Clinical trials: Cardiovascular Adaption
Multiple Myeloma
Study Association of Lenalidomide, Ixazomib, Dexamethasone and Daratumumab in Newly Diagnosed Standard Risk Multiple Myeloma
The main objective of this study is to evaluate the minimal residual disease-negativity rate after administration of the combination of Lenalidomide, Ixazomib, Dexamethasone and Daratumumab as induction and consolidation therapy…
- Trial name
- IFM2018-01 (NCT03669445)
- Testing
- Ixazomib, Lenalidomide, Dexamethasone
- Where
- 12 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Toulouse
Multiple Myeloma (MM)
Benefits of a 6-month, Individualized, Hybrid, "Real-life" Adapted Physical Activity Program on the Quality of Life of Patients Treated for Multiple Myeloma
The goal of this clinical trial is to evaluate the effect of a long-term, individualized, hybrid adapted physical activity program on the quality of life of patients with multiple myeloma.
- Trial name
- BAPAMM (NCT07547007)
- Testing
- Adapted physical activity
- Where
- 2 sites in France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Metropole Savoie
Cardiovascular Disease
Effect of ACE Genotype on Cardiovascular Rehabilitation
The study aims to systematically investigate the interaction between training modality, ACE genotype and disease in heart patients whom complete a cardiovascular rehabilitation program.
- Trial name
- ACE-REHAB (NCT02845063)
- Testing
- concentric cardiovascular training, eccentric cardiovascular training, ACE genotyping
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Arthritis, Rheumatoid, Activities of Daily Living
Adaptation of EDAQ Into Turkish, Examining The Reliability and Validity For People With RA
The aim of the study is to adapt the Evaluation of Daily Activity Questionnaire into Turkish language, and to examine the reliability and validity for people with rheumatoid arthritis.
- Trial name
- NCT05244824
- Testing
- Adaptation into Turkish, Examining The Reliability and Validity for People with RA
- Where
- Turkey (Türkiye)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Stroke, Spinocerebellar Ataxia
Laryngeal Adaptation for Speech and Swallowing
This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6.
- Conditions
- Stroke, Spinocerebellar Ataxia, Cerebral Stroke, Dysphagia
- Trial name
- NCT03770377
- Testing
- Intermittent Perturbation to Continuous Perturbation, Continuous Perturbation to Intermittent Perturbation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Florida
IVF, Frozen Embryo Transfer (FET)
Maternal Cardiovascular Adaption to Pregnancy in IVF Patients Following Frozen Embryo Transfer (FET)
Aim of the study is to explore the effect of a lacking corpus luteum on maternal cardiovascular and metabolic adaption to pregnancy by the use of magnetic resonance imaging (MRI).
- Conditions
- IVF, Frozen Embryo Transfer (FET), Cardiovascular Adaption, Magnetic Resonance Imaging (MRI)
- Trial name
- NCT06471140
- Testing
- magnetic resonance imaging (MRI)
- Where
- Denmark
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Hypertensive Disorders of Pregnancy (HDP)
Roy Adaptation Model-Based Prenatal Education in Hypertensive Pregnant Women
This study aims to evaluate the effect of Roy Adaptation Model-based prenatal education on perceived stress and quality of life in pregnant women with hypertensive disorders of pregnancy.
- Trial name
- NCT07820306
- Testing
- Roy Adaptation Model-Based Prenatal Education
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people
- Sponsor
- Istanbul University - Cerrahpasa
Cancer, Cardiovascular Diseases
Healthy Lifestyles After Cancer for Adolescents and Young Adults: A Program to Reduce Cardiovascular Risk Factors
There are close to 700,000 survivors of adolescent and young adult (AYA) cancer (aged 15 to 39 at diagnosis) in the US. Survivorship for AYAs is often complicated by long-term and late-effects.
- Conditions
- Cancer, Cardiovascular Diseases, Weight Management, Pain
- Trial name
- HEALTHY-AYA (NCT05869604)
- Testing
- HEALTHY AYA, Education Control
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Duke University
Previously Untreated Symptomatic Multiple Myeloma
Lenalidomide, Adriamycin, Dexamethasone (RAD) Versus Lenalidomide, Bortezomib, Dexamethasone (VRD) for Induction in Newly Diagnosed Multiple Myeloma Followed by Response-adapted Consolidation and Lenalidomide Maintenance
The investigators propose this study utilizing Lenalidomide, Adriamycin, Dexamethasone (RAD) as comparator arm for Lenalidomide, Bortezomib, Dexamethasone (VRD) with the latter being considered a novel "standard" as an induction…
- Trial name
- NCT01685814
- Testing
- Lenalidomide, Bortezomib, autologous stem cell transplant, allogeneic stem cell transplant
- Where
- 32 sites in Germany
- Volunteers
- 406 people
- Sponsor
- Wuerzburg University Hospital
Heart Failure
Effect of Personalized Follow-up in Adapted Physical Activities in Subjects With Chronic Heart Failure.
France has one million people with heart failure (HF). Exercise intolerance, characterised by dyspnoea, is the main clinical symptom in HF patients and a key determinant of reduced quality of life.
- Trial name
- BougeTonCoeur (NCT06222762)
- Testing
- Experimental arm
- Where
- 2 sites in France
- Volunteers
- 90 people
- Sponsor
- University Hospital, Brest
Postexercise Hypotension
Histamine as a Molecular Transducer of Adaptation to Exercise
This study is investigating the role of histamine in generating adaptation to exercise
- Trial name
- NCT05206227
- Testing
- Aerobic Exercise, alpha-FMH, Resistance and Aerobic Exercise
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oregon
Stroke, Acquired Brain Injury
Evaluation of an Adapted ACT Group for Stroke & Brain Injury Survivors
Stroke and Acquired Brain Injury (ABI) represent a major cause of long-term disability among survivors. Many psychological difficulties can also occur including: depression, anxiety, fatigue, and post-traumatic stress disorder.
- Conditions
- Stroke, Acquired Brain Injury, Acceptance and Commitment Therapy, Brain Injuries
- Trial name
- NCT04995705
- Testing
- Acceptance and Commitment Therapy (ACT)
- Where
- United Kingdom
- Volunteers
- 39 people
- Sponsor
- Anna Pennington
Hypertension
Home Blood Pressure SMS Telemonitoring in the Primary Care Setting
Hypertension is a public health problem worldwide, being responsible for 9.4 million deaths worldwide each year, as well as contributing to the burden of coronary, cerebrovascular, renal diseases, among others.
- Trial name
- NCT03524456
- Testing
- Home blood pressure monitoring
- Where
- Peru
- Volunteers
- 40 people
- Sponsor
- Universidad Peruana Cayetano Heredia
Healthy Participants
The UBC Long-distance Triathlon Adaptation Study
The purpose of this study is to investigate the effect of 12-months of individualized endurance-training (swimming, cycling and running) on physiological and psychological adaptations in exercise naïve individuals.
- Trial name
- ULTRA (NCT06467656)
- Testing
- Individualized, periodized endurance training for ultra-endurance triathlon., Time-Aligned Control
- Where
- Canada
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Acute Stroke
COmparing CeNters ThRombectomy Aspiration STentretriever
Our aims is to evaluate the equality in efficacy and safety between direct aspiration technique and stent retriever thrombectomy procedure in anterior circulation strokes in a multicenter, prospective study.
- Trial name
- CONTRAST (NCT03412851)
- Testing
- A Direct Aspiration First Pass Technique, Stentriever Thrombectomy
- Where
- 9 sites in Spain
- Volunteers
- 1,000 people
- Sponsor
- Hospitales Universitarios Virgen del Rocío
Post Stroke Aphasia
Adaptation of Melodic Intonation Therapy to Spanish
This study was conducted in three phases: The first phase involved creation of a Spanish adaptation of the Melodic Intonation therapy; the second phase consisted of a pilot non-randomized intervention study to analyse its…
- Trial name
- NCT03433495
- Testing
- Melodic Intonation Therapy
- Volunteers
- 20 people
- Sponsor
- Instituto de Investigación Hospital Universitario La Paz
Venous Thromboembolism, Pulmonary Embolism
A Different Approach to Preventing Thrombosis
The purpose of this study is to perform a pragmatic randomized controlled trial to compare the use of low molecular weight heparin (LMWH, lovenox, enoxaparin) versus acetylsalicylic acid (ASA) for venous thromboembolism (VTE)…
- Trial name
- ADAPT (NCT02774265)
- Testing
- VTE prophylaxis with Enoxaparin 30mg BID, VTE prophylaxis with Aspirin 81mg BID
- Where
- United States
- Volunteers
- 329 people
- Sponsor
- University of Maryland, Baltimore
Pseudoxanthoma Elasticum
Impact of Optimized Recruitment and Follow-up of Patients With Pseudoxanthoma Elasticum (PXE)
Pseudoxanthoma elasticum (PXE) is a rare genetic disorder characterized by ectopic calcifications in the skin, retina and arterial walls. Angers University Hospital is the national rare disease reference center (CRMR) for PXE.
- Trial name
- REMOTE-PXE (NCT06636344)
- Testing
- Pseudoxanthoma Elasticum
- Where
- France
- Volunteers
- 650 people
- Sponsor
- University Hospital, Angers
Transgender
Body Composition Assessment in Transgender Population.
Gender-affirming hormone therapy (GAHT) is a fundamental component of medical transition in transgender men, promoting body composition changes that align physical characteristics with gender identity and alleviate gender…
- Trial name
- BIVATRANS (NCT07481942)
- Testing
- gender affirming hormone therapy
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Celia Bañuls
Cardiovascular Diseases
ADAPT Micro-Randomized Trial
The goal of this study is to collect quantitative and qualitative data that can be used to optimize the HeartSteps mHealth intervention for physical activity.
- Trial name
- ADAPT MRT (NCT06915220)
- Testing
- mobile health app
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- University of Michigan