Clinical trials: Cardiomyopathy
Hypertrophic Cardiomyopathy
Risk Stratification Using PET in HCM
The overall rationale is to reduce the risk of sudden cardiac death in individuals with hypertrophic cardiomyopathy (HCM). The novel approach of this study is to correlate Positron Emission Tomography (PET) findings to…
- Trial name
- HCM-PET (NCT03278457)
- Testing
- Positron Emission Tomography
- Where
- Sweden
- Volunteers
- 25 people
- Sponsor
- Region Gävleborg
Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy, Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy
Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of NTLA-2001 in Patients With Hereditary Transthyretin Amyloidosis With Polyneuropathy (ATTRv-PN) and Patients With Transthyretin Amyloidosis-Related Cardiomyopathy (ATTR-CM)
This study will be conducted to evaluate the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of NTLA-2001 in participants with hereditary transthyretin amyloidosis with polyneuropathy (ATTRv-PN) and…
- Conditions
- Transthyretin-Related (ATTR) Familial Amyloid Polyneuropathy, Transthyretin-Related (ATTR) Familial Amyloid Cardiomyopathy, Wild-Type Transthyretin Cardiac Amyloidosis
- Trial name
- NCT04601051
- Testing
- NTLA-2001
- Where
- 4 sites in France, New Zealand and 2 more
- Volunteers
- 72 people
- Sponsor
- Intellia Therapeutics
Congestive Heart Failure, Non-ischemic Cardiomyopathy
Study of the Acute Effects of Triheptanoin in Heart Failure
Patients with dilated cardiomyopathy who present for indwelling right heart catheterization will be enrolled and randomized to either control or triheptanoin oil for five days. Hemodynamics will be assess serially.
- Trial name
- ACETO-TCA (NCT01787851)
- Testing
- Triheptanoin oil
- Where
- United States
- Sponsor
- University of Texas Southwestern Medical Center
Chronic Kidney Diseases
Anti-Inflammatory Treatment of Uremic Cardiomyopathy With Colchicine
This study is designed to determine the efficacy and safety of colchicine in patients with chronic kidney disease.
- Trial name
- NCT04500665
- Testing
- Colchicine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Brigham and Women's Hospital
Coronary Endothelial Dysfunction, Apical Ballooning Syndrome
The Relationship Between the Response to Mental Stress and Vascular Endothelial Function
The aim of this study is to measure how different people respond to mental stress. The investigators will measure if there are differences in cardiovascular responses to mental stress among different groups of subjects.
- Conditions
- Coronary Endothelial Dysfunction, Apical Ballooning Syndrome, Myocardial Infarction
- Trial name
- NCT00975559
- Where
- United States
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
HCM, oHCM
Valsalva SBP Drop and LVOT Obstruction
This study aimed to evaluate the efficacy of non-invasive dynamic blood pressure monitoring in assessing left ventricular outflow tract obstruction in patients with hypertrophic cardiomyopathy.
- Conditions
- HCM, oHCM, nHCM
- Trial name
- NCT07483125
- Testing
- participants are not assigned an intervention as part of the study
- Where
- China
- Volunteers
- 800 people
- Sponsor
- Shanghai Zhongshan Hospital
Gap co2, Cardiac Output, Low
Gap CO2 in Septic Patient to Predict Cardiomyopathy Septic
the investigators included 98 patients admitted for sepsis and septic shock (68.4% men, 31.6% women) with an average age of 60.42 years ± 15.13, ranging from 21 to 96 years. The average length of hospital stay was 7.53 days.
- Conditions
- Gap co2, Cardiac Output, Low, Cardiac Defect
- Trial name
- NCT06326762
- Testing
- comparaison
- Where
- Morocco
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Mohammed VI University Hospital
Chronic Kidney Diseases, Cardio-Renal Syndrome
Left Ventricular Fibrosis in Chronic Kidney Disease
This study aims to understand the onset an functional consequences of left ventricular interstitial fibrosis in patients with chronic kidney disease (stage 2 to 5), as well as assess whether transplantation results in a…
- Conditions
- Chronic Kidney Diseases, Cardio-Renal Syndrome, Myocardial Fibrosis, Uraemic Cardiomyopathy
- Trial name
- FibroCKD (NCT03176862)
- Testing
- cardiac magnetic resonance scan, Cardiopulmonary exercise test with stress echocardiogram, 24-hour ECG holter monitor
- Where
- United Kingdom
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Dr Manvir Kaur Hayer
Myocardial Reperfusion Injury, Cardiac Output, Low
Myocardial Protection With Perhexiline in Left Ventricular Hypertrophy
Open-heart surgery causes injury of the heart muscle. Although this is usually mild, temporary and reversible, if it is severe it can endanger life and require additional high cost care.
- Conditions
- Myocardial Reperfusion Injury, Cardiac Output, Low, Hypertrophy, Left Ventricular
- Trial name
- HYPER (NCT00989508)
- Testing
- Perhexiline
- Where
- United Kingdom
- Volunteers
- 220 people
- Sponsor
- University Hospital Birmingham
Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS)
Derivation of Human Induced Pluripotent Stem (iPS) Cells to Heritable Cardiac Arrhythmias
Human induced pluripotent stem cells (hiPSCs) have driven a paradigm shift in the modeling of human disease; the ability to reprogram patient-specific cells holds the promise of an enhanced understanding of disease mechanisms and…
- Conditions
- Inherited Cardiac Arrythmias, Long QT Syndrome (LQTS), Brugada Syndrome (BrS), Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
- Trial name
- NCT02413450
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Cancer
Cardioprotective Empagliflozin for Cancer Patients Receiving Doxorubicin
Doxorubicin induced cardiomyopathy is the most common and serious side effect associated with doxorubicin treatment in cancer patients receiving doxorubicin.
- Trial name
- NCT06103279
- Testing
- Empagliflozin 10 MG
- Volunteers
- 40 people
- Sponsor
- Ain Shams University
Hypertrophic Obstructive Cardiomyopathy
Speckle Tracking Echocardiography Analysis of Left Ventricular Myocardium After Percutaneous Intramyocardial Septal Radiofrequency Ablation for Hypertrophic Obstructive Cardiomyopathy
Objective to investigate the left ventricular (LV) systolic function by speckle tracking echocardiography before and after percutaneous intramyocardial septal radiofrequency ablation for hypertrophic obstructive cardiomyopathy…
- Trial name
- NCT04777188
- Testing
- Percutaneous Intramyocardial Septal Radiofrequency Ablation for hypertrophic obstructive cardiomyopathy
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Xijing Hospital
Apical Ballooning Syndrome
Cardiac Sympathetic Activity in Patients With the Apical Ballooning Syndrome
Our hypothesis is that altered cardiac sympathetic activity is present and may contribute to the myocardial stunning observed in the apical ballooning syndrome.
- Trial name
- NCT00586183
- Testing
- PET scan
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Mayo Clinic
Heart Failure, Cardiomyopathy
123-I mIBG (AdreView) Heart-to-Mediastinal (H/M) Ratio and SPECT Imaging on a Small Field of View-High Efficiency Cardiac SPECT System
The purpose of this study is to demonstrate correlation of the H/M ratio of AdreView when derived from a large field of view Anger SPECT system and from a small field of view high sensitivity (CZT) SPECT system.
- Trial name
- NCT01868841
- Testing
- AdreView, Single Photon Emission Computed Tomography
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Timothy M. Bateman
Myocardial Reperfusion Injury, Treatment Outcome
Clinical Efficacy of Extracorporeal Cardiac Shock Wave Therapy in Patients With Ischemia-reperfusion Injury
This trial was a prospective, open-label, single-center, randomized trial, To observe the clinical efficacy of extracorporeal cardiac shock wave in the treatment of patients with myocardial ischemia-reperfusion injury and the…
- Conditions
- Myocardial Reperfusion Injury, Treatment Outcome, Prognosis, ST Elevation Myocardial Infarction
- Trial name
- CEECSWIRI (NCT05624203)
- Testing
- Extracorporeal cardiac shock wave therapy(ECSW)
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital of Kunming Medical University
Kidney Diseases, Congestive Heart Failure
Brain Natriuretic Peptide (BNP) to Preserve Renal Function in Hospitalized Patients With Heart Failure
Patients hospitalized for treatment of decompensated heart failure (CHF) are at risk for prolonged length of stay (LOS) and frequent readmissions.
- Conditions
- Kidney Diseases, Congestive Heart Failure, Cardiomyopathy
- Trial name
- NCT00170183
- Testing
- Nesiritide
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Mayo Clinic
Cardiomyopathy, Dilated, Tachycardia, Ventricular
The Leiden Nonischemic Cardiomyopathy Study
Rationale: Sudden cardiac death, mainly caused by ventricular arrhythmias (VA), is a major cause of morbidity and mortality in non-ischemic cardiomyopathy (NICM). Therapies that effectively prevent VA are lacking.
- Conditions
- Cardiomyopathy, Dilated, Tachycardia, Ventricular, Ventricular Fibrillation
- Trial name
- NCT01940081
- Testing
- Transthoracic echocardiography, Exercise test, 24-hour Holter electrocardiogram
- Where
- Netherlands
- Volunteers
- 148 people
- Sponsor
- Leiden University Medical Center
Stroke
Atrial Cardiomyopathy in Patients With Stroke of Undetected Mechanism
The goal of this study is to evaluate left atrial structural and functional abnormalities in stroke of undetected mechanism and atherosclerotic stroke with cardiac MRI.
- Trial name
- NCT03830983
- Where
- Denmark
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
HCM - Hypertrophic Cardiomyopathy, Anderson Fabry Disease
Myocardial Perfusion CMR for Differentiating and Characterizing Hypertrophic Cardiomyopathy Phenotypes
This observational study aims to evaluate myocardial perfusion abnormalities using quantitative and qualitative cardiac magnetic resonance (CMR) perfusion imaging in patients with hypertrophic cardiomyopathy (HCM) phenotypes…
- Conditions
- HCM - Hypertrophic Cardiomyopathy, Anderson Fabry Disease, Cardiac Magnetic Resonance Imaging, Amyloid Cardiomyopathy
- Trial name
- MyoPerf-HCM (NCT07382128)
- Where
- Italy
- Volunteers
- 250 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Cardiovascular Diseases, Heart Failure
Development of CIRC Technologies
Cardiovascular disease is the leading cause of death worldwide. Advanced cardiovascular imaging using Magnetic Resonance Imaging (MRI) has proven to be effective in providing gold standard myocardial tissue characterization.
- Conditions
- Cardiovascular Diseases, Heart Failure, Ischemic Heart Disease, Non-ischemic Cardiomyopathy
- Trial name
- CIRC (NCT05654272)
- Testing
- MRI
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic