Clinical trials: Cardiopulmonary-bypass
Cardiopulmonary Bypass, Hemorrhage
Processed Residual Pump Blood in Cardiac Surgery: The PRBC Trial
The study is an randomized controlled trial (RCT) of 198 coronary artery bypass graft (CABG) patients, exploring whether ultrafiltration of residual blood in the cardiopulmonary bypass circuit reduces transfusion and bleeding.
- Conditions
- Cardiopulmonary Bypass, Hemorrhage, Surgery
- Trial name
- PRBC (NCT01173822)
- Testing
- Ultrafiltration of residual blood
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Hamilton Health Sciences Corporation
Heart Valve Diseases, Coronary Artery Disease
Performance of the CARDIOGARD Cannula
This is a single center, prospective study: The 'CardioGard Cannula' Gaseous emboli capture results - shows an improvement from the control group.
- Trial name
- GECG (NCT02764645)
- Testing
- CardioGard Cannula, 22Fr curved Cannula
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Rambam Health Care Campus
Bypass Complications, Disorder of Blood Gas
Difference Between Central and Peripheral Arterial Blood Oxygen Saturation With Different CPB Strategy
Femoro-femoral cardiopulmonary bypass with retrograde perfusion is needed for totally thoracoscopic cardiac surgery. one of the major complication of retrograde perfusion is organ hypoperfusion.
- Trial name
- NCT01698853
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Atrial Septal Defect, Ventricular Septal Defects
Comparison of Dynamic Compliance and Airway Resistance in Pressure-Controlled Versus Volume-Controlled Ventilation in Children Undergoing Corrective Heart Surgery
The goal of this clinical trial was to compare two settings on a breathing machine used during heart surgery in children. The children in this study were born with a hole inside the heart.
- Conditions
- Atrial Septal Defect, Ventricular Septal Defects, Pulmonary Hypertension, Intracardiac and Septal Defects
- Trial name
- NCT07754591
- Testing
- Pressure Controlled Ventilation, Volume Controlled Ventilation
- Where
- India
- Volunteers
- 72 people
- Sponsor
- Nilratan Sircar Medical College
Atrial Fibrillation
Heart Rhythm Changes in Patients With Atrial Fibrillation After Cardiopulmonary Bypass: a Retrospective Analysis
The goal of this observational study is to learn about the lthe effect of the tetralogy of medication regimen on intraoperative cardioversion in patients with persistent AF.
- Trial name
- NCT06553391
- Testing
- The tetralogy of medication regimen
- Where
- China
- Volunteers
- 106 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Defects, Congenital
The Management of Systemic-Pulmonary Collateral Blood Flow in Cyanotic Children During Cardiopulmonary Bypass - Pilot Study
The purpose of the study is to determine whether it is possible to manage the flow of blood through blood vessels using varying levels of carbon dioxide during cardiac surgery, and what effect this has on how well the major…
- Trial name
- NCT02358382
- Testing
- pH Stat
- Where
- United Kingdom
- Volunteers
- 20 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
Intraoperative Bleeding
DDAVP Effect by TEG6 in Cardiac Surgery
Cardiopulmonary bypass (CPB) is a process that uses a pump that temporarily takes over the function of the heart and lungs during cardiac surgery to maintain blood circulation and oxygenation.
- Trial name
- NCT07179991
- Testing
- Desmopressin after protamine reversal
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Complication of Extracorporeal Circulation, Kidney Circulation Disorder
Impact of CArdiopulmonary Bypass Flow on Renal Blood Flow, Function and OXygenation
Cardiac surgery with cardiopulmonary bypass (CPB), especially when oxygen delivery is low, is associated with acute kidney injury.
- Conditions
- Complication of Extracorporeal Circulation, Kidney Circulation Disorder, Renal Function Disorder
- Trial name
- ICAROX (NCT02549066)
- Testing
- Increased cardiopulmonary bypass flow, Milrinone
- Where
- Sweden
- Volunteers
- 18 people
- Sponsor
- Sahlgrenska University Hospital
Heart Disease
Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery
The SHAPE study is a prospective, randomized study evaluating changes in cardiac function in adult patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- SHAPE (NCT07770269)
- Testing
- BIS-guided anesthesia: BIS 45-55, BIS-guided anesthesia: BIS 30-35
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- AHEPA University Hospital
Acute Kidney Injury, Renal Resistive Index
Association Between Renal Resistive Index(RRI) and AKI(Acute Kidney Injury) in Cardiac Surgery Patients With Cardiopulmonary Bypass (CPB)
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity. The conventiional marker for detecting AKI is serum creatinine, however, which has many limits.
- Trial name
- NCT06464666
- Testing
- Renal interlobar artery US, Renal inter-lobular artery US
- Volunteers
- 250 people
- Sponsor
- Yonsei University
Low Cardiac Output Syndrome Bypass Children
Performance of Carbon Dioxide (CO2)-Derived Parameters in Predicting Low Cardiac Output Syndrome
In congenital cardiac intensive care, low cardiac output syndrome (LCOS) after surgery is defined by a decrease in cardiac output due to cardiac dysfunction.
- Trial name
- GAP-CO2 (NCT07770386)
- Where
- France
- Volunteers
- 306 people
- Sponsor
- University Hospital, Lille
Congenital Heart Disease, Sepsis
Pro-Calcitonin Levels Following Pediatric Cardiac Surgery
First, we, the researchers, hope to find out the PCT response to heart surgery in children by taking blood before surgery and each day for four days after surgery.
- Conditions
- Congenital Heart Disease, Sepsis, Infection
- Trial name
- NCT00284570
- Where
- United States
- Volunteers
- 49 people
- Sponsor
- Emory University
Nosocomial Pneumonia
High-dose Inhaled NO Therapy for the pREvenvention of NP After Cardiac Surgery Under CPB
The primary aim of this single-center, prospective, randomized, controlled, study is to test the hypothesis that inhalation of NO 200 ppm prevents the development of nosocomial pneumonia in patients at risk after cardiac surgery…
- Trial name
- NCT06261827
- Testing
- 200-ppm NO
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Advanced Heart Failure, Ischemic Heart Failure
HiCM-188 Cell Therapy in Adults With Advanced Heart Failure Undergoing Heart Bypass Surgery
This clinical study will evaluate the safety and tolerability of HiCM-188, an investigational allogeneic induced pluripotent stem cell (iPSC)-derived cardiomyocyte therapy, in adults with advanced heart failure who are undergoing…
- Trial name
- NCT07646210
- Testing
- HiCM-188 Cells
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- HELP Therapeutics Co., Ltd.
Renal Insufficiency, Acute, Cardiac Surgery Associated - Acute Kidney Injury
Renal Resistive Index in Early Detection of Postoperative Acute Kidney Injury
The primary aim of our study was to investigate the role of renal doppler ultrasonography (USG) and preoperative/postoperative renal resistive index (RRI) in the early prediction of AKI.
- Trial name
- NCT06791304
- Where
- Turkey (Türkiye)
- Volunteers
- 143 people
- Sponsor
- Bursa Yuksek Ihtisas Training and Research Hospital
Coronary Artery Disease, Cardiopulmonary Bypass
Propofol Pharmacokinetics and Pharmacodynamics During Cardiopulmonary Bypass
Cardiopulmonary bypass (CPB) is known to alter pharmacokinetics (PK) and brain sensitivity to several drugs, including propofol.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Coronary Artery Bypass Graft
- Trial name
- NCT00622791
- Where
- Brazil
- Volunteers
- 20 people
- Sponsor
- University of Sao Paulo
Valvular Heart Disease
The Safety and Efficacy of the Enhanced Recovery After Surgery(ERAS)Applied on Cardiac Surgery With Cardiopulmonary Bypass
This study evaluates the enhanced recovery after surgery (ERAS) concept over conventional postoperative care in patients with heart valve disease undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- ERAS (NCT02479581)
- Testing
- ERAS group, Conventional control group
- Where
- China
- Volunteers
- 226 people
- Sponsor
- Xiangya Hospital of Central South University
Thoracic Surgical Procedures, Gastrointestinal Tract
Postoperative Gastrointestinal Dysfunction After Cardiac Surgery - Occurrence and Search for Biomarkers
The purpose of this study is to investigate the frequency and grade of gastrointestinal dysfunction in patients after thoracic cardiovascular surgery, and to search for biomarkers of gastrointestinal dysfunction.
- Conditions
- Thoracic Surgical Procedures, Gastrointestinal Tract, Cardiopulmonary Bypass, Biomarkers
- Trial name
- GAINDYSFUNCS (NCT02732301)
- Where
- Sweden
- Volunteers
- 501 people
- Sponsor
- Region Örebro County
Analgesia
NOL-Guided Superficial Parasternal Intercostal Plane Block Versus Erector Spinae Plane Block
This clinical trial focuses on an elaborate, propensity-matched, non-inferiority comparison of NOL-guided Superficial Parasternal Intercostal Plane Block (SPIPB) and Erector Spinae Plane Block (ESPB) within the context of…
- Trial name
- NESP-II (NCT06070701)
- Testing
- Superficial Parasternal Block (SIPB), Erector Spinae Plane Block (ESPB), General anesthetic
- Where
- Romania
- Volunteers
- 40 people
- Sponsor
- Institutul de Urgenţă pentru Boli Cardiovasculare Prof.Dr. C.C. Iliescu
Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass
A Comparison Between 5% Albumin and 6% Hydroxyethyl Starch 130/0.4 in Priming Solution for Cardiopulmonary Bypass and Post-bypass Maintenance Fluid in High-risk Patients
It is advantageous to use 5% human albumin (HA) in patients undergoing cardiopulmonary bypass (CPB), because preexposure of the synthetic surfaces of the CPB circuit to albumin decreases coagulopathy, platelet aggregation, immune…
- Trial name
- NCT01644084
- Testing
- Hydroxyethyl starch 130/0.4
- Where
- South Korea
- Volunteers
- 54 people
- Sponsor
- Yonsei University