Clinical trials: Cardiopulmonary-bypass
Neonatal Congenital Heart Disease
Magnetic Resonance Imaging (MRI) to Evaluate Brain Injury in Congenital Heart Disease
Infants with congenital heart disease (CHD) requiring surgery frequently have brain injury seen on magnetic resonance imaging (MRI).
- Trial name
- CHD Brain (NCT00932633)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Emory University
Cardiopulmonary Bypass, Inflammatory Response
Platelets and Complement Activation in Coronary Artery Bypass Graft Surgery (CABG)
Patients undergoing coronary artery bypass graft surgery (CABG) frequently exhibit postoperative bleeding complications which are still a major cause for morbidity and mortality.
- Conditions
- Cardiopulmonary Bypass, Inflammatory Response, Platelet Dysfunction
- Trial name
- PAC (NCT05033236)
- Where
- Austria
- Volunteers
- 190 people
- Sponsor
- Medical University Innsbruck
Anemia, Cognitive; Disorder, Due to General Medical Condition
Haemo-autologous Antegrade Repriming (HAR) as Minimum Impact Perfusion Strategy for Cardiopulmonary Bypass
Haemo-autologous Antegrade Repriming (HAR) is a procedure based in the combination of evidence proven measures designed to reduce the haemodilution caused by establishing the cardiopulmonary bypass (CPB) during cardiac surgery.
- Conditions
- Anemia, Cognitive; Disorder, Due to General Medical Condition, Embolism, Air, Transfusion
- Trial name
- HARjbm1 (NCT03720184)
- Testing
- HAR
- Where
- Spain
- Volunteers
- 116 people
- Sponsor
- Juan Blanco Morillo
Cardiac Surgery, Coronary Artery Bypass Graft CABG
Effects of a Hybrid Model of Cardiac Rehabilitation on Patient Outcomes
Determine if the standard of care at a cardiac rehabilitation center using what the investigators term to be "hybrid model" on the exercise component of cardiac rehabilitation is associated with improved adherence and outcomes.
- Conditions
- Cardiac Surgery, Coronary Artery Bypass Graft CABG, Stent, Valve Replacement
- Trial name
- NCT06030115
- Testing
- Exercise Component Of Cardiac Rehabilitation (Hybrid Model) Intensity Recovery Progression Protocol (IRPP)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Good Shepherd Integrated Healthcare Systems
Congenital Heart Disease
Angiotensin Converting Enzyme Inhibitors During Cardiopulmonary Bypass in Infants and Children
The purpose of this study is to determine whether ACE inhibitors alter the fibrinolytic, inflammatory, and hemodynamic response to cardiopulmonary bypass in infants and children with congenital heart disease.
- Trial name
- NCT00848250
- Testing
- Angiotensin Converting Enzyme Inhibitor, No ACE Inhibitor
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Vanderbilt University Medical Center
Clinical Outcomes, Cardiac Surgery
Predictors Of Outcome After Coronary Artery Bypass Graft Surgery Using Cardiopulmonary Bypass
In cardiac operations, high values of blood lactate have been associated with bad outcomes if detected both during CPB and at the arrival in the intensive care unit (ICU) in adult patients.
- Conditions
- Clinical Outcomes, Cardiac Surgery, Cardio-pulmonary Bypass
- Trial name
- NCT07034716
- Testing
- CORONARY BYPASS SURGERY USING CARDIOPULMONARY BYPASS, cardiac surgical patients who will undergo isolated elective cardiopulmonary bypass
- Volunteers
- 60 people
- Sponsor
- Alexandria University
Blood Coagulation Disorders
The Effect of the Hemobag® Ultrafiltration System on Blood Conservation and Coagulation After Cardiopulmonary Bypass
This proposal is designed to mitigate hemodilution (blood diluted with an electrolyte solution) and loss of plasma proteins responsible for normal blood clotting as well as platelets at the completion of cardiopulmonary bypass…
- Trial name
- NCT01435304
- Testing
- method of returning residual CPB blood ( Hemobag®)
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- MaineHealth
Vasoplegia, Vasoplegic Shock
Endotoxinemia and Vasoplegia Following Cardiothoracic Surgery With Cardiopulmonary Bypass (CPB)
This observational study investigates the effect of endotoxinemia on the postoperative incidence of vasoplegia or vasoplegic shock in patients undergoing cardiac surgery with the use of cardiopulmonary bypass.
- Trial name
- NCT05925348
- Testing
- Patients with cardiopulmonary bypass
- Where
- Germany
- Volunteers
- 200 people
- Sponsor
- Universität Münster
Anticoagulant Antagonist Toxicity
Strategies for Protamine Dosing After Anticoagulation in Cardiovascular Surgery
In cardiovascular surgery, patients are anticoagulated with heparin during cardiopulmonary bypass, subsequently, anticoagulation is reversed with protamine to reduce bleeding due to residual heparin-induced coagulopathy, which…
- Trial name
- SEPARATION (NCT04628884)
- Testing
- Conventional dose, Dosing according residual heparin
- Where
- Colombia
- Volunteers
- 136 people
- Sponsor
- Fundación Clínica Shaio
Ischemic Heart Disease, Aortic Stenosis, Severe
Influence of Lung Ultrasonography on the Prognosis and Postoperative Outcomes in Cardiac Surgical Patients
The goal of this interventional is to assess advantages of the ultrasound examination of the lungs in the early postoperative period in cardiac surgical patients after heart surgeries requiring cardiopulmonary bypass.
- Conditions
- Ischemic Heart Disease, Aortic Stenosis, Severe, Aortic Insufficiency, Mitral Stenosis
- Trial name
- NCT06377449
- Testing
- Ultrasound examination of the lungs
- Where
- Russia
- Volunteers
- 186 people
- Sponsor
- Saint Petersburg State University, Russia
Acquired Antithrombin III Deficiency, Coronary Artery Bypass
Use of Antithrombin in Cardiac Surgery With Cardiopulmonary Bypass
The purpose of this trial is to study the effects of preoperative antithrombin supplementation in patients undergoing cardiac surgery with cardiopulmonary bypass in order to maintain antithrombin levels in a range greater than…
- Trial name
- NCT00823082
- Testing
- Antithrombin III
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Instituto Grifols, S.A.
Cardiopulmonary Bypass, AKI - Acute Kidney Injury
Prophylactic Methylprednisolone for Renal Protection in Cardiac Surgeries With Cardiopulmonary Bypass
The aim of the planned study is to assess the prophylactic effect of intraoperative administration of a single dose of methylprednisolone 2 (mg/kg) in decreasing the incidence of postoperative acute kidney injury after cardiac…
- Trial name
- NCT06917859
- Testing
- Methylprednisolone group
- Where
- Egypt
- Volunteers
- 170 people
- Sponsor
- Ain Shams University
Congenital Heart Disease (CHD), Cardiopulmonary Bypass
Research on Circulation Management Strategy Based on Oxygen Metabolism Balance After CHD Surgery
The objective is to investigate a goal-oriented postoperative circulation management strategy centered on "oxygen metabolism balance".
- Conditions
- Congenital Heart Disease (CHD), Cardiopulmonary Bypass, Children, Oxygen Delivery
- Trial name
- NCT06747546
- Testing
- "goal-directed" treatment strategy based on oxygen supply and consumption balance, Conventional Treatment group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Children's Hospital of Fudan University
Cognitive Decline
Gastrodin Prevents Cognitive Decline Related to Cardiopulmonary Bypass
The incidence of cognitive decline related to CPB ranges from 20% to 80%, which may affect length of hospital stay, quality of life, the rehabilitation process, and work performance.However, there is no method to prevent the…
- Trial name
- NCT00297245
- Testing
- cognitive function
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Huazhong University of Science and Technology
Cardiac Disease, Bleeding Postoperative
Fresh Autologous Whole Blood Transfusion After Cardiopulmonary Bypass
Autologous blood transfused at the end of cardiopulmonary bypass will reduce total blood loss 24 hours after surgery and improve mitochondrial oxygen delivery measured by plasma succinate levels.
- Trial name
- NCT03204357
- Testing
- Fresh Autologous whole Blood, Standard of Care Expectant management of bleeding
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Colorado, Denver
Undergoing Open-Heart Surgery
Opioids Continue to Play a Primary Role in the Management of Perioperative Pain Due to Opioid-Free Anesthesia in Open Heart Surgery.
Due to their superior efficacy in analgesia, opioids continue to play a primary role in the control of intraoperative and postoperative pain.
- Trial name
- Opioid-Free (NCT06683911)
- Testing
- non Opioids, Opioid
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Ankara City Hospital Bilkent
Cardiopulmonary Bypass, Inflammation
Bradykinin Receptor Antagonism During Cardiopulmonary Bypass
Each year over a million patients worldwide undergo cardiac surgery requiring cardiopulmonary bypass (CPB). CPB is associated with significant morbidity including the transfusion of allogenic blood products, inflammation and…
- Conditions
- Cardiopulmonary Bypass, Inflammation, Fibrinolysis, Surgery
- Trial name
- BRAC (NCT00223704)
- Testing
- HOE 140, Aminocaproic Acid
- Where
- 2 sites in United States
- Volunteers
- 150 people
- Sponsor
- Vanderbilt University
Ischaemic Reperfusion Injury
Remote Ischaemic Preconditioning in Children Undergoing Cardiac Surgery
Surgical correction of congenital heart defects in children requires the utilization of cardiopulmonary bypass, a technique that temporarily substitutes heart and lung functions during surgery.
- Trial name
- NCT01680601
- Testing
- Remote ischaemic preconditioning (RIPC)
- Where
- United Kingdom
- Volunteers
- 51 people
- Sponsor
- NHS Greater Glasgow and Clyde
Extracorporeal Circulation, Cardiac Surgery
Priming of Cardiopulmonary Bypass With Hydroxyethyl Starch 130/0.4 or Sodium Chloride 0.9% : Pilot Study in Adult Elective Conventional Cardiac Surgery
Best priming for cardiopulmonary bypass in cardiac surgery is unknown. Efficacy and toxicity of Hydroxyethyl Starch 130/0.4 used in this context are uncertain.
- Trial name
- OPTIMUS-PRIME (NCT02906514)
- Testing
- Non balanced Hydroxyethyl starch 130/0.4 (Voluven®, Fresenius), Sodium Chloride 0.9% (Fresenius)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Heart Diseases
POC - Transfusion Algorithm Cardiac Study
This multi-centre study will provide sound, generalizable data on the effectiveness of a POC-based algorithm to determine to what extent this guideline can reduce blood product transfusions.
- Trial name
- TACS (NCT02200419)
- Testing
- POC-based transfusion algorithm
- Where
- 12 sites in Canada
- Volunteers
- 7,402 people
- Sponsor
- University Health Network, Toronto