Clinical trials: Cardiopulmonary-bypass
Congenital Heart Disease
Pharmacokinetics of Tranexamic Acid (TXA) in Children Undergoing Repair of Congenital Heart Defects Utilizing Cardiopulmonary Bypass
The purpose of this study is to measure blood levels of TXA in children having cardiac surgery which requires cardiopulmonary bypass. TXA is used to reduce bleeding during surgery.
- Trial name
- NCT01045356
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Cardiosurgery
The Kallikrein-Kinin System in Cardiac Surgery
We aimed to established an interlink among the kallikrein-kinin system (KKS), endothelial dysfunction and POD in response to cardiosurgery , using clinic investigation.
- Trial name
- NCT06080295
- Where
- China
- Volunteers
- 287 people
- Sponsor
- Qin Zhang
Myocardial Reperfusion Injury, Heart Diseases
Coronary Sinus Blood Sevoflurane and Desflurane Concentration and Lactate Changes in Patients Undergoing Heart Surgery
In the last few years, anaesthetics gas such as isoflurane, desflurane and sevoflurane used in heart surgery have shown some benefits to reduce the risk of heart muscle damage than total intravenous anesthetics.
- Conditions
- Myocardial Reperfusion Injury, Heart Diseases, Postoperative Complications
- Trial name
- SEVO-DES (NCT02866630)
- Testing
- Blood samples
- Sponsor
- University of Malaya
Cardiac Surgery Recovery, Inflammation
Jafron Cytokine Adsorber During Pediatric Open-Heart Surgeries
This prospective single-center randomized controlled trial aims at evaluating the safety and feasibility of an hemoadsorption protocol using Jafron HA-60 during cardio-pulmonary bypass in 20 pediatric patients undergoing…
- Conditions
- Cardiac Surgery Recovery, Inflammation, Complex Cardiovascular Surgery With Cardiopulmonary Bypass, Cytokine Storm
- Trial name
- JACKPOT (NCT07393087)
- Testing
- Hemoadsorption
- Where
- Switzerland
- Volunteers
- 20 people
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Heart Failure
CentriMag Ventricular Assist System in Treating Failure-to-Wean From Cardiopulmonary Bypass for Pediatric Patients
The purpose of the study is to evaluate the safety and effectiveness of the CentriMag ventricular assist system to help pediatric patients who have experienced heart failure during surgery and cannot be removed from cardiac…
- Trial name
- NCT01171950
- Testing
- CentriMag Ventricular Assist System
- Sponsor
- Abbott Medical Devices
Acute Kidney Injury, Acute Kidney Disease
Effect of CVP and IOH on AKI and AKD
This study was aimed to explore the effect of intraoperative venous congestion and intraoperative hypotension (IOH) on acute adverse kidney events, defined as acute kidney injury (AKI) and acute kidney disease (AKD), after…
- Trial name
- NCT05222074
- Testing
- Venous congestion, Introperation hypotension
- Where
- China
- Volunteers
- 5,127 people
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Cardiopulmonary Bypass Surgery, Aortic Valve Surgery
Methylene Blue-Enhanced Ultrafiltration Improves Outcomes After Cardiopulmonary Bypass
Introduction: Fluid overload and systemic inflammation are major contributors to postoperative complications in patients undergoing cardiac surgery with cardiopulmonary bypass (CPB).
- Conditions
- Cardiopulmonary Bypass Surgery, Aortic Valve Surgery, Mitral Valve Surgery, Myocardial Revascularization Surgery With Extracorporeal Circulation
- Trial name
- NCT07212842
- Testing
- Methylene Blue, Conventional ultrafiltration, Zero-balance ultrafiltration
- Where
- Brazil
- Volunteers
- 124 people
- Sponsor
- University of Sao Paulo
Cardiac Surgery
DMSO Cryopreserved Platelets in Cardiopulmonary Bypass Surgery (CRYPTICS)
A randomized, parallel group, active comparator-controlled trial to evaluate the non-inferiority or superiority of Cryopreserved Platelets with Liquid Stored Platelets in controlling blood loss in patients undergoing…
- Trial name
- CRYPTICS (NCT04709705)
- Testing
- Human platelets
- Where
- 16 sites in United States
- Volunteers
- 161 people
- Sponsor
- Cellphire Therapeutics, Inc.
Hypoxemia
HFLVV for Hypoxemia in Robot-assisted Cardiac Surgery
These robot-assisted cardiac surgeries usually require single-lung ventilation (SLV) to facilitate surgical exposure. SLV creates ventilation/perfusion mismatch and shunt (Qs:Qt) through the collapsed lung and leads to hypoxemia.
- Trial name
- NCT04926649
- Testing
- Differential ventilation to the non-dependent lung
- Where
- China
- Volunteers
- 56 people
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Heart Defects, Congenital
Colloid Osmotic Pressure During Heart Surgery in Children
Clinical oedema is seen after open heart surgery with the use of cardiopulmonary bypass and hypothermia in children. The oedema formation is due to increased fluid transport from blood to tissue.
- Trial name
- NCT01397526
- Where
- Norway
- Volunteers
- 9 people
- Sponsor
- Oslo University Hospital
Cardiac Surgery Under Extra Corporeal Circulation
Immune Responses and Pulmonary Complications After Cardiac Surgery With Cardiopulmonary Bypass
Cardiac surgery under cardiopulmonary bypass (CPB) is associated with a high incidence of postoperative pulmonary complications (PPCs; 10% to 30% incidence).
- Trial name
- IIRIS (NCT07865533)
- Testing
- Blood sample collection, Bronchoalveolar lavage fluid collection
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Open-heart Surgery, Cardiopulmonary Bypass
Intravenous Phenoxybenzamine Use in Pediatric Patients Undergoing Open-Heart Surgery
Cardiopulmonary bypass is done with a machine that does the work of the heart and lungs during open-heart surgery. This study is to determine if intravenous (i.v.) phenoxybenzamine is safe.
- Trial name
- NCT00569855
- Testing
- Phenoxybenzamine
- Where
- United States
- Volunteers
- 785 people
- Sponsor
- University of Arkansas
Coronary Artery Disease (CAD), Bypass, Cardiopulmonary
Multivessel Minimally Invasive Coronary Bypass Grafting as HYBRID Revascularization Versus Conventional Off-pump Coronary Artery Bypass Grafting
The MICRA-HYBRID trial is a prospective, multicenter, randomized controlled study comparing multivessel hybrid coronary revascularization (HCR) as minimally invasive arterial bypass grafting to left-sided coronary targets (LAD…
- Conditions
- Coronary Artery Disease (CAD), Bypass, Cardiopulmonary, Minimally Invasive Coronary Revascularization Surgery, Off-pump Coronary Artery Bypass
- Trial name
- MICRA-HYBRID (NCT07314138)
- Testing
- Multivessel Hybrid Coronary Revascularization, Off-pump coronary arterial bypass grafting (OPCAB)
- Where
- 2 sites in Belgium, Netherlands
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Embolic Stroke, Postoperative Cognitive Dysfunction
Perfusion Pressure Cerebral Infarction Trial (PPCI)
STUDY HYPOTHESIS In cardiac surgery the volume of perioperative cerebral infarctions can be reduced by increasing mean arterial pressure (MAP) during the cardiopulmonary bypass procedure.
- Trial name
- PPCI (NCT02185885)
- Testing
- Increased bloodpressure during CPB.
- Where
- Denmark
- Volunteers
- 197 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Coronary Artery Disease, Low Cardiac Output Syndrome
Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass Grafting
Background: Despite improvements in surgical and anesthesia procedures over the past 15 years complications during cardiac surgery still remain high. Bridgewater B et al.
- Conditions
- Coronary Artery Disease, Low Cardiac Output Syndrome, Atrial Fibrillation, Postoperative Complications
- Trial name
- NCT05514652
- Testing
- Low opioid anesthesia
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Heart Institute, Ministry of Health of Ukraine
Vasoplegia, Vasoplegic Shock
Differential Regulation of RAAS-axis in Patients Undergoing Cardiac Surgery
This study investigates the question of whether there are differences in the plasma concentration of hormones of the RAAS-axis between patients undergoing on-pump cardiac surgery and those receiving off-pump surgery
- Trial name
- RAAS-HLM (NCT05833828)
- Testing
- on-pump surgery, off-pump surgery
- Where
- 2 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Universität Münster
Ventricular Septal Defect, Atrioventricular Septal Defect
A Study Evaluating the Efficacy and Safety of IV L-Citrulline for the Prevention of Clinical Sequelae of Acute Lung Injury Induced by Cardiopulmonary Bypass in Pediatric Patients Undergoing Surgery for Congenital Heart Defects
This is a randomized, double-blind, placebo controlled, multicenter study to compare the efficacy and safety of L-citrulline versus placebo in patients undergoing surgery for congenital heart defects.
- Conditions
- Ventricular Septal Defect, Atrioventricular Septal Defect, Primum Atrial Septal Defect
- Trial name
- NCT05253209
- Testing
- L-citrulline, Plasmalyte A
- Where
- 10 sites in United States
- Volunteers
- 64 people
- Sponsor
- Asklepion Pharmaceuticals, LLC
Undergo Elective Cardiac Surgery, Cardiopulmonary Bypass
Evaluation of the Effectiveness of Ultrasound-Guided Stellate Ganglion Block in Cardiac Surgery Anesthesia on Postoperative Recovery
Heart surgery is a complex and delicate procedure that affects more than one million people worldwide each year. Patients who undergo this surgery are generally elderly and have multiple comorbidities, which places them in…
- Conditions
- Undergo Elective Cardiac Surgery, Cardiopulmonary Bypass, CPB
- Trial name
- ECLAIR (NCT07676487)
- Testing
- Elective surgery (≥ 24 hours) with cardiopulmonary bypass (more than 2 procedures)
- Where
- France
- Volunteers
- 250 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Platelet Dysfunction, Cardiopulmonary Bypass
Influence of Oxygenator Selection on Platelet Function and Rotational Thromboelastometry Following Cardiopulmonary Bypass
Open-heart surgery requires temporarily stopping the heart and lungs and diverting the patient's blood to an outside system that takes over the function of the heart and lungs.
- Trial name
- NCT05588011
- Testing
- Terumo, LivaNova
- Where
- Canada
- Volunteers
- 68 people
- Sponsor
- BRADEN DULONG
Acute Myocardial Infarction: Rehabilitation Phase, Coronary Artery Bypass Graft Triple Vessel
Cardiopulmonary and Metabolic Responses to Early Exercise in Patients After Coronary Arterial Bypass Grafting
Coronary arterial bypass graft surgery (CABG) is proven safe with improved survival and greater quality of life in patients with coronary arterial disease.
- Conditions
- Acute Myocardial Infarction: Rehabilitation Phase, Coronary Artery Bypass Graft Triple Vessel, Physical Activity
- Trial name
- NCT02758600
- Testing
- Cycle ergometer exercise rehabilitation protocol
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- Federal University of São Paulo