic-combination
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- Bonn Education Association for Dietetics r.A., Cologne, Germany
Hypercholesterolemia
Investigating Effects of a Novel Nutraceutical on Hypercholesterolaemia in Australian Adults
To evaluate the effects of daily consumption of 3 capsules of Swisse Nutra+ Cholesterol Balance on serum LDL-cholesterol in adults with hypercholesterolaemia compared to placebo over four months.
- Trial name
- CLoNE (NCT04783714)
- Testing
- Swisse Nutra+ Cholesterol Balance
- Where
- Australia
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Swisse Wellness Pty Ltd
Healthy Volunteers, Cardiometabolic Diseases
A Study to See How Safe a New Medicine (NNC6022-0001) is in Healthy People
The study is testing a new study medicine, which is being tested as a potential medicine to treat cardiometabolic diseases. The aim of this study is to see if the study medicine is safe, how it works in participants body, and…
- Trial name
- NCT06336005
- Testing
- NNC6022-0001
- Where
- Netherlands
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Cardiovascular Diseases
Qatar Cardiometabolic Registry
Type 2 diabetes mellitus (T2DM) and cardiovascular disease (CVD) are closely related. T2DM risk equivalent for CVD and it remains the major cause of death in T2DM.
- Trial name
- NCT03394313
- Where
- Qatar
- Volunteers
- 50,000 people
- Sponsor
- Hamad Medical Corporation
Type 2 Diabetes
Impact of a Digital Self-Management Program on A1C for Individuals With Type 2 Diabetes
The goal of this study is to evaluate a digital chronic disease self-management program designed to provide virtual support and guidance for patients with type 2 diabetes.
- Trial name
- NCT04892680
- Testing
- Online Diabetes Self-Management Education and Support (DSMES) Program
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Omada Health, Inc.
Metabolic Syndrome
The BANGALORE Study; Combination of Berberine, Lipoic Acid, and Picrorhiza
Though medical treatment has been effective in the treatment of cardiometabolic diseases (including coronary atherosclerosis and diabetes mellitus), the incidence of these disorders continues to be high.
- Trial name
- CAR-191 (NCT01696448)
- Testing
- CAR-191
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Carmel Biosciences
Insulin Resistance
Impact of Starch Digestibility on Glycemic Variability and Control, Cardiometabolic and Inflammatory Profiles, Microbiota and Intestinal Health in Subjects With Insulin Resistance
To study the potential impact of a diet rich in both Slowly Digestible Starch (SDS) and Resistant Starch (RS), we propose a 2-month nutritional intervention study in which we will study the evolution of carbohydrate variability…
- Trial name
- GLYMICARE (NCT07408479)
- Testing
- Balanced diet high in Slowly Digestible Starch and Resistant Starch, Balanced diet low in Slowly Digestible Starch and Resistant Starch
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Obesity, Microalbuminuria
Evaluation of the Rimonabant Impact on the Regression of Asymptomatic Damage Caused by Cardiovascular Risk Factors
Primary objective: To assess the effect on microalbuminuria levels of treatment with rimonabant 20 mg versus a placebo during a 12 month period.
- Conditions
- Obesity, Microalbuminuria, Diabetes Mellitus, Type 2, Dyslipidemia
- Trial name
- RIALTO (NCT00458081)
- Testing
- Rimonabant
- Where
- Spain
- Volunteers
- 174 people
- Sponsor
- Sanofi
Psoriasis, Inflammation
A Proof-of-Activity Study With Orticumab in Subjects With Psoriasis and Cardiometabolic Risk Factors
The primary purpose of this proof-of-activity, phase 2 trial is to evaluate the safety and activity of orticumab in subjects with moderate to severe psoriasis and cardiometabolic risk factors.
- Conditions
- Psoriasis, Inflammation, Coronary Artery Disease, Cardiometabolic Syndrome
- Trial name
- NCT04776629
- Testing
- Orticumab
- Where
- 13 sites in United States
- Volunteers
- 77 people
- Sponsor
- Abcentra