Clinical trials: Cardiopulmonary-bypass
Open Heart Surgery
Dose for Reversal of Heparin After Cardiopulmonary Bypass
Protamine sulfate is routinely used to reverse heparin anticoagulation after cardiopulmonary bypass (CPB). The conventional dosing strategy of 1 mg protamine per 100 IU of heparin may result in excess protamine exposure, which…
- Trial name
- NCT07477977
- Testing
- Protamine sulfate
- Where
- Egypt
- Volunteers
- 195 people
- Sponsor
- Sohag University
Bleeding, Platelets
Autologous Cold-stored Apheresis Platelets
The Auto-PLTS Study is a single-centre trial performed at Toronto General Hospital (TGH) that uses a randomized, patient preference design.
- Conditions
- Bleeding, Platelets, Cardiopulmonary Bypass, Cardiac Surgery
- Trial name
- Auto-PLTS (NCT07064954)
- Testing
- Autologous Cold-Stored Platelets, Allogeneic Room Temperature-Stored Platelets (Standard of Care)
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Hemodynamic Instability
Compare Hemodynamic Parameters of Propofol and Sevoflurane During CPB Time in Undergoing CABG to Avoid Lactate Level
Hemodynamic parameters and lactate level will be on CBP during CABG surgery patients.
- Trial name
- NCT05004545
- Testing
- Propofol
- Where
- Pakistan
- Volunteers
- 126 people
- Sponsor
- Chaudhry Pervaiz Elahi Institute of Cardiology
Atrial Fibrillation
Prevention of Atrial Fibrillation Following Valvular Replacement With Cardiopulmonary Bypass: a Prospective, Randomized Clinical Study Comparing Oral Caffeine With Placebo
Atrial fibrillation remains a major cause of morbidity following cardiac surgery with cardiopulmonary bypass. Many mechanisms have been implicated.
- Trial name
- NCT01999829
- Testing
- citrate of caffeine
- Where
- France
- Volunteers
- 110 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury
The Association Between Tau & GFAP and Postoperative Neurological Impairment in Patients Undergoing Cardiac Surgery
Patients born with heart defects often undergo surgical procedures on a heart lung machine. With improvements in medical and surgical management, their survival has significantly improved, but their brain insult has not been paid…
- Conditions
- Cardiac Surgery Requiring Cardiopulmonary Bypass, Brain Injury, Congenital Heart Defect
- Trial name
- NCT06899971
- Testing
- Collecting discarded blood samples
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Boston Children's Hospital
Hypertrophy, Left Ventricular, Aortic Stenosis
Glutamate and Diastolic Function in Patients Undergoing Aortic Valve Repair
Purpose: The effect of intravenous glutamate infusion on myocardial diastolic function and overall hemodynamics were studied in patients undergoing elective aortic valve replacement with severe aortic stenosis and associated left…
- Conditions
- Hypertrophy, Left Ventricular, Aortic Stenosis, Myocardial Ischemia, Cardiopulmonary Bypass
- Trial name
- NCT01144039
- Testing
- LG-group, HG-group
- Where
- Austria
- Volunteers
- 27 people
- Sponsor
- Medical University of Vienna
Surgery, Cardiac Event
Effect of Oxiris® Membrane on Microcirculation Following Cardiac Surgery Under Cardiopulmonary Bypass: a Pilot Prospective Monocentric Study (Oxicard Study).
Oxiris membrane is an efficient tool for inflammatory cytokines adsorption. Cardiac surgery is followed by an inflammatory state mimicking sepsis.
- Trial name
- OXICARD (NCT04201119)
- Testing
- Oxiris
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Frailty, Cardiac Surgery
SAGE-Heart : Senior Assessment fraGility and Post-opErative QALYs 1 Year After Emergency HEART Surgery for Patients Aged 75 and Older
The hypothesis is that the preoperative Clinical Frailty Score (CFS) is a predictive factor for a loss in quality-adjusted life years (QALYs) one year after emergency cardiac surgery under cardiopulmonary bypass (CPB) in patients…
- Conditions
- Frailty, Cardiac Surgery, QALYs
- Trial name
- SAGE-Heart (NCT07677319)
- Testing
- Phone Calls
- Where
- France
- Volunteers
- 265 people
- Sponsor
- University Hospital, Bordeaux
Minimally Invasive Coronary Revascularization Surgery, Elective Surgery
Impact of Total Coronary Revascularization Via Left Anterior Thoracotomy (TCRAT) vs. Robotic-Assisted Harvesting of LIMA (ITcrats)
The two types of total coronary revascularization via left anterior thoracotomy (TCRAT) might have their potential benefits and disadvantages.
- Trial name
- ITcrats (NCT06988735)
- Testing
- Nonrobotic TCRAT, Robotic TCRAT
- Where
- Saudi Arabia
- Volunteers
- 182 people
- Sponsor
- Mohamed R El Tahan
Acquired Bleeding Disorder, Cardiac Surgery Requiring Cardiopulmonary Bypass
Activated Recombinant Human Factor VII Following Cardiac Bypass Surgery for Paediatric Congenital Heart Disease
This trial is conducted in Oceania. The aim of this trial is to investigate the efficacy of activated recombinant human factor VII and standard treatment compared with standard haemostatic replacement therapy in cardiopulmonary…
- Trial name
- NCT01562574
- Testing
- activated recombinant human factor VII
- Where
- Australia
- Volunteers
- 82 people
- Sponsor
- Novo Nordisk A/S
Vasoplegia, Endothelial Dysfunction
Evaluation of the Association Between Pre-existing Endothelial Dysfunction and the Onset of Vasoplegia During Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery patients have many risk factors for endothelial dysfunction (hypertension, atherosclerosis, dyslipidemia, chronic renal failure ...).
- Trial name
- DYVA (NCT02965339)
- Where
- France
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Postoperative Hemorrhage
Antithrombin III Supplementation for Cardiopulmonary Bypass in Neonates
A prospective, randomized, placebo-controlled, double-blinded pilot study is planned. Neonates undergoing surgeries requiring cardiopulmonary bypass will receive antithrombin III (ATIII) supplementation or placebo in addition to…
- Trial name
- NCT01158729
- Testing
- Antithrombin (Recombinant)
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Medical College of Wisconsin
Congenital Heart Disease
Evaluating Precision of Therapy - Milrinone
Children with congenital heart disease have significant morbidity including low cardiac output syndrome and subsequent organ dysfunction that may be prevented by optimization of circulatory function.
- Trial name
- NCT01841177
- Testing
- Milrinone
- Where
- 2 sites in Canada
- Volunteers
- 52 people
- Sponsor
- The Hospital for Sick Children
Coronary Disease
Impact of Pumps on Internal Thoracic Arteries (IPITA)
Cardiopulmonary bypass (CPB) induces a systemic inflammatory response and affects the organ vascular bed. Experimentally, the lack of pulsatility alters myogenic tone of resistance arteries and increases the parietal inflammatory…
- Trial name
- IPITA (NCT04168853)
- Testing
- vascular reactivity of internal thoracic arteries
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Adrenal Insufficiency Neonatal
Impact of Pre-operative Steroids on Adrenal Insufficiency
Little is known regarding the incidence and clinical impact of AI in neonates during the acute postoperative period following separation from CPB.
- Trial name
- NCT02956707
- Testing
- No pre-operative steroids
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Alabama at Birmingham
Acute Respiratory Distress Syndrome
Plasma Biomarkers of Cardiopulmonary Bypass Induced Acute Respiratory Distress Syndrome (CPB-ARDS)
The investigators aimed to establish a prospective cohort of patients undergoing cardiopulmonary bypass (CPB) in cardiac surgery from April 2021 to September 2022, in Wuhan.
- Trial name
- PBOARDS (NCT04696172)
- Where
- 2 sites in China
- Volunteers
- 525 people
- Sponsor
- Huazhong University of Science and Technology
Cardiac Surgery
Goal Directed Hemodynamic Management of Acute Heart Failure After Cardiac Surgery in Children
Goal directed therapy (GDT) utilises various monitoring techniques to assess cardiovascular performance and allows for timely interventions based on predetermined algorithms.
- Trial name
- NCT02617602
- Testing
- Goal directed therapy, Control
- Where
- Russia
- Volunteers
- 40 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Ischemia-Reperfusion Injury
Effect of Dexmedetomidine Preconditioning on Myocardial Ischemia-reperfusion Injury in Patients Undergoing Open Heart Surgery With Cardiopulmonary Bypass
About 200000 cardiac operations are performed in China every year. Cardiopulmonary bypass is the basic strategy of open-heart surgery, which may lead to myocardial ischemia-reperfusion injury and low cardiac output syndrome.
- Trial name
- NCT05598177
- Testing
- dexmedetomidine
- Where
- China
- Volunteers
- 64 people
- Sponsor
- Affiliated Hospital of Nantong University
Postoperative Delirium
Cerebral Blood Supply During Cardiopulmonary Bypass
Postoperative delirium is an acute and fluctuating state of confusion and disorientation with an incidence of 25-70% after cardiac surgery.
- Trial name
- NCT03117712
- Testing
- Delirium Scores, Carotis duplex sonography, TCD for detection of HITS
- Where
- Austria
- Volunteers
- 40 people
- Sponsor
- Medical University of Vienna
Coronary Artery Bypass
Comparison of Minimal Versus Conventional Extracorporeal Circulation in Coronary Surgery
The aim of this study is to assess the effect of minimal (MiECC) versus conventional (CECC) extracorporeal circulation on perfusion characteristics and remote end-organ protection (lungs, brain, kidneys, liver, stomach…
- Trial name
- NCT01603589
- Testing
- Coronary artery bypass grafting with the use of minimal invasive extracorporeal circulation, Coronary artery bypass grafting under conventional extracorporeal circulation
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- AHEPA University Hospital