Clinical trials: Cardiopulmonary Diseases
Postoperative Cardiorespiratory Failure
Hypertonic Saline-hetastarch in Cardiac Surgery
Cardiopulmonary bypass(CPB) is associated with increased fluid extravasation and edema formation. A continuous infusion of a mixture of hypertonic saline/hydroxyethyl starch (HSH)during CPB reduced fluid extravasation and total…
- Trial name
- HH (NCT00469716)
- Testing
- Hypertonic saline (7.2%) hetastarch (6 %)(200/0.5)
- Where
- Norway
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Haukeland University Hospital
Idiopathic Pulmonary Arterial Hypertension
The Study of Apelin-APJ System on Pulmonary Hypertension Patients and Healthy Subjects
The purpose of this study is to Determine blood peptide levels and investigate any tissue gradients of apelin in patients with idiopathic pulmonary arterial hypertension and healthy volunteers.
- Trial name
- EXAP (NCT01590108)
- Testing
- (Pyr1)apelin-13, Saline
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cardiac Arrest With Successful Resuscitation, Cardiac Arrest, Cause Unspecified
Optimization of Transport and Use of a Mobile ECMO Team in Patients With Sudden Cardiac Arrest in the Moravian-Silesian Region
This study evaluates the feasibility of implementing a mobile extracorporeal membrane oxygenation (ECMO) team and optimizing patient transport logistics.
- Trial name
- NCT07009652
- Testing
- Extracorporeal cardiopulmonary resuscitation (ECPR)
- Where
- 2 sites in Czechia
- Volunteers
- 100 people
- Sponsor
- University Hospital Ostrava
Acute Lymphoblastic Leukemia
How Effective is the Dose-graded Aerobic Training in Children Survivors of Acute Lymphoblastic Leukemia?
The purpose of this study was to evaluate the impact of a 12-week dose-graded aerobic exercise program (D-GAE) on cardiopulmonary fitness and physical performance in children survivors of acute lymphoblastic leukemia (ALL).
- Trial name
- NCT05679817
- Testing
- Dose-graded aerobic exercises, Traditional physical rehabilitation
- Where
- Saudi Arabia
- Volunteers
- 58 people
- Sponsor
- Cairo University
Neuromuscular Blockade, Postoperative Pulmonary Atelectasis
Rocuronium vs Cis-atracurium: Do Rocuronium Still 'ROCKS' In Coronary Artery Bypass Grafting
The current trend in most cardiac surgeries was to use rocuronium as it provides faster recovery in train-of-four ratio compared to other aminosteroid non-depolarising neuromuscular blocker.
- Conditions
- Neuromuscular Blockade, Postoperative Pulmonary Atelectasis, Postoperative Pulmonary Complication, Coronary Artery Disease
- Trial name
- NCT06102915
- Testing
- Rocuronium Bromide 10 MG/ML, Nimbex 10 MG in 5 ML Injection
- Where
- Malaysia
- Volunteers
- 289 people
- Sponsor
- Institut Jantung Negara
Coronary Artery Disease
Continued Ventilation During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is well known to induce a strong anti-inflammatory response. The investigators examined whether continued mechanical ventilation during CPB alters systemic immune activation.
- Trial name
- NCT01627756
- Testing
- Lung Ventilation, Non-ventilated Group
- Where
- Hungary
- Volunteers
- 30 people
- Sponsor
- Medical University of Vienna
Congenital Heart Disease (CHD)
Physical Rehabilitation in Patients With Complex Congenital Heart Disease
Studies have shown that patients with congenital heart disease have functional changes compared to healthy individuals. Several interventions can be performed to minimize these changes; physical rehabilitation is one of these…
- Trial name
- Rehabkids (NCT07089264)
- Testing
- Physical rehabilitation
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- Hospital do Coracao
Cardiac Arrest
Assessing CPR Quality During In-Hospital Cardiac Arrest
Using an investigational monitor/defibrillator that passively records CPR quality parameters, including chest compression rate and depth and ventilation rate and volume, we are prospectively recording CPR quality during…
- Trial name
- NCT00228293
- Testing
- investigational monitor/defibrillator with CPR feedback
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Chicago
Corona Virus Infection, Critical Illness
The Change of Critical Patient Managements and Subsequent Influences Under Epidemic of Coronavirus Disease 19 (COVID-19)
In the ER of National Taiwan University Hospital, the critical patients are treated (including tracheal intubation and cardiopulmonary resuscitation) in either resuscitation area or negative pressure isolation rooms based on the…
- Trial name
- NCT04479332
- Testing
- Tracheal intubation and cardiopulmonary resuscitation
- Where
- Taiwan
- Volunteers
- 198 people
- Sponsor
- National Taiwan University Hospital
Cardiovascular Diseases, Coronary Artery Disease
The Effect Of An Expanded Long Term Periodization Exercise Training In Patients With Cardiovascular Disease
Benefits from cardiac rehabilitation (CR) programs are evidence based and widely recognized. Less than 50% of people who participate in hospital-based CR programs maintain an exercise regimen for as long as six months after…
- Trial name
- NCT03335319
- Testing
- Periodized Exercise Training Regime, Non Periodized Exercise Training Regime
- Where
- Portugal
- Volunteers
- 50 people
- Sponsor
- University of Lisbon
Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia
Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs
Pulmonary arteriovenous malformations (PAVMs) are a rare vascular condition affecting the lungs. PAVMs lead to low blood oxygen levels, yet are very well tolerated by patients.
- Trial name
- NCT02436213
- Testing
- Cardiopulmonary exercise test, Blood test
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Cardiopulmonary Diseases
Indoor Air Filtration and Young Adults Health Study
This study aims to explore the cardiopulmonary health effects of indoor air purification and other indoor environmental conditions among young healthy college students in Beijing, China.
- Trial name
- NCT05172388
- Testing
- Air purifier
- Where
- China
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Peking University
Congenital Heart Disease, Heart Defects, Congenital
Cardiopulmonary Rehabilitation for Adolescents and Adults With Congenital Heart Disease
The hypothesis of this study is that participation in a formal cardiopulmonary rehabilitation program improves aerobic exercise capacity and quality of life over the medium term for patients with congenital heart disease with…
- Trial name
- NCT01822769
- Testing
- Cardiopulmonary rehabilitation, Standard of care
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Boston Children's Hospital
Coronary Artery Disease, Cardiac Surgical Procedures
Does Modified Ultrafiltration Improves Inflammatory Response and Cardiopulmonary Function After CABG Procedures?
The inflammatory response after cardiac surgery increases mortality and morbidity. Modified ultrafiltration (MUF) has been shown to decrease the post-cardiac surgery inflammatory response, to improve respiratory function, and…
- Trial name
- NCT01140113
- Testing
- Modified Ultrafiltration
- Where
- Brazil
- Volunteers
- 60 people
- Sponsor
- University of Campinas, Brazil
Stage 1 Hypertensives
Additional Effect of Coherent Breathing With Aerobic Exercise on Cardiopulmonary Parameters and Quality of Life in Stage 1 Hypertensive Individuals
This study will use a randomized controlled trial to evaluate the added effects of coherent breathing combined with aerobic exercise versus aerobic exercise alone in 40 adults aged 30-65 with stage 1 hypertension.
- Trial name
- NCT07573683
- Testing
- Coherent Breathing., Aerobic Exercises
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Foundation University Islamabad
Lung Cancer
Video-Assisted Surgery Followed by Radiation Therapy in Treating Patients With Stage I Non-small Cell Lung Cancer and Poor Heart and Lung Function
RATIONALE: Video-assisted surgery followed by radiation therapy may be an effective treatment in patients whose poor heart and lung function make them high risk for standard surgery.
- Trial name
- NCT00002624
- Testing
- adjuvant therapy, diagnostic thoracoscopy, therapeutic thoracoscopy
- Where
- 16 sites in United States, Australia and 2 more
- Volunteers
- 66 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Cardiac Valve Disease
Ultrafiltration on Coagulation Performance in Cardiac Surgery
In cardiac surgery patients with CPB-induced dilutional coagulopathy, ultrafiltration (UF) was applied to reduce free water and concentrate all blood components before the weaning from CPB.
- Trial name
- NCT05252559
- Testing
- ultrafiltration, maximal clot firmness in EXTEM assay of ROTEM test
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Konkuk University Medical Center
Obesity, Morbid, Hypertension
Comparison of Extremely Obese Patients Undergoing Gastric Sleeve Surgery
By the comparison of the preoperative and postoperative data of approximately 160 patients undergoing gastric sleeve surgery, we try to draw conclusions about the effectiveness of gastric sleeve surgery, expected complication…
- Conditions
- Obesity, Morbid, Hypertension, Diabetes Mellitus, Type 2
- Trial name
- NCT05929170
- Where
- Hungary
- Volunteers
- 160 people
- Sponsor
- University of Pecs
Coronary Artery Disease, Aortic Valve Stenosis
Comparative Analysis of the Microcirculation During Cardiac Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation
The aim of the proposed study is to evaluate microcirculatory alterations in patients undergoing open heart surgery with minimal invasive versus conventional extracorporeal circulation.
- Conditions
- Coronary Artery Disease, Aortic Valve Stenosis, Mitral Disease
- Trial name
- NCT05479188
- Testing
- Sublingual microscopy
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aristotle University Of Thessaloniki
Cardiac Surgery With Cardiopulmonary Bypass
Evaluation of Plasma Renin Concentrations in Cardiac Surgery
The purpose of this research is to learn more about how renin (a blood test) is affected by cardiopulmonary bypass, the heart-lung machine used during open heart surgery.
- Trial name
- NCT06895213
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Mayo Clinic
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