Clinical trials: Cardiovascular Biomarkers
Thrombosis, Bleeding
Multi-Omics-Based Novel Thrombosis and Bleeding Markers and Risk Model for CHD
Patients with coronary heart disease who take dual antiplatelet therapy face two serious risks: thrombosis and major bleeding. This study aims to develop better ways to predict these risks and guide personalized treatment.
- Conditions
- Thrombosis, Bleeding, Coronary Artery Disease (CAD)
- Trial name
- NCT07523880
- Where
- 3 sites in China
- Volunteers
- 12,154 people
- Sponsor
- Xueyan Zhao
Atrial Fibrillation, Heart Failure, Diastolic
Atrial Fibrillation Ablation
Objective. Atrial fibrillation (AF) recurrence after catheter ablation (CA) is a relevant clinical problem. Methods. 123 patients with paroxysmal AF will be identified and screened for participation in this randomized…
- Trial name
- NCT03410966
- Testing
- trans cateheter ablation
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- University of Campania Luigi Vanvitelli
Coronary Artery Disease
Genetic Polymorphisms Associated With CAD
The design and purpose of the current study is to expand and validate previous findings that the IL-1 gene cluster composite genotype patterns potentiate the risk for coronary artery disease (CAD) and cardiovascular events…
- Trial name
- NCT02307422
- Testing
- IL-1 Genotypes, other SNPs associated with CAD
- Volunteers
- 1,173 people
- Sponsor
- Interleukin Genetics, Inc.
Heart Failure With Reduced Ejection Fraction, Coronary Artery Disease
Assessment of Biomarkers in Patients With Decompensated Heart Failure and Underlying Coronary Artery Disease
Assessment of Biomarkers in Patients with Decompensated Heart Failure and Underlying Coronary Artery Disease
- Trial name
- NCT03551756
- Testing
- Biomarker Assessment
- Where
- 3 sites in United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- CirQuest Labs, LLC
Cardiovascular Disease, Cigarette Smoking
Cardiovascular Disease Biomarkers in Smokers and Moist Snuff Consumers
This cross-sectional study was primarily a cardiovascular disease (CVD) study designed a) to compare selected CVD biomarker data between subjects who were long-term consumers of cigarettes or moist snuff and non-consumers of…
- Trial name
- NCT01692353
- Testing
- Subject's usual brand (UB) tobacco product
- Where
- United States
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- R.J. Reynolds Tobacco Company
Cardiomyopathy
Natural History Study in Pediatric Patients With MYBPC3 Mutation-associated Cardiomyopathy
The objective of this study is to collect information on patients with cardiomyopathy (CM) due to mutations in the MYBPC3 gene, to evaluate their disease course, burden of illness, risk factors for this disease, and the quality…
- Trial name
- MyCLIMB (NCT05112237)
- Where
- 29 sites in United States, Canada and 2 more
- Volunteers
- 200 people
- Sponsor
- Tenaya Therapeutics
Postmenopausal Flushing, Cardiovascular Risk Factor
Hot Flash as a Marker of Cardiovascular Risk in Recent Postmenopause: Effects of Non-hormonal Treatments
Hot flashes, vasomotor symptoms that affect many postmenopausal women, are associated with cardiovascular disease and endothelial dysfunction.
- Conditions
- Postmenopausal Flushing, Cardiovascular Risk Factor, Endothelial Dysfunction
- Trial name
- NCT03149419
- Testing
- Paroxetine
- Where
- Brazil
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Monoclonal B-Cell Lymphocytosis, Chronic Lymphocytic Leukemia
Risk and Clinical Consequences of Low Count Monoclonal B-cell Lymphocytosis (LC MBL)
The aim of this proposal is to identify immune biomarkers, genetic risk, and the clinical consequences of low count monoclonal B-cell lymphocytosis (LC MBL), a common premalignant condition affecting up to 17% of European adults…
- Conditions
- Monoclonal B-Cell Lymphocytosis, Chronic Lymphocytic Leukemia, Infections, Cancers
- Trial name
- MBL RiskConseq (NCT06416267)
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Haifa
Multiple System Atrophy
A Biomarker Study of ATH434 in Participants With MSA
This study will assess the safety and efficacy of ATH434 in participants with a clinical diagnosis of Multiple System Atrophy
- Trial name
- NCT05864365
- Testing
- ATH434
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Alterity Therapeutics
Paroxysmal Atrial Fibrillation
Biomarker-Guided Optimization of Transcutaneous Vagal Stimulation for Atrial (BiG tVNS-AF)
This proposal aims to determine the effects of tVNS on autonomic tone, atrial substrate and neuromodulators in patients with paroxysmal atrial fibrillation (AF), investigate the chronic effects of optimal tVNS on AF burden in…
- Trial name
- NCT05172765
- Testing
- Transcutaneous Electrical Nerve Stimulation Device
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- University of Oklahoma
Angio Edema
Research of Biomarkers Associated With the Diagnosis and Severity of Bradykinin Angioedema
The unpredictable nature of the attacks is one of the essential characteristics of bradykinin angioedema. The two main difficulties for physicians managing a patient with bradykinin angioedema are to make the diagnosis and…
- Trial name
- BRADYDIAG (NCT04963634)
- Testing
- Biobanking
- Where
- France
- Volunteers
- 1 people
- Sponsor
- University Hospital, Lille
Acute Stroke
Helsinki Ultra-acute Stroke Biomarker Study
The aim of this study is to establish diagnostic and predictive biomarkers for patients with suspected acute stroke, that are transported by EMS as candidates for thrombolytic treatment.
- Trial name
- NCT02145663
- Where
- Finland
- Volunteers
- 1,046 people
- Sponsor
- Helsinki University Central Hospital
Stroke, Acute, Ischemic Stroke
Rheo-Erythrocrine Dysfunction as a Biomarker for RIC Treatment in Acute Ischemic Stroke
This study aims to investigate whether Remote Ischemic Conditioning (RIC) improves rheo-erythrocrine dysfunction in acute ischemic stroke
- Conditions
- Stroke, Acute, Ischemic Stroke, Cerebrovascular Disorders, Central Nervous System Diseases
- Trial name
- ENOS (NCT04266639)
- Testing
- Remote Ischemic Conditioning
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Grethe Andersen
Peripheral Artery Disease
Utility of Sortilin as a Biomarker of Restenosis After Lower Extremity Endovascular Revascularization
Sortilin is a 95-kDa protein related to circulating cholesterol. It is found inside different cell types and circulating in blood and it has been associated with the risk of atherosclerosis development and cardiovascular…
- Trial name
- NCT05759130
- Where
- Italy
- Volunteers
- 207 people
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Deep Vein Thrombosis, Inflammatory Response
Effect of Tinzaparin on Inflammatory Biomarkers During the Acute Phase of Deep Vein Thrombosis
Anticoagulants influence either coagulation, inflammation and inflammatory processes in deep vein thrombosis (DVT). Acute DVT cause an inflammatory response that may persist for a long period of time.
- Trial name
- Aticks Live (NCT04741464)
- Testing
- Tinzaparin
- Where
- France
- Volunteers
- 9 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Coronary Disease
Plasma TMAO (Trimethylamine N-oxide) as a Predictive Marker in Coronary Disease Patients
The primary aim of the current research project is to determine whether the TMAO concentration in the blood can serve as a prognostic indicator of myocardial infarction.
- Trial name
- NCT03899389
- Testing
- plasma samples collection
- Where
- Poland
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Gdansk University of Physical Education and Sport
Congestive Heart Failure
Plasma ExtrAcellular RNAs and Biomarkers of Heart FaiLure During Decongestion: PEARL-HF Study
The primary objective is to measure the association between extracellular RNA (ex-RNA) levels in plasma in patients receiving aggressive outpatient therapy for CHF with (1) cardiac remodeling and (2) cardiovascular events.
- Trial name
- PEARL-HF (NCT02632656)
- Testing
- Monitoring on heart failure therapy
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Massachusetts General Hospital
Cardiomyopathies, Skeletal Muscle Disorder
Observational Study on Cardiac Biomarkers Testing in Patients with Muscular Dystrophy Cardiomyopathy
The objective of this study is to evaluate acute changes of cardiac troponin (and other cardiac biomarkers) and mid-term biovariability in patients with cardiomyopathy associated with chronic skeletal muscle disease.
- Trial name
- KYMA (NCT05779202)
- Testing
- No intervention is planned.
- Where
- Germany
- Volunteers
- 35 people
- Sponsor
- University Hospital Heidelberg
Chronic Kidney Disease
Managing Chronic Kidney Disease in Eastern North Carolina
The purpose of this program is to educate primary care physicians in four underserved clinics in eastern North Carolina about chronic kidney disease.
- Trial name
- NCT01054066
- Testing
- Chronic Kidney Disease Education
- Where
- United States
- Volunteers
- 1,257 people
- Sponsor
- East Carolina University
Ataxia Telangiectasia
Oxidative Stress, Low Grade Inflammation, Tissue Breakdown and Biomarkers in Cerebrospinal Fluid of A-T
Ataxia telangiectasia (A-T) is a rare devastating human recessive disorder characterized by progressive cerebellar ataxia, immunodeficiency, chromosomal instability, and cancer susceptibility.
- Trial name
- NCT02285348
- Testing
- Lumbar puncture
- Where
- Germany
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Johann Wolfgang Goethe University Hospital
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