Clinical trials: Cardiovascular Abnormality
Isolated Noncompaction of the Ventricular Myocardium
Risk Stratification and Early Prevention Strategies for Non-compaction of Ventricular Myocardium (CAPTAIN)
This study intends to retrospectively-prospectively enroll NVM patients from multiple centers to establish a natural population cohort of NVM patients.
- Trial name
- NCT06504056
- Testing
- Diagnosis of NVM
- Where
- China
- Volunteers
- 2,000 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Stroke, PFO - Patent Foramen Ovale
GORE® CARDIOFORM Septal Occluder and Antiplatelet Medical Management for Reduction of Recurrent Stroke in Patients With Patent Foramen Ovale (PFO): the REDUCE Post Approval Study
This study will assess the safety and effectiveness of GORE® CARDIOFORM Septal Occluder in a post approval setting and evaluate the quality of operator education and training and transferability of trial experience to a…
- Trial name
- REDUCE PAS (NCT03821129)
- Testing
- PFO closure with GORE® CARDIOFORM Septal Occluder
- Where
- 45 sites in United States
- Volunteers
- 636 people
- Sponsor
- W.L.Gore & Associates
Adults With Congenitally Malformed Hearts
Follow up of Adults With Congenitally Malformed Hearts With Focus on Computer-Based Education and Psychosocial Support
The number of adults with congenitally malformed hearts is increasing. According to a prospective population-based cohort study from Sweden (1992-2001) the prevalence of cardiovascular defects was 9.1 per 1,000 births, which is…
- Trial name
- NCT01234753
- Testing
- Physician and nurse consultation
- Volunteers
- 114 people
- Sponsor
- University Hospital, Linkoeping
Cardiac Diseases, Sickle Cell Disease
Domestication and Implementation of the PEN-Plus Clinical Model in the Zambian Health System
Cognizant of the prevalence of complicated non communicable diseases (NCD) and the attendant capacity problems faced by the health workers in primary care settings, we propose to adapt and pilot the Package of Essential…
- Conditions
- Cardiac Diseases, Sickle Cell Disease, Hypertension, Diabetes Mellitus
- Trial name
- PEN Plus (NCT07753681)
- Testing
- Supportive treatment
- Where
- Zambia
- Volunteers
- 2,084 people
- Sponsor
- Centre for Infectious Disease Research in Zambia
Patent Ductus Arteriosus, Neonate
Combination of Acetaminophen and Ibuprofen in the Management of Patent Ductus Arteriosus
Patent ductus arteriosus or PDA is a blood vessel that connects the right and left side of the heart that usually closes after birth but remains open in some premature infants born before 30 weeks' gestation.
- Trial name
- NCT03103022
- Testing
- Acetaminophen, ibuprofen
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Florida
Diagnosis of Coarctation of the Aorta and VSD, Surgical Repair at CHOA
Surgical Outcomes in Pediatric Patients With Coarctation and VSD
Recently, a paper was published that compared outcomes of patients requiring repair of aortic coarctation and ventricular septal defect.
- Conditions
- Diagnosis of Coarctation of the Aorta and VSD, Surgical Repair at CHOA, Between January 1, 2002 and December 31, 2005
- Trial name
- NCT00327795
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Children's Healthcare of Atlanta
Sex Chromosome Disorders
Clinical and Genetic Aspects in Fetuses and Children With Sex Chromosome Disorders
The aim of the project is to: 1. Investigate organ development and growth in fetuses with sex chromosome disorders; 2. Investigate growth, development, and morbidity in children with sex chromosome disorders during the first…
- Trial name
- NCT07341412
- Where
- Denmark
- Volunteers
- 300 people
- Sponsor
- University of Aarhus
Dental Anxiety, Cardiovascular Abnormalities
Cardiovascular Response in Implant Surgery
The aim of this study was to observe the level of anxiety and its relationship with cardiovascular changes in each implant.
- Trial name
- NCT04037930
- Testing
- multiple implant surgery
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Erzincan University
May-Thurner Syndrome
Rivaroxaban for the Prevention of Deep Vein Thrombosis in Patients With Left Iliac Vein Compression - The PLICTS Study
The purpose of this study is to evaluate the efficacy and safety of rivaroxaban for the prevention of deep vein thrombosis in patients with left iliac vein compression treated with stent implantation.
- Trial name
- PLICTS (NCT04067505)
- Testing
- Rivaroxaban, Warfarin, Nadroparin
- Where
- 9 sites in China
- Volunteers
- 224 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Williams Syndrome, Angelman Syndrome
Study of Phenotype and Genotype Correlations in Patients With Contiguous Gene Deletion Syndromes
OBJECTIVES: I. Investigate phenotype and genotype correlations in patients with Smith-Magenis syndrome (SMS) associated with del(17p11.2). II.
- Conditions
- Williams Syndrome, Angelman Syndrome, Prader-Willi Syndrome, Shprintzen Syndrome
- Trial name
- NCT00004351
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Congenital Heart Disease, ICU Acquired Weakness
Muscle Catabolism and Outcomes in Children Following Cardiac Surgery
Background \& Significance. Children with congenital heart disease (CHD) have experienced improved postoperative survival shifting the focus away from minimizing mortality to curtailing morbidities.
- Conditions
- Congenital Heart Disease, ICU Acquired Weakness, Catabolic State
- Trial name
- MOCHI (NCT04998643)
- Testing
- Muscle ultrasound to estimate lean body mass
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston Children's Hospital
Migraine With Aura
Neurogenetic And Hemodynamic Of Migraine Aura And Pfo
The PFOCUS Study aims to clarify the relationship between patent foramen ovale (PFO) and migraine with aura (MA). Patients diagnosed with MA according to ICHD-3 criteria will be classified as cases (PFO+) or controls (PFO-) based…
- Trial name
- PFOCUS (NCT07349004)
- Testing
- Intervention
- Where
- Italy
- Volunteers
- 240 people
- Sponsor
- Azienda Usl di Bologna
Migraine Disease, Patent Foramen Ovale
Migraine Headaches Elimination With Patent Foramen Ovale-Directed Therapy
Migraine is a common and often disabling condition, but its exact causes are not fully understood. Some people with migraines have a small opening in the heart wall called a patent foramen ovale (PFO).
- Trial name
- COMFORT-PFO (NCT07629635)
- Testing
- Prasugrel 5mg, Transcatheter Closure of Patent Foramen Ovale
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Columbia University
Postoperative; Dysfunction Following Cardiac Surgery
Oral Triiodothyronine for Children Undergoing Cardiopulmonary Bypass in Indonesia
A condition of decreased serum T3 level in children after cardiac surgery using cardiopulmonary bypass has been commonly recognized as euthyroid sick syndrome (ESS).
- Trial name
- OTICC (NCT02521168)
- Testing
- Oral triiodothyronine
- Where
- Indonesia
- Volunteers
- 177 people
- Sponsor
- National Cardiovascular Center Harapan Kita Hospital Indonesia
Aortic Coarctation, Congenital Heart Disease
Contribution of Multimodal Imaging in Early Coarctation
The CT-Coarct-PED study is a multicentred observational study aiming to describe the population of early coarctation during the last 10 years in South of France.
- Trial name
- CT-COARCT-PED (NCT05203874)
- Where
- France
- Volunteers
- 800 people
- Sponsor
- University Hospital, Montpellier
Hereditary Hemorrhagic Telangiectasia, Gastrointestinal Hemorrhage
Octreotide in Patients With GI Bleeding Due to Rendu-Osler-Weber
The purpose of this study is to determine whether long-acting octreotide is safe and effective in the treatment of patients with Rendu-Osler-Weber (e.g. HHT).
- Conditions
- Hereditary Hemorrhagic Telangiectasia, Gastrointestinal Hemorrhage, Anemia
- Trial name
- ROW (NCT02874326)
- Testing
- Octreotide LAR
- Where
- 2 sites in Netherlands
- Volunteers
- 15 people
- Sponsor
- Radboud University Medical Center
Intracranial Aneurysm
Assessment of the Embolization of Neurovascular Lesions Using the Penumbra Smart Coil
The primary objective of this study is to gather post market data on the Penumbra SMART COIL® System (Smart System) in the treatment of intracranial aneurysms and other malformations.
- Trial name
- SMART (NCT02729740)
- Testing
- Penumbra Smart Coil, Penumbra Coil 400TM (PC400), Penumbra Occlusion DeviceTM(POD)
- Where
- 72 sites in United States, Canada
- Volunteers
- 995 people
- Sponsor
- Penumbra Inc.
Growth Hormone Disorder, Growth Hormone Deficiency in Children
Norditropin NordiFlex® Device Compared to the Device Previously Used by Patients or Parents
This study is conducted in Europe. The aim of this study is to compare the easiness of use of Norditropin NordiFlex® device to the device previously used by patients or parents.
- Conditions
- Growth Hormone Disorder, Growth Hormone Deficiency in Children, Foetal Growth Problem, Small for Gestational Age
- Trial name
- NCT01245374
- Testing
- Norditropin NordiFlex®
- Where
- France
- Volunteers
- 103 people
- Sponsor
- Novo Nordisk A/S
Tetralogy of Fallot
Effects of Changes in Fluid Status on Right Ventricular Volumes and Function
The purpose of this study is to evaluate the correlation between fluid volume status and right ventricular volume and function, in those with free pulmonary valve insufficiency after Tetralogy of Fallot (TOF) repair.
- Trial name
- NCT02967315
- Testing
- Cardiac Magnetic Resonance Imaging (CMRI), Central venous line placement, Chest X-ray
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of Wisconsin, Madison
Hypoplastic Left Heart, Congenital Heart Disease
Use of Oxandrolone to Promote Growth in Infants With HLHS
The primary aim of this study is to determine if clinically relevant doses of buccally administered oxandrolone are safe and tolerable in neonates with hypoplastic left heart syndrome (HLHS) or other single right ventricular…
- Trial name
- NCT04090697
- Testing
- Oxandrolone
- Where
- 10 sites in United States, Canada
- Volunteers
- 34 people
- Sponsor
- Carelon Research