Clinical trials: Cardiopulmonary Disease
Heart Arrest, Birth Asphyxia
SI + CC Versus 3:1 C:V Ratio During Neonatal CPR
Research question In newborn infants requiring CPR, does CC superimposed by sustained inflation compared to 3:1 compression to ventilation ratio improves return of spontaneous circulation? Overall objective: CC superimposed by…
- Conditions
- Heart Arrest, Birth Asphyxia, Bradycardia
- Trial name
- SURV1VE (NCT02858583)
- Testing
- CC+SI, 3:1 C:V
- Where
- 4 sites in Austria, Canada
- Volunteers
- 27 people
- Sponsor
- University of Alberta
Coronary Artery Bypass Grafting, Mitral Valve Surgery
Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass
A study to evaluate levosimendan compared with placebo in reducing the composite event rate of all-cause death, perioperative MI, need for new dialysis, or use of mechanical assist (IABP, LVAD or ECMO) in subjects with reduced…
- Conditions
- Coronary Artery Bypass Grafting, Mitral Valve Surgery, Low Cardiac Output Syndrome
- Trial name
- LEVO-CTS (NCT02025621)
- Testing
- Levosimendan
- Where
- 60 sites in United States, Canada
- Volunteers
- 882 people
- Sponsor
- Tenax Therapeutics, Inc.
Cardiac Arrest
Amiodarone, Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia
The primary objective of the trial is to determine if survival to hospital discharge is improved with early therapeutic administration of a new Captisol-Enabled formulation of IV amiodarone (Nexterone-PM101) compared to placebo.
- Trial name
- ALPS (NCT01401647)
- Testing
- amiodarone, Lidocaine, Normal saline
- Where
- 9 sites in United States, Canada
- Volunteers
- 3,024 people
- Sponsor
- University of Washington
Heart Arrest
Resuscitation Outcomes Consortium (ROC) Prehospital Resuscitation Using an Impedance Valve
The purpose of this study is to look at two different treatments during a cardiac arrest that occurs outside of the hospital and whether either or both treatments will increase the number of people who live to hospital discharge.
- Trial name
- NCT00394706
- Testing
- Impedance Threshold Device (ITD), Analyze early, Analyze later
- Where
- 9 sites in United States, Canada
- Volunteers
- 11,738 people
- Sponsor
- University of Washington
Blood Coagulation Disorders
The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass
This proposal is designed to mitigate hemodilution (blood diluted with an electrolyte solution) and loss of plasma proteins responsible for normal blood clotting as well as platelets at the completion of cardiopulmonary bypass…
- Trial name
- NCT01435304
- Testing
- method of returning residual CPB blood ( Hemobag®)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- MaineHealth
Hypofibrinogenemia, Afibrinogenemia
Human Fibrinogen Concentrate in Pediatric Cardiac Surgery
The goal of the study is to determine whether the use of Human Fibrinogen Concentrate (RiaSTAP) will decrease blood loss and the need for component blood therapy in neonates and infants undergoing cardiopulmonary bypass.
- Conditions
- Hypofibrinogenemia, Afibrinogenemia, Bleeding Disorders
- Trial name
- RiaSTAP (NCT02822599)
- Testing
- RiaStAP, Saline
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Nicklaus Children's Hospital f/k/a Miami Children's Hospital
Cardiomyopathy, Hypertrophic, Cardiomyopathy, Hypertrophic, Familial
Open-Label Study of Perhexiline in Patients With Hypertrophic Cardiomyopathy and Moderate to Severe Heart Failure
The purpose of this study is to evaluate the effect of perhexiline on exercise performance (efficacy) and safety in patients with hypertrophic cardiomyopathy and moderate-to-severe heart failure following dosing for 16 weeks.
- Trial name
- NCT02862600
- Testing
- Perhexiline, Use of bioanalytical assay to monitor plasma levels of perhexiline
- Where
- 11 sites in United States
- Volunteers
- 35 people
- Sponsor
- Heart Metabolics Limited
Cerebral Palsy, Physical Activity
Effects of Hippotherapy on Physical Fitness and Attention in Cerebral Palsy
This research analyzes whether hippotherapy improves the physical activity, cardiopulmonary fitness, and attention in children with cerebral palsy and whether this enhances their general health and quality of life.
- Conditions
- Cerebral Palsy, Physical Activity, Attention Disorder
- Trial name
- NCT03870893
- Testing
- hippotherapy
- Where
- South Korea
- Volunteers
- 47 people
- Sponsor
- Samsung Medical Center
Cardiac Arrest, Heart Arrest
ECPR for Refractory Out-Of-Hospital Cardiac Arrest
In the U.S. alone, over 300,000 people per year have sudden out-of-hospital cardiac arrest (OHCA), and less than 1 out of 10 survive.
- Conditions
- Cardiac Arrest, Heart Arrest, Sudden Cardiac Arrest, Cardiopulmonary Arrest
- Trial name
- EROCA (NCT03065647)
- Testing
- Expedited Transport With Mechanical CPR
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Michigan
Pulmonary Hypertension, Heart Failure, Diastolic
Inhaled Nitrite in Subjects With Pulmonary Hypertension
This is a single-center, open label phase II study to evaluate the effect of inhaled nitrite delivered in a dose escalation manner on the change in pulmonary vascular resistance (PVR) in subjects with pulmonary hypertension…
- Trial name
- NCT01431313
- Testing
- Inhaled Nitrite
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Schmidhofer, Mark, MD
Heart Failure, Congestive
Evaluation of the Safety and Effectiveness of the OPTIMIZER System in Subjects With Heart Failure: FIX-HF-5
The purpose of this study is to determine whether treatment with the OPTIMIZER System is safe and effective in patients with moderate to severe heart failure symptoms.
- Trial name
- NCT00112125
- Testing
- OPTIMIZER System
- Where
- United States
- Volunteers
- 428 people
- Sponsor
- Impulse Dynamics
Coronary Artery Bypass, Myocardial Infarction
The Effect Of Acadesine On Reducing Cardiovascular and Cerebrovascular Adverse Events In Coronary Artery Bypass Graft (CABG) Surgery (Study P05633 AM1)(TERMINATED)
The purpose of this study is to determine whether acadesine is effective in reducing the cardiovascular and cerebrovascular adverse events in high-risk participants undergoing CABG surgery.
- Conditions
- Coronary Artery Bypass, Myocardial Infarction, Ventricular Dysfunction, Left, Stroke
- Trial name
- RED-CABG (NCT00872001)
- Testing
- Acadesine, Normal Saline
- Volunteers
- 3,080 people
- Sponsor
- Merck Sharp & Dohme LLC
Heart Failure, Respiratory Failure
Heart And Lung Failure - Pediatric INsulin Titration Trial
Stress hyperglycemia, a state of abnormal metabolism with supra-normal blood glucose levels, is often seen in critically ill patients.
- Trial name
- HALF-PINT (NCT01565941)
- Testing
- Insulin
- Where
- 35 sites in United States, Australia and 1 more
- Volunteers
- 713 people
- Sponsor
- Boston Children's Hospital
Congenital Heart Disease, Congenital Heart Defect
A Pilot Study of Optic Nerve Ultrasound Following Cardiopulmonary Bypass
The purpose of the proposed study is to evaluate the incidence of subtle increases in intracranial pressure (ICP) following cardiopulmonary bypass (CPB) using optic nerve sheath diameter (ONSD), measured by non-invasive…
- Trial name
- NCT03757312
- Testing
- Ultrasound
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Marco Corridore
Pulmonary Hypertension, Pulmonary Arterial Hypertension
Study of Ralinepag on Exercise Capacity by Cardiopulmonary Exercise Testing (CPET) in WHO Group 1 PH Subjects
Study ROR-PH-302, ADVANCE CAPACITY, was designed to evaluate the effects of ralinepag therapy on exercise capacity as assessed by change in peak oxygen consumption (VO2) derived from cardiopulmonary exercise testing (CPET) after…
- Trial name
- CAPACITY (NCT04084678)
- Testing
- Ralinepag
- Where
- 33 sites in United States, Argentina and 10 more
- Volunteers
- 10 people
- Sponsor
- United Therapeutics
Heart Failure
Biventricular Pacing After Cardiopulmonary Bypass
The purpose of this study is to investigate the efficacy of optimized temporary biventricular pacing (BiVP) in patients undergoing open-heart surgery with preoperative LV dysfunction and an intraventricular conduction delay.
- Trial name
- BIPACS (NCT00498940)
- Testing
- Optimization Testing, Temporary Biventricular Pacing
- Where
- United States
- Volunteers
- 111 people
- Sponsor
- Henry M. Spotnitz
Oxidative Stress, Cognition Disorders
The Effect of Dexmedetomidine Infusion on Post-operative Cognitive Function and Oxidative Stress in Cardiac Surgery
Objective: The aim of this study was to determine the effect of dexmedetomidine in reducing postoperative cognitive dysfunction (POCD) in cardiac surgical patients which use cardiopulmonary bypass machine (CPB).
- Trial name
- NCT03054857
- Testing
- Dexmedetomidine
- Volunteers
- 100 people
- Sponsor
- Chulalongkorn University
Complication of Extracorporeal Circulation, Renal Impairment
Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)
Acute kidney injury is a common complication after cardiac surgery with cardiopulmonary bypass (CPB). This study aims to investigate the effects of CPB on renal perfusion, filtration and oxygenation.
- Trial name
- ECCSTUD (NCT02405195)
- Testing
- cardiopulmonary bypass
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- Sahlgrenska University Hospital
Complication of Surgical Procedure, Acute Respiratory Failure, Adult
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric…
- Conditions
- Complication of Surgical Procedure, Acute Respiratory Failure, Adult, Postoperative Respiratory Complications, Pulmonary Failure
- Trial name
- PERISCOPE (NCT01346709)
- Where
- 63 sites in Albania, Belgium and 19 more
- Volunteers
- 5,450 people
- Sponsor
- European Society of Anaesthesiology
Cardiac Arrest
Survey of Attitudes and Factors Associated With CPR in an Older Population
The goal of this study is to conduct a survey to better understand the factors associated with undertaking cardiopulmonary resuscitation (CPR) training and performing CPR in an emergency situation.
- Trial name
- NCT00665288
- Where
- Canada
- Volunteers
- 412 people, healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute