Clinical trials: Cardiopulmonary-bypass
Postoperative Cognitive Dysfunction
Identification of Factors Causing Postoperative Cognitive Dysfunction in Patients Undergoing Cardiac Surgery With CPB
The incidence of cognitive decline occurs in 53% of patients after cardiac surgery. Causes of POCD can be various: age, duration of cardiac bypass, medicaments and many others.
- Trial name
- NCT03641833
- Testing
- blood sample for brain biomarkers
- Where
- Lithuania
- Volunteers
- 130 people
- Sponsor
- Rasa Bukauskiene
Analgesia, Congenital Heart Disease
Morphine IV vs Paracetamol IV in Neonates and Infants After Cardiac Surgery
The goal of this clinical trial is to compare pain management in neonates and infants under 3 years of age undergoing cardiac surgery with use of cardiopulmonary bypass.
- Conditions
- Analgesia, Congenital Heart Disease, Surgery
- Trial name
- PACS (NCT05853263)
- Testing
- paracetamol, Morphine
- Volunteers
- 208 people
- Sponsor
- Erasmus Medical Center
Aortic Valve Surgery, Coronary Artery Bypass Graft (CABG)
Metabolic Profile and Tissue Perfusion in Patients Undergoing Open Heart Surgery With Minimal Invasive Versus Conventional Extracorporeal Circulation
The aim of the present study is to investigate the protective effect of minimal invasive versus the conventional extracorporeal circulation on tissue homeostasis as evidenced by the preservation of tissue metabolism and cerebral…
- Conditions
- Aortic Valve Surgery, Coronary Artery Bypass Graft (CABG), Cardiac Surgery
- Trial name
- MiECC MET (NCT07516938)
- Testing
- Real-time tissue oximetry monitoring
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- Aristotle University Of Thessaloniki
Cardiac Surgery, Cardiopulmonary Bypass
Safety and Efficacy of Preoperative Antithrombin Supplementation in Patients Undergoing High-Risk Cardiopulmonary Bypass
This is a prospective, multicenter, randomized, double-blind, placebo-controlled study. The purpose of this study is to determine the safety and effectiveness of human-derived antithrombin III (AT-III [Human]) supplementation…
- Trial name
- NCT02037555
- Testing
- AT-III (Human)
- Where
- 41 sites in United States
- Volunteers
- 425 people
- Sponsor
- Grifols Therapeutics LLC
Cardiac Output
Cardiac Output Measurement at the Conclusion of Cardiopulmonary Bypass
Cardiac output, the amount of blood pumped by the heart in one minute, will be measured in pediatric patients undergoing surgery involving cardiopulmonary bypass (CPB).
- Trial name
- NCT01103908
- Testing
- HCE101 Cardiopulmonary Support Monitor
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Transonic Systems Inc.
Postoperative; Dysfunction Following Cardiac Surgery
Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia
A condition of decreased serum T3 level in children after cardiac surgery using cardiopulmonary bypass has been commonly recognized as euthyroid sick syndrome (ESS).
- Trial name
- OTICC (NCT02521168)
- Testing
- Oral triiodothyronine
- Where
- Indonesia
- Volunteers
- 177 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Hypoxemia, ARDS
Soluble VE-cadherin in Prediction and Diagnosis of Early Postoperative Hypoxemia After Cardiopulmonary Bypass
More than 2 million patients worldwide receive heart surgery every year, majority of these surgical patients will undergo cardiopulmonary bypass.
- Conditions
- Hypoxemia, ARDS, Lung Injury, Acute, Cardiopulmonary Bypass
- Trial name
- NCT05647382
- Testing
- blood cell analysis, blood gas surveillance, chest radiograph and echocardiography
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Zhuan Zhang
Coronary Artery Disease, Coronary Artery Bypass Surgery
Double-Blind Comparison of Combined General-Spinal Anesthesia to General Anesthesia for Coronary Artery Surgery
Use of neuraxial agents in anesthesia for cardiac surgery is expanding. We have used combined general-spinal anesthesia for cardiac surgery for 12 years.
- Trial name
- NCT00242697
- Testing
- spinal analgesia and anesthesia for coronary artery surgery
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- University of Calgary
Cardiac Surgery, Cardiopulmonary Bypass
Dexmedetomidine and Myocardial Protection
Dexmedetomidine, an alpha-2 agonist, is a sedative that is widely used in various clinical settings because, compared to benzodiazepines, it preserves respiratory function better and its duration of action is short.
- Trial name
- DEXCARD (NCT04871308)
- Testing
- Dexmedetomidine, Control
- Where
- South Korea
- Volunteers
- 224 people
- Sponsor
- Seoul National University Hospital
Pediatric, Cardiac Surgery
Cardiopulmonary Circuits in the Pediatric Population
During open-heart surgery, blood flow is supported by a heart-lung machine that both pumps the blood and gives it oxygen. A problem associated with a heart-lung machine is the damage to some of the blood caused by protein in the…
- Trial name
- NCT00208728
- Testing
- PC/SMART cardiopulmonary bypass circuit, PMEA modified cardiopulmonary bypass circuit, Standard of care uncoated cardiopulmonary bypass circuit
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Emory University
Cardiopulmonary Bypass, Hemorrhage
Dose-ranging Study of Two Doses of Tranexamic Acid During Cardiac Surgery
Cardiac surgery with CardioPulmonary Bypass (CPB) exposes to per and postoperative bleeding, and may lead to allogenic blood transfusion re-intervention and many adverse outcomes.
- Trial name
- Exacylcardio (NCT00809393)
- Testing
- tranexamic acid
- Where
- 4 sites in France
- Volunteers
- 600 people
- Sponsor
- Hopital Foch
Cardiac Surgery, Oxidative Stress
The Effects of Peep and Tidal Volume on Oxidative Stress in Cardiopulmonary Bypass Surgery
Although cardio-pulmonary bypass surgery (CPBS) is a routine procedure worldwide, patient morbidity and mortality are still high due to postoperative negative complications.Inflammatory response and systemic oxidative stress have…
- Trial name
- NCT03601364
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Cardiac On-pump Surgery
Organ Protection With Sevoflurane Postconditioning After Cardiac Surgery With Cardiopulmonary Bypass
Organ protection, volatile anesthetics, postconditioning. Sedation of patients on ICU after cardiac surgery with cardiopulmonary bypass with either propofol or sevoflurane.
- Trial name
- NCT00924222
- Testing
- Sevoflurane, Propofol
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Cardiovascular Disease, Cardiopulmonary Bypass
Protective Effect of Probacine Against Negative Gut Metabolism and Organ Dysfunction After Cardiovascular Surgery (PANDA IV)
Cardiovascular diseases (CVDs) continue to be the primary cause of illness and death globally, emphasizing the pressing requirement for efficient prevention methods.
- Trial name
- PANDA (NCT04444362)
- Testing
- Intestinal Microbiota Transplant (IMT) Capsules
- Where
- 5 sites in China
- Volunteers
- 500 people
- Sponsor
- Nanjing Medical University
Cardiac Surgery, Intraoperative Hemodynamic Instability
Impact of Intraoperative Hemodynamic Instability on Outcomes in Cardiac Surgery
Intraoperative hemodynamic instability (IOHI) is a common occurrence during cardiac surgery and is associated with organ hypoperfusion. However, the specific impact of IOHI on composite adverse outcomes remains unclear.
- Conditions
- Cardiac Surgery, Intraoperative Hemodynamic Instability, Postoperative Complication, Acute Kidney Injury
- Trial name
- NCT07324694
- Where
- Turkey (Türkiye)
- Volunteers
- 351 people
- Sponsor
- Saglik Bilimleri Universitesi Gazi Yasargil Training and Research Hospital
Cardiac Surgery Subjects
Ionized Calcium and Bleeding in Cardiac Surgery
This retrospective study investigates the association between perioperative plasma ionized calcium concentration and perioperative bleeding in open-heart surgery.
- Trial name
- NCT07634042
- Where
- Finland
- Volunteers
- 4,300 people
- Sponsor
- Helsinki University Central Hospital
Coronary Artery Disease
Postoperative Respiratory Depression After Cardiac Surgery
Coronary artery bypass graft surgery (CABG) is associated with postoperative respiratory depression. In this study we aimed at investigating perioperative parameters that could predict the nadir of postoperative respiratory…
- Trial name
- CABG PRD (NCT02074371)
- Where
- Brazil
- Volunteers
- 44 people
- Sponsor
- Ovidiu Constantin Baltatu
Cardiac Anaesthesia, Cardiopulmonary Bypass
Comparison of Milrinone and Epinephrine on TAPSE
Cardiopulmonary bypass (CPB) is a critical technology in cardiac surgery, allowing for the temporary replacement of the heart and lung functions during intricate surgical procedures.
- Trial name
- Milrinone (NCT07144267)
- Testing
- Epinephrine, Milrinone Injection
- Where
- Egypt
- Volunteers
- 102 people
- Sponsor
- Mansoura University
Thoracic Aneurysm, Aneurysm Stent
The Effects of Anesthesia on Patients Undergoing Surgery for Repair of a Thoracoabdominal Aneurysm.
Alzheimer's disease represents a growing public health problem in developed countries. Although the pathogenesis is not clearly defined, accumulation of extracellular amyloid, neurofibrillary tangles and neuronal loss are the…
- Conditions
- Thoracic Aneurysm, Aneurysm Stent, Cardiopulmonary Bypass, Abdominal Aneurysm
- Trial name
- NCT01772537
- Testing
- Propofol, isoflurane
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Johns Hopkins University
Myocardial Protection
Myocardial Biopsy in Congenital Cardiac Surgery
Despite major advances in the technical aspects of surgical repair of congenital heart diseases, perioperative myocardial damage with low cardiac output remains the most common cause of morbidity and death after repair of…
- Trial name
- NCT03595111
- Testing
- myocardial biopsy
- Volunteers
- 60 people
- Sponsor
- Assiut University