Clinical trials: Cardiovascular Biomarkers
Multiple Myeloma, Vertebral Fracture
Vertebral Fat Quantitative MRI as a Marker of Bone Fragility in Multiple Myeloma (MYELOMEFRAGIQUANTI)
Multiple myeloma is a disease that causes increased bone fragility which is often revealed or complicated by vertebral fractures. Invasion of bone marrow by tumor plasma cells leads to bone destruction and reduced fat fraction.
- Trial name
- NCT04609150
- Testing
- Bone marrow fat quantification by MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Pulmonary Embolism
Adrenomedullin in Context With Pulmonary Embolism
The pulmonary embolism (PE) causes a blockade of the pulmonary arteries typical due to a thrombus which is formed in the lower region of the body or pretty rare to other materials (tumor, air, fat).
- Trial name
- NCT04875130
- Testing
- blood samples
- Where
- 2 sites in Austria, Hungary
- Volunteers
- 24 people
- Sponsor
- University of Pecs
Giant Cell Arteritis (GCA)
The VGR GCA Cohort: Ultrasound, Biopsy and Biomarkers - Novel Methods for Diagnosis, Monitoring and Prognosis in Giant Cell Arteritis.
Giant cell arteritis (GCA) is the most common vasculitis in the elderly and is usually treated with long-term corticosteroid therapy. Many patients experience relapses and treatment-related side effects.
- Trial name
- NCT07246577
- Where
- Sweden
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region
Hypertension
HT-ENDO: A Multiomics-based Biomarker for the Diagnosis of Endocrine Hypertension: a Pragmatic, Diagnostic, Randomized, Outcome-based Trial
Rationale: Diagnosis of endocrine forms of hypertension (primary aldosteronism, pheochromocytoma/paraganglioma and Cushing syndrome) is a lengthy and tedious process.
- Trial name
- HT-ENDO (NCT06578975)
- Testing
- HT-ENDO-MOS-A13, Normal diagnosis
- Volunteers
- 250 people
- Sponsor
- JDeinum
Cerebral Amyloid Angiopathy, Intracranial Hemorrhages
Multimodal Biomarkers for Diagnosis and Prognosis in CAA
By combination of plasma (Aβ40, Aβ42, total tau, and phosphorylated tau, etc.), genetic (ApoE ε2 or ε4 allele), MRI (cerebral perfusion, microbleeds, cortical superficial siderosis, enlarged perivascular space, etc.) and PET…
- Conditions
- Cerebral Amyloid Angiopathy, Intracranial Hemorrhages, Alzheimer Disease
- Trial name
- CAA (NCT03969732)
- Testing
- 1. amyloid PET；2. T807 PET
- Where
- Taiwan
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Coronary Heart Disease, Clonal Hematopoiesis of Indeterminate Potential (CHIP)
A Study to Investigate the Efficacy, Safety, and Tolerability of DFV890 and MAS825 for Inflammatory Marker Reduction in Adult Participants With Coronary Heart Disease and Clonal Hematopoiesis of Indeterminate Potential (CHIP)
This Phase 2a clinical trial evaluated the effectiveness, safety, and tolerability of increasing dose strengths of an oral daily medication, DFV890, administered for 12 weeks, or a single s.c.
- Trial name
- NCT06097663
- Testing
- MAS825, DFV890
- Where
- 6 sites in United States, Canada and 1 more
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Coronary Artery Disease, Menopause
The Effects of Resveratrol on Sirtuins and Apoptosis Biomarkers
Cardiovascular diseases (CVD) and neoplasms are the main causes of death in Brazilian women. Coronary artery disease (CAD) and stroke were responsible for approximately 54% of deaths from CVD in this population.
- Conditions
- Coronary Artery Disease, Menopause, Endothelial Dysfunction
- Trial name
- RE-AGES (NCT05808387)
- Testing
- Resveratrol
- Where
- Brazil
- Volunteers
- 80 people
- Sponsor
- InCor Heart Institute
Heart Failure
Edge AI-deployed DIGItal Twins for PREDICTing Disease Progression and Need for Early Intervention in Infectious and Cardiovascular Diseases Beyond COVID-19 - Investigation of Biomarkers in Dermal Interstitial Fluid
The study will investigate, if inflammatory and cardio-circulatory biochemical biomarkers are detectable in dermal interstitial fluid (dISF) of heart failure patients, and if there are detectable kinetics of these biomarkers…
- Trial name
- NCT06200636
- Testing
- Use of the PELSA System for dISF extraction
- Where
- Germany
- Volunteers
- 20 people
- Sponsor
- Charite University, Berlin, Germany
Uveitis, Diabetic Retinopathy
Biomarkers of Common Eye Diseases
To identify biomarkers of common eye diseases based on single-cell sequencing technologies using PBMC samples. These diseases include uveitis, diabetic retinopathy, age-related macular degeneration and polypoid choroidal…
- Conditions
- Uveitis, Diabetic Retinopathy, Age-related Macular Degeneration, Polypoidal Choroidal Vasculopathy
- Trial name
- NCT04101604
- Testing
- Collection of blood samples
- Where
- China
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Posttraumatic Stress Disorder
Predicting Responses to PTSD Treatment With Iris and Cardiovascular Tests
Post-traumatic stress disorder (PTSD) affects many individuals who experience a traumatic event. There are a variety of treatment options for PTSD, including psychotherapy (talk therapy) options, as well as medications, such as…
- Trial name
- PREDICT (NCT03539614)
- Testing
- Prazosin
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- VA Office of Research and Development
Cardiovascular Disease Risk, Type 2 Diabetes Risk
The Effect of Pecans on Biomarkers of Risk for Cardiovascular Disease and Diabetes
The objective of this randomized, controlled feeding study is to investigate the potential health benefits of a pecan-containing diet.
- Trial name
- NCT01950806
- Testing
- Pecan-containing diet, Nut-free diet
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Tufts University
Atrial Fibrillation, Biomarker
The Application of Biomarkers in the Care of Patients With Atrial Fibrillation
From 2020 to 2023, we established a longitudinal AF patient cohort with comprehensive clinical data collection. In our previous work, we utilized the Milliplex platform to screen 52 circulating biomarkers and identified several…
- Trial name
- NCT07565337
- Where
- Taiwan
- Sponsor
- National Taiwan University Hospital
Acute Myocardial Infarction
Impact of EMpagliflozin on Cardiac Function and Biomarkers of Heart Failure in Patients With Acute MYocardial Infarction
This study is planned to investigate the impact of Empagliflozin on biomarkers of heart failure in patients with myocardial infarction with and without type 2 diabetes mellitus within 6 months after the event.
- Trial name
- EMMY (NCT03087773)
- Testing
- Empagliflozin 10 mg
- Where
- 11 sites in Austria
- Volunteers
- 476 people
- Sponsor
- Medical University of Graz
Heart Transplant Rejection
A New Biomarker for the Non-invasive Diagnosis of Rejection After Heart Transplantation
This study is a prospective, observational multi-center cohort study. The study will consist of patients undergoing heart transplantation.
- Trial name
- BIODRAFT (NCT03477383)
- Testing
- donor-derived cell-free DNA (dd-cfDNA)
- Where
- 4 sites in Sweden
- Volunteers
- 134 people
- Sponsor
- Vastra Gotaland Region
Vascular Disease, CKD-MBD - Chronic Kidney Disease Mineral and Bone Disorder
Biomarkers and Event Patterns of Vascular Disease in Hemodialysis
Parathyroid hormone (PTH) remains the central biomarker to classify CKD-metabolic bone disease (CKD-MBD) in hemodialysis patients.
- Trial name
- HEMOcalc (NCT07170761)
- Where
- Austria
- Volunteers
- 475 people
- Sponsor
- Medical University of Graz
Stroke Acute
Study of Inflammatory Cells in the Blood and Cerebral Thrombus of Patients Affected by Cerebral Ischemia
This is an observational, prospective and retrospective, single-center study of thrombotic material and blood samples obtained from patients undergoing mechanical endovascular thrombectomy for ischemic stroke caused by large…
- Trial name
- ClotBioInsight (NCT07033988)
- Where
- Italy
- Volunteers
- 380 people
- Sponsor
- IRCCS San Raffaele
Coronary Heart Disease
Trial of Lycopene/Ateronon for Secondary Prevention of Coronary Heart Disease
The purpose of this study is to determine whether Ateronon, a nutritional supplement that contains lycopene from tomatoes has a favorable effect on carotid atherosclerosis, lipid levels, and other biomarkers of coronary heart…
- Trial name
- NCT00939237
- Testing
- Ateronon
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- Brigham and Women's Hospital
Peripheral Arterial Disease
DANCE Partner: Inflammatory Biomarker Analysis by Femoropopliteal Revascularization Method and Treatment Outcomes
This is a prospective, multi-center, observational registry to document the baseline, 24-hour and 30-day inflammatory response and procedural outcomes out to 12 month follow-up after femoropopliteal angioplasty or…
- Trial name
- NCT02469532
- Testing
- Balloon Angioplasty, Atherectomy System
- Where
- 6 sites in United States
- Volunteers
- 31 people
- Sponsor
- Mercator MedSystems, Inc.
Transthyretin Amyloidosis
New Biomarkers and Plasma Prothrombotic Potential in Cardiac Transthyretin Amyloidosis
The development of cardiac amyloidosis is caused by the deposition of misfolded, insoluble proteins in the extracellular matrix of tissues.
- Trial name
- NCT06345235
- Testing
- blood test
- Where
- Poland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- John Paul II Hospital, Krakow
Coronary Artery Disease
The Use of Aging Biomarkers to Predict Adverse Outcomes After Cardiac Surgery
Cardiac surgery associated acute kidney injury (CSA-AKI) has been recognized as the second most common cause of hospital acquired AKI.
- Trial name
- NCT02496234
- Where
- United States
- Volunteers
- 186 people
- Sponsor
- Sapere Bio