Clinical trials: Cardiovascular Biomarkers
Cardiac Arrest
Prognostic Value of Plasma Mitochondrial DNA and Cytochrome C After Cardiac Arrest
The aim of the study is to determine prognostic value of plasma mitochondrial DNA and cytochrome C after cardiac arrest. The study will be conducted in three parts: 1.
- Trial name
- NCT03539497
- Testing
- Biomarker
- Where
- Slovenia
- Volunteers
- 87 people
- Sponsor
- University Medical Centre Ljubljana
Hypertrophic Cardiomyopathy
HCMR - Novel Markers of Prognosis in Hypertrophic Cardiomyopathy
Hypertrophic cardiomyopathy (HCM) is the most common monogenic heart disease and the most frequent cause of sudden cardiac death (SCD) in the young.
- Trial name
- HCMR (NCT01915615)
- Testing
- None - this is an observational study
- Where
- 44 sites in United States, Canada and 4 more
- Volunteers
- 2,750 people
- Sponsor
- University of Virginia
Aortic Dissection, Biomarkers and Early Diagnosis
Potential Biomarkers for Early Diagnosis of Acute Aortic Dissection
Acute aortic dissection (AAD) is an acute vascular lesions with high early misdiagnosis rate(31.8%), and mortality rate was 38%. In recent years, the incidence is rising and serious threat to human health.
- Trial name
- NCT01860768
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Central South University
Diabetes, Diabetic Foot
C-myc Biomarker Study for Diabetic Foot Ulcers
This is a multi-center observational cohort study of patients with diabetic foot ulcers (DFU) to develop and validate potential tissue-based biomarkers that predict complete wound healing.
- Conditions
- Diabetes, Diabetic Foot, Diabetic Foot Ulcer, Diabetic Wound
- Trial name
- NCT04591691
- Where
- 6 sites in United States
- Volunteers
- 140 people
- Sponsor
- University of Michigan
Coronary Artery Calcification, Coronary Artery Disease
MAP-Calcification: MicroRNAs as Potential Biomarkers for Coronary Artery Calcification
Coronary artery disease (CAD) remains the leading cause of mortality in the UK with an estimated 80,000 fatalities in 2010. Coronary artery calcification (CAC) is associated with atherosclerotic plaque burden and cardiovascular…
- Conditions
- Coronary Artery Calcification, Coronary Artery Disease, Osteoporosis, Osteopenia
- Trial name
- NCT01992848
- Testing
- Venous blood sampling, 4-day food diary, 1 week UV dosimeter
- Where
- 2 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Surrey
Acute Coronary Syndrome
Myocardial Infarction Registry
The single-center MIR-registry was created to assess real-world prevalence, demographic characteristics and management of patients with acute coronary syndrome presenting in the emergency department (ED) of University of…
- Trial name
- MIR (NCT06128317)
- Testing
- no intervention is intended.
- Where
- Germany
- Volunteers
- 2,500 people
- Sponsor
- University Hospital Heidelberg
Multiple Myeloma Survival Outcome, Multiple Myeloma and Malignant Plasma Cell Neoplasms
Multiple Myeloma Extramedulary Disease Samples FFPE
This observational study aims to evaluate the feasibility of assembling a retrospective cohort of formalin-fixed paraffin-embedded (FFPE) tissue samples from patients with extramedullary multiple myeloma, together with their…
- Trial name
- MMExFFPE (NCT07354555)
- Where
- France
- Volunteers
- 15 people
- Sponsor
- BIWAKO
Preterm Birth, Cardiovascular Diseases
Preterm Birth and Biomarkers for Cardiovascular Disease
Preterm birth is associated with maternal increased risk of cardiovascular disease later in life. In an observational case- control study, investigators want to evaluate whether women with preterm birth have increased levels of…
- Trial name
- BIO-PRETERM (NCT05693285)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Uppsala University
Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch
Effects of Remimazolam on Postoperative Cognitive Dysfunction and Neuroinflammatory Biomarkers in Patients Undergoing Aortic Arch Surgery
The purpose of this study is to compare remimazolam- and propofol-based anesthesia for their effects on postoperative cognitive dysfunction in patients undergoing aortic arch surgery.
- Conditions
- Aortic Aneurysm of the Proximal Arch, Aortic Aneurysms Arch, Aortic Arch Disease, Postoperative Delirium (POD)
- Trial name
- NCT07816068
- Testing
- Remimazolam Besylate, propofol
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Seoul National University Hospital
Myocarditis
FDG-PET/CT Images Comparing to MRI and Endomyocardial Biopsy in Myocarditis
Fifty hospitalized consecutive patients with clinically suspected myocarditis (MC) who meet the inclusion/exclusion criteria will be enrolled to the study.
- Trial name
- STREAM (NCT04085718)
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Cirrhosis, Diabetes Mellitus
Efficacy of Esmolol in the Identification of Cardiovascular Disorders by Cirrhosis, Diabetes Mellitus and Cardiotoxic Treatments
The purpose of this study is to assess the superiority of esmolol echocardiography over conventional echocardiography in the diagnosis of subclinical myocardial involvement associated with diabetes mellitus 2, cirrhosis and…
- Conditions
- Cirrhosis, Diabetes Mellitus, Oncologic Disorders
- Trial name
- CIBERbBECHO (NCT05769868)
- Testing
- Esmolol Injection [Brevibloc]
- Where
- 6 sites in Spain
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Consorcio Centro de Investigación Biomédica en Red (CIBER)
Prostate Cancer
Hydroxyethyl Starch and Renal Function After Radical Prostatectomy
The purpose of this project is to investigate if hydroxyethyl starch (HES) is potential nephrotoxic and examine the effects on the circulation and kidneys during administration of HES during surgery.
- Trial name
- VORA (NCT01486563)
- Testing
- Voluven (Hydroxyethyl starch 130/0,4), Sodium Chloride 9 mg/ml
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Regional Hospital Holstebro
Sudden Cardiac Death, Implantable Defibrillator User
Implantable Cardioverter Defibrillators - Improving Risk Stratification
Worldwide three million people a year die from sudden cardiac death (SCD). In most cases there is no warning and the heart is stopped by a sudden arrhythmia.
- Conditions
- Sudden Cardiac Death, Implantable Defibrillator User, Myocardial Infarction, Arrhythmias, Cardiac
- Trial name
- ICD-IRS (NCT01944514)
- Volunteers
- 92 people, healthy volunteers welcome
- Sponsor
- University Hospitals, Leicester
Lupus Nephritis, Diastolic Dysfunction
Diastolic Dysfunction and Inflammatory Biomarkers in Lupus Nephritis
This cross-sectional observational study aims to investigate the correlation between echocardiographic parameters of left ventricular diastolic dysfunction (E/A ratio, e', E/e' ratio, LAVI, and LVEF) and systemic inflammatory…
- Conditions
- Lupus Nephritis, Diastolic Dysfunction, Systemic Lupus Erythematosus, Heart Failure, Diastolic
- Trial name
- NCT07837544
- Volunteers
- 90 people
- Sponsor
- Assiut University
PRE-HYPERTENSION
Cardiovascular Effects of Purple-Fleshed Potatoes
This study is being done to evaluate the effect on cardiovascular biomarkers and anthocyanin-derived plasma metabolites of Peruvian native purple-fleshed potato consumed over a 4-week period by prehypertensive men ages 18-40…
- Trial name
- NCT07734948
- Testing
- Purple flesh potato, White flesh potato
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Instituto de Investigacion Nutricional, Peru
Ataxia Telangiectasia
Neurofilament Light- Chain in Ataxia Telangiectasia
Ataxia telangiectasia (A-T) is a rare autosomal recessive neurodegenerative disorder characterized by progressive cerebellar ataxia, immunodeficiency, chromosomal instability, and cancer susceptibility.
- Trial name
- NCT04605523
- Testing
- blood withdrawal
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Johann Wolfgang Goethe University Hospital
Cardiomyopathy, Heart Failure
An Arrhythmia Risk Predictor Trial
This prospective single-center study is an observational risk stratification trial in about 250 patients with standard indications for ICD treatment.
- Trial name
- NCT02010515
- Where
- Germany
- Volunteers
- 282 people
- Sponsor
- University Medical Center Goettingen
Venous Thromboembolism, Cancer
Prediction of Venous Thrombosis During chemotherapy-the PINPOINT Study
Cancer patients are at higher risk of getting a blood clot (known as venous thromboembolism (VTE)) especially during chemotherapy and some patients are more at risk than others.
- Trial name
- PINPOINT (NCT07196020)
- Where
- 3 sites in Ireland
- Volunteers
- 380 people
- Sponsor
- University of Dublin, Trinity College
Heart Block, CIED Related Infection
Biomarkers & Infection After Prophylactic Antibiotic in Cardiac Implantable Electronic Device Implantation
Effect of single dose \& intrapocket prophylactic antibiotic to cardiac implantable electronic device-related infection \& biomarkers
- Conditions
- Heart Block, CIED Related Infection, CIED-related Infections, Antibiotic Prophylaxis
- Trial name
- BI-PACED (NCT06448624)
- Testing
- Ampicillin sulbactam 3 days
- Where
- Indonesia
- Volunteers
- 60 people
- Sponsor
- Universitas Diponegoro
Acute Coronary Syndrome
Magnetic Nanoparticles System in Acute Coronary Syndrome
To improve the sensitivity and specificity of immunoassay, the developing trends are to lower the detection threshold and to minimize the cross reaction.
- Trial name
- NCT02226523
- Where
- 3 sites in Taiwan
- Volunteers
- 455 people
- Sponsor
- Far Eastern Memorial Hospital
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