Clinical trials: Cardiopulmonary Bypass
Cardiac Surgery, Cardiopulmonary Bypass
Change in Platelet Lipid Metabolism and Procoagulant Phenotype Induced by Cardiopulmonary Bypass. Impact on Postoperative Inflammatory Response and Bleeding Complications During Cardiac Surgery.
The PLACARD research project aims to investigate the impact of CPB-induced platelet modifications during cardiac surgery on the post-operative inflammatory response and bleeding complications.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Platelet Activation
- Trial name
- PLACARD (NCT07630987)
- Testing
- Arterial blood sample
- Where
- Belgium
- Volunteers
- 100 people
- Sponsor
- Université Catholique de Louvain
Cardiopulmonary Bypass
Post-market Clinical Follow-up Study on the Performance and Safety of Coronary Artery Perfusion Cannula Used During Cardiopulmonary Bypass
Prior to the implementation of the Medical Device Regulation (MDR), clinical evaluation of older devices was carried out by Notified Bodies (MBs) based on clinical data obtained from equivalent devices, and CE certification was…
- Trial name
- NCT07620847
- Testing
- coronary artery perfusion cannula
- Volunteers
- 20 people
- Sponsor
- Bıçakcılar Tıbbi Cihazlar Sanayi ve Ticaret A.Ş.
AKI - Acute Kidney Injury, Cardiac Surgical Procedures
rhBNP for Prevention of Cardiac Surgery-Associated Acute Kidney Injury (CSA-AKI)
Cardiac surgery-associated acute kidney injury (CSA-AKI) is a common and serious perioperative complication, independently associated with prolonged hospitalization, increased mortality, and progression to chronic kidney disease.
- Conditions
- AKI - Acute Kidney Injury, Cardiac Surgical Procedures, Cardiopulmonary Bypass
- Trial name
- PROTECT-CS (NCT07617675)
- Testing
- Recombinant Human Brain Natriuretic Peptide (rhBNP)
- Where
- China
- Volunteers
- 694 people
- Sponsor
- China National Center for Cardiovascular Diseases
Nitric Oxide, Cardiac Surgery
Nitric Oxide for Reduced Intensive Support in Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery is a procedure that is commonly performed worldwide. Despite these technological advances, cardiac surgery remains a high-risk surgery.
- Conditions
- Nitric Oxide, Cardiac Surgery, Cardiopulmonary Bypass, Adult Patients Undergoing Cardiovascular Surgery With Cardiopulmonary Bypass
- Trial name
- NORISC (NCT06702553)
- Testing
- Nitric Oxide Gas, Standard Care Arm
- Where
- 3 sites in United States, China and 1 more
- Volunteers
- 3,650 people
- Sponsor
- Xijing Hospital
Lung Protective Ventilation, Cardiopulmonary Bypass
Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery
This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in…
- Conditions
- Lung Protective Ventilation, Cardiopulmonary Bypass, High-risk Cardiac Patients, Lung Ultrasound
- Trial name
- NCT07612709
- Testing
- Ventilated lung, Non-ventilated lung.
- Where
- Austria
- Volunteers
- 45 people
- Sponsor
- Medical University of Vienna
Cardio Vascular Disease, Cardiopulmonary Bypass
Perioperative Vericiguat in Patients Undergoing Cardiovascular Surgery
The purpose of this study is to evaluate the efficacy and safety of perioperative vericiguat in patients undergoing cardiovascular surgery.
- Trial name
- NCT07594509
- Testing
- Vericiguat, Standard of Care Group
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Nanjing Medical University
Lung Injury, Cardiopulmonary Bypass
Neutrophil Phenotypic Profiling and Acute Lung Injury in Patients After Cardiopulmonary Bypass (CPB)
Acute lung injury (ALI) following cardiopulmonary bypass (CPB) is a serious complication, often prolonging the length of stay in ICU and potentially dealing to mortality.
- Trial name
- NCT04296071
- Testing
- Research study
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Sophia Koutsogiannaki
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Artificial Intelligence for Ulinastatin Responder Outcome & Risk Assessment in CPB
This is a multicenter, retrospective, real-world observational study aimed at developing and validating an artificial intelligence-based tool for identifying ulinastatin treatment responders and risk stratification in cardiac…
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome, Multiple Organ Dysfunction Syndrome
- Trial name
- AURORA (NCT07583290)
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Heparin Resistance, Cardiac Surgery
Antithrombin as a Predictor of Heparin Resistance in Cardiac Surgery With Cardiopulmonary Bypass
This study aims to investigate whether the level of antithrombin (AT) in the blood before cardiac surgery can predict how well patients respond to heparin, a medication used to prevent blood clotting during surgery with a…
- Conditions
- Heparin Resistance, Cardiac Surgery, Cardiopulmonary Bypass
- Trial name
- NCT07549568
- Testing
- No intervention (observational study)
- Where
- Sweden
- Volunteers
- 300 people
- Sponsor
- Sahlgrenska University Hospital
Cardiac Surgery, Cardiopulmonary Bypass
Low-dose Dexmedetomidine and Postoperative Delirium After Cardiac Surgery
Delirium is an acutely occurred and fluctuating cerebral dysfunction characterized with inattention, altered consciousness, cognitive decline and/or abnormal perception.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Dexmedetomidine, Delirium
- Trial name
- NCT03624595
- Testing
- Dexmedetomidine
- Where
- 2 sites in China
- Volunteers
- 504 people
- Sponsor
- Dong-Xin Wang
Cardiac Surgery Associated - Acute Kidney Injury, Cardiac Surgery With Cardiopulmonary Bypass
Inhaled Nitric Oxide for Prevention of Postoperative AKI in High-Risk Cardiac Surgery Patients
The goal of this clinical trial is to learn if giving inhaled nitric oxide during heart surgery can prevent acute kidney injury (AKI) in patients who are at high risk of developing this complication.
- Trial name
- NCT07544147
- Testing
- Inhaled Nitric Oxide (iNO)
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Shanghai Zhongshan Hospital
Platelet Dysfunction, Cardiopulmonary Bypass
Influence of Oxygenator Selection on Platelet Function and Rotational Thromboelastometry Following Cardiopulmonary Bypass
Open-heart surgery requires temporarily stopping the heart and lungs and diverting the patient's blood to an outside system that takes over the function of the heart and lungs.
- Trial name
- NCT05588011
- Testing
- Terumo, LivaNova
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- BRADEN DULONG
Heart Valve Diseases, Aortic Diseases
Effective Myocardial Protection Time of Del Nido Cardioplegia in Adult Cardiac Surgery
This single-center, prospective, observational cohort study quantifies the effective myocardial protection window of Del Nido cardioplegia during adult open-heart surgery performed under cardiopulmonary bypass (CPB) and aortic…
- Conditions
- Heart Valve Diseases, Aortic Diseases, Myocardial Ischemia, Reperfusion Injury, Myocardial
- Trial name
- DN-TIME-2025 (NCT07249424)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Muhammet Talha Ceran, MD
Coronary Surgery With Cardiopulmonary Bypass
Effects of a Goal-directed Hemodynamic Therapy Driven by ECOM on Morbidity and Mortality After Cardiac Surgery?
Goal-directed hemodynamic and fluid optimizations are shown to be a key factor of the medical care during anesthesia.According to medical literature, goal-directed fluid and hemodynamic optimizations are more efficient when based…
- Trial name
- ECOMIII (NCT01535716)
- Testing
- hemodynamic optimization strategy driven by the ECOM, standard management strategy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Bypass, Cardiopulmonary
Menthol Massage for Post-Bypass Pain & Anxiety
This randomized controlled trial aims to evaluate the effectiveness of mentholated ointment massage in reducing pain and anxiety levels in patients who have undergone coronary bypass surgery, volunteered to participate in the…
- Trial name
- Menthol Care (NCT07508371)
- Testing
- Menthol Massage, Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people
- Sponsor
- Istanbul Medipol University Hospital
Postoperative Delirium (POD), Cardiopulmonary Bypass
Effect of Low Tidal Volume Ventilation on Postoperative Delirium
This study aims to evaluate the effect of low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) on postoperative delirium.
- Conditions
- Postoperative Delirium (POD), Cardiopulmonary Bypass, Low Tidal Volume Ventilation, Cognitive Dysfunction, Postoperative
- Trial name
- CLEVER (NCT06752421)
- Testing
- Group B: Low tidal volume
- Where
- Turkey (Türkiye)
- Volunteers
- 130 people
- Sponsor
- Nevsehir Public Hospital
Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury
The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery
Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid…
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury, Congenital Heart Defect
- Trial name
- NCT06899971
- Testing
- Collecting discarded blood samples
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Cardiac Surgery, Cardiopulmonary Bypass
Heparin Based on Ideal Body Weight for Cardiopulmonary Bypass in Obese Patients
The optimal heparin regimen during cardiopulmonary bypass (CPB) has not been well established in obese patients. Results of a preview study show that the standard heparin management based on total body weight in obese patients…
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Obese Patients (BMI ≥ 30 kg/m²)
- Trial name
- HEPOIRINE (NCT02675647)
- Testing
- Heparin, IV route, based on patients body weights (UI/kg), Cardiopulmonary bypass, Protamin administration
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France
Congenital Heart Disease (CHD), Cardiopulmonary Bypass
Research on Circulation Management Strategy Based on Oxygen Metabolism Balance After CHD Surgery
The objective is to investigate a goal-oriented postoperative circulation management strategy centered on "oxygen metabolism balance".
- Conditions
- Congenital Heart Disease (CHD), Cardiopulmonary Bypass, Children, Oxygen Delivery
- Trial name
- NCT06747546
- Testing
- "goal-directed" treatment strategy based on oxygen supply and consumption balance, Conventional Treatment group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Children's Hospital of Fudan University
Coronary Artery Bypass Graft (CABG), Cardioplegia
Cardioplegic Protection of the Heart
This study seek to compare two different solutions used to protect the heart during cardiac surgery. 40 adult patients planned for coronary artery bypass surgery with cardiopulmonary bypass machine assistance will be included in…
- Conditions
- Coronary Artery Bypass Graft (CABG), Cardioplegia, Cardiopulmonary Bypass, Perioperative Myocardial Injury
- Trial name
- NCT07386990
- Testing
- Modified Buckberg cardioplegic solution, Modified St Thomas´ cardioplegic solution
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane