Clinical trials: Cardiometabolic Risk
Healthy
Effect of Herbs and Spices on Metabolic Regulation and Appetite in Healthy Subjects
The purpose of the study is to investigate how herbs and spices affect acute/postprandial glucose and insulin responses, inflammatory markers, appetite control peptides, antioxidative capacity, as well as subjective appetite…
- Trial name
- AFC-SPICES (NCT02035241)
- Testing
- Spices 1, Spices 2, Spices 3
- Where
- Sweden
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Lund University
Endocrine Disruptors, Inflammation
The Plastic Exposure Reduction Transforms Health Trial
The goal of this randomized controlled trial is to learn if an intervention of reducing plastic exposure through diet, personal care and cleaning products can improve health outcomes in adult participants with cardiometabolic…
- Conditions
- Endocrine Disruptors, Inflammation, Cardiometabolic Risk Factors
- Trial name
- PERTH (NCT06571994)
- Testing
- Low Plastic Intervention
- Where
- Australia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Western Australia
Cardiometabolic Risk Factors
Effect of Vitamin D on Cardiovascular Metabolic Risk in Overweight/Obesity Adolescents in China
The goal of this randomized controlled clinical trial is to investigate the effects of vitamin D3 supplementation on cardiometabolic risk in Chinese adolescents with overweight/obesity and vitamin D deficiency.
- Trial name
- NCT07053657
- Testing
- Dietary Supplement: Vitamin D3
- Where
- 2 sites in China
- Volunteers
- 130 people
- Sponsor
- Anhui Medical University
Shift Workers' Health, Time Restricted Eating
The Healthy Heroes Study
This is the first study of its kind to assess and test an intervention to improve biological rhythms and general health of shift workers, specifically first responders with San Diego Fire and Rescue.
- Conditions
- Shift Workers' Health, Time Restricted Eating, Fasting
- Trial name
- NCT03533023
- Testing
- Time Restricted Eating + Standard of Care, Standard of Care
- Where
- United States
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Obesity
Modified Intermittent Eating on Weight Loss (INTEREST-3 Trial)
Calorie restriction (CR) is the most important treatment for weighting loss. In recent years, two novel types of intermittent fasting recently have gained more attention: the 5:2 diet and time-restricted eating (TRE).
- Trial name
- INTEREST-3 (NCT06302803)
- Testing
- Intermittent fasting plus time-restricted eating, Calorie restriction
- Where
- China
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Nanfang Hospital, Southern Medical University
Obesity, Morbid, Bariatric Surgery Candidate
Exercise Following Bariatric Surgery for Severe/Morbid Obesity (EFIBAR)
Severe/morbid obesity is an international public health issue that importantly increases the risk of cardiovascular events and cardiovascular and all-cause mortality.
- Trial name
- EFIBAR (NCT03497546)
- Testing
- Exercise
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Universidad de Almeria
Pre-Gestational Diabetes, Type2diabetes
A Randomized Controlled Trial of Diabetes Screening Immediately Postpartum (DIP) and Follow Up PP CARE
DIP : To conduct a pragmatic, non-blinded randomized controlled trial (pRCT) of immediate in-patient postpartum OGTT prior to delivery discharge (intervention) versus 4-12 week outpatient postpartum OGTT (current standard care)…
- Conditions
- Pre-Gestational Diabetes, Type2diabetes, Pregnancy in Diabetic, Pregnancy, High Risk
- Trial name
- NCT05909046
- Testing
- Immediate inpatient postpartum OGTT, Standard of care 4-12 week postpartum OGTT
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Ohio State University
Glucose Metabolism, Lipid Metabolism
Effects of 10-gram Collagen Protein Hydrolysate on Cardiometabolic Health
The effects of a 10g/day collagen hydrolysate for a period of 4 weeks on glycemic control and cardiovascular health in a parallel design study using overweight/ obese men and women who are likely to have a disturbed lipid and…
- Trial name
- NCT05282641
- Testing
- 10 g of collagen hydrolysate
- Where
- Netherlands
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
ASCVD, Hyperlipidemia
Duke Cardiometabolic Prevention Clinic's Impact on High-risk Cardiovascular Patients With Uncontrolled Risk Factors
This project is studying whether a team-based specialty clinic can help people with type 2 diabetes and heart disease better manage their blood pressure and cholesterol.
- Conditions
- ASCVD, Hyperlipidemia, Hypertension
- Trial name
- DUKE PREVENT (NCT07117695)
- Testing
- Referral to the Duke Cardiometabolic Prevention Clinic
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Duke University
NAFLD, Liver Fibroses
Liver Damage and Cardiometabolic Disorders in NAFLD
Liver fibrosis is the most important prognostic factor in patients with non-alcoholic factor disease. Clinical and biological condition, as diabetes or mutation for PNPLA3, are well known factors associated with liver fibrosis…
- Conditions
- NAFLD, Liver Fibroses, Cardiovascular Diseases, Cardiovascular Risk Factor
- Trial name
- PLINIO (NCT04036357)
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- University of Roma La Sapienza
Visceral Obesity, Atherosclerosis
Abdominal Fat and Imaging Measurements of Heart Disease
Although it is frequently mentioned in the media that overweight and obesity have reached epidemic proportions worldwide and in this country, some Canadians are perplexed and sometimes confused about the role of obesity in…
- Conditions
- Visceral Obesity, Atherosclerosis, Metabolic Syndrome
- Trial name
- NCT01447745
- Where
- Canada
- Volunteers
- 357 people, healthy volunteers welcome
- Sponsor
- Laval University
Exercise, Cerebral Palsy
RaceRunning for Young People With Moderate-to-severe Cerebral Palsy
Physical inactivity in people with cerebral palsy (CP) has been linked with increased risk of cardiometabolic disease. Exercise studies rarely include people with CP with severe walking impairments and assess the sustainability…
- Trial name
- NCT04034342
- Testing
- RaceRunning
- Where
- 2 sites in United Kingdom
- Volunteers
- 25 people
- Sponsor
- Queen Margaret University
Type 2 Diabetes
Effects of Exercise on sRAGE Levels and Cardiometabolic Risk Factors
The purpose of this study is to examine the effects of exercise on diverse cardiometabolic risk factors and indicators of atherosclerosis in patients with type 2 diabetes mellitus (T2DM).
- Trial name
- NCT01542775
- Testing
- Aerobic Exercise Group, Control Group
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Korea University
Gestational Diabetes Mellitus, Continuous Glucose Monitoring
The Project for Managing Cardiometabolic Risk in Women Diagnosed With Gestational Diabetes Mellitus
This study aims to examine the effects of a lifestyle intervention based on a health belief model (HBM) supported by mobile health (mHealth) and the impact of continuous glucose monitoring (CGM) on maternal glycemic parameters…
- Trial name
- NCT06648174
- Testing
- Continuous glucose monitor, Perinatal nursing care for gestational diabetes, Blood glucose meters (BGM)
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Taiwan University Hospital
Obesity and Overweight
Plant-Based Foods and (Poly)Phenol Supplementation in Gut Microbiota Modulation, Body Weight, and Cardiometabolic Risk
This single-blind, randomized controlled trial aims to evaluate the effects of increased dietary polyphenol intake-either through a healthy plant-based diet (PBD) or supplementation-on body weight and cardiometabolic risk factors…
- Trial name
- PREDIET-ARAC (NCT06911346)
- Testing
- Diet supplementation, Polyphenol-rich supplement
- Where
- Chile
- Volunteers
- 100 people
- Sponsor
- Universidad Catolica de Temuco
Physical Inactivity, Cardiovascular Risk Factor
The Clinical Referral to Activity Study
The main aim of this effort is to test a physical activity intervention, for adult clinical care patients at risk of developing cardiovascular disease.
- Conditions
- Physical Inactivity, Cardiovascular Risk Factor, Obesity, Blood Pressure
- Trial name
- NCT04743856
- Testing
- ActiveGOALSv2, PAT
- Where
- United States
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Preeclampsia, Gestational Diabetes Mellitus (GDM)
Cardiometabolic Disease and Substrate Metabolism
This study's primary purpose is to determine the potential relationship between cardiometabolic disease, specifically insulin resistance (HOMA-IR), and maternal lipid oxidation.
- Conditions
- Preeclampsia, Gestational Diabetes Mellitus (GDM), Preeclampsia (PE), Preeclampsia (PE) Risk
- Trial name
- CAP (NCT07565727)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Tennessee Graduate School of Medicine
Diabetes, Sleep Apnea
Effective Treatment of Sleep Apnea in Prediabetes to Reduce Cardiometabolic Risk
Although obstructive sleep apnea (OSA) is associated with impaired glucose tolerance and diabetes, it remains unclear whether OSA treatment with continuous positive airway pressure (CPAP) has metabolic benefits.
- Trial name
- NCT01156116
- Testing
- CPAP mask
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- University of Chicago
Cardiometabolic Risk Factors, Inflammation
FILIP: Fat Intake, Inflammation and LIPids
Low-grade inflammation is involved in the pathogenesis of type 2 diabetes and cardiovascular disease. Increasing evidence suggests that dietary intake may be involved in the inflammatory process.
- Conditions
- Cardiometabolic Risk Factors, Inflammation, Microbiota
- Trial name
- FILIP (NCT06640036)
- Testing
- Rapeseed oil, Butter, Coconut oil
- Where
- Sweden
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Göteborg University
Cardiovascular Diseases, Cardiovascular Risk Factor
The Use of Icosapent Ethyl on Vascular Progenitor Cells in Individuals With Elevated Cardiovascular Risk
IPE-PREVENTION is a prospective, randomized, 3-month long, open-label study. A total of 70 individuals with elevated cardio-metabolic risk and heightened triglyceride levels, and who are on stable statin therapy will be…
- Conditions
- Cardiovascular Diseases, Cardiovascular Risk Factor, Triglycerides High, Diabetes Mellitus, Type 2
- Trial name
- IPE-PREVENTION (NCT04562467)
- Testing
- Icosapent Ethyl 1000 MG Oral Capsule [Vascepa]
- Where
- 3 sites in Canada
- Volunteers
- 70 people
- Sponsor
- Canadian Medical and Surgical Knowledge Translation Research Group