Clinical trials: Cardiopulmonary-bypass
Nosocomial Pneumonia
High-dose Inhaled NO Therapy for the pREvenvention of NP After Cardiac Surgery Under CPB
The primary aim of this single-center, prospective, randomized, controlled, study is to test the hypothesis that inhalation of NO 200 ppm prevents the development of nosocomial pneumonia in patients at risk after cardiac surgery…
- Trial name
- NCT06261827
- Testing
- 200-ppm NO
- Where
- Russia
- Volunteers
- 160 people
- Sponsor
- Tomsk National Research Medical Center of the Russian Academy of Sciences
Coronary Artery Disease, Low Cardiac Output Syndrome
Anesthesia Standard Operating Procedure During On-pump Coronary Artery Bypass Grafting
Background: Despite improvements in surgical and anesthesia procedures over the past 15 years complications during cardiac surgery still remain high. Bridgewater B et al.
- Conditions
- Coronary Artery Disease, Low Cardiac Output Syndrome, Atrial Fibrillation, Postoperative Complications
- Trial name
- NCT05514652
- Testing
- Low opioid anesthesia
- Where
- Ukraine
- Volunteers
- 120 people
- Sponsor
- Heart Institute, Ministry of Health of Ukraine
Cardiac Surgery With Cardiopulmonary Bypass
Beta Blocker Use in Cardiac Surgery and Association With Postoperative Course
The objective of this study is to describe in a cohort of cardiac surgery patients the use of beta-blockers before surgery and their maintenance or withdraw according to international recommendations in order to compare patients…
- Trial name
- BLOCK (NCT04769752)
- Testing
- collection of the allocated treatment, collection of medical complications
- Where
- France
- Volunteers
- 1,789 people
- Sponsor
- Centre Hospitalier Universitaire Dijon
Pathologic Fibrinolysis
Fibrinolysis Before Cardiopulmonary Bypass?
It is common practice to use antifibrinolytic agents before and during cardiopulmonary bypass. They are not without side effects.
- Trial name
- NCT01981863
- Testing
- Epsilonaminocaproic acid
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Cardiopulmonary Bypass Surgery
Assessing the Hemostatic Efficacy of Pathogen Reduced Platelets in Children Undergoing Cardiopulmonary Bypass Surgery: A Pilot Clinical Trial
This study is testing whether pathogen reduced platelets can control bleeding as well as non-pathogen reduced platelets (otherwise known as large volume delayed sampling).
- Trial name
- PEDITREC (NCT05293106)
- Testing
- Platelet Transfusion
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Weill Medical College of Cornell University
Surgery, Cardiac, Tranxemic Acid
The Effect of ACT and Tranexamic Acid on Bleeding in Cardiac Surgery
The goal of this clinical trial is to the dose effect of tranexamic acid and the level of ACT on bleeding in adult cardiac surgery. The main questions it aims to answer are: 1.
- Conditions
- Surgery, Cardiac, Tranxemic Acid, Activated Clotting Time, Heparin
- Trial name
- NCT06109155
- Testing
- Tranexamic acid
- Where
- 2 sites in Taiwan
- Volunteers
- 150 people
- Sponsor
- Taichung Veterans General Hospital
Extracorporeal Circulation, Cardiac Surgery
Priming of Cardiopulmonary Bypass With Hydroxyethyl Starch 130/0.4 or Sodium Chloride 0.9% : Pilot Study in Adult Elective Conventional Cardiac Surgery
Best priming for cardiopulmonary bypass in cardiac surgery is unknown. Efficacy and toxicity of Hydroxyethyl Starch 130/0.4 used in this context are uncertain.
- Trial name
- OPTIMUS-PRIME (NCT02906514)
- Testing
- Non balanced Hydroxyethyl starch 130/0.4 (Voluven®, Fresenius), Sodium Chloride 0.9% (Fresenius)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Hospices Civils de Lyon
Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure
Serum Phosphatemia Predictive Marker for AKI Diagnosis After Cardiac Surgery
Cardiac surgery associated acute kidney injury is an independent factor of morbidity and mortality . Despite its delayed elevation, serum creatinine (Cr) remains the goal standard to diagnose AKI.
- Conditions
- Cardiac Surgery With Cardiopulmonary Bypass, Complete Serum Phosphorus Measure, Complete Serum Creatinine Measure
- Trial name
- PhosphoIRA (NCT02900313)
- Testing
- cardiac surgery
- Where
- France
- Volunteers
- 264 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Inflammation, Thoracic Surgery
The Importance of Wnt-signaling After Cardiac Surgery
Cardiac surgery saves lives when patients suffer from cardiac disease. Local inflammation is important for tissue repair and wound healing after such an operation.
- Trial name
- NCT04058496
- Testing
- Blood sampling
- Where
- Switzerland
- Volunteers
- 64 people
- Sponsor
- Alain Rudiger
Vasoplegia, Hypotension
Hemodynamic Effects of Methylene Blue vs Hydroxocobalamin in Patients at Risk of Vasoplegia During Cardiac Surgery
This is a pilot study to determine the hemodynamic effects when hydroxocobalamin vs methylene blue is administered during cardiopulmonary bypass in patients at risk of vasoplegia by measuring mean arterial pressure (MAP)…
- Conditions
- Vasoplegia, Hypotension, Coronary Artery Disease, Cardiac Valve Disease
- Trial name
- NCT03446599
- Testing
- Hydroxocobalamin, Methylene Blue, Normal saline
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Coronary Artery Bypass
Comparison of Minimal Versus Conventional Extracorporeal Circulation in Coronary Surgery
The aim of this study is to assess the effect of minimal (MiECC) versus conventional (CECC) extracorporeal circulation on perfusion characteristics and remote end-organ protection (lungs, brain, kidneys, liver, stomach…
- Trial name
- NCT01603589
- Testing
- Coronary artery bypass grafting with the use of minimal invasive extracorporeal circulation, Coronary artery bypass grafting under conventional extracorporeal circulation
- Where
- Greece
- Volunteers
- 150 people
- Sponsor
- AHEPA University Hospital
Coronary Artery Disease, Delirium
The PATHFINDER Study: A Feasibility Trial
The main purpose of this study is to determine whether a rational strategy of EEG guided multimodal general anesthesia using target specific sedative and analgesics could result in enhanced recovery after anesthesia and surgery…
- Trial name
- PATHFINDER (NCT04016740)
- Testing
- Ropivacaine, Ketamine, Remifentanil
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Beth Israel Deaconess Medical Center
Cardiac Disease, Cardiac Surgery
Platelet Transfusion During Neonatal Open Heart Surgery
Hypothesis: Dilutional thrombocytopenia after cardiopulmonary bypass (CPB) is universal and administration of donor apheresis platelets just prior to termination of bypass will assist in early correction of coagulopathy, early…
- Conditions
- Cardiac Disease, Cardiac Surgery, Cardiopulmonary Bypass, Platelet Transfusion
- Trial name
- CPB (NCT03045068)
- Testing
- Platelet Transfusion, FFP and Cryoprecipitate, PRBC and cell saver Transfusion
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- The University of Texas Health Science Center, Houston
Heart Valve Diseases, Cardiopulmonary Bypass
Acupuncture Improves Sleep in Patients Undergoing Cardiopulmonary Bypass
Due to various causes, such as brain impairment, environment changes, anxious,et al. patients, who undergo cardiopulmonary bypass, often suffer from poor quality of sleep.
- Trial name
- NCT01231776
- Testing
- electronic acupuncture
- Where
- 2 sites in China
- Volunteers
- 60 people
- Sponsor
- Xijing Hospital
Levosimendan, Cardiac Surgery
Interest of Levosimendan Preconditioning for Cardiac Surgery Under CEC in Heart Failure Patients With Impaired Ejection Fraction
Levosimendan, a drug with inotropic, vasodilatory and myocardial protective properties, has been proposed for the prevention and treatment of postoperative low cardiac output syndrome in cardiac surgery.
- Conditions
- Levosimendan, Cardiac Surgery, Heart Failure With Reduced Ejection Fraction
- Trial name
- LevoCV (NCT06021587)
- Testing
- Levosimendan, No Levosimendan
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Central Hospital, Nancy, France
Coronary Artery Bypass Grafting, Mitral Valve Surgery
Levosimendan in Patients With Left Ventricular Systolic Dysfunction Undergoing Cardiac Surgery On Cardiopulmonary Bypass
A study to evaluate levosimendan compared with placebo in reducing the composite event rate of all-cause death, perioperative MI, need for new dialysis, or use of mechanical assist (IABP, LVAD or ECMO) in subjects with reduced…
- Conditions
- Coronary Artery Bypass Grafting, Mitral Valve Surgery, Low Cardiac Output Syndrome
- Trial name
- LEVO-CTS (NCT02025621)
- Testing
- Levosimendan
- Where
- 60 sites in United States, Canada
- Volunteers
- 882 people
- Sponsor
- Tenax Therapeutics, Inc.
Coronary Artery Bypass, Cardiopulmonary Bypass
The Effect of Nitroglycerin Infusion Rate on Cerebral Rewarming During Hypothermic Coronary Artery Bypass Grafting
Glyceryl trinitrate is used in coronary artery bypass grafting surgery. This surgery frequently employs hypothermic cardiopulmonary bypass, where the whole body is cooled down to 28-32 °C to arrest the heart, and protect the…
- Trial name
- nitrotherm (NCT03251599)
- Testing
- Glyceryl trinitrate 0.2, Glyceryl trinitrate 0.5
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Recep Tayyip Erdogan University
Surgical Site Infection
Plasma Concentrations of Prophylactic Cefazolin in Pediatric Patients Undergoing Cardiac Surgery With CPB
Surgical site infection (SSI) is a serious operative complication that may be associated with any surgical procedures. It increases morbidity and mortality after cardiac surgery.
- Trial name
- NCT03141450
- Where
- Thailand
- Volunteers
- 18 people
- Sponsor
- Mahidol University
Cardiopulmonary Bypass
TEG 6s® for Perioperative Monitoring of Platelet Function During Cardiopulmonary Bypass for Cardiac Surgery
Excessive bleeding is common during cardiopulmonary bypass (CPB) for cardiac surgery. This may result from the systemic activation of the coagulation pathway and the acquired platelet dysfunction during the procedure.
- Trial name
- TEG-PM (NCT04746560)
- Testing
- TEG®6S device with its Platelet mapping® cartridge
- Where
- France
- Volunteers
- 6 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Coronary Artery Disease, Cardiopulmonary Bypass
Long-Term Cognitive Decline After Coronary Artery Bypass Grafting: is Off-Pump Surgery Beneficial?
Coronary artery bypass surgery is associated with postoperative cognitive decline, which has largely been attributed to the use of the heart lung machine.
- Conditions
- Coronary Artery Disease, Cardiopulmonary Bypass, Cognition Disorders
- Trial name
- NCT00189215
- Testing
- cardiac stabilizer instead of cardiopulmonary bypass
- Where
- Netherlands
- Volunteers
- 280 people
- Sponsor
- UMC Utrecht