Clinical trials: Cardiomyopathy, Stress
Apical Ballooning Syndrome, Nervous System Diseases, Sympathetic
Sympathetic Heart Innervation in Patients With Tako-Tsubo Cardiomyopathy
Stress (tako-tsubo) cardiomyopathy (SC) is a rapidly reversible form of acute heart failure reported to be triggered by stressful events and associated with a distinctive left ventricular (LV) contraction pattern.
- Trial name
- NCT01524861
- Testing
- alpha-lipoic acid, L-acetyl carnitine
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- University of Campania Luigi Vanvitelli
Takotsubo Cardiomyopathy, Takotsubo Syndrome
Adenosin to Rapidly Reverse Left Ventricle Impairment in Takotsubo Syndrome
The investigators will randomize patients admitted to hospital with Takotsubo diagnosis to systematic high-dose adenosine infusion for 3 minutes (in addition to standard of care) vs. standard of care.
- Trial name
- TITAN (NCT02867878)
- Testing
- Adenosine, Saline solution
- Where
- Italy
- Volunteers
- 5 people
- Sponsor
- University Hospital of Ferrara
Takotsubo Cardiomyopathy
The Broken Heart Study II (BHS-II)
The goals of this study are as follows: 1. To rigorously establish and characterize heterogeneity in the pathophysiology of Takotsubo Syndrome (TS). 2.
- Trial name
- BHS (NCT04325321)
- Testing
- Stress reactivity test
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- The Miriam Hospital
Transient Left Ventricular Ballooning Syndrome
Insights in the Pathophysiology of Transient Left Ventricular Ballooning Syndrome (TLVBS)
Transient left ventricular ballooning syndrome (TLVBS) is a cardiac syndrome that is characterised by acute but transient left ventricular (LV) dysfunction.
- Trial name
- NCT01076946
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- University Hospital, Gasthuisberg
Heart Failure, Cardiomyopathies
The Impact of Zinc Supplementation on Left Ventricular Function in Nonischemic Cardiomyopathy
Heart failure affects over 5.3 million Americans and, while other cardiovascular diseases have enjoyed a reduction in mortality rates over the last decade, the mortality from heart failure continues to rise[1].
- Trial name
- NCT00696410
- Testing
- Zinc Acetate
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- University of Michigan
Tako-tsubo Cardiomyopathy
Persistent Symptoms and Early Incomplete Recovery After Acute Stress-induced Cardiomyopathy: Is There Ongoing Heart Distress? The HEROIC Study
Acute stress induced (Tako-tsubo) cardiomyopathy (TTC) or broken heart syndrome, a condition typically occurring after acute stress has a death rate similar to heart attacks and is frequently associated with long-term symptoms…
- Trial name
- HEROIC (NCT02989454)
- Testing
- Assessment of exercise capacity and cardiac energetics
- Where
- United Kingdom
- Volunteers
- 42 people
- Sponsor
- University of Aberdeen
Peripartum Cardiomyopathy
Peripartum Cardiomyopathy in Nigeria Registry
Peripartum cardiomyopathy (PPCM) is a global disease with significant morbidity and mortality, and Nigeria probably has the highest burden of the disease in the world.
- Trial name
- PEACE (NCT03081949)
- Testing
- Oral Sodium Selenite 200 µg/day for 3 months
- Where
- 2 sites in Nigeria
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Aminu Kano Teaching Hospital
Diabetes Mellitus, Type II
Detection of Diffuse Scar in Patients With Diabetes
People with diabetes are at an increased risk of heart attacks and heart failure, and it is important to be able to treat people with diabetes who are at risk for heart disease to prevent these outcomes.
- Trial name
- NCT01794091
- Testing
- Eplerenone
- Where
- United States
- Sponsor
- Brigham and Women's Hospital
Apical Ballooning Syndrome
Personality Profile of Patients With Apical Ballooning Syndrome
The investigators' hypothesis is that patients with apical ballooning syndrome (ABS) will manifest a personality profile that differs than that of a population of similar range of ethnic and socioeconomic status.
- Trial name
- NCT01885975
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Mayo Clinic
Takotsubo Cardiomyopathy
The Cedars-Sinai Smidt Heart Institute Takotsubo Registry & Proteomic Study
The Cedars-Sinai SHI Takotsubo Registry and Proteomic Study is an observational registry that will collect retrospective and prospective demographic, clinical, hemodynamic, laboratory and other diagnostic parameters, therapy and…
- Trial name
- NCT03910569
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Cedars-Sinai Medical Center
Takotsubo Cardiomyopathy
International Takotsubo Registry (InterTAK Registry)
This is a multicenter, multinational, prospective and retrospective, observational study of patients with Takotsubo cardiomyopathy (TTC).
- Trial name
- InterTAK (NCT01947621)
- Where
- Switzerland
- Volunteers
- 4,000 people
- Sponsor
- University of Zurich
Takotsubo Cardiomyopathy
The Role of Emotional Stress in Patients With Stress-induced Cardiomyopathy
The event-related potentials may be different in patients with Takotsubo cardiomyopathy than in patients without Takotsubo.
- Trial name
- NCT02361073
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Magdeburg
Mental Illness, Stress
HEAlth Dialogues for Patients With Mental Illness in Primary Care
In the current project, primary health care patients with mental illness such as anxiety, depression, fatigue or sleep disorders will be followed.
- Conditions
- Mental Illness, Stress, Fatigue, Sleep Disorder
- Trial name
- HEAD-MIP (NCT05181254)
- Testing
- health dialogue
- Where
- Sweden
- Volunteers
- 167 people
- Sponsor
- Region Skane
Myocardial Infarction With Non-Obstructive Coronary Artery, Myocarditis Acute
Comparison of Free-breathing 3D Quantitative Perfusion in Patients With MINOCA and MINOCA-mimics
This clinical study examines patients presenting with acute myocardial infarction and no significant coronary artery disease on coronary angiography (MINOCA) and patients with MINOCA-mimics with advanced CMR.
- Conditions
- Myocardial Infarction With Non-Obstructive Coronary Artery, Myocarditis Acute, Takotsubo Cardiomyopathy, Spontaneous Coronary Artery Dissection
- Trial name
- COPE-CMR (NCT06323811)
- Testing
- CMR
- Where
- Switzerland
- Volunteers
- 75 people
- Sponsor
- University of Zurich
Takotsubo Syndrome
Takotsubo Syndrome and Air Pollution
Takotsubo syndrome (TTS) is an acute and reversible form of myocardial injury characterized by typical regional wall motion abnormalities in the absence of culprit epicardial coronary artery disease frequently precipitated by…
- Trial name
- Tako-Air (NCT05731830)
- Testing
- Data extraction, Clinical follow-up
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Stroke, Epilepsy
Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases
Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs.
- Conditions
- Stroke, Epilepsy, Transient Global Amnesia (TGA)
- Trial name
- G-HeBra (NCT07009990)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald