Clinical trials: Cardiopulmonary-bypass
Coronary Artery Bypass Graft (CABG), Cardioplegia
Cardioplegic Protection of the Heart
This study seek to compare two different solutions used to protect the heart during cardiac surgery. 40 adult patients planned for coronary artery bypass surgery with cardiopulmonary bypass machine assistance will be included in…
- Conditions
- Coronary Artery Bypass Graft (CABG), Cardioplegia, Cardiopulmonary Bypass, Perioperative Myocardial Injury
- Trial name
- NCT07386990
- Testing
- Modified Buckberg cardioplegic solution, Modified St Thomas´ cardioplegic solution
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Region Skane
Congenital Heart Disease, Cardiopulmonary Bypass
Acetaminophen for Oxidative Stress After Cardiopulmonary Bypass
The current proposal tests the central hypothesis that acetaminophen will attenuate the oxidative stress response associated with cardiopulmonary bypass (CPB)-induced hemolysis in children undergoing cardiac surgery.
- Trial name
- NCT01228305
- Testing
- Acetaminophen
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Vanderbilt University Medical Center
Cardiac Surgery, Intraoperative Hemodynamic Instability
Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery
Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear.
- Conditions
- Cardiac Surgery, Intraoperative Hemodynamic Instability, Postoperative Complication, Acute Kidney Injury
- Trial name
- NCT07324694
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Atrial Fibrillation
Homeopathy for Prevention of Atrial Fibrillation After Aortocoronary Bypass Surgery
After heart surgery, about 30% of patients suffer from atrial fibrillation. Patients are randomized into two groups receiving either potentized Strychnos Nux vomica or placebo under double blind conditions.
- Trial name
- NCT00861237
- Testing
- Nux vomica (active comparator)
- Where
- Austria
- Volunteers
- 12 people
- Sponsor
- Medical University of Vienna
Cardio-pulmonary Bypass, Cardiovascular Surgery
Protective Effect of Angong Niuhuang Against Negative Inflammatory Response and Neurologic Dysfunction After Cardiovascular Surgery
Neurologic Dysfunction is one of the main factors contributing to poor outcomes in cardiac surgery patients, except for heart failure.
- Conditions
- Cardio-pulmonary Bypass, Cardiovascular Surgery, Cerebral Protection, Brain Injury
- Trial name
- NCT06723366
- Testing
- Angong Niuhuang Pill (ANP), Control (Standard treatment)
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- Nanjing Medical University
Transcatheter Aortic Valve Replacement, Mechanical Circulatory Support
Application of Emergent Peripheral Mechanical Circulatory Support in Transcatheter Aortic Valve Replacement for 6 Patients
Objective: To explore the experience of transcranial aortic valve replacement (TAVR) under emergency mechanical assisted circulation (MCS).Methods: A total of 6 patients who completed TAVR with the assistance of emergency MCS in…
- Trial name
- NCT04464356
- Testing
- mechanical circulatory support
- Where
- China
- Volunteers
- 6 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Platelets, Bleeding
Delayed Cold-Stored Platelets -PLTS-1
PLTS-1 is a multicentre, randomized, controlled, pilot trial, using a conventional, parallel group, two-armed design at 2 cardiac surgery centres in Canada.
- Conditions
- Platelets, Bleeding, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- PLTS-1 (NCT06147531)
- Testing
- Delayed Cold-Stored Buffy Coat Platelets, Room Temperature Buffy Coat Platelets
- Where
- 2 sites in Canada
- Volunteers
- 150 people
- Sponsor
- University Health Network, Toronto
Acute Kidney Injury, Neurological Injury
Mini Versus Conventional Cardiopulmonary Bypass In CABG in Asian Patients
Our intention is to perform a randomized controlled trial to compare the efficacy and safety of mini cardiopulmonary bypass system to a modified conventional bypass circuit in 80 Asian patients undergoing elective CABG.
- Trial name
- MiniCPB (NCT03657225)
- Testing
- Utilization of the mini CPB circuit, Utilization of the conventional circuit
- Where
- Singapore
- Volunteers
- 80 people
- Sponsor
- National University Hospital, Singapore
Cardiovascular Diseases
Continuous Hemofiltration During Cardiopulmonary Bypass and Its Effect on Lactatemia
This study aims to analyze the impact of using polysulfone membranes on continuous ultrafiltration with volume replacement in patients undergoing cardiac surgery.
- Trial name
- CPB-LACTATE (NCT03412968)
- Testing
- Polysulfone Filter, Procedure/ Surgery: without Polysulfone Filter
- Where
- Spain
- Volunteers
- 76 people
- Sponsor
- University of Cadiz
Inflammatory Response, Chronic Renal Disease
Hemadsorption During and After Cardiopulmonary Bypass to Modulate the Inflammatory Response
Chronic kidney disease (CKD) is a risk factor for the development of cardiovascular disease, which increases the risk of death after cardiac surgery.
- Conditions
- Inflammatory Response, Chronic Renal Disease, Cardiac Surgery
- Trial name
- IMHeS (NCT04157647)
- Testing
- CytoSorb, Control
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University Magna Graecia
Congenital Heart Defect, Blood Coagulation Disorder
Bedside Evaluation of Coagulation in Children With Congenital Heart Disease
The purpose of this study is to assess coagulation and platelet function in children with congenital heart disease, measured with a bedside device (thromboelastometry and impedance aggregometry).
- Trial name
- POCHEMO (NCT02387944)
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Cardiopulmonary Bypass
Prothrombin Complex Concentrate (PCC)
The overall objective of this study is to determine whether ROTEM (rotational thromboelastometry) guided dosing of four-factor prothrombin complex concentrate (4F-PCC) results in superior perioperative bleeding control compared…
- Trial name
- NCT07881393
- Testing
- Four Factor Prothrombin Complex Concentrate, ROTEM (Rotational Thromboelastometry) analyzer (TEM International GmbH)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Miami
Congenital Heart Disease
Platelets or Fibrinogen as First-line Treatment for Bleeding During Pedatric Heart Surgery
The study aims to test whether platelet transfusion or fibrinogen concentrate is the most effective treatment of intraoperative bleeding, when performing open heart surgery with cardiopulmonary bypass on children with congenital…
- Trial name
- NCT04807621
- Testing
- Platelet transfusion, Fibrinogen concentrate
- Where
- Sweden
- Volunteers
- 40 people
- Sponsor
- Sahlgrenska University Hospital
Acute Kidney Injury, Congenital Heart Disease
Nitric Oxide During Cardiopulmonary Bypass in Neonates to Reduce Risk of Acute Kidney Injury
Acute kidney injury following cardiac surgery for congenital heart defects in children is a major cause of both short- and long-term morbidity and mortality, affecting up to 60% of high risk patients.
- Trial name
- NCT04259684
- Testing
- gases Nitric Oxide (gNO)
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Aortic Surgery, Coagulation Management
Application of ROTEM Technology in Aortic Surgery
Comparison of the diagnostic capabilities of rotational thromboelastometry (ROTEM) and standard coagulogram in the detection of disorder and correction of the hemostasis system in the perioperative period in patients who…
- Trial name
- NCT05171023
- Testing
- ROTEM and standard coagulation tests
- Where
- Russia
- Volunteers
- 81 people
- Sponsor
- Petrovsky National Research Centre of Surgery
Delirium
Delirium Reduction by Volatile Anesthesia in Cardiac Surgery
Parallel group, prospective, randomized, controlled, single-blinded trial. The aim of our study is to test the hypothesis that volatile anesthesia would reduce the incidence of early postoperative delirium in patients undergoing…
- Trial name
- DELICATE (NCT03729011)
- Testing
- Volatile agent, Propofol
- Where
- 5 sites in Russia
- Volunteers
- 405 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Hyperoxia
Intermittent Normoxia Reduces Myocardial Reperfusion Injury
This study aims to determine the effect of intermittent normoxic cardiopulmonary bypass (CPB) on inflammatory response, oxidative stress and myocardial reperfusion injury in adult patients undergoing valve replacement.
- Trial name
- INCPB (NCT01348906)
- Testing
- intermittent normoxia
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Central South University
Pulmonary Hypertension
Iloprost-Study: Comparison of Nitric Oxide to Iloprost (Ventavis) for Treatment of Pulmonary Hypertension in Children After Cardiopulmonary Bypass Surgery
Inhaled nitrous oxide (iNO) will be compared to aerosolized iloprost (ILO) in pediatric patients after cardiac surgery with pulmonary hypertension.
- Trial name
- NCT00235521
- Testing
- aerosolized iloprost
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- Heidelberg University
Coronary Surgery With Cardiopulmonary Bypass
Effects of a Goal-directed Hemodynamic Therapy Driven by ECOM on Morbidity and Mortality After Cardiac Surgery?
Goal-directed hemodynamic and fluid optimizations are shown to be a key factor of the medical care during anesthesia.According to medical literature, goal-directed fluid and hemodynamic optimizations are more efficient when based…
- Trial name
- ECOMIII (NCT01535716)
- Testing
- hemodynamic optimization strategy driven by the ECOM, standard management strategy
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Caen
Cardio Vascular Disease, Cardiopulmonary Bypass
Perioperative Vericiguat in Patients Undergoing Cardiovascular Surgery
The purpose of this study is to evaluate the efficacy and safety of perioperative vericiguat in patients undergoing cardiovascular surgery.
- Trial name
- NCT07594509
- Testing
- Vericiguat, Standard of Care Group
- Where
- China
- Volunteers
- 600 people
- Sponsor
- Nanjing Medical University