Clinical trials: Cardiopulmonary-bypass
Acute Lung Injury
Effects of Remote Ischemic Preconditioning and Postconditioning on Lung Injury During Cardiopulmonary Bypass
Remote Ischemic Preconditioning(RIPC) and remote ischemic postconditioning(RIPoC) seems to have a protective effect during ischemic period.
- Trial name
- NCT01144585
- Testing
- remote ischemic preconditioning and postconditioning, Control
- Where
- South Korea
- Volunteers
- 76 people
- Sponsor
- Seoul National University Hospital
Acute Kidney Injury
Plasma Cystatin C and Acute Kidney Injury
To evaluate the utility of plasma cystatin C(pCysC) as a predictive and diagnostic marker of acute kidney injury(AKI) in patients undergone cardiopulmonary bypass surgery.
- Trial name
- NCT01652755
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Jinhua Central Hospital
Coronary Artery Disease
Cost-effectiveness of EGDT Using FloTrac/EV1000
Coronary artery bypass graft (CABG) with cardiopulmonary bypass (CPB) is a high-risk surgery with significant morbidity that results in a prolonged stay in the intensive care unit (ICU) at an increased cost.
- Trial name
- NCT05826795
- Testing
- Early goal-directed therapy (EGDT)
- Where
- 2 sites in Thailand
- Volunteers
- 60 people
- Sponsor
- Khon Kaen University
Post-Operative Complications in Cardiac Surgery
Effect of RBT-1 on Reducing the Risk of Post-Operative Complications in Subjects Undergoing Cardiac Surgery
The purpose of this study is to evaluate the effect of RBT-1 on reducing the risk of post-operative complications in subjects undergoing cardiac surgery on cardiopulmonary bypass (CPB).
- Trial name
- NCT06021457
- Testing
- RBT-1
- Where
- 41 sites in United States, Canada
- Volunteers
- 454 people
- Sponsor
- Renibus Therapeutics, Inc.
Cardiopulmonary Bypass, Hemorrhage
Dose-ranging Study of Two Doses of Tranexamic Acid During Cardiac Surgery
Cardiac surgery with CardioPulmonary Bypass (CPB) exposes to per and postoperative bleeding, and may lead to allogenic blood transfusion re-intervention and many adverse outcomes.
- Trial name
- Exacylcardio (NCT00809393)
- Testing
- tranexamic acid
- Where
- 4 sites in France
- Volunteers
- 600 people
- Sponsor
- Hopital Foch
Aortic Valve Surgery, Coronary Artery Bypass Graft (CABG)
Metabolic Profile and Tissue Perfusion in Patients Undergoing Open Heart Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation
The aim of the present study is to investigate the protective effect of minimal invasive versus the conventional extracorporeal circulation on tissue homeostasis as evidenced by the preservation of tissue metabolism and cerebral…
- Conditions
- Aortic Valve Surgery, Coronary Artery Bypass Graft (CABG), Cardiac Surgery
- Trial name
- MiECC MET (NCT07516938)
- Testing
- Real-time tissue oximetry monitoring
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- Aristotle University Of Thessaloniki
Acute Kidney Dysfunction
Cardiopulmonary-bypass and Reno-protective Effect of Atorvastatin Trial
Acute kidney dysfunction is common after cardiac surgery. While many patients suffer no long-term ill effects from post-operative kidney dysfunction, some require initiation of dialysis therapy that can contribute to long-term…
- Trial name
- CREAT (NCT00910221)
- Testing
- Atorvastatin
- Where
- Australia
- Volunteers
- 100 people
- Sponsor
- Austin Health
Cardiac Surgery With Cardiopulmonary Bypass, Valve Heart Disease
Transfusion in Cardiac Valve Surgery
This prospective, randomized controlled study is aimed to figure out suitable transfusion threshold in patients undergoing cardiac valve surgery under cardiopulmonary bypass(CPB).
- Trial name
- TICVS (NCT06332547)
- Testing
- Restrictive Transfusion Strategy, Liberal Transfusion Strategy
- Where
- China
- Volunteers
- 1,600 people
- Sponsor
- Guangdong Provincial People's Hospital
Postoperative Pain, Postoperative Atelectasis
Erector Spina Block or Parasternal Block Plus Chest Tube Wound Infiltration for Cardiac Surgeries
Pain management is important after coronary artery bypass graft (CABG) surgery. Intravenous morphine is the gold standard for pain relief, but its sedation, cough suppression and decreased bowel movements limit its use.
- Conditions
- Postoperative Pain, Postoperative Atelectasis, Analgesia
- Trial name
- NCT06267443
- Testing
- Comparison of erector spina plane block, parasternal block plus local infiltration to the tube sides for postoperative analgesia
- Volunteers
- 100 people
- Sponsor
- TC Erciyes University
Cardiac Surgical Procedures
Low Dose Dexmedetomidine and Delirium After Cardiac Surgery
Delirium after cardiac surgery can occur in up to 50% of the patients and has been shown to be significantly associated with increased morbidity and mortality. Advanced age is a significant risk factor of delirium.
- Trial name
- LOWDEXDEL (NCT03388541)
- Testing
- Dexmedetomidine
- Where
- Belgium
- Volunteers
- 420 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Granulocyte Immature Forms, Inflammatory Response Syndrome, Systemic
Bands in Peripheral Blood After Coronary Artery Bypass Grafting With and Without Cardiopulmonary Bypass
Coronary artery bypass graft (CABG) surgery is associated with reperfusion syndrome and activation of inflammatory reaction (SIRS). These are more exaggerated when cardiopulmonary bypass (CPB) is used.
- Trial name
- NCT00563030
- Where
- Poland
- Volunteers
- 44 people
- Sponsor
- Medical University of Gdansk
Coronary Artery Disease, Cardiac Disease
Effects of Early Telerehabilitation in Coronary Artery Bypass Surgery Patients
The aim of this study was to investigate the effects of phase I and early phase II rehabilitation with telerehabilitation method and sleep hygiene training on physical capacity, cardiac functions, anxiety level, quality of life…
- Trial name
- NCT06240702
- Testing
- Telerehabilitation Group
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Necmettin Erbakan University
Acute Kidney Injury
Neutrophil, Lymphocyte and Platelet as a Predictor for AKI and Mortality
Cell-count related risk factors for acute kidney injury after cardiovascular surgery have been reported. The authors attempted to investigate whether the perioperative cell counts of neutrophil, lymphocyte, platelet are…
- Trial name
- NCT02916043
- Testing
- Cardiovascular surgery with cardiopulmonary bypass
- Where
- South Korea
- Volunteers
- 1,099 people
- Sponsor
- Seoul National University Hospital
Cardiac Surgery-associated Acute Kidney Injury
A Study to Understand How Cardiac Surgery-associated Acute Kidney Injury Develops in Participants Who Undergo Heart Surgery With the Use of Heart-lung Machine
Researchers are looking for a better way to treat and prevent cardiac surgery-associated acute kidney injury (CSA-AKI) in people who undergo heart surgeries.
- Trial name
- NCT06772025
- Testing
- No investigational study intervention
- Where
- 4 sites in Germany, United Kingdom
- Volunteers
- 100 people
- Sponsor
- Bayer
Psychological Stress, Cardiopulmonary Bypass Surgery
CARINAE for Stress Relief in Perioperative Care
Preventing pre-surgical stress can help patients achieve positive outcomes on health and well-being. However, very few patients receive adequate stress relief support prior to a surgical procedure.
- Conditions
- Psychological Stress, Cardiopulmonary Bypass Surgery, Coronary Artery Bypass Surgery, Cardiac Valve Replacement
- Trial name
- CARINAE (NCT05184725)
- Testing
- SaMD CARINAE
- Where
- 5 sites in Italy, Netherlands and 1 more
- Volunteers
- 50 people
- Sponsor
- Adhera Health, Inc.
Prevention of Venous Thromboembolism
Efficacy And Safety Of Unfractionated Heparin In Patients With Cardiovascular Surgery Using Cardiopulmonary Bypass
The primary objective of this study is to verify, through a randomized, blinded, parallel clinical trial, the efficacy of bovine heparin from Bergamo Laboratory ACTIPARIN ® product when compared to porcine heparin APP…
- Trial name
- NCT01072747
- Testing
- bovine heparin, Porcine heparin
- Where
- Brazil
- Volunteers
- 104 people
- Sponsor
- Azidus Brasil
Bypass Complications
Best Cardiac Output During Cardiopulmonary Bypass
The purpose of this study is to determine whether the patients cardiac output measured before cardiopulmonary bypass (CPB), is more sufficient to secure the patients oxygen needs than the estimated cardiac output from Ficks…
- Trial name
- NCT01379638
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Aalborg University Hospital
Coronary Artery Disease
Vascular Function on the First Day After Cardiac Surgery
This study examines the flow mediated dilation (FMD) of the brachial artery before and after cardiac surgery. FMD is measured with ultrasound technique.
- Trial name
- NCT02001090
- Where
- Norway
- Volunteers
- 25 people
- Sponsor
- Norwegian University of Science and Technology
Vascular Occlusion Test
Near-Infrared Spectroscopic (NIRS) Tissue Oxygen Saturation and the Vascular Occlusion Test in Cardiac Surgery Patients
Tissue oxygen saturation (StO2) and its recovery during a vascular occlusion test (VOT) will be measured in elective cardiac surgery patients undergoing cardiopulmonary bypass using a non-invasive near infrared spectrometry…
- Trial name
- NCT01712750
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- London Health Sciences Centre
Cardiac Perfusion
Del Nido Cardioplegia Randomized Trial
The use of a modified depolarizing cardioplegia solution in adult cardiac surgery would allow for prolonged re-dosing intervals while providing equivalent myocardial protection.
- Trial name
- NCT02442050
- Testing
- del Nido solution, Blood-based cardioplegia
- Where
- 2 sites in United States
- Volunteers
- 99 people
- Sponsor
- Inova Health Care Services