Clinical trials: Cardiovascular Biomarkers
Heart Defects, Congenital
Lactate Levels During Cardiopulmonary Bypass in Pediatric Patients
Many variables measured in critically ill patients have been used to estimate severity of disease, prognosticate morbidity and mortality, evaluate costs of treatment, and finally indicate specific treatment and monitor the…
- Trial name
- NCT02618707
- Testing
- Lactate
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Assiut University
Acute Stroke
Evaluation Study of Early Administration of Evolocumab After Thrombolysis in Patients With Atherosclerotic Acute Ischemic Stroke
This study is a Phase IIa clinical trial initiated by the researchers, which is prospective, single-center, randomized, open-label, with blinded endpoint evaluation (PROBE design).
- Trial name
- EPOCH-LYSIS (NCT07301372)
- Testing
- Ivolumab 420mg (three vials)
- Where
- China
- Volunteers
- 132 people
- Sponsor
- The Affiliated Hospital of Xuzhou Medical University
Heart Failure, Heart Failure, Systolic
Apple-CPET Ted Rogers Understanding Exacerbations of Heart Failure
Heart Failure (HF) is a complex disease associated with the highest burden of cost to the healthcare system. The cardiopulmonary exercise test (CPET) is instrumental in determining the prognosis of patients with HF.
- Conditions
- Heart Failure, Heart Failure, Systolic, Heart Failure, Diastolic, Heart Transplantation
- Trial name
- TRUE-HF (NCT05008692)
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University Health Network, Toronto
Thromboembolism, Postpartum DVT
Impact of Prophylactic Low-molecular Weight Heparin Dosing on Clotting Parameters Following Cesarean Delivery
The aim of this study is to evaluate the efficacy of two dosing regimens of low molecular weight heparin (LMWH) to reach prophylactic anti-factor Xa levels in post-cesarean delivery women.
- Conditions
- Thromboembolism, Postpartum DVT, Thrombosis
- Trial name
- NCT04305756
- Testing
- Enoxaparin
- Where
- United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- University of Utah
Aortic Valve Stenosis, Aortic Valve Insufficiency
Von Willebrand Factor Point-of-care Testing to Improve Minimally Invasive TAVI Outcomes
Paravalvular regurgitation (PVR) is an important complication of Transcatheter Aortic Valve Implantation (TAVI) that is associated with a 2.5-fold increase risk of mortality.
- Trial name
- WITAVI-REAL (NCT03728049)
- Testing
- CT-ADP performed during TAVI procedure, No CT-ADP performed during TAVI procedure
- Where
- 9 sites in France
- Volunteers
- 944 people
- Sponsor
- University Hospital, Lille
Diabetes Mellitus, Diabetic Foot
Identification of Biomarkers for the Study of the Diabetic Foot and Evolution.
The European Working Group on Sarcopenia in the Elderly1 defines sarcopenia as a disorder of the progressive and generalized musculoskeletal system [1], which is associated with the increase and probability of adverse outcomes…
- Conditions
- Diabetes Mellitus, Diabetic Foot, Sarcopenia, Neuropathy, Diabetic
- Trial name
- SCFOOT (NCT05783700)
- Testing
- BIOIMPEDANCEMETRY
- Volunteers
- 300 people
- Sponsor
- Esther Soler
Preeclampsia, Eclampsia
Cardiac Biomarkers in Preeclampsia: Prediction of Disease and the Risk of Future Cardiovascular Events in Survivors
SUMMARY Background: Improvements in the management and prevention of obstetric haemorrhage and sepsis, in addition to magnesium sulphate for preeclampsia have led to significant reduction in global maternal mortality rates; thus…
- Trial name
- PreeclampBIO (NCT04468763)
- Where
- Nigeria
- Volunteers
- 263 people, healthy volunteers welcome
- Sponsor
- Babcock University
Diabetic Foot Ulcer (DFU)
Acute-to-chronic Glycemic Ratio (ACGR) is a Marker of DFUs .
Diabetic foot ulcers (DFUs) have resulted from peripheral arterial ischemia and peripheral neuropathy that are complicated with infections and amputation of the lower extremities.
- Trial name
- ACGR (NCT06725238)
- Testing
- Acute-to-chronic glycemic ratio
- Where
- Iraq
- Volunteers
- 80 people
- Sponsor
- University of Diyala
Influence of 8 Months of Increased Physical Activity Workload on Osteoprotegerin and Endocan Levels
IPHAAB-study Influence of Physical Activity on Atherosclerosis Biomarkers
This study investigates the influence of an increased physical activity and sports workload in formerly nonsporting healthy individuals on current promising biomarkers of atherosclerosis research.
- Trial name
- NCT02097199
- Testing
- Increased sports workload
- Where
- Austria
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Cardiovascular Disease, Oxidative Stress
Study of Chokeberry to Reduce Cardiovascular Disease Risk in Former Smokers
The purpose of this project is to determine whether chokeberry polyphenols mitigate cardiovascular disease risk in former smokers.
- Trial name
- NCT01541826
- Testing
- Chokeberry Extract, Chokeberry extract capsule, acute
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- University of Connecticut
Heart Failure, Dyspnea
Diagnostic and Prognostic Value of New Biomarkers in Patients With Heart Disease
The objective of this work is to investigate and then to sequence new biomarkers in the plasma of patients presenting with dyspnea secondary or not to heart failure, and study their diagnostic and prognostic value.
- Conditions
- Heart Failure, Dyspnea, Pulmonary Disease
- Trial name
- NCT01374880
- Where
- France
- Volunteers
- 3,000 people
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Pediatric Hypertension, Primary Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial…
- Conditions
- Pediatric Hypertension, Primary Hypertension, Endothelial Dysfunction
- Trial name
- HYPER-endoEV-c (NCT07728643)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Preterm Birth, Cardiovascular Diseases
Preterm Birth and Biomarkers for Cardiovascular Disease
Preterm birth is associated with maternal increased risk of cardiovascular disease later in life. In an observational case- control study, investigators want to evaluate whether women with preterm birth have increased levels of…
- Trial name
- BIO-PRETERM (NCT05693285)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Uppsala University
Acute Ischemic Stroke
Proteomic Study of Chuanhong Zhongfeng Capsule in the Treatment of ACI
Acute cerebral infarction is characterized by high disability rate and high recurrence rate, which poses a great threat to the life and health of the nation.
- Trial name
- NCT06874140
- Testing
- Chuanhong Zhongfeng capsule
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Yingyue Ding
Intraabdominal Hypertension, Prone Postion
Changes of Intra Abdominal Pressure During Surgeries in Prone Position as a Marker of Renal Damage
Background: Patients undergoing surgical operations in prone position do not have a measure of intra abdominal pressure as a standard procedure.
- Conditions
- Intraabdominal Hypertension, Prone Postion, Spine Surgery
- Trial name
- NCT05626868
- Testing
- Intra abdominal pressure measurement
- Where
- Poland
- Volunteers
- 24 people
- Sponsor
- Medical University of Warsaw
AKI - Acute Kidney Injury, Fluid Balance
Fluid Balance Guided by Modified Venous Excess Ultrasonography Versus Standard Care in Patients With Acute Kidney Injury Receiving Continuous Renal Replacement Therapy
The goal of this randomised controlled trial is to compare the cumulative fluid balance over the first 72 h following inclusion guided by mVExUS versus standard of care in critically ill patients with acute kidney injury…
- Conditions
- AKI - Acute Kidney Injury, Fluid Balance, Acute Circulatory Failure, Continuous Renal Replacement Therapy (CRRT)
- Trial name
- mVExUS-CRRT (NCT07346118)
- Testing
- mVExUS-guided fluid management
- Where
- 2 sites in Thailand
- Volunteers
- 126 people
- Sponsor
- Chulalongkorn University
Cadasil, Angiopathy; Cerebral
Development of New Biomarkers With Magnetic Resonance Imaging for Longitudinal Studies in CADASIL Angiopathy
CADASIL (Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy) is an cerebral microangiopathy secondary to mutations in the NOTCH3 gene located on chromosome 19.
- Trial name
- BIOMRI_CADA (NCT04036084)
- Testing
- Cerebral Magnetic resonance imaging (MRI)
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cigarette Smoking, Inflammatory Response
Menthol, Inflammation, and Nicotine Transition Study
This study will focus on examining the potential impact of menthol flavoring in cigarettes on biomarkers of systemic inflammation as a subclinical indicator of cardiovascular disease risk.
- Trial name
- MINT (NCT06232447)
- Testing
- Cigarette Type Switching
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Rosalind Franklin University of Medicine and Science
Sepsis, Infective Endocarditis
Study of Leukocyte Immunophenotype and the Lipid Transport System as Predictive Biomarkers of Severe Bacterial Infections
Current study evaluates the relationship between cell immunity and lipid transport systems in patients with severe bacterial infections (on the model of pneumonia, infective endocarditis, sepsis) in order to develop new methods…
- Conditions
- Sepsis, Infective Endocarditis, Pneumonia, Bacterial
- Trial name
- NCT04178915
- Testing
- Bood leukocyte subsets, The cholesterol content of the cell membrane of T-cells and monocytes
- Where
- Belarus
- Volunteers
- 100 people
- Sponsor
- The Republican Research and Practical Center for Epidemiology and Microbiology
Hypertrophic Cardiomyopathy
Predictive Factors and Consequences of Myocardial Fibrosis in Hypertrophic Cardiomyopathy
Fibrosis, myocardial deformation and biomarkers in hypertrophic cardiomyopathy (HCM)
- Trial name
- HCM (NCT02922517)
- Where
- France
- Volunteers
- 115 people
- Sponsor
- Nantes University Hospital