Clinical trials: Cardiomyopathy, Congestive
LMNA-Related Dilated Cardiomyopathy
A Study With NVC-001 in Patients With LMNA-related Dilated Cardiomyopathy (SUNBEAM-LMNA)
This study is designed to evaluate the safety and tolerability of NVC-001 in adults with LMNA-related dilated cardiomyopathy (LMNA-DCM). The study will also assess exploratory measures of efficacy.
- Trial name
- NCT07606274
- Testing
- NVC-001 - Low Dose, NVC-001 - Intermediate Dose, NVC-001 - High Dose
- Where
- 8 sites in United States
- Volunteers
- 21 people
- Sponsor
- Nuevocor Pte. Ltd.
Cardiomyopathy, Dilated, Prognosis
Cardiac Magnetic Resonance-Clinical Prediction Model-Dilated Cardiomyopathy
Dilated cardiomyopathy (DCM) is a common and serious heart disease characterized by left ventricular enlargement and impaired pumping function, with adverse prognosis (including heart failure, arrhythmia, heart-related…
- Conditions
- Cardiomyopathy, Dilated, Prognosis, Magnetic Resonance Imaging, Cardiac, Death, Sudden, Cardiac
- Trial name
- MPS-CMR-DCM (NCT07527715)
- Testing
- left ventricular ejection fraction
- Where
- China
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shandong Provincial Hospital
Heart Failure, Dilated Cardiomyopathy
Follow-up Safety Trial in Children With Chronic Heart Failure Therapy Receiving Orodispersible Minitablets of Enalapril
Paediatric long-term safety follow-up clinical trial in maximum 100 children with heart failure due to dilated cardiomyopathy or congenital heart disease, from 1 day to less than 12 years of age at recruitment into the preceding…
- Conditions
- Heart Failure, Dilated Cardiomyopathy, Congenital Heart Disease
- Trial name
- LENA-WP10 (NCT02654678)
- Testing
- Enalapril Orodispersible Minitablet
- Where
- 6 sites in Austria, Hungary and 3 more
- Volunteers
- 100 people
- Sponsor
- Ethicare GmbH
Dilated Cardiomyopathy, Ischemic Cardiomyopathy
Left Cardiac Sympathetic Denervation for Cardiomyopathy Feasibility Pilot Study
A randomized controlled trial to test the potential safety and efficacy of LCSD in patients with heart failure due to non-ischemic and ischemic cardiomyopathy at the University of Cape Town.
- Conditions
- Dilated Cardiomyopathy, Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
- Trial name
- LCSD (NCT03071653)
- Testing
- Left Cardiac Sympathetic Denervation (LCSD), Optimal Medical Therapy
- Where
- South Africa
- Volunteers
- 30 people
- Sponsor
- University of Cape Town
Dilated Cardiomyopathy
Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Ancillary Study
The Dilated Cardiomyopathy-Cardiac Magnetic Resonance (DCM-CMR) Study is an ancillary study from the parent study, DCM Precision Medicine Study.
- Trial name
- NCT04638621
- Where
- United States
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Idiopathic Dilated Cardiomyopathy
Infusion Intracoronary of Mononuclear Autologous Adult no Expanded Stem Cells of Bone Marrow on Functional Recovery in Patients With Idiopathic Dilated Cardiomyopathy and Heart Failure.
Clinical trial phase IIb, double-blind, randomized, controlled with placebo. There is sufficient preliminary evidence to consider intracoronary injection of bone marrow progenitor cells as a viable, safe and beneficial treatment…
- Trial name
- NCT02033278
- Testing
- Infusion of autologous mononuclear bone marrow cells
- Where
- 9 sites in Spain
- Volunteers
- 27 people
- Sponsor
- Andalusian Initiative for Advanced Therapies - Fundación Pública Andaluza Progreso y Salud
Cardiovascular Diseases, Cardiomyopathy, Dilated
Intravenous Allopurinol to Improve Heart Function in Individuals With Dilated Cardiomyopathy
This study will determine whether an acute infusion of intravenous allopurinol improves the inotropic response to dobutamine in patients with idiopathic dilated cardiomyopathy (DCM) as measured by cardiac magnetic resonance…
- Conditions
- Cardiovascular Diseases, Cardiomyopathy, Dilated, Heart Diseases, Heart Failure, Congestive
- Trial name
- NCT00281255
- Testing
- Allopurinol, Dobutamine
- Where
- United States
- Sponsor
- University of Pennsylvania
Heart Failure, Circulatory Disorders Postprocedural Complication
Observational Hemodynamic Monitoring During LVAD Implantation Among Individuals With Advanced Heart Failure
The overall objective of this pilot analysis is to characterize the hemodynamic changes that occur during implantation of a left ventricular assist device (LVAD) in patients with advanced heart failure - specifically, how right…
- Conditions
- Heart Failure, Circulatory Disorders Postprocedural Complication, Cardiomyopathy, Congestive, Surgery
- Trial name
- BATMAN (NCT03464981)
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Colorado, Denver
Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes
Remote Ischaemic Conditioning (RIC) in Heart Failure
This study will test the impact of remote ischaemic conditioning combined with exercise on myocardial perfusion in patients with or at risk of heart failure
- Conditions
- Heart Failure With Preserved Ejection Fraction, Type 2 Diabetes, Dilated Cardiomyopathy
- Trial name
- ENRICH (NCT06616233)
- Testing
- Remote Ischaemic Conditioning with exercise, Other: Remote Ischaemic Conditioning
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Leicester
Cardiomyopathies, Hypertrophic Cardiomyopathy
The SMARTER Cardiomyopathy Study
Cardiomyopathies are diseases of the heart muscle. Known genetic factors may account for some cardiomyopathy cases but there is still much to understand about the genetic and environmental causes and how the disease progresses.
- Conditions
- Cardiomyopathies, Hypertrophic Cardiomyopathy, Dilated Cardiomyopathy
- Trial name
- SMARTER-CM (NCT05750147)
- Testing
- Blood Sample Collection
- Where
- 2 sites in United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Imperial College London
Myocardial Ischemia, Congestive Heart Failure
Stem Cell Study for Subjects With Congestive Heart Failure
The purpose of this study is to determine if cell therapy with your own cells (autologous cells) delivered with a catheter to regions of the heart with poor blood flow will be safe and if it will improve your ejection fraction…
- Conditions
- Myocardial Ischemia, Congestive Heart Failure, Cardiovascular Disease
- Trial name
- NCT00620048
- Testing
- Intramyocardial injection of autologous CD34-positive cells (stem cells)
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Losordo, Douglas, M.D.
Chronic Systolic Heart Failure (Dilated Cardiomyopathy)
NORDIC: Nitric Oxide-Derived Oxidants and Regional Endothelial and Diastolic Dysfunction in Dilated Cardiomyopathy
The principal aim is to investigate the safety and efficacy of rosiglitazone in patients with chronic systolic heart (Dilated cardiomyopathy).
- Trial name
- NORDIC (NCT00293137)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Congestive Heart Failure
Assess Measurements of Wireless Cardiac Output Device
Heart failure is a common cardiovascular problem which is increasing in both prevalence and incidence and associated with substantial morbidity and mortality.
- Trial name
- Remote-CO-1 (NCT02252757)
- Testing
- CoVa
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Aventyn, Inc.
Dilated Cardiomyopathy
Simvastatin Therapy in Patients With Dilated Cardiomyopathy.
Dilated cardiomyopathy (DCM) is the most common childhood cardiomyopathy and is associated with significant early morbidity and mortality. About half of patients die or require heart transplantation within 5 years of diagnosis.
- Trial name
- SavDCM (NCT03775070)
- Testing
- Simvastatin
- Where
- Taiwan
- Volunteers
- 8 people
- Sponsor
- National Taiwan University Hospital
Heart Failure, CT Angiography
Efficacy and Safety of Ivabradine to Reduce Heart Rate Prior to Coronary CT-angiography in Advanced Heart Failure: Comparison With β-Blocker
The aim of this study is to compare the effects of Ivabradine and metoprolol to reduce heart rate prior to coronary CT angiography in patients with advanced heart failure.
- Conditions
- Heart Failure, CT Angiography, Ischemic Cardiomyopathy, Non-ischemic Cardiomyopathy
- Trial name
- NCT03830957
- Testing
- Ivabradine, Metoprolol
- Where
- Iran
- Volunteers
- 200 people
- Sponsor
- Rajaie Cardiovascular Medical and Research Center
Heart Failure
The SMARTEX Heart Failure Study
This protocol describes a randomized multicenter clinical trial designed to test the hypothesis that a 12-week program of high-intensity interval training (HIIT) yields larger beneficial effects in stable heart failure patients…
- Trial name
- SMARTEX (NCT00917046)
- Testing
- high-intensity interval training, Moderate continuous training, Recommendation of regular moderate exercise
- Where
- 11 sites in Belgium, Denmark and 5 more
- Volunteers
- 261 people
- Sponsor
- Norwegian University of Science and Technology
Prostatic Hyperplasia, Urinary Retention
Comparing Clean Intermittent Self-catheterization and Indwelling Catheterization for the Management of Urinary Retention Before BPH Surgery.
The CATHETERS trial is a multicenter, randomized, open-label superiority study comparing two methods of managing urinary retention before surgery for benign prostatic hyperplasia (BPH): clean intermittent self-catheterization…
- Conditions
- Prostatic Hyperplasia, Urinary Retention, Urinary Catheterization, Intermittent Urethral Catheterization
- Trial name
- CATHETERS (NCT07555964)
- Testing
- ICSC, IDC
- Where
- 5 sites in France
- Volunteers
- 106 people
- Sponsor
- University Hospital, Bordeaux
Dilated Cardiomyopathy
The Influence of Atorvastatin on the Parameters of Inflammation and the Function of Left Ventricle
The aim of the study was to assess of the influence of atorvastatin on selected indicators of an inflammatory condition, function of the left ventricle and factors affecting the occurrence of undesired events like…
- Trial name
- NCT01015144
- Testing
- Tulip
- Sponsor
- Medical University of Lodz
Dilated Cardiomyopathy
Nesiritide - Dilated Cardiomyopathy
Nesiritide is a rapid vasodilator that mimics the action of an endogenous hormone - human B-type natriuretic peptide (BNP). BNP is produced naturally in the ventricles of the heart in response to stretch.
- Trial name
- NCT00709163
- Testing
- Nesiritide, 5% Dextrose
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, Los Angeles
Heart Disease
Cardiomyopathy Tissue Bank in a Cancer Population
Any time the words "you," "your," "I," or "me" appear, it is meant to apply to the potential participant. The goal of this laboratory research study is to collect and store blood and tissue from patients who have a diagnosis of…
- Trial name
- NCT00500734
- Testing
- Blood Sample
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- M.D. Anderson Cancer Center