Clinical trials: Cardiovascular Biomarkers
Cancer, Solid Tumor
Exploring Cancer-Associated Thromboembolism Prognosis Biomarkers and Polymorphisms
This study aims to assess biomarkers and their related polymorphisms in the context of cancer-associated thromboembolism, with a particular focus on their interaction with the immune system.
- Conditions
- Cancer, Solid Tumor, Thromboembolism, Cardiovascular Diseases
- Trial name
- CAT_PB (NCT06065592)
- Testing
- Palbociclib, Rivaroxaban, SNP
- Where
- 2 sites in Lebanon
- Volunteers
- 500 people
- Sponsor
- Lebanese University
MRI, Acquired Heart Disease
Noninvasive Imaging of Heart Failure: A Pilot Study
Background: Heart failure is a common cardiovascular disorder whose incidence increases with age, affecting up to 10% of people older than 65 years of age.
- Conditions
- MRI, Acquired Heart Disease, Myocardial Fibrosis
- Trial name
- NCT01160471
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Acute Coronary Syndromes
Investigation of the Biomarker Copeptin in Patients With Acute Myocardial Infarction
While troponin is not detectable until several hours after an Acute Myocardial Infarction (AMI), copeptin is expected to be elevated very early after an AMI.
- Trial name
- CHOPIN (NCT00952744)
- Where
- 11 sites in United States
- Volunteers
- 2,071 people
- Sponsor
- Brahms AG
Angioedema
Determination of Specific Biomarkers of Angioneurotic Crisis
Diagnosis of angioedema (AE) is difficult especially in emergency room. Two forms should be evoked: histaminic AE (allergic or not, which represent 95% of cases) and bradykinic AE (hereditary or acquired deficiency, with or…
- Trial name
- BIOBRAD (NCT02833675)
- Where
- France
- Volunteers
- 120 people
- Sponsor
- University Hospital, Grenoble
Atrial Fibrillation
Role of Cardiac Biomarkers in Prediction of Outcome in Atrial Fibrillation Patients Undergoing Catheter Ablation
The purpose of this study is to assess if pre-ablation levels of inflammatory biomarkers serve as independent predictors of procedure outcome To evaluate the inflammatory activation following catheter ablation by measuring…
- Trial name
- IMPACTII (NCT02208102)
- Testing
- Radio-frequency catheter ablation
- Where
- United States
- Volunteers
- 155 people
- Sponsor
- Texas Cardiac Arrhythmia Research Foundation
Cardiovascular Diseases
Effect of Short-term Chinese Tea-flavor Liquor Consumption
Human studies of Chinese liquor are sparse. The investigators hypothesize that short-term Chinese Tea-flavor liquor (TFL) consumption may be beneficial to inflammation biomarkers and CVD risk factors.
- Trial name
- ESTCTFLC (NCT01294995)
- Testing
- Tea-flavor Liquor, Guizhou Meijiao Liquor
- Where
- China
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zhejiang University
Congenital Disorders
Biomarkers for Detection of Brain Ischemia
Brain injury occurs in one-quarter to one-half of congenital heart defect infants during the perioperative period. A blood test using a biomarker to diagnose brain injury would be important.
- Trial name
- NCT00490295
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Emory University
Atherosclerosis
Genetic and Inflammatory Markers in Cardiovascular Disease (GEM) Registry
This is an investigator initiated registry aimed at assembling a blood/serum and genomic resource (bank) of human blood samples with accompanying clinical data mainly from patients who are scheduled to undergo cardiac…
- Trial name
- GEM (NCT00584467)
- Volunteers
- 21 people
- Sponsor
- University of California, Davis
Coronary Artery Disease, Coronary Stenosis
Maastricht Biomarker CT Study
Introduction Cardiovascular disease is the leading cause of death in the Western world. The main cause for cardiovascular events is the development of atherosclerosis in the coronary arteries.
- Trial name
- NCT01671930
- Where
- Netherlands
- Volunteers
- 5,000 people
- Sponsor
- Maastricht University Medical Center
Arterial Disease
Dynamic Arterial Elastance: an Indirect Marker of the Critical Capillary Pressure at the Microcirculatory Level
The measurement of dynamic arterial elastance (Eadyn) was proposed as a marker of vascular tone. It is calculated by the ratio of the respiratory variation of the pulse pressure and the respiratory variation of stroke volume.
- Trial name
- POEME (NCT03478709)
- Testing
- volume expansion, norepinephrine
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Retinal Imaging, Cardiovascular Biomarker
High Resolution Imaging of Retinal Vessels as a Biomarker of Cardiovascular Disease in Patients With Renal Insufficiency - RI
The objectives are to better understand, in the dialysis patient, the relationships between microvascular morphometry and cardiovascular events, survival, arterial hypertension, the pathology responsible for renal failure, the…
- Conditions
- Retinal Imaging, Cardiovascular Biomarker, Renal Insufficiency
- Trial name
- IRIR (NCT04116814)
- Testing
- wall-to-lumen ratio measurement
- Where
- France
- Volunteers
- 83 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Fatty Liver Disease
Portal Hypertension in Non-alcoholic Fatty Liver Disease: Association With Cardiovascular Risk and Identification of Non-invasive Biomarkers (THESIS)
Non-alcoholic fatty liver disease (NAFLD) is the most frequent cause of chronic liver disease in our environment. Preliminary data suggest that portal hypertension may exist in the initial phases of NAFLD due to mechanisms that…
- Trial name
- THESIS (NCT04191044)
- Testing
- A complete cardiovascular and liver characterization will be carried out
- Volunteers
- 170 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Heart Failure
Edge AI-deployed DIGItal Twins for PREDICTing Disease Progression and Need for Early Intervention in Infectious and Cardiovascular Diseases Beyond COVID-19 - Investigation of Biomarkers in Dermal Interstitial Fluid
The study will investigate, if inflammatory and cardio-circulatory biochemical biomarkers are detectable in dermal interstitial fluid (dISF) of heart failure patients, and if there are detectable kinetics of these biomarkers…
- Trial name
- NCT06200636
- Testing
- Use of the PELSA System for dISF extraction
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Atrial Fibrillation, Rate Control
Rate Control in Patients With Atrial Fibrillation
To search for the best marker for the patients in atrial fibrillation with rate control
- Conditions
- Atrial Fibrillation, Rate Control, Cardiopulmonary Exercise Test
- Trial name
- RaP-AF (NCT04513509)
- Testing
- Atenolol, Bisoprolol, Metoprolol, Nebivolol, Propranolol, Diltiazem, Verapamil, digoxin
- Where
- Taiwan
- Volunteers
- 13 people
- Sponsor
- National Taiwan University Hospital
Atrial Fibrillation
Blood Pressure Assessment in Atrial Fibrillation
This is a cross-sectional study including patients with permanent atrial fibrillation. Assessment will include: clinic blood pressure measurements (mercury sphygmomanometer and automated oscillometric device) 24-hour ambulatory…
- Trial name
- NCT01088269
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Chronic Kidney Disease
Evaluation of Serum Klotho as a Predictor of Progression of Cardiovascular Calcification in Chronic Kidney Disease
This prospective observational study aims to investigate the relationship between CVC and serum Klotho for renal function correction in patients with different CKD stages
- Trial name
- NCT03996746
- Testing
- No intervention
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Xinhua Hospital, Shanghai Jiao Tong University School of Medicine
Hyperthyroidism, Graves Disease
Effect of Hyperthyroidism and Its Treatment in Graves' Disease to Early Marker of Atherosclerosis
During July 2019 to August 2020, a single-blind clinical trial was done to 36 patients with Graves' disease. At the beginning of the study, subjects were accommodated into 2 groups, 17 into PTU groups and 19 into methimazole…
- Conditions
- Hyperthyroidism, Graves Disease, Atherosclerosis of Artery, Pathophysiology
- Trial name
- NCT05118542
- Testing
- Propylthiouracil, Methimazole
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Universitas Indonesia
Myocardial Injury, Atherosclerosis Cardiovascular Disease
Multimodal Biomarkers in Coronary Artery Disease Pathogenesis: The Oxford Acute Myocardial Infarction Study (OXAMI Study)
Coronary artery disease is one of the most common causes of illness and death. It develops when fatty deposits, known as plaques, build up in the arteries that supply blood to the heart.
- Conditions
- Myocardial Injury, Atherosclerosis Cardiovascular Disease, Cardiac Imaging Techniques, Genetics
- Trial name
- OXAMI (NCT07772570)
- Testing
- blood sampling, Intracoronary Imaging, Cardiovascular Magnetic Resonance Imaging
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Pulmonary Embolism
Assessing the Prognosis of Pulmonary Embolism Using Clinical and Imaging Biomarkers (Retrospective & Prospective )
Venous thromboembolism (VTE), which clinically manifests as deep vein thrombosis (DVT) and pulmonary embolism (PE), is a common but elusive illness that can cause significant disability and death if not promptly diagnosed and…
- Trial name
- NCT00805246
- Where
- 2 sites in United States
- Volunteers
- 910 people
- Sponsor
- University of Pittsburgh
Stable Angina, Periodontitis
Non-Surgical Periodontal Therapy and Cardiac Biomarkers in Stable Angina
The goal of this clinical study is to learn whether gum treatment can improve heart health. Researchers will compare blood markers related to heart disease before and after routine gum treatment.
- Trial name
- NCT07412795
- Testing
- Non-surgical periodontal therapy (scaling and root planing), Non-surgical periodontal therapy (Professional dental cleaning)
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
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