Clinical trials: Cardiopulmonary Bypass
Cardiopulmonary Bypass, Hypothermia; Anesthesia
Effect of Hypothermia on BIS and PSI Correlation During Cardiopulmonary Bypass
The goal of this observational study is to evaluate whether hypothermia affects the relationship between electroencephalography-derived indices during cardiac surgery in adult patients undergoing cardiopulmonary bypass.
- Conditions
- Cardiopulmonary Bypass, Hypothermia; Anesthesia, Depth of Anesthesia Monitoring
- Trial name
- NCT07508579
- Testing
- Simultaneous BIS and PSI Monitoring
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Sakarya University
Neurological Manifestations
Brain Oxygenation Monitoring in Patients Undergoing Coronary Artery Bypass Surgery
The purpose of this study is to determine whether intraoperative brain oxygenation monitoring in cardiac surgery patients is effective in reducing postoperative neurologic and neurocognitive dysfunction.
- Trial name
- NCT00137527
- Testing
- Optimizing hemodynamic and anesthetic parameters to improve cerebral perfusion
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Atlantic Health System
Acquired Bleeding Disorder, Cardiac Surgery Requiring Cardiopulmonary Bypass
Use of Activated Recombinant Human Factor VII in Cardiac Surgery
This trial is conducted in Africa, Asia, Europe, South America and the United States of America (USA). The trial is planned to investigate the safety and efficacy of NovoSeven® in the management of post-operative bleeding in…
- Trial name
- NCT00154427
- Testing
- activated recombinant human factor VII
- Where
- 63 sites in United States, Argentina and 12 more
- Volunteers
- 172 people
- Sponsor
- Novo Nordisk A/S
Valvular Heart Disease
Normothermia Versus Hypothermia for Valvular Surgery Patients
Cardiopulmonary bypass (CPB) has been used successfully for cardiac surgery for over half a century. Hypothermia became a ubiquitous practice for adult patients undergoing CPB.
- Trial name
- NCT01338961
- Testing
- Hypothermic CPB
- Where
- Russia
- Volunteers
- 140 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Acute Kidney Injury, Hemolysis
Optimizing Pulsatility During Cardiopulmonary Bypass to Reduce Acute Kidney Injury
The objective is to determine the effectiveness of pulsatile flow during cardiopulmonary bypass to reduce the incidence of acute kidney injury after cardiac surgery.
- Conditions
- Acute Kidney Injury, Hemolysis, Thrombocytopenia, Surgery
- Trial name
- NCT06349577
- Testing
- Non-pulsatile blood flow, Pulsatile blood flow
- Where
- United States
- Volunteers
- 1,100 people
- Sponsor
- University of Colorado, Denver
Thoracic Surgery, Cardiopulmonary Bypass
Variations of the Lung Compliance During Extracorporeal Circulation and Post Operative Pulmonary Complications
the decrease in thoracopulmonary compliance after cardiac surgery is well known . The investigators hypothesize that the major factor determining pulmonary outcome after cardiac surgery is the alteration of pulmonary compliance…
- Trial name
- COMPLI (NCT02654600)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Chirurgical Marie Lannelongue
Hearing Loss, Cardiac Surgery
Prevalence of Auditory Dysfunction and ICU-acquired Delirium Following Cardiac Surgery With Cardiopulmonary Bypass: a Prospective Observational Study
AUDICS-ICU is a prospective observational aiming to evaluate the prevalence of auditive dysfunction following cardiac surgery. Participants will undergo audiometric testings before and 3 months after cardiac surgery with…
- Conditions
- Hearing Loss, Cardiac Surgery, Cardiopulmonary Bypass, Postoperative Cognitive Dysfunction
- Trial name
- AUDICS-ICU (NCT04151914)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- European Georges Pompidou Hospital
Perioperative Respiratory Function, Diaphragmatic Dysfunction
LTV (Low Tidal Volüme) Ventilation and Diaphragmatic Motion in CABG (Coronary Artery Bypass Grafting)
The goal of this clinical trial is to evaluate whether low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) surgery helps preserve diaphragmatic excursion in adult patients undergoing coronary artery bypass…
- Conditions
- Perioperative Respiratory Function, Diaphragmatic Dysfunction, Low Tidal Volume Ventilation
- Trial name
- NCT07067684
- Testing
- Low Tidal Volume Ventilation During CPB
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Konya City Hospital
Lung Protective Ventilation, Cardiopulmonary Bypass
Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery
This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in…
- Conditions
- Lung Protective Ventilation, Cardiopulmonary Bypass, High-risk Cardiac Patients, Lung Ultrasound
- Trial name
- NCT07612709
- Testing
- Ventilated lung, Non-ventilated lung.
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Fibrinogen Deficiency in Complex Cardiac Surgery
Individualized Dose of Fibrinogen Following Cardiopulmonary Bypass
Heart surgery is essential for many cardiovascular conditions, but it is a major operation with a significant mortality rate of around 4% in Europe.
- Trial name
- INDOFIB (NCT07425600)
- Testing
- Blood samples for PK
- Where
- 2 sites in France
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Ischemic Heart Disease, Aortic Stenosis, Severe
Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients
The goal of this interventional is to assess advantages of the ultrasound examination of the lungs in the early postoperative period in cardiac surgical patients after heart surgeries requiring cardiopulmonary bypass.
- Conditions
- Ischemic Heart Disease, Aortic Stenosis, Severe, Aortic Insufficiency, Mitral Stenosis
- Trial name
- NCT06377449
- Testing
- Ultrasound examination of the lungs
- Where
- Russia
- Volunteers
- 186 people
- Sponsor
- Saint Petersburg State University, Russia
Hyperglycemia
Computerized Tight Glycemic Control in Cardiac Surgery
The debate about tight glycemic control (TGC) in the operating room and on the intensive care unit is ongoing, especially in cardio-surgical patients treated with blood cardioplegia, due to high blood glucose levels during…
- Trial name
- NCT01886365
- Testing
- Space GlucoseControl System, B. Braun, Melsungen, Germany, Conventional therapy with a fixed insulin dosing scheme
- Where
- Germany
- Volunteers
- 75 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Cardiac Disease
The Effects of Neurophysiological Facilitation Techniques After Coronary Artery Bypass Graft Surgery
The aim of the study is to investigate the effects of neurophysiological facilitation techniques, applied in addition to Phase I cardiac rehabilitation in the early postoperative period after coronary artery bypass graft (CABG)…
- Trial name
- NCT06640699
- Testing
- exercise
- Volunteers
- 36 people
- Sponsor
- Istanbul University - Cerrahpasa
Systemic Inflammatory Response Syndrome
Perioperative Sitagliptin Medication for Reduction of the Inflammatory Response Associated With Cardiopulmonary Bypass
Sitagliptin is an inhibitor of the enzyme dipeptidylpeptidase-4 (DPP-4) and represents an established drug in type 2 diabetes mellitus treatment. However, Sitagliptin may also have several antiinflammatory properties.
- Trial name
- SiCa-Flam (NCT05725798)
- Testing
- Sitagliptin
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- University Hospital Muenster
AKI, Renal Replacement Therapy
Hyperoxia vs Normoxia During Cardiopulmonary Bypass
This single-center randomized controlled pilot trial evaluates the effects of intraoperative hyperoxia compared with normoxia during cardiopulmonary bypass (CPB) in adult patients undergoing elective cardiac surgery.
- Conditions
- AKI, Renal Replacement Therapy, NGAL, Arrythmia
- Trial name
- IPEROXIA (NCT07510672)
- Testing
- Hyperoxia group, Normoxia group (control)
- Where
- Italy
- Volunteers
- 104 people
- Sponsor
- University of Padova
Congenital Heart Disease
Pre Bypass Ultrafiltration (PBUF) in Children Requiring Cardiopulmonary Bypass
Newborn babies and children with congenital heart defects who need heart surgery need to be placed on the heart-lung machine for heart surgery.
- Trial name
- PBUF (NCT03576534)
- Testing
- Use of prebypass ultrafiltration (PBUF)
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Boston Children's Hospital
Selenium Level
Effect of Heart-lung-machine on Selenium Status of Cardiac Surgical Patients Undergoing Coronary Bypass Surgery
Since selenium has demonstrated significant characteristics for a series of biochemical processes, for antioxidant activity and immune stimulation, this observational study should represent the effect of heart-lung-machine on…
- Trial name
- SEOPCAB (NCT01409057)
- Where
- Germany
- Volunteers
- 46 people
- Sponsor
- RWTH Aachen University
Congenital Heart Defects
Plasma Angiopoietin Levels in Children Following Cardiopulmonary Bypass
During cardiopulmonary bypass (CPB) after heart surgery, a child's blood is exposed to many foreign entities. These conditions trigger the body's inflammatory response which results in leaky capillaries, increased swelling and…
- Trial name
- NCT01489475
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Surgery, Cardiac Event
Effect of Oxiris® Membrane on Microcirculation Following Cardiac Surgery Under Cardiopulmonary Bypass: a Pilot Prospective Monocentric Study (Oxicard Study).
Oxiris membrane is an efficient tool for inflammatory cytokines adsorption. Cardiac surgery is followed by an inflammatory state mimicking sepsis.
- Trial name
- OXICARD (NCT04201119)
- Testing
- Oxiris
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Hemostasis
Three Dose Regimen of Tranexamic Acid in Cardiac Surgery
Tranexamic acid is thought to be a promising substitute for aprotinin when the latter has seceded in 2007. Yet the ideal dosage and dosing regimen of tranexamic acid in cardiopulmonary bypass cardiac surgery in Chinese population…
- Trial name
- NCT01060176
- Testing
- Tranexamic Acid, Saline Solution
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital