Clinical trials: Cardiopulmonary-bypass
Peripheral Circulation During On-pump Cardiac Surgery
Assessment of Skin Perfusion Pressure as an Indicator of Tissue Oxygenation in Cardiac Surgery Patients Undergoing Cardiopulmonary Bypass
This study is aim to evaluate usefulness of the perioperative monitoring of skin perfusion pressure as an indicator of perpheral perfusion in patients undergoing on-pump cardiac surgery.
- Trial name
- NCT02329392
- Where
- South Korea
- Volunteers
- 72 people
- Sponsor
- Yonsei University
Cardiac Surgery, Cardiopulmonary Bypass
Effect of Rewarming Rate During Cardiopulmonary Bypass on Clinical Prognosis of Infants Undergoing Cardiac Surgery
The purpose of this study is to investigate the relationship between rewarming rate during cardiopulmonary bypass and clinical prognosis in infants undergoing cardiac surgery.
- Conditions
- Cardiac Surgery, Cardiopulmonary Bypass, Rewarming Rate
- Trial name
- NCT01398709
- Testing
- Slow rewarming strategy, Fast rewarming strategy
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Xijing Hospital
Hearing Loss, Cardiac Surgery
Prevalence of Auditory Dysfunction and ICU-acquired Delirium Following Cardiac Surgery With Cardiopulmonary Bypass: a Prospective Observational Study
AUDICS-ICU is a prospective observational aiming to evaluate the prevalence of auditive dysfunction following cardiac surgery. Participants will undergo audiometric testings before and 3 months after cardiac surgery with…
- Conditions
- Hearing Loss, Cardiac Surgery, Cardiopulmonary Bypass, Postoperative Cognitive Dysfunction
- Trial name
- AUDICS-ICU (NCT04151914)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- European Georges Pompidou Hospital
Cardiac Diseases, Cardio-pulmonary Bypass
A Monitoring System Based on the Multifactorial Dynamic Perfusion Index to Predict and Prevent the Onset of Postoperative Acute Kidney Injury After Cardiac Surgery, Based on a Dynamic Collection of Hemodynamic and Clinical Parameters During Cardiopulmonary Bypass
This project is based on a predictive alghorithm (Multifactorial Dynamic Perfusion Index-MDPI) already published and covered by a patent.
- Conditions
- Cardiac Diseases, Cardio-pulmonary Bypass, Acute Kidney Injury, Adult Cardiac Surgery
- Trial name
- PEQUOD 2 (NCT06786416)
- Testing
- PEQUOD
- Where
- Italy
- Volunteers
- 800 people
- Sponsor
- IRCCS Policlinico S. Donato
Cardiac Surgery and Cardiopulmonary Bypass
High-Dose N-Acetylcysteine in Cardiac Surgery
At least 14% of patients develop kidney failure after cardiac surgery. Although this kidney failure can usually be treated effectively, a longer stay in intensive care is often required.
- Trial name
- NCT00332631
- Testing
- N-acetylcysteine
- Where
- Australia
- Volunteers
- 60 people
- Sponsor
- Austin Health
Myocardial Injury
Propofol Cardioprotection for Type II Diabetics
The purpose of this study is to determine if an intravenous anesthetic with antioxidant properties will protect the heart of diabetic patients from injury while undergoing coronary bypass surgery.
- Trial name
- NCT00734383
- Testing
- Propofol
- Where
- Canada
- Volunteers
- 137 people
- Sponsor
- University of British Columbia
Cytokine Release Syndrome
Jafron Haemoadsorption During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is often associated with degrees of complex inflammatory response mediated by various cytokines. This response can, in severe cases, lead to systemic hypotension and organ dysfunction.
- Trial name
- JAFRONCPB (NCT05349669)
- Testing
- Jafron use during CPB
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Anthea Hospital Bari
Kidney Failure, Intraoperative Complications
Hemodilution and Outcome in Cardiac Surgery
An hematocrit of 21-25% is supposed to perform the best organ protection during cardiopulmonary bypass for cardiac surgery. The investigators want to establish the best timing for a transfusion (in patients with a predicted low…
- Trial name
- NCT00364494
- Testing
- Different timing of red blood cells transfusion (substudy 1); Acute hemodilution versus no hemodilution (substudy 2)
- Where
- Italy
- Sponsor
- Università Vita-Salute San Raffaele
Heart Diseases, Cardiovascular Diseases
Algorithmic Protamine Dosing for Reversal of Heparin After Cardiopulmonary Bypass
The PRODOSE trial is investigating a bespoke pharmacokinetic algorithm that calculates a tailored dose of protamine, required after cardiopulmonary bypass to reverse the action of heparin, based on individual patients and their…
- Trial name
- PRODOSE (NCT03532594)
- Testing
- PRODOSE Algorithm, Standard Care
- Where
- United Kingdom
- Volunteers
- 228 people
- Sponsor
- Papworth Hospital NHS Foundation Trust
Hypothermia, Rewarming
Heated Humidified Breathing Circuit Rewarming in Hypothermic Post Cardiopulmonary Bypass Patients.
Hypothermia on admission to the intensive care unit (ICU) following cardiopulmonary bypass (CPB) is common. The investigators propose that rewarming hypothermic (≤ 35 C) patients admitted to the intensive care unit following…
- Trial name
- NCT03697122
- Testing
- Heated Humidified Breathing Circuit and Forced Air Blanket
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Duke University
Pulmonary Hypertension, Mitral Regurgitation
Effect of Brief Nebulization of Milrinone on Pulmonary Arterial Pressure Before Cardiopulmonary Bypass on Mitral Valve Surgery Patients
Our main hypothesis is that inhalation of milrinone can reduce the elevated pulmonary arterial pressure due to severe mitral valve regurgitation without compromising systemic hemodynamics.
- Trial name
- NCT01621971
- Testing
- inhaled milrinone, intravenous milrinone
- Where
- South Korea
- Volunteers
- 20 people
- Sponsor
- Konkuk University Medical Center
Pleural Effusions Post Coronary Artery Bypass Graft, Hypoxia
Efficacy of 20% Human Albumin in Reducing Pleural Effusion After Cardiopulmonary Bypass
Human albumin is a widely used additive in cardiopulmonary bypass all around the world, but its effect on various outcomes has been debated.
- Conditions
- Pleural Effusions Post Coronary Artery Bypass Graft, Hypoxia, Hypoalbuminemia
- Trial name
- NCT06681415
- Testing
- Adding 100ml of 20% human albumin to cardiopulmonary bypass priming solution
- Where
- Latvia
- Volunteers
- 70 people
- Sponsor
- Pauls Stradins Clinical University Hospital
Pathologic Fibrinolysis
Fibrinolysis Before Cardiopulmonary Bypass?
It is common practice to use antifibrinolytic agents before and during cardiopulmonary bypass. They are not without side effects.
- Trial name
- NCT01981863
- Testing
- Epsilonaminocaproic acid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Heart; Dysfunction Postoperative, Cardiac Surgery
Suppression Of Atrial Fibrillation With Ranolazine After Cardiac Surgery
The objective of this study is to show that ranolazine is a safe, viable and potent alternative for post-operative atrial fibrillation suppression in patients undergoing cardiac surgery
- Trial name
- NCT01352416
- Testing
- Ranolazine
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Corewell Health East
Low Cardiac Output Syndrome, Transposition of Great Vessels
Nitric Oxide During Bypass for Arterial Switch Operation
This trial will test if adding nitric oxide (NO) gas to the cardiopulmonary bypass (CPB) circuit in infants undergoing an arterial switch operation (ASO) for Transposition of the Great Arteries (TGA) changes the incidence of…
- Trial name
- NASO (NCT03661385)
- Testing
- Nitric Oxide
- Where
- 4 sites in Australia, Canada and 2 more
- Volunteers
- 300 people
- Sponsor
- Murdoch Childrens Research Institute
Heart Defect, Congenital
Tranexamic Acid Effect on Platelet Aggregation Following Infant Cardiopulmonary Bypass
Tranexamic acid is a relatively safe medicine that is used to help the body develop clots and slow down bleeding after large surgeries.
- Trial name
- NCT02122679
- Testing
- Tranexamic Acid
- Where
- United States
- Sponsor
- Emory University
Cardiac Surgical Procedures, Pediatrics
Bayesian Networks in Pediatric Cardiac Surgery
Pediatric cardiac surgery with cardiopulmonary bypass is associated with significant morbidity and mortality. Also score systems for risk factors, such as Risk Adjustment for Congenital Heart surgery (RACHS 1) score or the…
- Conditions
- Cardiac Surgical Procedures, Pediatrics, Cardiopulmonary Bypass
- Trial name
- NCT05537168
- Testing
- Pediatric cardiac surgery under cardiopulmonary bypass
- Where
- Belgium
- Volunteers
- 1,364 people
- Sponsor
- Brugmann University Hospital
Obesity
Influence of Obesity on Propofol Pharmacokinetics During Cardiopulmonary Bypass
The primary objective of this study is to develop a descriptive and predictive pharmacokinetics model propofol disposition during cardiopulmonary bypass (CPB) in obese and lean patients.
- Trial name
- NCT02477982
- Volunteers
- 34 people
- Sponsor
- Cairo University
Respiratory Failure, Pneumothorax
Driving Pressure And EFL in Adult Cardiac Surgery
During general anesthesia, functional residual capacity (FRC) is reduced. If the FRC is lower than the minimum volume required to maintain the opening of the airways, there is a derecruitment of the lung parenchyma, leading to…
- Conditions
- Respiratory Failure, Pneumothorax, Atelectasis, Respiratory Infection
- Trial name
- NCT03064659
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Ospedale San Raffaele
Cardiovascular Surgical Procedures, Intensive Care
Energy Expenditure Estimation in Cardiac Surgery
Estimation of energy requirements is essential for adequate nutritional support in ICU. Indirect calorimetry being the golden standard of resting energy expenditure estimation is not available in most intensive care units.
- Trial name
- NCT02463123
- Testing
- Indirect calorimetry
- Where
- Russia
- Volunteers
- 240 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation