Clinical trials: Cardiomyopathy, Congestive
Breast Cancer
Intraoperative Use of the BP Device for Detecting Positive Margins During Lumpectomy Procedure
This protocol was designed for testing the intraoperative use of the Dune device. This multicenter study will take place in Israel at 12 sites.
- Trial name
- NCT00380952
- Testing
- Dune Device
- Where
- 9 sites in Israel
- Volunteers
- 300 people
- Sponsor
- Dune Medical Devices
Dilated Cardiomyopathy (DCM), Ischemic Cardiomyopathy
Dilated cardiomYopathy iNtervention With Allogeneic MyocardIally-regenerative Cells (DYNAMIC)
To determine the safety profile of CAP-1002 administered by multi-vessel intracoronary infusion in subjects with DCM. The study will further explore safety and exploratory efficacy endpoints of CAP-1002.
- Conditions
- Dilated Cardiomyopathy (DCM), Ischemic Cardiomyopathy, Nonischemic Cardiomyopathy, Heart Failure
- Trial name
- DYNAMIC (NCT02293603)
- Testing
- Allogeneic Cardiosphere-Derived Cells (CDCs)
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Capricor Inc.
Ischemic Cardiomyopathy, Dilated Cardiomyopathy
Inflammation, Cardiac Sympathetic Innervation, and Arrhythmic Sudden Death
Despite pharmacologic advances for the treatment of congestive heart failure (HF), sudden cardiac death (SCD) and pump failure remain the leading causes of mortality in patients with HF.
- Conditions
- Ischemic Cardiomyopathy, Dilated Cardiomyopathy, Inflammation, Sudden Cardiac Death
- Trial name
- NCT01919983
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Johns Hopkins University
Cardiomyopathy, Congestive Heart Failure
AiDing Diuresis wIth Tolvaptan (ADD-IT)
The purpose of this study is to test the use of tolvaptan (commercial name Samsca) when given in addition to intravenous (IV) diuretics early during an episode of acute heart failure.
- Trial name
- ADD-IT (NCT02646540)
- Testing
- Tolvaptan 30 mg + IV Diuretics, Metolazone 5 mg + IV Diuretics, 2.5 times the Diuretics Dose
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- Emory University
Invasive Breast Cancer
EpCAM and p53 Expressions in Infiltrating Duct Carcinoma of the Breast
Breast cancer represents the most frequently diagnosed cancer in women. It represents the 5th leading cause of cancer mortality all over the world.
- Trial name
- NCT05703815
- Volunteers
- 40 people
- Sponsor
- Sohag University
Dilated Cardiomyopathy
Supramaximal Titrated Inhibition of RAAS in Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is a poorly understood cause of systolic heart failure and is the most common indication for heart transplantation worldwide.
- Trial name
- NCT01917149
- Testing
- Benazepril, Valsartan, Metoprolol
- Where
- China
- Volunteers
- 480 people
- Sponsor
- Xijing Hospital
Congestive Heart Failure, Cardiomyopathy
FAST (Fluid Accumulation Status Trial)
Heart failure is a progressive disease that decreases the pumping action of the heart. This may cause a backup of fluid in the heart and may result in heart beat changes.
- Conditions
- Congestive Heart Failure, Cardiomyopathy, Dyspnea, Pulmonary Edema
- Trial name
- NCT00289276
- Testing
- Fluid Status Monitoring (OptiVol™)
- Where
- 16 sites in United States, Canada and 1 more
- Volunteers
- 156 people
- Sponsor
- Medtronic Cardiac Rhythm and Heart Failure
Assessment of Some Hormone Levels in Children With Dilated Cardiomyopathy
Endocrinal Dysfunction Among Children With Dilated Cardiomyopathy
All patients in this study will be subjected to the following (as detailed in the attached patient's data sheet). 1. Clinical History: focusing on: Socio-demographic factors, especially age, gender, family history, and degree of…
- Trial name
- NCT07567417
- Testing
- Echocardiography assessment., Laboratory investigations and Hormone assessment.
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sohag University
Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies
Mayo AVC Registry and Biobank
Arrhythmogenic ventricular cardiomyopathy (AVC) is a genetic condition which affects the heart and can lead to heart failure and rhythm problems, of which, sudden cardiac arrest or death is the most tragic and dangerous.
- Conditions
- Arrhythmogenic Right Ventricular Cardiomyopathy, Cardiomyopathies, Heart Diseases, Cardiovascular Diseases
- Trial name
- NCT03049254
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Congestive Heart Failure
Oxidative Stress Markers and Cardiac Resynchronization Therapy (CRT) Outcomes
This is a research study that is evaluating blood markers which may predict which patients who receive CRT will improve. Congestive heart failure (CHF) is associated with increased oxidative stress, a condition where abnormal…
- Trial name
- NCT01151553
- Testing
- CRT Therapy
- Volunteers
- 5 people
- Sponsor
- Emory University
Dilated Cardiomyopathy
Use of Ixmyelocel-T (Formerly Cardiac Repair Cell [CRC] Treatment) in Patients With Heart Failure Due to Dilated Cardiomyopathy (IMPACT-DCM)
This study is designed to assess the safety and tolerability of Cardiac Repair Cells (CRCs) compared to standard-of-care in patients with dilated cardiomyopathy (DCM).
- Trial name
- NCT00765518
- Testing
- Ixmyelocel-T, Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vericel Corporation
Ischemic Dilated Cardiomyopathy
Intracoronary Autologous Mesenchymal Stem Cells Implantation in Patients With Ischemic Dilated Cardiomyopathy
Despite the recent advances in medical and surgical treatment, heart failure resulting from ischemic cardiomyopathy (ICM) remains the leading cause of cardiovascular mortality.
- Trial name
- NCT01720888
- Testing
- BM-MSCs
- Where
- Malaysia
- Volunteers
- 80 people
- Sponsor
- National University of Malaysia
Non-ischemic Dilated Cardiomyopathy
PercutaneOus StEm Cell Injection Delivery Effects On Neomyogenesis in Dilated CardioMyopathy (The POSEIDON-DCM Study)
The technique of transplanting progenitor cells into a region of damaged myocardium, termed cellular cardiomyoplasty1, is a potentially new therapeutic modality designed to replace or repair necrotic, scarred, or dysfunctional…
- Trial name
- PoseidonDCM (NCT01392625)
- Testing
- Autologous hMSCs, Allogeneic hMSCs
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Joshua M Hare
Heart Failure, Congestive
BNP Testing in Patients With SOB on Presentation to ED
A trial to examine whether a new heart failure blood test can improve the outcome of patients presenting to the Emergency Department with shortness of breath.
- Trial name
- NCT00163709
- Testing
- BNP test
- Where
- Australia
- Volunteers
- 600 people
- Sponsor
- Bayside Health
Symptomatic Genetic Dilated Cardiomyopathy (DCM)
A Study of the Long-term Safety and Efficacy of Danicamtiv in Adults With Symptomatic Genetic and Familial Dilated Cardiomyopathy
Danicamtiv is an investigational medication, which means it is still being studied and has not been approved. The purpose of this study is to learn how well danicamtiv works, how safe it is, how well people can take it when used…
- Trial name
- KINSHIP-OLE (NCT07771465)
- Testing
- Danicamtiv
- Where
- 78 sites in United States, Belgium and 9 more
- Volunteers
- 332 people
- Sponsor
- Kardigan, Inc.
Heart Diseases, Cardiomyopathy, Congestive
Idiopathic Dilated Cardiomyopathy
To determine the familial occurrence and pathogenesis of idiopathic dilated cardiomyopathy.
- Trial name
- NCT00005201
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Dilated Cardiomyopathy, Left Ventricular Systolic Dysfunction
Cardiovascular Magnetic Resonance GUIDEd Insertion of Implantable Cardiac Defibrillator in Dilated CardioMyopathy
CMR GUIDE DCM is a randomized controlled trial with a registry for non-randomized patients. Patients enrolled will have non-ischemic cardiomyopathy (NICM) with mild to severe Left Ventricular (LV) systolic dysfunction with…
- Conditions
- Dilated Cardiomyopathy, Left Ventricular Systolic Dysfunction, Fibrosis Myocardial
- Trial name
- CMR GUIDE DCM (NCT03993730)
- Testing
- ICD, ILR
- Volunteers
- 1,880 people
- Sponsor
- Flinders University
Dilated Cardiomyopathy, Thrombosis
Intraventricular Stasis in Non Ischemic Dilated Myocardiopathy
This study is designed to quantify the ventricular stasis in patients with non-ischemic dilated cardiomyopathy by post-processing of 2D color Doppler echocardiography images in order to establish the relationship between…
- Conditions
- Dilated Cardiomyopathy, Thrombosis, Stroke
- Trial name
- ISBIDCM (NCT03415789)
- Testing
- Doppler echocardiogram exam, Cardiac Magnetic Resonance, Brain Magnetic Resonance
- Where
- Spain
- Volunteers
- 80 people
- Sponsor
- Hospital General Universitario Gregorio Marañon
Chagas Cardiomyopathy, Heart Failure
A Randomized Trial of Carvedilol in Chronic Chagas Cardiomyopathy
Chronic Chagas cardiomyopathy causes substantial morbidity and mortality in Latin America. Whether RAS inhibitors and beta-blockers are safe and beneficial has been challenged because of the lack of formal trials.
- Conditions
- Chagas Cardiomyopathy, Heart Failure, Dilated Cardiomyopathy
- Trial name
- NCT01557140
- Testing
- RASi plus carvedilol
- Where
- Brazil
- Volunteers
- 42 people
- Sponsor
- Federal University of Minas Gerais
Cardiomyopathy
Acute Dietary Nitrate in Dilated Cardiomyopathy
Acute consumption of dietary nitrate (as beetroot juice) has been shown to improve exercise capacity in athletes, healthy adults and subjects with both peripheral vascular disease or COPD.
- Trial name
- NCT02471417
- Testing
- Dietary nitrate
- Volunteers
- 12 people
- Sponsor
- Royal College of Surgeons, Ireland