Clinical trials: Cardiovascular Biomarkers
Subarachnoid Haemorrhage (SAH), Delayed Cerebral Ischemia
Metabolomics in Subarachnoid Hemorrhage
The goal of this observational study is to learn whether blood and cerebrospinal fluid markers, combined with clinical, imaging and brain monitoring data, can help predict the outcome of adults with spontaneous subarachnoid…
- Trial name
- NeuroMetas (NCT07865182)
- Testing
- Blood and cerebrospinal fluid sampling
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Unidade Local de Saude Sao Jose
Coronary Heart Disease (CHD)
Proteomic and Inflammatory Omics Changes With Colchicine Therapy in Coronary Heart Disease
The goal of this exploratory clinical trial is to investigate the proteomic changes induced by low-dose colchicine anti-inflammatory therapy in coronary heart disease (CHD) patients, with the aim of identifying novel biomarkers…
- Trial name
- PIC-CHD (NCT07462325)
- Testing
- colchicine
- Volunteers
- 176 people
- Sponsor
- Chinese Academy of Medical Sciences, Fuwai Hospital
Heart Failure, ASCVD
Serial Biomarker Testing and Cardiovascular Risk Stratification (ACHILLES)
The goal of this observational study is to learn how blood levels of biomarkers, e.g. hsCRP and Lp(a) - two markers linked to heart disease risk - change over time in patients who have had these levels tested more than once.
- Conditions
- Heart Failure, ASCVD, CKD
- Trial name
- ACHILLES (NCT07817576)
- Where
- Germany
- Volunteers
- 110,000 people
- Sponsor
- University Hospital Freiburg
Transient Ischemic Attack, Minor Stroke
China Registry of Non-disabling Ischemic Cerebrovascular Events
The burden of non-disabling ischemic cerebrovascular events (NICE) is significantly increased. In order to achieve accurate risk stratification and effective treatments, developing new diagnostic, therapeutic, and prognostic…
- Trial name
- CR-NICE (NCT03079674)
- Testing
- observational only- no intervention
- Where
- 44 sites in China
- Volunteers
- 10,000 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Acute Coronary Syndrome
Multimarker Evaluation of Platelet Activity and Agregation in ACS
Patients with acute coronary syndrome (ACS) who undergo percutaneous coronary intervention (PCI) are at a higher risk of ischemic complications, even while receiving proper dual antiplatelet therapy.
- Trial name
- NCT06177587
- Testing
- Assesment of biomarkers in acute coronary syndromes
- Where
- Poland
- Volunteers
- 150 people
- Sponsor
- Medical University of Warsaw
Ischemic Stroke
CoHort of Patients to Identify Biological and Imaging markerS of CardiovascUlar Outcomes in Stroke - HIBISCUS-STROKE II
Ischemic stroke is the first cause of acquired disability of the adult, the second cause of dementia and the third cause of death in the industrialized countries, what constitutes à major public health issue.
- Trial name
- HIBI STROKE II (NCT05263804)
- Testing
- Collection of blood samples and MRI imaging in order to create a bio- and imaging-collection, Cardiac MRI with gadolinium injection - Ancillary Study
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Hospices Civils de Lyon
CADASIL
Development and Validation of a Functional MRI Biomarker of Cerebral Small Vessel Dysfunction in CADASIL
Cerebral small vessel diseases (cSVD) are diseases of brain tissue involving vessels (arterioles or capillaries) with a diameter of less than 400 microns.
- Trial name
- fMRI BioSVD (NCT06859658)
- Testing
- Functional MRI at 3T
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Diabetic Retinopathy
Biomarker of Diabetic Retinopathy
Diabetic retinopathy (DR) is a complication of diabetes in which blood vessels supplying blood to the back of the eye (retina) are dysfunctional.
- Trial name
- NCT05079399
- Testing
- Blood draw
- Where
- 3 sites in United States
- Volunteers
- 192 people
- Sponsor
- Indiana University
Arrhythmia, Cardiovascular Diseases
Diagnostic Investigation of Sudden Cardiac Event Risk
The overall objective of the DISCERN study is to develop and validate a genomic diagnostic assay to identify patients at increased risk for lethal ventricular arrhythmias and sudden cardiac death (SCD).
- Conditions
- Arrhythmia, Cardiovascular Diseases, Heart Failure, CVD
- Trial name
- DISCERN (NCT00500708)
- Where
- 8 sites in United States
- Volunteers
- 1,564 people
- Sponsor
- CardioDx
Hypertension, Diabetes Mellitus Type 2
Endothelial Function as a Marker for Blood Pressure Control Among Hypertensive Diabetic Patients
Our aim is to examine the influence of blood pressure and glycemic control together with N-acetylcystein utilization on the endothelia function of hypertensive diabetic patient.The study population will include 50 diabetic…
- Trial name
- NCT00337038
- Testing
- N-acetylcystein(drug)
- Volunteers
- 50 people
- Sponsor
- Soroka University Medical Center
Plaque, Atherosclerotic Disease
BioImage Study: A Clinical Study of Burden of Atherosclerotic Disease in an At-Risk Population
The BioImage Study is a study of the characteristics of subclinical cardiovascular disease, as measured by imaging modalities, unsupervised circulating biomarker measurements, and risk factors that predict progression to overt…
- Conditions
- Plaque, Atherosclerotic Disease, Heart Disease, Stroke
- Trial name
- NCT00738725
- Where
- 2 sites in United States
- Volunteers
- 7,687 people, healthy volunteers welcome
- Sponsor
- BG Medicine, Inc
Clonal Hematopoiesis, Clonal Hematopoiesis of Indeterminate Potential
CHIP in Health and Disease
Clonal hematopoiesis (CH), including clonal hematopoiesis of indeterminate potential (CHIP), is an age-associated condition characterized by the expansion of hematopoietic stem and progenitor cell clones carrying acquired somatic…
- Conditions
- Clonal Hematopoiesis, Clonal Hematopoiesis of Indeterminate Potential, Clonal Cytopenia of Undetermined Significance (CCUS), Myelodysplastic Syndrome
- Trial name
- CHIP2 (NCT07780552)
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- VASCage GmbH
Cardio-Renal Syndrome, Heart Failure
Cardiorenal Risk Stratification Pilot Study
This is prospective cohort study with the purpose of improving our understanding of morbidity and mortality risk in patients with heart failure and chronic kidney disease.
- Conditions
- Cardio-Renal Syndrome, Heart Failure, Chronic Kidney Diseases
- Trial name
- CRiSPS (NCT03628443)
- Testing
- Fibroblast Growth Factor 23
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Coney Island Hospital, Brooklyn, NY
Coronary Heart Disease, Dyslipidemia
The Hellenic Postprandial Lipemia Study (HPLS)
Coronary heart disease (CHD) is the leading cause of death worldwide. The disease is characterized by a high mortality rate (about 40%) and a course continuously altered by lifestyle, gene polymorphisms and therapeutic treatment.
- Trial name
- HPLS (NCT02163044)
- Where
- Greece
- Volunteers
- 580 people
- Sponsor
- Hellenic College of Treatment of Atherosclerosis
Heart Failure, Pathophysiology
Responders and Non-responders in the Management of Heart Failure - Significance of Genetic Influence and Identification of Novel Informative Biomarkers
A biobank within the Swedish national heart failure quality registry SwedeHF.
- Trial name
- Responders (NCT06435585)
- Where
- Sweden
- Volunteers
- 5,000 people
- Sponsor
- Karolinska University Hospital
Metabolic Diseases
Intensity Training and Cardiovascular Health in Colombian Adults
Several studies have shown relationship between exercise intensity and improvement cardiometabolic health. It has been suggested that high intensity interval training and also moderate training generate positive effects on…
- Trial name
- HIIT-Heart (NCT02738385)
- Testing
- High Intensity Interval Training, Moderate Intensity Interval Training
- Where
- Colombia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universidad Santo Tomas
Cardiac Anaesthesia
Cardiac Anesthesia Registry Including Biosignal Database for Prognostication of Postoperative Renal Outcome
AKI(Acute Kidney Injury) is a common complication after cardiac surgery which is associated with increased mortality and morbidity.
- Trial name
- NCT06581289
- Where
- South Korea
- Volunteers
- 10,000 people
- Sponsor
- Yonsei University
Sickle Cell Anemia, Pulmonary Hypertension
Tricuspid Regurgitant Jet Velocity as an Independent Marker for Mortality in Sickle Cell Anemia
The purpose of this study is to evaluate patients with pulmonary hypertension and sickle cell disease who have had multiple echocardiograms.
- Trial name
- NCT01783093
- Testing
- Data Collection
- Where
- United States
- Volunteers
- 209 people
- Sponsor
- Namita Sood
Coronary Artery Disease
Comparing Blood Loss, RBC Transfusions and Inflammatory Marker Changes Among Methods of CPB
The purpose of this study is to compare blood loss and the number of transfusions received by each patient having coronary bypass surgery.
- Trial name
- NCT01083914
- Where
- United States
- Volunteers
- 102 people
- Sponsor
- Baylor Research Institute
Disease, Cardiovascular Diseases
Biomarkers of Acrylamide, Glycidol, POPs, PFAS and Disease Outcomes and OMICs Signatures
The aim of the project is to assess the associations between biomarkers of acrylamide and glycidol exposure and disease outcomes in a case-cohort study based on two prospective cohorts with biobanks.
- Conditions
- Disease, Cardiovascular Diseases, Cancer, Environmental Exposure
- Trial name
- NCT05930626
- Testing
- Biomarkers of acrylamide, glycidol, POPs, PFAS
- Volunteers
- 9,254 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
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