Clinical trials: Cardiopulmonary-bypass
Acute Kidney Injury
Effect of Nitric Oxide in Cardiac Surgery Patients With Endothelial Dysfunction.
The purpose of this study is to determine whether nitric oxide is effective in the treatment of acute kidney injury in cardiac surgical patients with sign and laboratory data suggesting endothelial dysfunction undergoing…
- Trial name
- MGHK23 (NCT02836899)
- Testing
- Nitric Oxide
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Massachusetts General Hospital
Coronary Artery Bypass Grafting
Dexmedetomidine Sedation and Cardiopulmonary Bypass
Dexmedetomidine is a unique sedative anesthetic agent that allows accurate control of the depth of sedation and provides analgesia, cardio protection, renal protection, and neuroprotection without causing respiratory depression.
- Trial name
- NCT02727621
- Testing
- Dexmedetomidine, propofol
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Assiut University
Heart Defects, Congenital, Surgery
Feasibility Study Over the NAVA Mode in Noninvasive Ventilation After Cardiac Surgery in Infants.
Neonates who underwent cardiac surgery with cardiopulmonary bypass almost always require non-invasive respiratory support (NIV) in relay to conventional ventilation.
- Trial name
- NIVNAVA (NCT01570933)
- Testing
- NivNava, Cpap
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Efficacy and Safety
Clemastine in Cardiovascular Surgery
In this study, a prospective, randomized, double-blind pilot trial designed to evaluate the effect of histamine H1 receptor antagonist clemastine on perioperative anaphylaxis in cardiovascular surgery with cardiopulmonary bypass…
- Trial name
- NCT03826004
- Testing
- Clemastine, Saline Solution
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Acute Kidney Injury, Surgery-Complications
Precision Medicine in Cardiovascular Surgery Associated Acute Kidney Injury
The goal of this prospective observational study is to define a risk profile for cardiovascular surgery associated acute kidney injury (AKI), using clinical patient characteristics, operation parameters as well as blood and urine…
- Conditions
- Acute Kidney Injury, Surgery-Complications, Frailty
- Trial name
- PEAK (NCT06471621)
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Coronary Disease, Heart Valve Diseases
CTI-01 (Ethyl Pyruvate) Safety and Complication Prevention in Cardiac Surgery Patients on Cardiopulmonary Bypass (CPB)
Over 500,000 patients undergo cardiac surgery with CPB in the United States annually. Although mortality rates have decreased with advances in perioperative care, many patients are affected by postoperative organ dysfunction.
- Trial name
- NCT00107666
- Testing
- CTI-01 (ethyl pyruvate)
- Where
- 17 sites in United States
- Volunteers
- 150 people
- Sponsor
- Critical Therapeutics
Opioid Use, Heart; Surgery, Heart, Functional Disturbance as Result
Opioid-free Anesthesia for Open Cardiac Surgery: A Prospective Randomized Controlled Trial
This study will compare an opioid free anesthetic, using dexmedetomidine, to a traditional opioid based anesthetic, using fentanyl, for patients undergoing cardiac surgery with regards to hemodynamic stability in the first 10…
- Conditions
- Opioid Use, Heart; Surgery, Heart, Functional Disturbance as Result, Anesthesia
- Trial name
- NCT04197570
- Testing
- Opioid Anesthetics, Non Opioid Analgesics
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Benaroya Research Institute
Pulmonary Hypertension
A Study to Evaluate the Efficacy, Safety and Tolerability of PDNO Infusion in Patients With Pulmonary Hypertension After Cardiopulmonary Bypass Surgery
This is an open-label, multicenter study evaluating the dose, effect, safety and tolerability of intravenous PDNO infusion given to patients undergoing cardiopulmonary bypass (CPB) surgery with post-operative acute pulmonary…
- Trial name
- NCT05699486
- Testing
- PDNO
- Where
- 2 sites in Sweden
- Volunteers
- 12 people
- Sponsor
- Attgeno AB
Cardiovascular Disease
Ulinastatin's Anti-inflammatory Reaction in Cardiac Surgery
The purpose of the present study is to determine whether ulinastatin, urinary anti-trypsin inhibitor, attenuates cardiopulmonary bypass (CPB)-activated systemic inflammatory response in cardiac surgery with CPB.
- Trial name
- ulistin (NCT01518569)
- Testing
- ulinastatin
- Where
- South Korea
- Volunteers
- 26 people
- Sponsor
- Konkuk University Medical Center
Heart Valve Diseases
Anesthetic Management and Remote Reperfusion Injuries
Ischemia- reperfusion ( IR ) injuries were not only seen in the transplanted organs but also the remote organs such as lungs that brings major postoperative complications.
- Trial name
- NCT00745810
- Testing
- Cardiopulmonary bypass
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- National Taiwan University Hospital
Lung Transplant; Complications
Bypass vs. Ecmo in Lung Transplantation (BELT)
This study seeks to compare outcomes of 2 different methods of cardiopulmonary support during lung transplant surgeries.
- Trial name
- BELT (NCT03021538)
- Testing
- Extracorporeal Membrane Oxygenation, Cardiopulmonary Bypass
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- The Cleveland Clinic
Coronary Artery Disease., Aortic Valve Stenosis.
Cerebral Oxymetry at Elective Coronary and Valve Surgery.
Use of vasopressor to maintain Mean Arterial Pressure on Cardio Pulmonary Bypass can lead to decreased cerebral flow and oxygenation in individual patients and this can be detected by means of cerebral oxymetry.
- Conditions
- Coronary Artery Disease., Aortic Valve Stenosis., Aortic Valve Regurgitation.
- Trial name
- Co-HLM (NCT01940874)
- Where
- Norway
- Volunteers
- 54 people
- Sponsor
- Oslo University Hospital
Cardio-pulmonary Bypass, AORTIC VALVE DISEASES
Clinical Validation of a Novel Handsfree Doppler Ultrasound Device, RescueDoppler, in Adult Cardiac Surgery Patients
The goal of this study is to evaluate a new device called RescueDoppler (RD), which measures continuous blood flow in the common carotid artery. The device is handsfree and operator- independent.
- Conditions
- Cardio-pulmonary Bypass, AORTIC VALVE DISEASES, Coronary Arterial Disease (CAD), Aortic Aneurysm of the Proximal Arch
- Trial name
- RD_CPB (NCT06637540)
- Testing
- RescueDoppler
- Where
- 3 sites in Norway
- Volunteers
- 42 people
- Sponsor
- St. Olavs Hospital
Cardiac Surgery With Cardiopulmonary Bypass
Beta Blocker Use in Cardiac Surgery and Association With Postoperative Course
The objective of this study is to describe in a cohort of cardiac surgery patients the use of beta-blockers before surgery and their maintenance or withdraw according to international recommendations in order to compare patients…
- Trial name
- BLOCK (NCT04769752)
- Testing
- collection of the allocated treatment, collection of medical complications
- Where
- France
- Volunteers
- 1,789 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Congenital Heart Disease
Evaluation of the Microcirculation During the Corrective Surgery of Congenital Heart Defects in Children
General objective of the research project: To evaluate the alterations of systemic microvascular reactivity during cardiopulmonary bypass (CPB), in children submitted to cardiac surgery for repair of congenital heart defects.
- Trial name
- NCT03144258
- Where
- Brazil
- Volunteers
- 100 people
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
NIRS, Cardiac Surgery Associated - Acute Kidney Injury
A Comparison of Renal vs Limb NIRS for Predicting Cardiac Surgery Associated Acute Kidney Injury
Acute kidney injury (AKI) is a complication of cardiac surgery that can affect outcome. Near Infrared Spectroscopy (NIRS) is a technology that uses light to determine how well oxygenated tissues are.
- Conditions
- NIRS, Cardiac Surgery Associated - Acute Kidney Injury, Cardiac Surgery Requiring Cardiopulmonary Bypass, AKI - Acute Kidney Injury
- Trial name
- NCT06705855
- Testing
- NIRS sensor placement
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- University of Utah
Cardiopulmonary Bypass, Cardiac Surgery
Prediction of PPC Using DAMPs in Adult Cardiac Surgery
DAMPs (damage associated molecular patterns) are endogenous molecules that are expressed by cell stress or cell damage and play an important role in tissue (or host) defense and repair by activating the innate immune system.
- Conditions
- Cardiopulmonary Bypass, Cardiac Surgery, Damage-associated Molecular Patterns
- Trial name
- NCT04945915
- Testing
- blood sampling
- Where
- South Korea
- Volunteers
- 53 people
- Sponsor
- Pusan National University Yangsan Hospital
Vasoplegia, Hypotension
Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery
This is a pilot study to determine the hemodynamic effects when hydroxocobalamin vs methylene blue is administered during cardiopulmonary bypass in patients at risk of vasoplegia by measuring mean arterial pressure (MAP)…
- Conditions
- Vasoplegia, Hypotension, Coronary Artery Disease, Cardiac Valve Disease
- Trial name
- NCT03446599
- Testing
- Hydroxocobalamin, Methylene Blue, Normal saline
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Tricuspid Regurgitation, Mitral Regurgitation
Concomitant Tricuspid Repair in Patients With Left Heart Surgery
Tricuspid regurgitation is common in patients with severe left heart diseases, such as degenerative mitral regurgitation. However, the evidence base is insufficient to inform a decision about whether to perform concomitant…
- Conditions
- Tricuspid Regurgitation, Mitral Regurgitation, Cardiopulmonary Bypass
- Trial name
- NCT05595187
- Testing
- Tricuspid repair
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Nanjing Medical University
Cardiac Anaesthesia
Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity.
- Trial name
- NCT06581289
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University