Clinical trials: Cardiopulmonary Diseases
Refractory Cardiac Arrest
Feasibility Study on a Prehospital Extracorporeal CardioPulmonary Resuscitation in the Pavia's Province.
This is a single Center interventional study, assessing the feasibility of a complex treatment strategy where an in-hospital standard care process is applied in an out-of-hospital cardiac arrest.
- Trial name
- eCPR on Site (NCT07155772)
- Testing
- Extracorporeal CardioPulmonary Resuscitation (eCPR)
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione IRCCS Policlinico San Matteo di Pavia
Coagulation; Intravascular
Optimal Protamine Dosing for Heparin Reversal Following Cardiopulmonary Bypass
The purpose of this study is to compare two different dosing strategies of a drug named protamine.
- Trial name
- NCT05426031
- Testing
- Protamine fixed dose, Protamine ratio dose
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Miami
Post Cardiac Surgery Systemic Inflammatory Response
Single Dose Administration of Alpha-1 Anti-Trypsin for the Amelioration of Organ Injury in Patients Undergoing Cardiac Surgery
Protocol Summary STUDY DESIGN A pilot, prospective, double blind, randomized, placebo controlled study. STUDY POPULATION Patients assigned to elective CABG with cardiopulmonary bypass (CPB) at the Department of Cardiothoracic…
- Trial name
- NCT02191839
- Testing
- Alpha 1-Antitrypsin
- Volunteers
- 20 people
- Sponsor
- Soroka University Medical Center
Valvular Heart Disease
The Impact of Sleep-disordered Breathing on the Incidence of Postoperative Acute Kidney Injury in Patients Undergoing Valvular Heart Surgery
Sleep-disordered breathing has a prevalence of 30~80% in patients with heart diseases. Various studies have revealed a correlation between the incidence and various diseases such as heart failure, hypertension, diabetes, and…
- Trial name
- NCT04080219
- Where
- South Korea
- Volunteers
- 414 people
- Sponsor
- Yonsei University
Coronary Heart Disease
Levosimendan Pretreatment for Weaning Patients From Cardio-Pulmonary Bypass
The study evaluates the efficacy of intravenous levosimendan treatment started during a coronary artery bypass operation to wean patients from a heart lung machine.
- Trial name
- NCT00130871
- Testing
- levosimendan
- Where
- 2 sites in Finland
- Volunteers
- 60 people
- Sponsor
- Orion Corporation, Orion Pharma
Cardiac Arrest, Anoxic Encephalopathy
TELSTAR: Treatment of ELectroencephalographic STatus Epilepticus After Cardiopulmonary Resuscitation
The purpose of this study is to estimate the effect of medical treatment of electro-encephalographic status epilepticus on neurological outcome of patients with postanoxic encephalopathy after cardiac arrest.
- Conditions
- Cardiac Arrest, Anoxic Encephalopathy, Status Epilepticus
- Trial name
- TELSTAR (NCT02056236)
- Testing
- Anti-epileptic drugs, No anti-epileptic drugs
- Where
- 11 sites in Belgium, Netherlands
- Volunteers
- 172 people
- Sponsor
- University of Twente
Covid19
Cardiac and Lung Assessment of Professional Soccer Players Following COVID-19 Disease
During this world COVID-19 outbreak, and according to the experience of team doctors, after their return, some players could have been affected by the SARS-cov2.
- Trial name
- NCT04871867
- Where
- France
- Volunteers
- 60 people
- Sponsor
- American Hospital of Paris
Cardiopulmonary Arrest
Compare Outcomes of CPR Between the Video-laryngoscopy (VL) Users and the Direct-laryngoscopy (DL) Users
This is a clinical study based on the analysis of video-clip data of cardiopulmonary resuscitation (CPR) and clinical data for out of hospital cardiac arrest patients between 2011 and 2015.
- Trial name
- NCT03256019
- Testing
- Endotracheal Intubation
- Volunteers
- 600 people
- Sponsor
- Konkuk University Medical Center
Coronary Artery Disease, Edema
The Efficacy and Safety of Hypertonic Saline in Cardiac Surgery Patients.
The organ dysfunction following cardiopulmonary bypass (CPB) occurs frequently in cardiac surgery patients. Systemic inflammatory response initiated by CPB through releasing of several mediators lead to altered endothelial…
- Trial name
- ESHHS (NCT01675453)
- Testing
- 7.2% NaCl plus 6% hydroxyethyl starch 200/0.5, 0.9% NaCl
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
out-of Hospital Cardiac Arrest
Pre-Hospital Cerebral Oxygenation and End-Tidal CO2 During Cardiopulmonary Resuscitation (CPR)
Cerebral saturation will be measured pre-hospital during an out-of hospital cardiac arrest with O3TM regional oximetry for Root® (Masimo®).
- Trial name
- CopernicusIb (NCT02850237)
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Hasselt University
Cardiac Disorder
Microcirculation in Cardiac Surgery
The purpose of this study is to determine whether cardiopulmonary bypass affects mesenteric microcirculatory function, using sublingual evaluation, in cardiac surgery.
- Trial name
- MICROCARD (NCT01330745)
- Testing
- sublingual microcirculatory evaluation
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Rouen
Obstructive Sleep Apnea, Coronary Heart Disease
Obstructive Sleep Apnea Treatment to Improve Cardiac Rehabilitation
This is a randomized clinical trial in U.S. Veterans to evaluate the impact of treatment for obstructive sleep apnea (OSA) on the effectiveness of cardiac rehabilitation, including impact on exercise capacity, disability, and…
- Trial name
- NCT02005445
- Testing
- CPAP, HLSE
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- VA Office of Research and Development
Adrenal Cortex Diseases, Infant Morbidity
Adrenal Responsiveness During the Perioperative Period in Children Undergoing Congenital Cardiac Surgery
Our objective was to determine whether a standard 1mg/kg intraoperative dose of dexamethasone results in similar drug levels for all patients and to characterize the relationship between these drug levels and the innate stress…
- Trial name
- NCT01839812
- Testing
- Cosyntropin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Mayo Clinic
Coronavirus 2019
Cardiovascular Function and Physical Activity in COVID-19
The purpose of this study is to a) assess how coronavirus 2019 (COVID-19) affects cardiac function in middle age and older adults and b) assess if a physical activity intervention (increased daily step count by 2,000) can affect…
- Trial name
- CV-COVID (NCT05492552)
- Testing
- Active-at-home-HF
- Where
- United Kingdom
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Coventry University
Cardiovascular Disease, Coronary Artery Disease
Smartphone Delivered In-home Cardiopulmonary Rehabilitation
The goal of this study is to determine if a remote cardiac or pulmonary rehabilitation program delivered via a smartphone application and regular telephone calls will lead to improved delivery of cardiac rehabilitation compared…
- Trial name
- NCT02791685
- Testing
- MULTIFIT Cardiac Rehabilitation, Movn Pulmonary Rehabilitation, Standard of Care Cardiac Rehabilitation
- Where
- United States
- Volunteers
- 258 people
- Sponsor
- Emory University
Acute Decompensated Heart Failure
Gas Exchange for Predicting Hospital Heart Failure Readmissions
To determine whether, and if so, which gas exchange parameters measured on the Shape-HF Cardiopulmonary Exercise Testing System predict 30 and 180 day re-hospitalization in subjects discharged from hospitalization for an episode…
- Trial name
- NCT01960218
- Where
- 7 sites in United States
- Volunteers
- 120 people
- Sponsor
- Shape Medical Systems, Inc.
Osteoarthritis, Knee, Physical Inactivity
Effect of Structured Exercise in Patients With Knee Osteoarthritis
The aim of this randomized controlled trial is to evaluate the effect of Nordic walking and inspiratory muscle training (IMT) on cardiopulmonary function in patients with knee osteoarthritis (OA).
- Trial name
- NCT06084949
- Testing
- Nordic walking or inspiratory muscle training
- Where
- Hong Kong
- Volunteers
- 80 people
- Sponsor
- The Hong Kong Polytechnic University
Chronic Obstructive Pulmonary Disease
Chronic Beta-blockade and Cardiopulmonary Exercise in COPD
What are the differential effects of beta-blockers on lung and heart function during exercise in chronic obstructive pulmonary disease (COPD)? COPD is a major cause of illness and death.
- Trial name
- CPET1 (NCT02380053)
- Testing
- Bisoprolol, Celiprolol
- Where
- United Kingdom
- Volunteers
- 10 people
- Sponsor
- University of Dundee
Cardiac Arrest
A Modified Delphi for ECPR Post Resuscitation Care
The objective of this study is to generate expert consensus statements on the management of out of hospital cardiac arrest (OHCA) patients treated with extracorporeal membrane oxygenation (ECMO) cardiopulmonary resuscitation…
- Trial name
- NCT06552312
- Testing
- Delphi Questionnaire
- Where
- Australia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Sydney Local Health District
Postoperative Pulmonary Dysfunction
Different Modes of Ventilation During Cardiopulmonary Bypass
66 patients divided into 3 groups with different modes of ventilation.
- Trial name
- NCT03824301
- Testing
- Volume controlled ventilation, Pressure controlled ventilation
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Ain Shams University
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