Clinical trials: Cardiovascular Adaption
Hypertension
Diet Intervention for Hypertension: Adaptation and Dissemination to Native Communities
We will conduct a randomized trial to test our DASH (Dietary Approaches to Stop Hypertension) based intervention in 370 adult American Indians with inadequately controlled systolic blood pressure (≥130 mmHg).
- Trial name
- NOSH (NCT02796313)
- Testing
- DASH Groceries + Weekly Sessions, Groceries + Brochure
- Where
- 4 sites in United States
- Volunteers
- 315 people
- Sponsor
- Washington State University
Aphasia, Stroke
Adapted Solution Focused Therapy for People With Aphasia (SOFIA Trial)
Around one third of stroke survivors will have aphasia, which means they will have difficulty talking, understanding, reading or writing.
- Trial name
- SOFIA (NCT03245060)
- Testing
- Adapted Solution Focused Brief Therapy
- Where
- United Kingdom
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- City, University of London
Stroke
Zambia Stroke Unit Study
The goal of this clinical trial is to evaluate the impact of a locally adapted stroke unit on outcomes of adults with stroke in Zambia.
- Trial name
- ZASUS (NCT06457048)
- Testing
- Stroke Unit
- Where
- Zambia
- Volunteers
- 300 people
- Sponsor
- Johns Hopkins University
Patient Education as Topic, Surveys and Questionnaires
Development and Validation of a Self-administered QUestionnaire to Identify Levers of Adhesion Behavior to Patient's Medication in Order to Adapt the Educational Monitoring.
Medication non-adherence is an economic problem and a major public health challenge. Factors influencing medication adherence can be modelled according to five dimensions: disease, medication, patient and its close relatives…
- Conditions
- Patient Education as Topic, Surveys and Questionnaires, Medication Adherence, Pulmonary Disease, Chronic Obstructive
- Trial name
- QUILAM (NCT02865525)
- Where
- France
- Volunteers
- 282 people
- Sponsor
- University Hospital, Grenoble
Peripheral Artery Disease
Validation of VascuQol-6 Spanish Version
VascuQol (VQ) is a specific questionnaire to assess the quality of life of patients with critical limb ischemia which is also used as an index in vascular registries.
- Trial name
- NCT04741321
- Testing
- VascuQol-6 questionnaire Spanish version
- Where
- 2 sites in Spain
- Volunteers
- 104 people
- Sponsor
- Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz
Right Ventricular Hypertrophy, d-TGA
Right Ventricular Hypertrophy After Atrial Switch and Cardiovascular Magnetic Resonance (CMR) Findings
Systemic RV hypertrophy and impaired systolic function occur after atrial switch (AS) in d-transposition of the great arteries (d-TGA). Echocardiography has limitation in the assessment of the right ventricle (RV).
- Trial name
- NCT01430897
- Where
- Germany
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Leipzig
Peripheral Artery Disease, Intermittent Claudication
Acute Cardiovascular Responses and Chronic Adaptations of Strength Exercise in Intermittent Claudication Patients
The aim of this study was to analyze the effects of resistance exercise and training on cardiovascular function of peripheral artery disease patients.
- Trial name
- NCT02778568
- Testing
- Resistance training, Control
- Where
- Brazil
- Volunteers
- 30 people
- Sponsor
- University of Pernambuco
Heart Failure
Impact of Cardiac Rehabilitation Adapted for Patients With Heart Failure
The aim of the study is to evaluate whether a tailored cardiac rehabilitation program, initiated during hospitalization and continued after discharge, can improve functional capacity, mobility, and quality of life in patients…
- Trial name
- RAP-IC (NCT07350941)
- Testing
- Cardiac rehabilitation program
- Where
- Spain
- Volunteers
- 114 people
- Sponsor
- Puerta de Hierro University Hospital
Stroke, Cardiovascular Diseases
Evaluation of Effectiveness of Nutritional Counseling in Patients After Stroke
Stroke is the leading cause of disability worldwide and the leading cause of death in Brazil. It is estimated that about 18 million people will have a stroke in 2015 and approximately one third of these resulting in death.
- Trial name
- NCT01517542
- Testing
- Nutritional Counseling
- Sponsor
- Hospital de Clinicas de Porto Alegre
Stroke, Tracheotomy Patients
Study on the Correlation Mechanism and Application of Genetic Susceptibility, Hemoglobin Adaptation Changes, and Extubation Success Rate in Stroke Patients With Tracheotomy at Different Altitudes
Patients with brain injuries caused by various reasons often need tracheotomy to improve breathing, but this procedure can cause the air to lose its nasal regulation, increase the risk of lung infections, and reduce their quality…
- Trial name
- NCT07014501
- Testing
- High altitude, Medium altitude, Low altitude group
- Where
- China
- Volunteers
- 717 people
- Sponsor
- The Second Affiliated Hospital of Kunming Medical University
Normal Physiology, Stroke
Effects of Prism Adaption and rTMS on Brain Connectivity and Visual Representation
Background: After a stroke, the balance between the two halves of the brain can be lost. This may cause people to lose the ability to perceive a side of space. This is called neglect.
- Trial name
- NCT02911129
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Multiple Myeloma
Evaluation of a PREHABilitation Protocol Using Adapted Physical Activity (APA) for Multiple Myeloma Patients Eligible for Intensive Autologous Stem Cell Transplantation Treatment
Adapted physical activity for patients with haematological malignancies generally has positive effects on quality of life, fatigue and physical condition. However, some studies show little or no effect.
- Trial name
- PREHAB-APA (NCT06789003)
- Testing
- Adapted exercises, No intervention, Quality of Life questionnaire
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Centre Hospitalier Henri Duffaut - Avignon
Spatial Neglect, Deficits in Attention Motor Control and Perception
Prism Adaptation Therapy for Spatial Neglect
The purpose of this research study with a randomized controlled design is to examine the effects of prism adaptation treatment on two visual-spatial recovery components.
- Trial name
- NCT00989430
- Testing
- Prism Adaptation Treatment
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- Kessler Foundation
Stroke
Augmentation of Locomotor Adaptation Post-Stroke
This project will evaluate two different methods of normalizing the center of mass acceleration (COMa) in individuals post-stroke, specifically focusing on rates and pattern of recovery to analyze walking-specific adaptations as…
- Trial name
- NCT02892084
- Testing
- tDCS
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Relapsed or Refractory Multiple Myeloma
Phase II Multicenter, Open-label, Single Arm Clinical Study of Pomalidomide and dexamethasonE and Cyclophosphamide
Highest treatment efficacy in patients with refractory myeloma may be achieved with regimens combining novel agents and alkylating agents.
- Trial name
- PERSPECTIVE (NCT02046915)
- Testing
- Imnovid (pomalidomide), Dexamethasone, Endoxan (Cyclophosphamide)
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Tuebingen
Healthy
Dose Adaptation to Offset the Interaction Between Ticagrelor and Ritonavir by Population-based PK Modeling
Ticagrelor is a new generation antiplatelet agent with higher efficacy as compared to clopidogrel and prasugrel in treatment of patients with moderate and high ischemic risks.
- Trial name
- NCT02435563
- Testing
- ticagrelor 180 mg administrated alone, Ticagrelor adjusted dose + ritonavir 100mg
- Where
- Switzerland
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- University Hospital, Geneva
Stroke, Mild Cognitive Impairment
Investigating Neurocognitive, Motor and Biological Effects of MindLenses Professional in Neurological Diseases
This study aims to explore the effects of the treatment with MindLenses Professional device on cognitive and motor performances,as well as on the levels of a neurotrophic factor implied in brain plasticity, that is the brain…
- Trial name
- MindLensesN (NCT05826626)
- Testing
- MindLenses Professional, Conventional rehabilitation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Coronary Artery Disease, Cardiovascular Diseases
VOLtage-based Contrast Media AdaptatioN in Coronary Computed Tomography Angiography
The purpose of this study is to prospectively evaluate the effectiveness of low-volume contrast media (CM) injection protocols adapted to tube voltage in patients undergoing Coronary Computed Tomography Angiography (CCTA).
- Trial name
- VOLCANIC-CTA (NCT03179592)
- Testing
- Ultravist 370Mg I/Ml Solution for Injection
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Medical University of South Carolina
Stroke, Hypertension
Validation And Turkish Cross-Cultural Adaptation of Stroke Knowledge Test
Cerebrovascular diseases are the leading cause of disability, work loss, and quality of life reduction, the third leading cause of death globally, and significantly impact hospital admissions and expenses.
- Trial name
- NCT06543121
- Testing
- Translating the Stroke Knowledge Test into Turkish and Related Processes, Validity, Internal consistency and Reliability
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul Bilgi University
Stroke
Reliability and Validity Study of Urdu Version of Modified Barthel Index in Stroke Patients
Aim of the study is to translate and culturally adapt the modified Barthel index into Urdu language and to investigate the reliability and validity of this scale in Urdu speaking Stroke population for performance evaluation.
- Trial name
- NCT05449314
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- Riphah International University