Clinical trials: Cardioprotection
Cardiometabolic Health
Effect of Differently Fed Farmed Gilthead Sea Bream Consumption
The trial was a double-blind randomized dietary intervention study with a 1:1 allocation ratio, conducted in accordance with the Declaration of Helsinki.
- Trial name
- NCT05417191
- Testing
- Conventional fish, Enriched fish
- Where
- Greece
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Ewing's Sarcoma, Neuroblastoma
New Therapeutic Strategies for Patients With Ewing's Sarcoma Family of Tumors, High Risk Rhabdomyosarcoma, and Neuroblastoma
The prognosis for patients with metastatic Ewing's sarcoma family of tumors (ESF), rhabdomyosarcoma (RMS), and neuroblastoma (NBL) remains dismal, with less than 25% long-term disease-free survival.
- Conditions
- Ewing's Sarcoma, Neuroblastoma, Rhabdomyosarcoma
- Trial name
- NCT00001335
- Testing
- ADR-529, Topotecan, G-CSF
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- National Cancer Institute (NCI)
Acute Coronary Syndrome
Ranolazine Cardioprotection in PCI
The investigators will test if upfront dosing of Ranolazine can reduce myocardial biomarker release (CK-MB, Troponin) post percutaneous coronary intervention (PCI).
- Trial name
- NCT01767987
- Testing
- Ranolazine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Harvey Hahn
Coronary Heart Disease, Cardiovascular Diseases
Comparison Between Propofol and Inhalational Anaesthetic Agents on Cardiovascular Outcomes Following Cardiac Surgery
The objective of this research proposal is to find out whether comparing the two different anaesthetic maintenance techniques (Propofol vs volatile anaesthetics) in adult patients undergoing heart surgery is practical for the…
- Trial name
- COPIA (NCT04039854)
- Testing
- Isoflurane, Sevoflurane or Desflurane, Propofol
- Where
- 2 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- King's College Hospital NHS Trust
Heart Failure
Persistent Cardiovascular Effects of COVID-19 Viral Infection Trial (PERCEIVE)
This is a prospective study in which a process of identifying and improving a reduction of functional capacity in COVID-19 survivors >50 years old.
- Trial name
- NCT04983823
- Testing
- Heart Failure intervention (Cardiac COVID Disease Management Plan (CC-DMP), Usual care
- Where
- Australia
- Volunteers
- 820 people, healthy volunteers welcome
- Sponsor
- Baker Heart and Diabetes Institute
Myocardial Infarction, Reperfusion Injury, Myocardial
Trans-coronary Cooling and Dilution for Cardioprotection During Revascularisation for ST-elevation Myocardial Infarction
A heart attack (myocardial infarction) occurs when an artery supplying blood to the heart is suddenly blocked resulting in damage to the heart muscle.
- Trial name
- STEMI-Cool (NCT06128993)
- Testing
- Transcoronary cooling and dilution, Standard of care
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- Royal Brompton & Harefield NHS Foundation Trust
Aortic Valve Disease, Valve Disease, Heart
Del Nido Versus HTK Cardioplegia in Adult Aortic Valve Replacement
The goal of this clinical trial is to compare del Nido and Bretschneider-HTK (HTK) cardioplegia solutions in patients undergoing elective aortic valve replacement.
- Conditions
- Aortic Valve Disease, Valve Disease, Heart, Cardiac Ischemia
- Trial name
- NCT06235424
- Testing
- Del Nido Cardioplegia Solution, HTK solution
- Where
- Poland
- Volunteers
- 100 people
- Sponsor
- Medical University of Gdansk
Coronary Artery Bypass Surgery
Nitrite Mediated Cardioprotection During Coronary Artery Bypass Surgery
The purpose of this study is to determine whether sodium nitrite administration 24 hours prior to or during coronary artery bypass surgery protects the heart better from lack of blood flow which occurs as part of this type of…
- Trial name
- NCT01098409
- Testing
- sodium nitrite, 0.9% sodium chloride
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- University Hospital Birmingham NHS Foundation Trust
Cardiometabolic Health
Cardioprotective Properties of Vegan Burger
Several studies over the last decades have demonstrated the important role of nutrition in the development of chronic diseases, such as cardiovascular disease and cancer.
- Trial name
- VeganBurger (NCT05582720)
- Testing
- Conventional burger, Vegan burger
- Where
- Greece
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Harokopio University
Off Pump Coronary Artery Bypass Graft
Volatile Versus Propofol Anesthesia in OPCAB
Off pump coronary artery bypass graft (OPCAB) still requires myocardial protection owing to intermittent regional ischemic episode.
- Trial name
- NCT02222142
- Testing
- Isoflurane
- Where
- South Korea
- Volunteers
- 1,080 people
- Sponsor
- Samsung Medical Center
Myocardial Infarction
Effect of METOprolol in CARDioproteCtioN During an Acute Myocardial InfarCtion. The METOCARD-CNIC Trial.
The purpose of this study is to test whether early pre-reperfusion metoprolol administration in patients suffering and acute myocardial infarction might reduce the size of myocardial necrosis.
- Trial name
- METOCARD-CNIC (NCT01311700)
- Testing
- Injectable (i.v.) metoprolol tartrate (up to 15 mg).
- Where
- 12 sites in Spain
- Volunteers
- 221 people
- Sponsor
- Fundación Centro Nacional de Investigaciones Cardiovasculares Carlos III
Coronary Artery Disease, Valvular Heart Disease
Randomized Isoflurane and Sevoflurane Comparison in Cardiac Surgery
Anesthesia practice in the 21st century is increasingly outcomes-oriented and evidence-based, but there remain significant gaps in our knowledge, even for commonly-encountered clinical situations.
- Trial name
- RISCCS (NCT01477151)
- Testing
- Volatile anesthetic
- Where
- Canada
- Volunteers
- 464 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Dialysis, Cardioprotection
Exercise Intensity
Patients receiving regular hemodialysis (HD) treatments are at a higher risk of cardiovascular events and death as HD can cause a decrease in the pumping of the heart during treatment called 'stunning'.
- Trial name
- NCT07119593
- Testing
- Intradialytic Cycling
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Anterior Myocardial Infarction, Heart Failure
Effect of Intravenous Metoprolol Combining RIC on Myocardial Protection in STEMI Patients
The main purpose of this study is to compare the myocardial protection effect of intravenous metoprolol combined with remote ischemic conditioning (RIC) and single treatment before reperfusion in Chinese patients with anterior…
- Trial name
- NCT03579914
- Testing
- Metoprolol Injectable Product, Romote Ischemic Conditioning (RIC), Metoprolol & RIC
- Where
- 16 sites in China
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Harbin Medical University
Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Obesity
Optimized Cardioprotection Therapy in Obese Subjects With CAD
The purpose of this study is to investigate the efficacy and mechanism of Adipokines Cardiac Protection in Obese Patients With coronary artery disease (CAD).
- Conditions
- Coronary Artery Disease (CAD) (E.G., Angina, Myocardial Infarction, and Atherosclerotic Heart Disease (ASHD)), Obesity, Adiposis; Heart
- Trial name
- NCT04570527
- Testing
- PCI
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Xijing Hospital
Myocardial Reperfusion Injury
Sevoflurane and Isoflurane - During Cardiopulmonary Bypass With the MECC System (Minimized Extracorporeal Circuit)
The use of volatile anesthetics in cardiac anesthesia is very common, because of their cardioprotective effects and their ability to ensure a sufficient depth of anesthesia.
- Trial name
- NCT01601795
- Testing
- Sevoflurane, Isoflurane
- Where
- Switzerland
- Volunteers
- 30 people
- Sponsor
- University Hospital, Basel, Switzerland
Cardiotoxicity, Toxicity Due to Chemotherapy
Pilot Study of an NTproBNP Guided Strategy of Cardioprotection
Investigators will evaluate the safety and feasibility of a biomarker-guided cardioprotection strategy using NTproBNP, as compared to usual care, in breast cancer and lymphoma patients treated with anthracyclines.
- Conditions
- Cardiotoxicity, Toxicity Due to Chemotherapy, Breast Cancer, Lymphoma
- Trial name
- NTproBNP-Guide (NCT04737265)
- Testing
- Biomarker Guided Intervention
- Where
- 3 sites in United States
- Volunteers
- 108 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Ischaemic Heart Disease, Aortic Stenosis
Remifentanil/Sufentanil for CABG+/-AVR Evaluated by Recovery, Cognitive Function, Haemodynamics and Biochemical Markers.
To evaluate the effect on cognitive function, recovery, cardioprotection and haemodynamics of standard Remifentanil anaesthesia to standard Sufentanil anaesthesia in patients undergoing coronary artery bypass with or without…
- Trial name
- PRECON2 (NCT02053818)
- Testing
- Remifentanil, Sufentanil
- Where
- Denmark
- Volunteers
- 60 people
- Sponsor
- Aarhus University Hospital
Heart Failure
Finerenone Plus SGLT2 Inhibitors in Heart Failure
The goal of this clinical study is to evaluate whether adding finerenone to standard treatment with a sodium-glucose cotransporter-2 (SGLT2) inhibitor provides additional benefits in patients with heart failure.
- Trial name
- FIN-SGLT2-HF (NCT07351864)
- Testing
- Finerenone, dapagliflozine
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Coronary Artery Bypass Graft Triple Vessel, Apoptotic DNA Damage
Remote Ischemic Preconditioning of Human Myocardium
The investigators aim to definitively show if human myocardium can be remotely preconditioned. In the writings there are no experiments that would prove that the remote preconditioning protocol effects on the higher protection of…
- Trial name
- NCT01994707
- Testing
- Remote ischemic preconditioning
- Where
- Poland
- Volunteers
- 134 people
- Sponsor
- Medical University of Silesia