Clinical trials: Cardiopulmonary Diseases
Heart Defects, Congenital
The Management of Systemic-Pulmonary Collateral Blood Flow in Cyanotic Children During Cardiopulmonary Bypass - Pilot Study
The purpose of the study is to determine whether it is possible to manage the flow of blood through blood vessels using varying levels of carbon dioxide during cardiac surgery, and what effect this has on how well the major…
- Trial name
- NCT02358382
- Testing
- pH Stat
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Lung Cancer
Video-Assisted Surgery Followed by Radiation Therapy in Treating Patients With Stage I Non-small Cell Lung Cancer and Poor Heart and Lung Function
RATIONALE: Video-assisted surgery followed by radiation therapy may be an effective treatment in patients whose poor heart and lung function make them high risk for standard surgery.
- Trial name
- NCT00002624
- Testing
- adjuvant therapy, diagnostic thoracoscopy, therapeutic thoracoscopy
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 66 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Out-Of-Hospital Cardiac Arrest, Ventricular Fibrillation
Real Time Amplitude Spectrum Area to Guide Defibrillation
AMSA trial is a multicenter, randomized, controlled study in out-of-hospital cardiac arrest patients. The purpose of the study is to test the hypothesis that a real time AMSA analysis during CPR may predict the success of…
- Trial name
- AMSA (NCT03237910)
- Testing
- AMSA, Defibrillation, CPR
- Where
- 2 sites in Italy
- Volunteers
- 31 people
- Sponsor
- Mario Negri Institute for Pharmacological Research
Cardiac Arrest (CA)
Hand vs. Foot Chest Compressions in Simulation
Cardiopulmonary resuscitation (CPR) is essential in the management of cardiorespiratory arrest (CA) to improve survival rates. High-quality chest compressions are the primary intervention to maintain circulation and oxygenation…
- Trial name
- NCT07074080
- Testing
- Performing chest compressions on a mannequin using the foot, Performance of standard chest compressions with the upper limbs.
- Where
- Spain
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Hospital Clinic of Barcelona
Eisenmenger Syndrome
Bosentan in Treatment of Pulmonary Arterial Hypertension
Eisenmenger's syndrome presents as a severe clinical picture of polymorbidity that constitutes a great burden at the individual as well as the familial and social level.
- Trial name
- NCT00266162
- Testing
- Bosentan administration
- Where
- 8 sites in Germany
- Volunteers
- 60 people
- Sponsor
- Competence Network for Congenital Heart Defects
Stage 1 Hypertensives
Additional Effect of Coherent Breathing With Aerobic Exercise on Cardiopulmonary Parameters and Quality of Life in Stage 1 Hypertensive Individuals
This study will use a randomized controlled trial to evaluate the added effects of coherent breathing combined with aerobic exercise versus aerobic exercise alone in 40 adults aged 30-65 with stage 1 hypertension.
- Trial name
- NCT07573683
- Testing
- Coherent Breathing., Aerobic Exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Foundation University Islamabad
Complication of Extracorporeal Circulation, Kidney Circulation Disorder
Impact of CArdiopulmonary Bypass Flow on Renal Blood Flow, Function and OXygenation
Cardiac surgery with cardiopulmonary bypass (CPB), especially when oxygen delivery is low, is associated with acute kidney injury.
- Conditions
- Complication of Extracorporeal Circulation, Kidney Circulation Disorder, Renal Function Disorder
- Trial name
- ICAROX (NCT02549066)
- Testing
- Increased cardiopulmonary bypass flow, Milrinone
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Sahlgrenska University Hospital
Esophageal Cancer, Radiation Pneumonitis
Neoadjuvant Therapy for Esophageal Cancer and Cardiopulmonary Physiology
Although recent global trends indicate reduced postoperative mortality after esophagectomy, major morbidity, in particular pulmonary, remains high, with considerable health and economic costs.
- Conditions
- Esophageal Cancer, Radiation Pneumonitis, Pulmonary Fibrosis, Respiratory Failure
- Trial name
- NCT03462524
- Testing
- Esophagectomy
- Where
- 2 sites in Ireland
- Volunteers
- 384 people
- Sponsor
- St. James's Hospital, Ireland
Heart Disease
Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery
The SHAPE study is a prospective, randomized study evaluating changes in cardiac function in adult patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- SHAPE (NCT07770269)
- Testing
- BIS-guided anesthesia: BIS 45-55, BIS-guided anesthesia: BIS 30-35
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- AHEPA University Hospital
Acute Kidney Injury, Renal Resistive Index
Association Between Renal Resistive Index(RRI) and AKI(Acute Kidney Injury) in Cardiac Surgery Patients With Cardiopulmonary Bypass (CPB)
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity. The conventiional marker for detecting AKI is serum creatinine, however, which has many limits.
- Trial name
- NCT06464666
- Testing
- Renal interlobar artery US, Renal inter-lobular artery US
- Volunteers
- 250 people
- Sponsor
- Yonsei University
Disorder Related to Cardiac Transplantation
Nordic Everolimus (Certican) Trial in Heart and Lung Transplantation
This study investigated whether initiation of everolimus together with reduction of calcineurin inhibitors (CNI) in maintenance heart or lung transplant patients with renal impairment would improve renal function.
- Trial name
- NOCTET (NCT00377962)
- Testing
- Everolimus, Mycophenolic acid (MPA)/azathioprine (AZA), Calcineurin inhibitors (CNI)
- Where
- 6 sites in Denmark, Norway and 1 more
- Volunteers
- 282 people
- Sponsor
- Novartis Pharmaceuticals
Cardiac Arrest, Fibrillation, Ventricular
Early Double Sequential Defibrillation in Out-of-hospital Cardiac Arrest
Some of the patients affected by Out-of-hospital cardiac arrest (OHCA) with ventricular fibrillation (VF)/ventricular tachycardia (VT) do not respond to initial defibrillation.
- Conditions
- Cardiac Arrest, Fibrillation, Ventricular, Sudden Cardiac Death, Sudden Cardiac Arrest
- Trial name
- DOUBLE-D (NCT06447805)
- Testing
- Double Sequential Defibrillation (DSD), Standard defibrillation
- Where
- 3 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Karolinska Institutet
Low Cardiac Output Syndrome Bypass Children
Performance of Carbon Dioxide (CO2)-Derived Parameters in Predicting Low Cardiac Output Syndrome
In congenital cardiac intensive care, low cardiac output syndrome (LCOS) after surgery is defined by a decrease in cardiac output due to cardiac dysfunction.
- Trial name
- GAP-CO2 (NCT07770386)
- Where
- France
- Volunteers
- 306 people
- Sponsor
- University Hospital, Lille
Covid19, Viral Syndrome
Cardiopulmonary Rehabilitation in COVID-19 Longhaulers
This study will test the efficacy of treadmill exercise combined with supplemental oxygen during exercise and recovery for the treatment of persistent post-acute COVID-19 symptoms.
- Trial name
- NCT04898205
- Testing
- Treadmill Exercise, Concentrated Oxygen, Concentrated Air
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Noah Greenspan
Respiration Failure, Cardio Vascular Disease
COMPARE-VENT Feasibility Pilot Study
Cardiac disease complicated by respiratory insufficiency comprises the most frequent indication for cardiac intensive care unit (CICU) admission, with nearly one-third patients requiring advanced respiratory support and over 20%…
- Conditions
- Respiration Failure, Cardio Vascular Disease, Cardiogenic Pulmonary Oedema, Critical Illness
- Trial name
- NCT07656259
- Testing
- Volume Controlled Mode, Pressure Controlled Mode
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- Mayo Clinic
Emergencies
Research on Key Technologies and System Optimization of Early Warning and Resuscitation of Cardiac Arrest
Studies have shown that early prevention and warning of cardiac arrest, rapid implementation of high-quality cardiopulmonary resuscitation, and strengthening of organ function protection after resuscitation are the keys to…
- Trial name
- NCT04955288
- Testing
- Aortic balloon assisted resuscitation, Traditional cardiopulmonary resuscitation, Esophageal cooling
- Where
- China
- Volunteers
- 1,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Congenital Heart Disease, Sepsis
Pro-Calcitonin Levels Following Pediatric Cardiac Surgery
First, we, the researchers, hope to find out the PCT response to heart surgery in children by taking blood before surgery and each day for four days after surgery.
- Conditions
- Congenital Heart Disease, Sepsis, Infection
- Trial name
- NCT00284570
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Emory University
Out-of-Hospital Cardiac Arrest
Combining Performance of Call EMS and Simultaneous Chest Compressions in a Lone Rescuer CPR
Investigators designed the novel combining technique that rescuer start the chest compression with one hand during calling for help to the Emergency Medical System (EMS) via a cell phone with another hand when he witnessed the…
- Trial name
- NCT02646046
- Testing
- Combi lone-CPR, Conventional lone-CPR
- Where
- South Korea
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Konkuk University Medical Center
Nosocomial Pneumonia
High-dose Inhaled NO Therapy for the pREvenvention of NP After Cardiac Surgery Under CPB
The primary aim of this single-center, prospective, randomized, controlled, study is to test the hypothesis that inhalation of NO 200 ppm prevents the development of nosocomial pneumonia in patients at risk after cardiac surgery…
- Trial name
- NCT06261827
- Testing
- 200-ppm NO
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Heart Arrest, Heart Arrest, Out-Of-Hospital
An Educational Program to Improve Cardiac Arrest Diagnostic Accuracy of Ambulance Telecommunicators
Cardiac arrest is the number one cause of death in Canada. It is often the first symptom of cardiac disease for the victims. Eighty-five percent of victims collapse in their own home.
- Conditions
- Heart Arrest, Heart Arrest, Out-Of-Hospital, Cardiac Arrest, Death, Sudden, Cardiac
- Trial name
- NCT03894059
- Testing
- Educational Intervention
- Where
- Canada
- Volunteers
- 12,224 people
- Sponsor
- Ottawa Hospital Research Institute
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