Clinical trials: Cardiopulmonary Disease
Blood Coagulation Disorders
The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass
This proposal is designed to mitigate hemodilution (blood diluted with an electrolyte solution) and loss of plasma proteins responsible for normal blood clotting as well as platelets at the completion of cardiopulmonary bypass…
- Trial name
- NCT01435304
- Testing
- method of returning residual CPB blood ( Hemobag®)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- MaineHealth
Cardiac Arrest
Prehospital Cerebral Oxygenation During Cardiopulmonary Resuscitation (CPR)
Near infrared spectroscopy (NIRS) is a technique that measures regional cerebral oxygenation in a non-invasive manner. Through the use of near infrared light, the difference between oxygenated and deoxygenated hemoglobin can be…
- Trial name
- NCT01806844
- Where
- 5 sites in Belgium
- Volunteers
- 200 people
- Sponsor
- Hasselt University
End of Life
Survey on Palliative Care and Law Perception
The primary objective of the current survey study is to obtain detailed information about European intensive care unit (ICU) clinicians' awareness of palliative care and relevant, local end-of-life (EoL) legislation.
- Trial name
- PCLAW (NCT06245525)
- Testing
- This is not an interventional study
- Where
- Greece
- Volunteers
- 523 people
- Sponsor
- University of Athens
Dilated Cardiomyopathy
Respiratory Muscles Training in Patients With Dilated Cardiomyopathy
The aim of this study was to determine the effects of respiratory muscles training on cardiopulmonary parameters and quality of life in patients with dilated cardiomyopathy (DCM).
- Trial name
- NCT04307823
- Testing
- Treadmill training, Treadmill protocol and Respiratory training
- Where
- Pakistan
- Volunteers
- 22 people
- Sponsor
- Riphah International University
Long COVID, Chronic Fatigue Syndrome
Telerehabilitation for Post COVID-19 Condition
Telerehabilitation is a great alternative to offering care during a global pandemic. 85% of patients with COVID-19 report persistent symptoms up to 8 months after the infection.
- Trial name
- Telecovie (NCT05973136)
- Testing
- Telerehabilitation program based on cardiorespiratory principles
- Where
- Canada
- Volunteers
- 7 people
- Sponsor
- Université de Sherbrooke
Cardiac Arrest, Cardiopulmonary Arrest With Successful Resuscitation
Pupillometry and Somatosensory Evoked Potential in Cardiac Arrest
Somatosensory Evoked Potentials (SSEP) and Pupillary Light Reflex (PLR) are key methods for neurologic prognostication in comatose survivors of cardiac arrest.
- Conditions
- Cardiac Arrest, Cardiopulmonary Arrest With Successful Resuscitation, Resuscitation
- Trial name
- PASCA (NCT04720482)
- Testing
- Somatosensory Evoked Potentials, Automated Pupillometry
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Sahlgrenska University Hospital
Heart Arrest, Seizures
Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest
Non-convulsive seizures (NCS) following cardiac arrest are common and are associated with worse neurologic outcomes and increased mortality. More prolonged seizures (status epilepticus) are associated with worse outcomes.
- Trial name
- NCT02458820
- Testing
- DSA EEG
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Children's Hospital of Philadelphia
Cardiac Arrest
Non Invasive Neuromonitoring After Cardiac Arrest
Cardiac Arrest is among the leading causes of death, with survival still well under 50% and the majority of the survivors suffering from moderate to severe neurologic deficits. The human, social and economic costs are staggering.
- Trial name
- NINCA (NCT02575196)
- Testing
- Non-invasive cerebral flow monitoring
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Obstructive Pulmonary Disease
Air Pollution and Health of COPD Patients
This panel study aims to evaluate the effects of air pollutants on cardiopulmonary health of patients with chronic obstructive pulmonary disease (COPD) and explore the potential biological mechanisms.
- Trial name
- NCT05076630
- Testing
- Air pollutants
- Where
- China
- Volunteers
- 110 people
- Sponsor
- Peking University
Hypofibrinogenemia, Afibrinogenemia
Human Fibrinogen Concentrate in Pediatric Cardiac Surgery
The goal of the study is to determine whether the use of Human Fibrinogen Concentrate (RiaSTAP) will decrease blood loss and the need for component blood therapy in neonates and infants undergoing cardiopulmonary bypass.
- Conditions
- Hypofibrinogenemia, Afibrinogenemia, Bleeding Disorders
- Trial name
- RiaSTAP (NCT02822599)
- Testing
- RiaStAP, Saline
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Delirium, Critical Illness
Remimazolam vs Midazolam to Reduce Delirium in Adults ≥65 Undergoing CPB Valve Surgery
"Postoperative delirium is a common and serious complication following cardiac surgery, particularly among older adults who require intensive care.
- Conditions
- Delirium, Critical Illness, Aged, Cardiopulmonary Bypass
- Trial name
- NCT07265128
- Testing
- Midazolam, Remimazolam
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Yonsei University
COVID-19 Respiratory Infection
Cardiopulmonary Rehabilitation in Long COVID-19 Patients With Persistent Breathlessness and Fatigue
The objective of this project is to assess the effects of a 2-month cardiopulmonary rehabilitation program on cardiorespiratory fitness in long COVID19 patients.
- Trial name
- COVID-Rehab (NCT05035628)
- Testing
- Cardiopulmonary exercise training
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Louis Bherer
Obstructive Sleep Apnea
Cardiopulmonary Exercise Test in Patient With Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) can be described as a condition characterized by repetitive obstruction of the upper airway resulting in oxygen desaturation and awakening from sleep, loud snoring, and increased daytime sleepiness .
- Trial name
- NCT03300700
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cardiac Arrest, Cardiopulmonary Resuscitation
Compression Is Life In Cardiac Arrest - Human Study (CILICA-HS).
The management of out-of-hospital cardiac arrest is complex and multifactorial. With an incidence between 5 and 15 per 10,000 (46,000 patients per year in France) and a survival rate of only 5% to 15%, the room for improvement…
- Trial name
- CILICA-HS (NCT03817892)
- Testing
- Guidance of the External Chest Compression, Rhythm of a relay 4 minutes
- Where
- 11 sites in France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Caen
Learning Disorders
Effects of the in Situ Simulation to Competencies in Cardiopulmonary Resuscitation in the Nursing Team.
Introduction: In situ simulation is a methodology that meets the concept of permanent education, since it allows learning from the context of practice and in the work environment itself.
- Trial name
- NCT03626272
- Testing
- educational intervention
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Federal University of Health Science of Porto Alegre
Ischemia-Reperfusion Injury
Effect of Dexmedetomidine Preconditioning on Myocardial Ischemia-reperfusion Injury in Patients Undergoing Open Heart Surgery With Cardiopulmonary Bypass
About 200000 cardiac operations are performed in China every year. Cardiopulmonary bypass is the basic strategy of open-heart surgery, which may lead to myocardial ischemia-reperfusion injury and low cardiac output syndrome.
- Trial name
- NCT05598177
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Affiliated Hospital of Nantong University
Cardiopulmonary Disease, Fluid Overload
Fluid Status and Body Composition Analysis by Bioelectrical Impedance in Patients After Cardiac Surgery (FLUBIACS)
Evaluation of fluid status in cardiac surgery patients using bioelectrical impedance and its impact on postoperative morbidity and mortality
- Trial name
- FLUBIACS (NCT06498375)
- Testing
- Bioelectrical impedance
- Where
- Slovenia
- Volunteers
- 150 people
- Sponsor
- University Medical Centre Ljubljana
Congenital Heart Defects
Plasma Angiopoietin Levels in Children Following Cardiopulmonary Bypass
During cardiopulmonary bypass (CPB) after heart surgery, a child's blood is exposed to many foreign entities. These conditions trigger the body's inflammatory response which results in leaky capillaries, increased swelling and…
- Trial name
- NCT01489475
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Yale University
Cardiac Arrest (CA), Simulation Training
Comparing Foot and Hand CPR
The goal of this simulation study is to evaluate whether chest compression using the foot is comparable to chest compression using the hand during cardiopulmonary resuscitation in trained participants.
- Trial name
- NCT06719401
- Testing
- Foot Chest Compression, Hand Chest Compression
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Hypertrophic, Familial
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
- Trial name
- NCT02862600
- Testing
- Perhexiline, Use of bioanalytical assay to monitor plasma levels of perhexiline
- Where
- 11 sites in United States
- Volunteers
- 35 people
- Sponsor
- Heart Metabolics Limited