Clinical trials: Cardioprotection
Hypertension, Metabolic Syndrome
The Study of Novel Dual Renin Angiotensin Aldosterone System (RAAS) Blockade; Valsartan/Aliskiren in African American Patients With Hypertension and the Metabolic Syndrome
Study purpose: African Americans with hypertension and markers of metabolic syndrome (small elevations in blood glucose, triglycerides and or weight) are at a high risk of cardiovascular (heart and blood vessel) problems.
- Trial name
- SAAVE (NCT01432106)
- Testing
- Aliskerin/Valsartan and Rampiril
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Right Coronary Artery Percutaneous Coronary Intervention, Right Ventricular Diastolic Dysfunction
Diastolic RV EvAluation With Millar Catheter to Investigate the Effect of Glucagon-Like Peptide-1 (GLP-1) on Right Ventricular Function During Elective Coronary Angioplasty and Stenting
The heart requires nutrients and oxygen carried in the blood to generate energy for healthy pump function. Blood is supplied via heart vessels called coronary arteries.
- Trial name
- DREAM GLP-1 (NCT02236299)
- Testing
- Right Coronary Artery Percutaneous Coronary Intervention, GLP-1 Infusion
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Dialysis, Cardioprotection
Exercise Intensity
Patients receiving regular hemodialysis (HD) treatments are at a higher risk of cardiovascular events and death as HD can cause a decrease in the pumping of the heart during treatment called 'stunning'.
- Trial name
- NCT07119593
- Testing
- Intradialytic Cycling
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
CABG
Transfer of Cardioprotection During RIPC
Remote ischemic preconditioning (RIPC) with transient upper limb ischemia/reperfusion provides peri-operative myocardial protection, is safe and improves prognosis in patients undergoing elective CABG surgery.
- Trial name
- NCT01956708
- Testing
- RIPC
- Where
- Germany
- Volunteers
- 392 people
- Sponsor
- University Hospital, Essen
Cardiometabolic Health
Cardioprotective Properties of ELAIOTSIPOURA
Several studies over the last decades have demonstrated the important role of nutrition for either the prevention of chronic diseases, such as cardiovascular disease and cancer, or the increase of their risk.
- Trial name
- NCT04440202
- Testing
- Conventional sea bream, Enriched sea bream
- Where
- Greece
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Hemodialysis
Intradialytic Exercise and Remote Ischaemic Preconditioning: a Cardioprotective Role ?
The aim of this clinical trial is to evaluate whether intermittent exercise and remote ischaemic preconditioning (rIPC) during haemodialysis (HD) can provide cardioprotection in adult patients (aged 20-79 years) undergoing HD for…
- Trial name
- EXPI-DIAL (NCT06856512)
- Testing
- Remote ischaemic preconditioning, Exercise, standard dialysis
- Where
- 3 sites in France
- Volunteers
- 33 people
- Sponsor
- University of Avignon
Cardioprotection
Cocoa and Endothelial Function in Adults With Elevated BMI
Cardiovascular disease is the leading cause of death in the United States. Studies have shown that obesity is an important risk factor for development of cardiovascular disease.
- Trial name
- Chocolate (NCT00538083)
- Testing
- Chocolate
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Griffin Hospital
Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly
Cardiovascular Prevention Strategies in Elderly Patients With Cancer (CARTIER Clinical Trial)
The CARTIER study is a randomized, multicenter, open-label clinical trial comparing, in elderly patients with cancer under anti-tumoral treatment, two different cardiotoxicity prevention strategies: primary (intensive…
- Conditions
- Cancer (Colon Cancer, Breast Cancer, Lymphoma, Chronic Lymphoma Leukemia, Multiple Myeloma), Elderly, Antineoplastic Agents, Cardiotoxicity
- Trial name
- CARTIER (NCT03711110)
- Testing
- Intensive cardiovascular monitoring, No intervention
- Where
- 14 sites in Spain
- Volunteers
- 514 people
- Sponsor
- Fundación Instituto de Estudios de Ciencias de la Salud de Castilla y León
Dyslipidemias
Effect of Aerobic Training and Moringa Oleifera on Dyslipidemia and Cardiac Endurance
Aerobic training is essential for maintaining and improving physical performance and has a positive effect on physiological functions as well as anthropometric characteristics.
- Trial name
- NCT04164771
- Testing
- Aerobic training and Moringa Oleifera
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
High Sensitive Troponin T Release
Cardioprotection by Sevoflurane Preconditioning in Noncardiac Thoracic Surgery
It has been shown that the use of volatile anaesthetics, that are usually used to perform a general anesthesia, have cardioprotective properties.
- Trial name
- NCT02217319
- Testing
- Sevoflurane, TIVA
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Dr. Horst Schmidt Klinik GmbH
Breast Cancer, Heart Failure
CardioPROTECTion with Dapagliflozin in Breast Cancer Patients Treated with AnthrAcycline - PROTECTAA TRIAL
The purpose of this study is to evaluate the effect of dapagliflozin on the incidence of cancer therapeutics-related cardiac dysfunction in patients with breast cancer receiving anthracycline treatment.
- Trial name
- PROTECTAA (NCT06304857)
- Testing
- Dapagliflozin
- Where
- 3 sites in Poland
- Volunteers
- 188 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Heart Failure
Finerenone Plus SGLT2 Inhibitors in Heart Failure
The goal of this clinical study is to evaluate whether adding finerenone to standard treatment with a sodium-glucose cotransporter-2 (SGLT2) inhibitor provides additional benefits in patients with heart failure.
- Trial name
- FIN-SGLT2-HF (NCT07351864)
- Testing
- Finerenone, dapagliflozine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Cardiometabolic Health
Cardioprotective Properties of Vegan Burger
Several studies over the last decades have demonstrated the important role of nutrition in the development of chronic diseases, such as cardiovascular disease and cancer.
- Trial name
- VeganBurger (NCT05582720)
- Testing
- Conventional burger, Vegan burger
- Where
- Greece
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Heart Failure, Systolic
Paced Heart Rate Acceleration for Cardiac Conditioning
A clinical trial of exercise-similar heart rate acceleration delivered via cardiac pacing vs. sham intervention in subjects at rest will be performed.
- Trial name
- HeartExcel (NCT06332391)
- Testing
- Exercise-similar cardiac pacing
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Denice Hodgson-Zingman, MD
Breast Cancer
Acute Exercise Cardioprotection From Doxorubicin
In rodents, a single bout of exercise prior to injection of a chemotherapy agent used to treat breast cancer prevents or attenuates a number of markers of cardiac injury.
- Trial name
- NCT02006979
- Testing
- exercise
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of British Columbia
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Obesity
Optimized Cardioprotection Therapy in Obese Subjects With CAD
The purpose of this study is to investigate the efficacy and mechanism of Adipokines Cardiac Protection in Obese Patients With coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Obesity, Adiposis; Heart
- Trial name
- NCT04570527
- Testing
- PCI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital
ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI)
Timing of Empagliflozin in Primary PCI: Pre-Reperfusion Versus Post-Reperfusion Versus Placebo in South Asian STEMI Patients
The goal of this clinical trial is to learn if giving the drug empagliflozin before versus after a heart procedure called primary PCI (percutaneous coronary intervention) affects how much heart muscle is damaged during a heart…
- Conditions
- ST-elevation Myocardial Infarction (STEMI), Acute Myocardial Infarction (AMI), Coronary Artery Disease
- Trial name
- TEMPO-STEMI (NCT07749014)
- Testing
- empagliflozin
- Where
- Pakistan
- Volunteers
- 480 people
- Sponsor
- Rehman Medical Institute - RMI
Acute Myocardial Infarction, Myocardial Reperfusion Injury
Optimized Cardioprotection Therapy in Obese Subjects With AMI
The purpose of this study is to investigate the efficacy and mechanism of Adipokines Cardiac Protection in Obese Patients With acute myocardial infarction (AMI) Who Have Undergone Percutaneous Coronary Intervention (PCI).
- Conditions
- Acute Myocardial Infarction, Myocardial Reperfusion Injury, Obesity, Adiposis; Heart
- Trial name
- NCT04570514
- Testing
- PCI
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Xijing Hospital
ST Elevation Acute Myocardial Infarction
COMBinAtion Therapy in Myocardial Infarction: The COMBAT-MI Trial
Remote ischemic conditioning (RIC) and intravenous exenatide administered immediately before primary angioplasty have been found to limit infarct size in patients with STEMI (ST segment elevation myocardial infarction), but the…
- Trial name
- COMBAT-MI (NCT02404376)
- Testing
- Exenatide, Remote Ischemic Conditioning (RIC)
- Where
- 6 sites in Spain
- Volunteers
- 378 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Thoracic Surgery, Cardiopulmonary Bypass
Protection During Cardiac Surgery.
This trial investigates whether a multimodal cardioprotection per-surgery therapeutic strategy could reduce myocardial injury in patients undergoing cardiac surgery compared to traditional management.
- Trial name
- ProCCard (NCT03230136)
- Testing
- multimodal cardioprotection strategy, standard anesthetic procedure
- Where
- 8 sites in France
- Volunteers
- 210 people
- Sponsor
- Hospices Civils de Lyon