Clinical trials: Cardiovascular Biomarkers
Cardiovascular Risk Factor, Burnout
Impact of Burnout on Cardiovascular and Immune Biomarkers in Healthcare Professionals - Covid-19 Pandemic in Abu Dhabi
The main objective of our project is to investigate the evolution of psychosocial, cardiovascular and immune markers in healthcare with different levels of exposure to the COVID-19 pandemic.
- Conditions
- Cardiovascular Risk Factor, Burnout, Immune Deficiency
- Trial name
- NCT04422418
- Where
- 4 sites in United Arab Emirates
- Volunteers
- 200 people
- Sponsor
- Khalifa University for Science and Technology
Heart Failure
Development of Specific Diagnostic Tools for Cardiac Insufficiency With Preserved Ejection Fraction
The MeDIAGSTOLE project aims to develop diagnostic tools for heart failure with preserved ejection fraction (IC / FEp), a pathology that is difficult to diagnose and to manage clinically in the absence of targeted treatment .
- Trial name
- MeDIAGSTOLE (NCT04699890)
- Testing
- Blood sampling, questionnaires and specific exams
- Where
- France
- Volunteers
- 91 people
- Sponsor
- University Hospital, Montpellier
Mitral Valve Reconstruction
Clinical Comparative Analysis of Bretschneider and St. Thomas Cardioplegia Solution in Case of Mitral Valve Repair Via Anterolateral Right Thoracotomy
Mitral valve reconstruction via minimal invasive antero- lateral thoracotomy is done in cardioplegia with a cardioplegic solution, either HTK-Bretschneider (Custidiol®) (a crystalloid intracellular solution) or St.
- Trial name
- NCT03818113
- Testing
- cardioplegia with HTK-Bretschneider cardioplegic solution, cardioplegia with St. Thomas cardioplegic solution
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Myocarditis, Pediatric Inflammatory Multisystem Syndrome
Multiparametric Echocardiography and Cardiac Biomarkers in Pediatric Inflammatory Heart Diseases
Acquired inflammatory or infectious cardiac diseases, in pediatrics, include Kawasaki disease, myocarditis, and Covid-19-related Pediatric Multisystemic Inflammatory Syndrome (PIMS).
- Conditions
- Myocarditis, Pediatric Inflammatory Multisystem Syndrome, Kawasaki Disease
- Trial name
- NCT05911386
- Testing
- study of biological samples and echocardiographic data and link with need of hemodynamic support
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Central Hospital, Nancy, France
Breast, Cardiovascular Calcification
Breast Arterial Calcifications as an Imaging Biomarker of Cardiovascular Risk
The goal of this observational study is to assess if there is an association between the presence of BAC and traditional cardiovascular risk factors and validate a Convolutional Neural Network (CNN) for the automatic segmentation…
- Trial name
- BAKER (NCT07156006)
- Testing
- Mammography
- Where
- Italy
- Volunteers
- 149 people
- Sponsor
- IRCCS Policlinico S. Donato
Delirium
Exploring of Serum Biomarkers of Delirium After Cardiovascular Surgery
The incidence of postoperative delirium in patients after cardiovascular surgery is very high, which seriously affects the short-term and long-term prognosis of patients, but its mechanism is not clear.
- Trial name
- NCT06007755
- Where
- China
- Volunteers
- 113 people
- Sponsor
- Huazhong University of Science and Technology
Diabetic Retinopathy, Diabetes Mellitus, Type 2
Longitudinal Observational Study of Diabetic Retinopathy Progression in Type 2 Diabetes Patients
The purpose of this clinical study is to explore structural and functional imaging and systemic biomarkers of diabetic retinopathy (DR) progression, in eyes from Type 2 Diabetes (T2D) patients with moderate to severe…
- Conditions
- Diabetic Retinopathy, Diabetes Mellitus, Type 2, Diabetic Complication, Retinal Disease
- Trial name
- IMPORTANT (NCT07458516)
- Where
- Portugal
- Volunteers
- 100 people
- Sponsor
- Association for Innovation and Biomedical Research on Light and Image
Intracranial Embolism
Electrical Cardioversion of Recent Onset Atrial Fibrillation - Silent Thromboembolic Events, Reverse Atrial Remodeling
The purpose of this study is to study the effects of transthoracic electrical cardioversion for restoration of sinus rhythm in patients who present with recent onset atrial fibrillation, with regard to new silent cerebral…
- Trial name
- ECAF-STAR (NCT02955004)
- Testing
- Electrical cardioversion
- Where
- 3 sites in Sweden
- Volunteers
- 43 people
- Sponsor
- Uppsala University Hospital
Coronary Artery Disease, Type 2 Diabetes
Empagliflozin Versus Vildagliptin in CAD Patients With T2DM
We compared the cardioprotective effects of empagliflozin, an SGLT2 inhibitor, with those of vildagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, focusing on various inflammatory biomarkers lipid profile, and cardiac…
- Trial name
- NCT06313008
- Testing
- Empagliflozin 10 MG, Vildagliptin 50 MG
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Damanhour University
Cardiovascular Diseases
Search of Biomarkers of Mineralocorticoid Receiver Activity : the Value of Neutrophil Gelatinase Associated Lipocalin (NGAL)in Serum or Urine in Human
Aldosterone and its target the mineralocorticoid receptor are implied in development of cardiovascular disease such as arterial high blood pressure or cardiac failure.
- Trial name
- NCT02129621
- Testing
- Urinary and blood lipococalin levels determination, Spironolactone
- Where
- 3 sites in France
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Cardiac Rehab, Coronary Artery Disease
Effects of Personalized Cardiac Rehabilitation on miRNAs and Biochemical Biomarkers in Patients With Coronary Artery Disease
This prospective interventional study aims to investigate changes in specific microRNAs (miRNAs) and biochemical biomarkers following a personalized cardiac rehabilitation program in patients with coronary artery disease.
- Trial name
- NCT07841847
- Testing
- Personalized Cardiac Rehabilitation Program
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Kutahya Health Sciences University
Vasculitis
Search for BIO Diagnostic and Prognostic Markers in Adult VAScularitis
To date, there are no reliable diagnostic blood markers of adult vasculitis. To date, the diagnosis of vasculitis is based on invasive procedure, biopsy of affected tissues potentially at risk of complication .
- Trial name
- BIOVAS (NCT05565885)
- Testing
- Sampling
- Where
- France
- Volunteers
- 225 people
- Sponsor
- University Hospital, Tours
Coronary Artery Disease, Ischemic Heart Disease
Volatilome and Single-Lead Electrocardiogram Optimize Ischemic Heart Disease Diagnosis Using Machine Learning Models
This is a prospective, case-control, single-center, observational, non-randomized study. It is designed to evaluate the diagnostic accuracy of functional tests involving physical exertion monitored via a 12-lead ECG, combined…
- Conditions
- Coronary Artery Disease, Ischemic Heart Disease, Chronic Coronary Disease, Angina Pectoris
- Trial name
- NCT06181799
- Testing
- Mass spectrometry using the PTR TOF-1000 (IONICON PTR-TOF-MS - Trace VOC Analyzer, Eduard-Bodem-Gasse 3, 6020 Innsbruck, Austria (Europe).
- Where
- Russia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Moyamoya Disease
Biomarker-Led Optimization of Successful Surgical Outcomes in Moyamoya
The goal of this work is to use advanced magnetic resonance imaging (MRI) methods to assess brain blood flow and vascular function in adults with moyamoya disease (MMD).
- Trial name
- BLOSSOM (NCT06634004)
- Testing
- BOLD MRI
- Where
- 2 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Premature Birth, Brain Injuries
S100B as a Marker of Brain Injury of Preterm Infants
The improvement of treatment of preterm neonates improved their survival, however there is still significant portion of preterm infants (specifically very preterm infants) that suffers from brain insults and as a result…
- Conditions
- Premature Birth, Brain Injuries, Leukomalacia Periventricular, Developmental Disabilities
- Trial name
- PTS100B (NCT02082535)
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Sheba Medical Center
End Stage Renal Disease, Cardiovascular Disease
Pomegranate and Hemodialysis Pilot Trial
In this study, the investigators will administer pomegranate juice or fruit extract as a targeted antioxidant therapy to hemodialysis patients.
- Conditions
- End Stage Renal Disease, Cardiovascular Disease, Inflammation
- Trial name
- POM Pilot (NCT01562340)
- Testing
- Pomegranate juice, Pomegranate fruit extract
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Washington
Heart Failure
The Role of Nuclear Imaging in Heart Failure
Heart failure is a clinical syndrome of exercise intolerance and/or congestion. The potential roles of myocardial perfusion and metabolic abnormalities in subjects with cardiovascular risks, metabolic disease and heart failure…
- Trial name
- NCT02697669
- Testing
- 18F-FDG PET
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Far Eastern Memorial Hospital
Burns
Cardiovascular Biomarkers and Lung Edema in Severe Burns Patients
Burn injury leads to hypovolemic then distributive shock. Fluid resuscitation remains the cornerstone of initial treatment of burn shock.
- Trial name
- CAROLE (NCT03271268)
- Where
- France
- Volunteers
- 36 people
- Sponsor
- Saint-Louis Hospital, Paris, France
ICAS - Intracranial Atherosclerosis, Stroke Ischemic
MPR for Stroke Risk Assessment of ICAS
Intracranial atherosclerotic stenosis (ICAS) carries substantial stroke risk despite optimal medical treatment. Current risk stratification relies primarily on stenosis severity, but novel hemodynamic markers may improve…
- Conditions
- ICAS - Intracranial Atherosclerosis, Stroke Ischemic, Hemodynamic
- Trial name
- NCT07309718
- Testing
- Standardized medical therapy targeting vascular risk factors and stroke prevention
- Where
- China
- Volunteers
- 400 people
- Sponsor
- Xuanwu Hospital, Beijing
Cardiac Arrhythmia
N-Acetylcysteine Protection Against Radiation Induced Cellular Damage
Catheter ablation procedures (CAPs) are first line treatment for a great variety of cardiac arrhythmias. CAPs require X-Ray imaging; consequently, CAPs cause ionizing radiation (IR) exposure for patients.
- Trial name
- CARAPACE (NCT04154982)
- Testing
- Acetyl cysteine
- Where
- Italy
- Volunteers
- 181 people
- Sponsor
- Centro Cardiologico Monzino
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