Clinical trials: Cardiopulmonary Diseases
Gastrointestinal Disorder, Functional
Analysis of the Impact of Used Probiotic Strains and Diet on Body Composition, Cardiopulmonary Efficiency and the Incidence of Gastrointestinal Disorders in Runners
The aim of the study was to assess the diet and the effect of probiotic therapy on reducing the incidence of gastrointestinal disorders and selected parameters determining the inflammation of the body, body composition…
- Trial name
- NCT04530929
- Testing
- SANPROBI BARRIER
- Where
- Poland
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Lung Injury, Acute
Lung Protection and Pediatric Cardiac Surgery
The lung is at risk for ischemic insults during total cardiopulmonary bypass because lung perfusion is maintained solely by the bronchial arterial system
- Trial name
- NCT03023670
- Testing
- cardiopulmonary bypass
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Assiut University
Cardiopulmonary Arrest
The Impact of Resuscitation Quality of CPR Team by Implantation of Electronic Checklist and Alarming System Through Video-recording Analyses
The quality of cardiopulmonary resuscitation (CPR) has been identified as an important determinants for patient survival, yet many studies revealed poor CPR guidelines compliance in real-life practice for both health care…
- Trial name
- NCT02209870
- Testing
- E-checklist Group
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- National Taiwan University Hospital
Cardiopulmonary Arrest, Cardiac Arrest
Trial of Vasopressin and Epinephrine to Epinephrine Only for In-Hospital Pediatric Cardiopulmonary Resuscitation
Cardiac arrest has a very poor prognosis, especially with prolonged efforts at resuscitation, and unfortunately, survivors are often severely neurologically impaired.
- Trial name
- Vasopressin (NCT00628550)
- Testing
- Vasopressin, Epinephrine
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Texas Southwestern Medical Center
Critical Stenosis of Aortic Valve
A Randomized Trial of Angiotensin Receptor bLocker,Fimasartan, in Aortic Stenosis (ALFA Trial)
We hypothesized that fimasartan, a new generation ARBs, would improve exercise capacity and decrease the rate of progression of AS by modifying hemodynamic factors and reducing adverse LV remodeling favorably in patients with…
- Trial name
- ALFA (NCT01589380)
- Testing
- Fimasartan
- Where
- 7 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Seoul National University Hospital
Pulmonary Hypertension, Congenital Heart Disease
Image-based Multi-scale Modeling Framework of the Cardiopulmonary System: Longitudinal Calibration and Assessment of Therapies in Pediatric Pulmonary Hypertension
This study looks to develop a multi-scale computational model of Pulmonary Hypertension, this clinical model will be calibrated using longitudinal, retrospectively and prospectively acquired human clinical data.
- Conditions
- Pulmonary Hypertension, Congenital Heart Disease, Pediatric Congenital Heart Disease
- Trial name
- NCT03564522
- Testing
- cardiac catheterization, Cardiac MRI
- Where
- 2 sites in United States
- Volunteers
- 35 people
- Sponsor
- University of Michigan
Oropharynx Cancers
Cardiopulmonary Fitness in Long-Term Survivors of HPV-related Oropharynx Cancers
This study is being done to learn about how the participants lungs and heart are working after treatment for throat cancer. The investigators are looking to see if there is a long-term impact on overall health from the cancer…
- Trial name
- NCT02628912
- Testing
- blood draw, study questionnaire, cardiopulmonary exercise testing (CPET)
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Kidney Failure
BNP (Nesiritide) vs. Placebo to Protect Kidney Function in Patients Undergoing Heart Bypass Surgery.
Use of BNP (nesiritide) vs placebo to help protect kidney function in patients undergoing heart bypass surgery.
- Trial name
- NCT00252200
- Testing
- Neseritide
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Mayo Clinic
Postoperative Delirium, Preoperative Sleep Disorder
Dexmedetomidine in Reducing Postoperative Delirium in Cardiac Surgery Patients
Delirium is a common consequence of cardiac surgery and associates with poor outcomes. Multiple causes can trigger delirium occurence, and it has been hypothesised that sleep disturbances can be one of them.
- Trial name
- DREAMS (NCT06619912)
- Testing
- Dexmedetomidine nasal spray
- Where
- China
- Volunteers
- 686 people
- Sponsor
- Xijing Hospital
Coronary Artery Disease, Angiotensin Converting Enzyme
The RAS, Fibrinolysis and Cardiopulmonary Bypass
Each year over a million patients worldwide undergo cardiac surgery requiring cardiopulmonary bypass (CPB).1 CPB is associated with significant morbidity including hemodynamic instability, the transfusion of allogenic blood…
- Conditions
- Coronary Artery Disease, Angiotensin Converting Enzyme, Angiotensin Receptor Blockers, Cardiopulmonary Bypass
- Trial name
- NCT00607672
- Testing
- Ramipril, Candesartan
- Where
- 2 sites in United States
- Volunteers
- 111 people
- Sponsor
- Vanderbilt University
Biomarkers, Coronary Artery Bypass Surgery
Dynamics of microRNA Expression and Systemic Inflammatory Response in POCD After Cardiac Surgery
Postoperative cognitive decline (POCD) is one of the most common complications after cardiac surgery. It is characterized by impaired memory, attention, and executive functions and can have long-term consequences.
- Conditions
- Biomarkers, Coronary Artery Bypass Surgery, Interleukin-6, MicroRNAs
- Trial name
- NCT07231731
- Where
- Croatia
- Volunteers
- 48 people
- Sponsor
- Osijek University Hospital
Hypertension
Clinical Effect of Individualized Exercise Prescription for Hypertension With 6-minute Walking Test (6MWT)
Obesity and lack of exercise are one of the reasons for high blood pressure. Exercise can reduce the risk of cardiovascular events by reducing weight and blood pressure.
- Trial name
- NCT06219512
- Testing
- CPET exercise prescription, 6MWT exercise prescription, Regular exercise
- Volunteers
- 126 people
- Sponsor
- Peking University People's Hospital
Ischemic Heart Disease
The Danish On-pump, Off-pump Randomization Study (DOORS)
Background: Coronary artery bypass grafting (CABG) can be performed either with or without the use of cardiopulmonary bypass (CPB) to obtain myocardial re-vascularisation.
- Trial name
- NCT00123981
- Testing
- Off-Pump Coronary Artery Bypass Grafting
- Where
- Denmark
- Volunteers
- 900 people
- Sponsor
- Kim Houlind
Coronary Artery Disease, Edema
The Efficacy and Safety of Hypertonic Saline in Cardiac Surgery Patients.
The organ dysfunction following cardiopulmonary bypass (CPB) occurs frequently in cardiac surgery patients. Systemic inflammatory response initiated by CPB through releasing of several mediators lead to altered endothelial…
- Trial name
- ESHHS (NCT01675453)
- Testing
- 7.2% NaCl plus 6% hydroxyethyl starch 200/0.5, 0.9% NaCl
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Cardiac Arrest (CA), Simulation Training
Comparing Foot and Hand CPR
The goal of this simulation study is to evaluate whether chest compression using the foot is comparable to chest compression using the hand during cardiopulmonary resuscitation in trained participants.
- Trial name
- NCT06719401
- Testing
- Foot Chest Compression, Hand Chest Compression
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Coronary Artery Disease
CPB and Aortic Cross-Clamp Durations and ICU Length of Stay After CABG Retrospective Observational Cohort Study
Cardiopulmonary bypass (CPB) and aortic cross-clamp (ACC) durations are important intraoperative factors that may influence postoperative recovery following coronary artery bypass graft (CABG) surgery.
- Trial name
- NCT07711951
- Testing
- Cardiopulmonary Bypass Duration, Aortic Cross-Clamp Duration
- Where
- Turkey (Türkiye)
- Volunteers
- 387 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Osteogenesis Imperfecta
Cardiopulmonary Outcomes in Osteogenesis Imperfecta: BBD7708
Osteogenesis imperfecta (OI) is a group of congenital and heritable bone disorders that currently affects at least 50,000 people in the United States. OI varies in severity from perinatally lethal to mild forms.
- Trial name
- NCT05317637
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Baylor College of Medicine
Congenital Heart Disease in Children, Cardiopulmonary Bypass
The Role of Dexmedetomidine As Myocardial Protection In Pediatric Cyanotic Congenital Heart Disease Undergoing Open Cardiac Surgery Using Cardiopulmonary Bypass Machine: A Preliminary Study
Congenital Heart Diseases (CHD) are one of the most common congenital anomalies. Worldwide, 8 to 9 out of 1000 of children are born with a CHD, of which 25 percent of are cyanotic CHD.
- Trial name
- NCT05300802
- Testing
- Dexmedetomidine Hcl 100 Mcg/mL Inj
- Where
- Indonesia
- Volunteers
- 15 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Pulmonary Heart Disease
A Study of Commercial DEFINITY® to Monitor the Effects of the Heart's Pulmonary Artery Pressure
The purpose of this clinical research is to learn if DEFINITY® 416 will cause any adverse effects during Right Heart Catheterization. This research was requested by the FDA.
- Trial name
- NCT00918866
- Testing
- Definity
- Where
- 8 sites in United States
- Volunteers
- 32 people
- Sponsor
- Lantheus Medical Imaging
Dyspnea, Cardiopulmonary Dysfunction
Effect of Different Breathing Techniques on Dyspnea and Cardiopulmonary Parameters Among Patients After Open Heart Surgery
Open heart surgery is often associated with postoperative pulmonary complications, reduced lung expansion, dyspnea, and impaired cardiopulmonary function.
- Conditions
- Dyspnea, Cardiopulmonary Dysfunction, Postoperative Respiratory Dysfunction, Coronary Artery Disease
- Trial name
- NCT07591987
- Testing
- Segmental Breathing Exercises, Active Cycle Breathing Technique, Standard postoperative care
- Where
- 3 sites in Iraq
- Volunteers
- 99 people
- Sponsor
- University of Baghdad
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