Clinical trials: Cardiomyopathy, Congestive
Cardiomyopathies, Hypertrophic Cardiomyopathy
The SMARTER Cardiomyopathy Study
Cardiomyopathies are diseases of the heart muscle. Known genetic factors may account for some cardiomyopathy cases but there is still much to understand about the genetic and environmental causes and how the disease progresses.
- Conditions
- Cardiomyopathies, Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy
- Trial name
- SMARTER-CM (NCT05750147)
- Testing
- Blood Sample Collection
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Cardiomyopathy, Dilated, Sudden Cardiac Death
Prediction of Sudden Cardiac Death in Dilated Cardiomyopathy
PREDICT-DCM Trial is a multi-centre, prospective observational trial including patients with DCM undergoing cardiac magnetic resonance imaging (CMR) prior to ICD or event recorder implantation.
- Trial name
- PREDICT-DCM (NCT03224156)
- Testing
- Cardiac Magnetic Resonance Imaging
- Where
- 2 sites in Germany
- Volunteers
- 150 people
- Sponsor
- University Hospital Heidelberg
Mitral Valve Regurgitation, Congestive Heart Failure
Effects of Mitral Valve Repair With the Geoform Ring on Cardiomyopathy
The primary aim of this study is to assess the changes on the shape and function of the left ventricle in patients with severe mitral valve regurgitation due to congestive heart failure and cardiomyopathy who undergo mitral valve…
- Conditions
- Mitral Valve Regurgitation, Congestive Heart Failure, Cardiomyopathy
- Trial name
- NCT00428103
- Testing
- 3 dimensional echocardiography
- Where
- United States
- Sponsor
- Juan Crestanello, MD
Heart Failure, Congestive
PET Scan to Determine Areas of Blood Flow and Activity in the Hearts of Patients With Heart Disease Taking Beta-Blockers
The human heart is divided into four chambers. One of the four chambers, the left ventricle, is the chamber mainly responsible for pumping blood out of the heart into the circulation.
- Trial name
- NCT00001402
- Testing
- PET scan
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Prostate Cancer
Study of Radiation Therapy in Combination With Darolutamide + Degarelix in Intermediate Risk Prostate Cancer
Prostate cancer (PCa) is the most frequently diagnosed cancer in men and second leading cause of cancer-related death. Men with PCa have a wide range of possible outcomes if the cancer has not spread and is classified as…
- Trial name
- SChLAP/IDC (NCT04176081)
- Testing
- Darolutamide, Degarelix, Radiation Therapy
- Where
- Canada
- Volunteers
- 208 people
- Sponsor
- University Health Network, Toronto
Heart Failure, Cardiomyopathy, Dilated
Therapy to Maintain Remission in Dilated Cardiomyopathy
One third of patients diagnosed with heart failure demonstrate left ventricular reverse remodelling and recovery of cardiac function following a period of medical therapy.
- Conditions
- Heart Failure, Cardiomyopathy, Dilated, Cardiomyopathies, Heart Diseases
- Trial name
- TRED-HF2 (NCT06091475)
- Testing
- Other
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Supraventricular Arrhythmia, Left Atrial Abnormality
Left Atrial Strain and Supraventricular Arrhythmia Burden in Cardiac Light Chain Amyloidosis Following Chemotherapy
The purpose of this study to assess the longitudinal changes in left atrial strain and supraventricular arrhythmia burden after chemotherapeutic strategies in cardiac light chain amyloidosis.
- Conditions
- Supraventricular Arrhythmia, Left Atrial Abnormality, Amyloid Cardiomyopathy, Congestive Heart Failure
- Trial name
- NCT05448716
- Testing
- Left Atrial Strain Imaging, Electrocardiography
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Istanbul University - Cerrahpasa
Dilated Cardiomyopathy
A Study of AZD4063 in PLN R14del Dilated Cardiomyopathy
The purpose of the study is to assess the safety, tolerability and the pharmacokinetics (PK) of AZD4063 after single dose administration in participants with phospholamban (PLN) R14del dilated cardiomyopathy.
- Trial name
- PULSE (NCT07241104)
- Testing
- AZD4063
- Where
- 4 sites in Netherlands
- Volunteers
- 23 people
- Sponsor
- AstraZeneca
Congestive Heart Failure, Sudden Cardiac Death
Study of the Implantable Cardioverter Defibrillator (ICD) Intracardiac Electrograms
The purpose of this study is to determine whether waveforms of the intracardiac electrograms, acquired through an ICD, can be used: to predict malignant ventricular arrhythmias, requiring appropriate ICD therapies, and to predict…
- Conditions
- Congestive Heart Failure, Sudden Cardiac Death, Arrhythmia, Cardiomyopathies
- Trial name
- ICD-EGMs (NCT00916435)
- Where
- 2 sites in United States
- Volunteers
- 630 people
- Sponsor
- Johns Hopkins University
Cardiomyopathies, Amyloidosis Cardiac
Characterization of Patients With Cardiomyopathy to Identify Critical Patients Candidates for Cardiac Transplantation
The study aims to identify new diagnostic and prognostic markers for CMP that can help predict disease progression. In particular, the study will focus on microRNAs (miRNAs) and spatial transcriptomics, which are emerging…
- Conditions
- Cardiomyopathies, Amyloidosis Cardiac, Fabry Disease, Arrhythmogenic Cardiomyopathy
- Trial name
- CMPMIRNA (NCT06813443)
- Where
- 3 sites in Italy
- Volunteers
- 700 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
LMNA-Related Dilated Cardiomyopathy
A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA)
This study is designed to evaluate the safety and tolerability of NVC-001 in adults with LMNA-related dilated cardiomyopathy (LMNA-DCM). The study will also assess exploratory measures of efficacy.
- Trial name
- NCT07606274
- Testing
- NVC-001 - Low Dose, NVC-001 - Intermediate Dose, NVC-001 - High Dose
- Where
- 8 sites in United States
- Volunteers
- 21 people
- Sponsor
- Nuevocor Pte. Ltd.
Dilated Cardiomyopathy
Use of Ixmyelocel-T (Formerly Cardiac Repair Cell [CRC] Treatment) in Patients With Heart Failure Due to Dilated Cardiomyopathy (IMPACT-DCM)
This study is designed to assess the safety and tolerability of Cardiac Repair Cells (CRCs) compared to standard-of-care in patients with dilated cardiomyopathy (DCM).
- Trial name
- NCT00765518
- Testing
- Ixmyelocel-T, Standard of Care
- Where
- 5 sites in United States
- Volunteers
- 40 people
- Sponsor
- Vericel Corporation
Dilated Cardiomyopathy
A Single Ascending Dose Study Assessing the Safety, Tolerability, PK and PD of MYK-491
Up to 72 healthy volunteers will be given a single dose of MYK-491 or placebo and be monitored for safety and tolerability over a 7 day period.
- Trial name
- NCT03062956
- Where
- Australia
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- MyoKardia, Inc.
Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy
Metabolomic Study of All-age Cardiomyopathy
This study aims to 1)characterize the differentially expressed metabolites between cardiomyopathy patients and healthy controls,2)identify the specific biomarkers associated with outcomes or risk evaluation in patients with…
- Conditions
- Dilated Cardiomyopathy, Hypertrophic Cardiomyopathy, Arrhythmogenic Right Ventricular Cardiomyopathy, Left Ventricular Non-compaction
- Trial name
- MAC (NCT03061994)
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Beijing Institute of Heart, Lung and Blood Vessel Diseases
Dilated Cardiomyopathy
A Study to Investigate Safety, Tolerability, and Pharmacokinetics of Oral AZD0233 Compared With Placebo in Healthy Adult Participants.
The purpose of this study is to assess the safety, tolerability, and pharmacokinetics of AZD0233 following single and multiple ascending dose (SAD and MAD) administration in healthy participants.
- Trial name
- NCT06381466
- Testing
- AZD0233
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Myocardial Infarction (MI), Hypertrophic Cardiomyopathy (HCM)
The Application of T1 Mapping in Real-World
The goal of this observational study is to create a comprehensive real-world spectrum of T1 mapping measurements across different heart conditions.
- Conditions
- Myocardial Infarction (MI), Hypertrophic Cardiomyopathy (HCM), Dilated Cardiomyopathy (DCM), Arrhythmogenic Cardiomyopathy
- Trial name
- NCT07354646
- Testing
- Magnetic Resonance Imaging with Contrast
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Dilated Cardiomyopathy (DCM), Heart Failure
Safety and Efficacy of Second Infusion of FAP iCDC in End-stage Dilated Cardiomyopathy
This study aims to evaluate the safety and preliminary efficacy of a second administration of fibroblast activation protein (FAP)-targeted immunosuppressive chimeric antigen receptor dendritic cells (CAR-DC) in patients with…
- Trial name
- NCT07516288
- Testing
- FAP immunosuppressive CAR-DC
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Heart Failure, Cardiomyopathy, Dilated
Impact of Intraventricular Electrical Activation in Resynchronization Therapy
Impact of intraventricular electrical activation in resynchronization therapy. We seek to evaluate the impact of Cardiac Resynchronization Therapy (CRT) on electrical activation of the Left Ventricle (LV).
- Conditions
- Heart Failure, Cardiomyopathy, Dilated, Coronary Disease
- Trial name
- CARTO-CRT (NCT01270646)
- Testing
- Invasive mapping with CARTO3 system and Non-Invasive mapping with CardioInsight Atlas EC Mapping system
- Where
- France
- Volunteers
- 18 people
- Sponsor
- University Hospital, Bordeaux
Acute on Chronic Systolic Congestive Heart Failure
Reversible Pulmonary Artery Banding as Simplified Management of End-stage Dilated Left Ventriculopathy in Early Life
The purpose of this study is to: 1) Remodel and restore left ventricular geometry and function. 2) Avoid the need for mechanical circulatory support (MCS) and/or cardiac transplantation (CT).
- Trial name
- NCT02652676
- Testing
- Reversible Pulmonary Artery Banding, GORE-TEX DualMesh EMERGE PLUS Biomaterial
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Loma Linda University
Myocardial Ischemia, Congestive Heart Failure
Stem Cell Study for Patients With Heart Failure
The purpose of this study is to determine if cell therapy with your own cells (autologous cells) delivered with a catheter to regions of the heart with poor blood flow will be safe and if it will improve your ejection fraction…
- Conditions
- Myocardial Ischemia, Congestive Heart Failure, Cardiovascular Disease
- Trial name
- NCT00346177
- Testing
- Autologous Stem Cells
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Losordo, Douglas, M.D.