Clinical trials: Cardiovascular Biomarkers
Cancer, Immune Checkpoint Inhibitor
Troponin to Detect Major Cardiovasculaire Advserse Events on Immune Checkpoint Inhibitors
Recent guidelines suggest the use of troponin to detect immnune related cardiovascular advserse events in patients treated by immune checkpoint inhibitors for cancer.
- Conditions
- Cancer, Immune Checkpoint Inhibitor, Cardiovascular Biomarkers
- Trial name
- TILT (NCT06007274)
- Testing
- No intervention
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Institut Mutualiste Montsouris
Stroke
Effects of Intensive Robot-assisted Therapy in Patients With Subacute Stroke
Robot-assisted training (RT) devices developed to date have a significant impact on stroke rehabilitation. Several research groups have developed the robotic devices and examined their efficacy on improving upper limb function…
- Trial name
- RT (NCT01767480)
- Testing
- RT, Conventional rehabilitation (CR)
- Where
- Taiwan
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Cardiovascular Diseases
Cleaner Air for Better Cardiac Biomarkers
This pilot project is a randomized, double-blind, sham-controlled trial investigating whether in-home air pollution reductions using portable air cleaners (PACs) can decrease circulating concentrations of biomarkers of…
- Trial name
- NCT05379400
- Testing
- Portable air cleaner (PAC)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- NYU Langone Health
Cardiovascular Disease (CVD)
The Effect of Pomegranate Juice (PJ) on Oxidative Stress Biomarkers During Treatment With IV Iron During One Dialysis Session
Atherosclerosis and its related cardiovascular morbidity and mortality, underlie many chronic diseases. Most atherosclerotic patients have multiple cardiovascular risk factors, which potentiate each other, causing a huge burden…
- Trial name
- NCT02107053
- Testing
- PJ, IV iron
- Where
- Israel
- Volunteers
- 25 people
- Sponsor
- Western Galilee Hospital-Nahariya
Postoperative Cardiovascular Complications
Preoperative BNP as Biomarker of Postoperative Cardiovascular Complications
BNP is a hormone that predicts preoperatively the occurrence of postoperative cardiovascular complications. In practice, the problem is that the practitioner don't know the most opportune moment for the preoperative sample or…
- Trial name
- BNP (NCT02570607)
- Testing
- BNP dosage
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Acute Coronary Syndromes, Heart Failure
Prospective Cohort of Acute Cardiology Referrals in an Ambulatory Day-Hospital Setting
Suspected acute or subacute cardiovascular diseases-including chest pain, dyspnea, and palpitations-are among the most common reasons for unscheduled emergency department visits and pre-hospital referrals.
- Conditions
- Acute Coronary Syndromes, Heart Failure, Pulmonary Embolism, Deep Vein Thrombosis, HTN-Hypertension
- Trial name
- CESAR (NCT07675434)
- Volunteers
- 25,000 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV, Atherosclerosis
Effect of Extra Virgin Olive Oil on Atherosclerosis Biomarkers in HIV-infected Patients
HIV infection is associated with systemic inflammation that is involved in pathogenesis of atherosclerosis. Treatment of HIV infection may cause lipid profile disturbance and consequently, atherosclerosis progression.
- Conditions
- HIV, Atherosclerosis, HIV Infections
- Trial name
- EVOO_HIV (NCT00925795)
- Testing
- consumption 1. EVOO; 2. ROO, consumption 1. ROO; 2. EVOO
- Where
- Croatia
- Volunteers
- 39 people
- Sponsor
- University Hospital for Infectious Diseases, Croatia
Sleep Apnea, Heart Failure
Effects of Nocturnal Nasal Oxygen on Biomarkers in Sleep Apnea Patients With Heart Failure
Sleep apnea syndrome is clinically defined by frequent pauses in breathing during sleep and symptoms, such as being tired. It can decrease the restfulness of sleep and decreases the level of oxygen in the blood.
- Trial name
- NCT01431157
- Testing
- Nocturnal nasal oxygen, No nasal oxygen
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- University of Maryland, Baltimore
Mild Cognitive Impairment, Alzheimer's Disease
Korea Alzheimer's Disease Neuroimaging Initiative
PRIMARY OBJECTIVES -Establish a registry for Alzheimer's disease (AD) and subcortical ischemic vascular dementia (SIVD) STUDY DESIGN -This is a non-randomized, natural history, observational, registry study.
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Subcortical Vascular Dementia
- Trial name
- K-ADNI (NCT01979419)
- Where
- South Korea
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Korean Alzheimers' Disease Neuroimaing Intitiative
Hypertension
New Biomarkers and Difficult-to-treat Hypertension
The purpose of this study is to determine the concentrations and variabilities of urinary exosomal sodium channels and plasma angiotensins in patients with difficult-to-treat arterial hypertension and to investigate their…
- Trial name
- NCT03034265
- Where
- Switzerland
- Volunteers
- 24 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hypotension, Postoperative Complications
Biomarkers, Blood Pressure, BIS: Risk Stratification/Management of Patients at Cardiac Risk in Major Noncardiac Surgery
Major adverse cardiovascular events (MACE) are a leading cause of serious complications and death following major noncardiac surgery.
- Conditions
- Hypotension, Postoperative Complications, Acute Coronary Syndrome, Heart Failure
- Trial name
- BBB (NCT02533128)
- Testing
- Liberal blood pressure management, Tight blood pressure management
- Where
- Switzerland
- Volunteers
- 458 people
- Sponsor
- Miodrag Filipovic, Prof. Dr. med.
Coronary Atheroscleroses, Coronary Angiography
Risk Factors of Intermediate Coronary Lesion Progression
Coronary intermediate lesions generally refer to lumen narrowing with diameter stenosis% (DS%) between 50% and 70% on angiography.
- Trial name
- NCT03855436
- Where
- China
- Volunteers
- 1,389 people, healthy volunteers welcome
- Sponsor
- China National Center for Cardiovascular Diseases
Stroke, Post-Stroke Cognitive Impairment
Immune-Inflammatory Biomarkers in Predicting Early Cognitive Impairment in Adults With Acute Basal Ganglionic Stroke
Post-stroke cognitive impairment (PSCI) is a common and disabling complication that affects memory, thinking, and daily functioning after a stroke.
- Conditions
- Stroke, Post-Stroke Cognitive Impairment, Ischemic Stroke, Intracerebral Hemorrhage
- Trial name
- NCT07837466
- Volunteers
- 100 people
- Sponsor
- Assiut University
Pulmonary Hypertension
Evaluation of Echocardiographic Indices and Blood Biomarkers in Group 1 Pulmonary Hypertension
To evaluate different echocardiographic indices in diagnosis and follow up of group 1 pulmonary hypertension. To evaluate blood biomarkers (troponin, uric acid and micro RNA) in naïve group 1 pulmonary hypertension.
- Trial name
- NCT04279145
- Testing
- swan ganze catheter /echocardiography
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Assiut University
Health, Subjective, Gastrointestinal Dysfunction
Personal Lifestyle Engine (PLX) - Personal Lifestyle Medicine Center (PLMC)
It has been suggested that the best medicine should include four principles (4P) - Medicine should be personalized, predictive, preventative and participatory.
- Conditions
- Health, Subjective, Gastrointestinal Dysfunction, Cardiovascular Risk Factor, Autoimmune Diseases
- Trial name
- NCT04007939
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Metagenics, Inc.
Fatty Liver Disease
Portal Hypertension in Non-alcoholic Fatty Liver Disease: Association With Cardiovascular Risk and Identification of Non-invasive Biomarkers (THESIS)
Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease in our environment. Preliminary data suggest that portal hypertension may exist in the initial phases of NAFLD due to mechanisms that…
- Trial name
- THESIS (NCT04191044)
- Testing
- A complete cardiovascular and liver characterization will be carried out
- Volunteers
- 170 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Hypoplastic Left Heart, Congenital Heart Disease
Cardiac Biomarkers in Patients With Single Ventricle Physiology
All neonates with congenital heart disease undergoing stage one palliation (Norwood procedure, Damus-Kaye-Stansel procedure) at Texas Children's Hospital will be regularly monitored for B-type natriuretic peptide (BNP) and…
- Conditions
- Hypoplastic Left Heart, Congenital Heart Disease, Cyanotic Congenital Heart Disease, Cardiac Disease
- Trial name
- NCT03678909
- Testing
- Norwood Palliation / DKS / Damus-Kaye-Stansel procedure
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Baylor College of Medicine
Cardiac Arrest
Biomarkers After Out-of-hospital Cardiac Arrest- a STEPCARE Substudy
A prospective multicenter biomarker study with adult patients treated on intensive care units after out-of-hospital cardiac arrest.
- Trial name
- NCT06471972
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 1,500 people
- Sponsor
- Region Skane
Cardiac Valve Disease
Cardiac Biomarkers for the Quantification of Myocardial Damage After Cardiac Surgery
The aim of the study is to clarify whether the perioperative release of the cardiac biomarkers troponin I, troponin T and CK-MB consistently correlate with visualizable myocardial damage, and to what extent these biomarkers are…
- Trial name
- RORSCHACH (NCT06066970)
- Where
- 5 sites in Germany
- Volunteers
- 100 people
- Sponsor
- Jena University Hospital
Myocardial Ischemia
Preconditioning With Sevoflurane and Propofol in Patients Undergoing Minimally Invasive Mitral Valve Surgery
The main aim of this study is to compare markers of cardiac injury (Troponin I), inflammatory response and platelets function during minimally invasive mitral valve repair or replacement (MIMV) via right mini-thoracotomy in two…
- Trial name
- MINI-SEVO (NCT02551328)
- Testing
- sevofluorane
- Where
- Italy
- Volunteers
- 48 people
- Sponsor
- Fondazione Toscana Gabriele Monasterio
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