Clinical trials: Cardiovascular Biomarkers
Heart Failure With Preserved Ejection Fraction
Biomarkers in HF: Circulating Biomarkers of Fibrosis and Cardiovascular Disease
Heart failure with preserved ejection fraction (HFpEF) represents one of the largest unmet needs in cardiovascular medicine. Heart muscle scarring (myocardial fibrosis) is a key HFpEF disease mechanism and represents an important…
- Trial name
- NCT05826821
- Testing
- Pirfenidone
- Where
- United Kingdom
- Volunteers
- 107 people
- Sponsor
- Manchester University NHS Foundation Trust
Abdominal Aortic Aneurysm
Endoprosthesis Treatment Effects on Human Abdominal Aorta Aneurysms (AAA) Metabolic Activity
The purpose of this study is to determine whether Positron Emission Tomography imaging can help to predict the evolutivity of AAA treated with endovascular prosthesis.
- Trial name
- AAAendo (NCT01253252)
- Testing
- [18F] Fluorodeoxyglucose PET Scan Imaging, CT scan, Blood sampling for biological investigations
- Where
- 7 sites in France
- Volunteers
- 45 people
- Sponsor
- Central Hospital, Nancy, France
Breast Cancer (Early Breast Cancer), Cardiotoxicity
Cardiac Side Effects of Systemic Therapy in Early-Stage Breast Cancer
The goal of this observational study is to evaluate cardiac side effects in women with early-stage breast cancer who receive systemic chemotherapy and/or anti-HER2 therapy as part of their standard cancer care.
- Conditions
- Breast Cancer (Early Breast Cancer), Cardiotoxicity, Cancer Therapy-Related Cardiac Dysfunction
- Trial name
- C-BREAST-01 (NCT07588425)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Fatih GURLER
Ischemic Stroke
Stroke Registration of Young Adults in China
This is a multi-center, prospective,continuous registry study. The investigators will include 3000 young adult (18-45 years old) patients with confirmed first-ever acute ischemic stroke in China.
- Trial name
- REACH (NCT03024164)
- Testing
- Treatment following current guidelines
- Where
- China
- Volunteers
- 3,000 people
- Sponsor
- Yi Yang
Diabetic Retinopathy, Depression
Diabetic Retinopathy as a Marker of Cognitive Dysfunction and Depression
In recent years damage to the nerve fibers in the retina has been experienced as an early sign of complications resulting from type 2 diabetes.
- Conditions
- Diabetic Retinopathy, Depression, Cognitive Impairment, Cognitive Dysfunction
- Trial name
- DIRMA (NCT04610749)
- Where
- Denmark
- Volunteers
- 148 people
- Sponsor
- Region of Southern Denmark
Heart Failure
The Role of Biomarkers and Echocardiography in Prediction of Prognosis of Chronic Heart Failure Patients
The Bio-SHiFT study aims to investigate whether disease progression in individual patients with chronic heart failure (CHF) can be accurately assessed by serial measurements of disease-related (novel) biomarkers.
- Trial name
- Bio-SHiFT (NCT01851538)
- Testing
- Observational study; no intervention.
- Where
- 2 sites in Netherlands
- Volunteers
- 398 people
- Sponsor
- Erasmus Medical Center
Diabetic Retinopathy, Diabetic Macular Edema
Aqueous Biomarker Levels in Diabetic Retinopathy and Diabetic Macular Edema
The DRAGONS study is a non-interventional, prospective study that will 1. characterize disease state biomarker (including cytokines, KKS metabolites, and cell adhesion molecules) levels from aqueous humor of subjects with various…
- Conditions
- Diabetic Retinopathy, Diabetic Macular Edema, Other Retinal Disorders
- Trial name
- DRAGONS (NCT05333055)
- Where
- 3 sites in United States
- Volunteers
- 107 people
- Sponsor
- Greater Houston Retina Research
Sudden Cardiac Death
Study of Paced QRS Duration as a Marker of Sudden Cardiac Death
The purpose of the study is to determine whether prolonged paced QRS duration is a marker of sudden cardiac death in subjects with implantable cardioverter-defibrillators (ICD).
- Trial name
- NCT01948206
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Pocono Medical Center
Heart Failure
Loop Diuretic Dosage in Patients With Acute Heart Failure and Renal Failure: Conventional Versus Carbohydrate Antigen 125-guided Therapy (IMPROVE-HF)
Worsening renal function (WRF) is a frequent finding in patients with decompensated acute heart failure (AHF) and it is associated to increased length of hospitalization and higher morbidity and mortality.
- Trial name
- IMPROVE-HF (NCT02643147)
- Testing
- CA125 guided strategy, Conventional Strategy
- Where
- Spain
- Volunteers
- 170 people
- Sponsor
- Fundación para la Investigación del Hospital Clínico de Valencia
Cigarette Smoking, Inflammatory Response
Menthol, Inflammation, and Nicotine Transition Study
This study will focus on examining the potential impact of menthol flavoring in cigarettes on biomarkers of systemic inflammation as a subclinical indicator of cardiovascular disease risk.
- Trial name
- MINT (NCT06232447)
- Testing
- Cigarette Type Switching
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Rosalind Franklin University of Medicine and Science
Diabetic Retinopathy, Diabetic Macular Edema (DME)
AI Prediction of Treatment Response in DME
Diabetic macular edema (DME) is a leading cause of vision loss among individuals with diabetes mellitus. Although intravitreal anti-vascular endothelial growth factor (anti-VEGF) therapy is the standard treatment for…
- Trial name
- NCT07707856
- Testing
- Artificial Intelligence-Based Imaging Analysis
- Where
- Egypt
- Volunteers
- 1,284 people
- Sponsor
- Benha University
Out-Of-Hospital Cardiac Arrest After Initial Successful Resuscitation
Transcriptome Assessment After Cardiac Arrest
The purpose of this study is to determine whether the blood transcriptome of patients resuscitated after out-of-hospital could be an early predictor of the neurological outcome.
- Trial name
- OMECARD (NCT03895736)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Type 2 Diabetes Mellitus
Vascular Function and Biomarker Assessments in Healthy Volunteers and in Patients With Type 2 Diabetes Mellitus
The purpose of this study is to evaluate the vascular function and biomarkers in healthy volunteers and type 2 diabetic patients.
- Trial name
- NCT04744636
- Testing
- Other
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut de Recherches Internationales Servier
Adrenaline; Aortic Dissection; Drug Dose; Nervous System; Ischemia Reperfusion Injury
Effects of Different Doses of Epinephrine on Biomarkers of Nervous System Ischemia-reperfusion Injury in Patients With Stanford Type A Dissection
Aortic dissection is the most common aortic disease leading to death. Among them, patients with Stanford type A dissection (TAAD) are prone to dissection rupture in the early stage, and their condition deteriorates rapidly.
- Trial name
- NCT05151536
- Volunteers
- 132 people
- Sponsor
- Yunlong Fan
COVID, Coronavirus
The COVID-19 Disease and CARdiac Events Study
An observational study of consecutive patients testing positive for COVID-19 who require admission to hospital to determine the degree of myocardial injury through biomarkers and echocardiography and the impact of this on…
- Trial name
- COVICARE (NCT04438993)
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- NHS Lanarkshire
Atrial Fibrillation
Impact of New Biomarkers on Maintenance of Sinus Rhythm After Cardioversion or Ablation of Atrial Fibrillation
The Biorhythm study aims to investigate the utility of new biomarkers (e.g. MR proANP, ST2) measured pre-procedure for the prediction of procedural success in patients with atrial fibrillation undergoing cardioversion or ablation.
- Trial name
- Biorhythm (NCT03351816)
- Testing
- Ablation of atrial fibrillation, Cardioversion
- Where
- 3 sites in France
- Volunteers
- 106 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Embolic Stroke of Undetermined Source, Ischemic Stroke
Biomarkers, Hemodynamic and Echocardiographic Predictors of Ischemic Strokes and Their Influence on the Course and Prognosis
A stroke is the second cause of deaths after heart attack, one of the most important causes of malfunction as far as adults are concerned and the second as for the frequency cause of dementia.
- Conditions
- Embolic Stroke of Undetermined Source, Ischemic Stroke, Atrial Fibrillation and Flutter, Myocardial Infarction
- Trial name
- NCT03377465
- Testing
- ADMA (asymmetric dimethylarginine) , NTproBNP (N-terminal pro b-type natriuretic peptide), IL-6 (Interleukin 6), Adiponectina, Leptine, Syndecan, Resistin
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Medical University of Lodz
Cardiotoxicity, Aluminum Phosphid Poisoning
Cardiotoxicity of Aluminum Phosphide Poisoning; Tropinin and CKmb as Early Biomarkers
Aluminum phosphide (AlP) or rice tablet is a cheap pesticide. When it comes in contact with acid (gastric acid) or moisture, it releases phosphine (PH3) gas.
- Trial name
- NCT04191265
- Testing
- serum tropinin, serum CKmb
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Susac Syndrome
Investigation of Biomarkers in Susac Syndrome
Susac Syndrome is a rare disease and the establishment of the diagnosis is often difficult. The aim of this investigation is to identify relevant biomarkers and to elucidate the pathogenesis of Susac syndrome
- Trial name
- NCT01273792
- Where
- Germany
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Dyspnea, Peripheral Edema
NT-proBNP and New Biomarkers in Patients With Dyspnea and/or Peripheral Edema
The objectives of this study are to: Evaluate the sensitivity and specificity of NT-proBNP (N-terminal prohormone brain natriuretic peptide) and new biomarker measurements for the diagnosis of heart failure in patients with acute…
- Trial name
- MANPRO (NCT00143793)
- Where
- Germany
- Volunteers
- 400 people
- Sponsor
- Universitätsmedizin Mannheim
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