Clinical trials: Cardiovascular Biomarkers
Healthy Volunteers
Evaluation of Egg Consumption and Its Enrichment With Annatto on Cardiovascular Risk and Satiety in Healthy Adults
Healthy adult volunteers (n= 105; 18-59 years) were randomly allocated to consume daily for 8 weeks, either two whole eggs (egg group), two whole eggs added with annatto (annatto-enriched egg group), or two egg whites (control).
- Trial name
- EGGANT (NCT05088577)
- Testing
- Whole egg, Annatto-enriched egg, Egg whites - Control
- Where
- Colombia
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Universidad de Antioquia
Prostatic Neoplasms, Cardiovascular Diseases
Endothelial Function in Prostate Cancer Patients on Degarelix vs. Luteinizing Hormone-Releasing Hormone Agonists
The purpose of this study is to test whether Degarelix is associated with less endothelial dysfunction (an intermediate in the development of cardiac disease) and cardiovascular biomarkers compared to LHRH agonists.
- Trial name
- NCT02475057
- Testing
- Degarelix (LHRH antagonist), LHRH agonist, EndoPAT2000
- Where
- 2 sites in Israel
- Volunteers
- 80 people
- Sponsor
- Rabin Medical Center
Cardiovascular Diseases, Metabolic Syndrome X
Aspirin Dose and Atherosclerosis in Patients With Metabolic Syndrome
The purpose of the study is to test higher versus lower doses of aspirin on markers of atherosclerosis in patients at risk of a first heart attack.
- Conditions
- Cardiovascular Diseases, Metabolic Syndrome X, Atherosclerosis
- Trial name
- PAD (NCT00272311)
- Testing
- Aspirin
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Florida Atlantic University
Acute Coronary Syndromes
Prognostic Value of Biomarkers Associated With Endothelial Progenitor Cells Mobilization in Acute Coronary Syndromes
This prospective study aimed to validate a new prognostic approach of endothelial progenitor cells associated biomarkers in patients with acute coronary syndromes .
- Trial name
- NCT02117037
- Testing
- blood sample
- Where
- France
- Volunteers
- 180 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Psoriasis, Cardiovascular Diseases
Serum Lipid Levels and Other Biomarkers of Cardiovascular Disease in Patients With Psoriasis
Psoriasis patients are known to be at increased risk for heart disease. This may be due to the increased prevalence of cardiovascular disease risk factors in this population, including high blood pressure, diabetes, obesity, and…
- Conditions
- Psoriasis, Cardiovascular Diseases, Dyslipidemia
- Trial name
- NCT01019200
- Where
- United States
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- George Washington University
Cardiomyopathy, Ischemic Heart Disease
Biomarkers of Inherited Cardiovascular Conditions
The National Heart Centre Singapore has recently created a biorepository that is IRB approved for the use in genetic studies: "molecular and imaging studies of cardiovascular health and disease (CIRB Ref: 2013/605/C)".
- Trial name
- NCT02804256
- Testing
- Blood Sample Collection
- Where
- Singapore
- Volunteers
- 10 people
- Sponsor
- National Heart Centre Singapore
Multiple Myeloma
Lenalidomide Maintenance Therapy for Multiple Myeloma
Background: Multiple myeloma is rarely curable, but it is treatable. Initial treatment is directed at controlling symptoms and reducing the number of myeloma cells. It continues until the cancer stops responding to treatment.
- Trial name
- NCT01675141
- Testing
- Lenalidomide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- National Cancer Institute (NCI)
Heart Failure With Reduced Ejection Fraction (HFrEF), Congestive Heart Failure(CHF)
BIOmarker Based Diagnostic TOOLkit to Personalize Pharmacological Approaches in Congestive Heart Failure
This retrospective study will take advantage of an existing EU-funded dataset, the BIOlogy Study to TAilored Treatment in Chronic Heart Failure (BIOSTAT-CHF), which was designed to identify biomarkers related to the response to…
- Trial name
- NCT07470554
- Where
- Italy
- Volunteers
- 4,254 people
- Sponsor
- IRCCS Azienda Ospedaliero-Universitaria di Bologna
Heart Failure, OSA - Obstructive Sleep Apnea
Mandibular Advancement to Reduce Ventricular Load and Improve Quality-of-life in Heart Failure
Heart failure with reduced ejection fraction (HFrEF) is a serious condition that limits daily activities and often leads to hospital stays and early death.
- Trial name
- MARVEL-HF (NCT07460505)
- Testing
- Mandibular advancement device
- Where
- Singapore
- Volunteers
- 328 people
- Sponsor
- National University Hospital, Singapore
Lung Cancer, Cardiovascular Disease (CVD)
Optimised Lung Cancer Screening to Prevent Cardiovascular and Pulmonary Diseases Coupled With Primary Prevention
This project aims to implement a health prevention program for smokers or former smokers including early detection of lung cancer, cardiovascular disease (CVD) and chronic obstructive pulmonary disease (COPD).
- Conditions
- Lung Cancer, Cardiovascular Disease (CVD), Chronic Obstructive Pulmonary Disease (COPD)
- Trial name
- SMAC-1 (NCT04315766)
- Where
- Italy
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Istituto Clinico Humanitas
Breast Cancer
Acute Exercise Cardioprotection From Doxorubicin
In rodents, a single bout of exercise prior to injection of a chemotherapy agent used to treat breast cancer prevents or attenuates a number of markers of cardiac injury.
- Trial name
- NCT02006979
- Testing
- exercise
- Where
- Canada
- Volunteers
- 27 people
- Sponsor
- University of British Columbia
Lung Transplant Failure
Biomolecular Phenotyping of Lung Transplant Recipients
Primary graft dysfunction (PGD) is a common problem after a lung transplant. It's a sudden lung injury that affects around 30% of patients within 72 hours of getting a new lung.
- Trial name
- LUTX_phenotype (NCT06125535)
- Testing
- Sub-phenotyping by biomarkers concentration
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- Policlinico Hospital
Osteoarthritis
Hydroxyethyl Starch and Renal Function After Hip Replacement Surgery
The purpose of this project is to investigate if hydroxyethyl starch (HES) is potential nephrotoxic and examine the effects on the circulation and kidneys during administration of HES during surgery.
- Trial name
- VOHO (NCT01486576)
- Testing
- Voluven (Hydroxyethyl starch 130/0,4), Sodium Chloride 9 mg/ml
- Where
- Denmark
- Volunteers
- 42 people
- Sponsor
- Regional Hospital Holstebro
Exercise
The Munich Cardiovascular Adaptation in Young Athletes Plus Study
The aim of the 3-year longitudinal study is to investigate the cardiovascular system's response to training loads in young athletes.
- Trial name
- MuCAYAplus (NCT06259617)
- Where
- Germany
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Technical University of Munich
Coronary Heart Disease
A Study to Investigate the Efficacy, Safety, and Tolerability of DFV890 for Inflammatory Marker Reduction in Adult Participants With Coronary Heart Disease and Elevated hsCRP
This Phase 2a clinical trial evaluated the effectiveness, safety, and tolerability of increasing dose strengths of an oral daily medication, DFV890, administered for 12 weeks, to reduce key markers of inflammation related to CVD…
- Trial name
- NCT06031844
- Testing
- DFV890
- Where
- 7 sites in United States, Canada
- Volunteers
- 24 people
- Sponsor
- Novartis Pharmaceuticals
Cerebrovascular Disorders, Ischemic Attack, Transient
Biomarkers for the Diagnosis of Transient Ischemic Attack
A transient ischemic attack (TIA) should be considered an emergency prevention opportunity in order to avoid recurrence as cerebral infarction (CI) serious (fatal or disabling).
- Trial name
- MAESTRO (NCT02799511)
- Testing
- protein expression
- Where
- France
- Volunteers
- 25 people
- Sponsor
- University Hospital, Caen
Congenital Heart Disease
Fontan Associated Liver Disease and the Evaluation of Biomarkers for Disease Severity Assessment
Background: In Fontan Associated Liver Disease (FALD), congestion of blood in the liver causes cirrhosis. This condition can cause death. Researchers want to understand what triggers this process and find new treatments for it.
- Trial name
- NCT05213598
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Cardiovascular Disease, Obstructive Sleep Apnea
Heart Biomarker Evaluation in Apnea Treatment
This study examines the role of sleep apnea treatment in improving cardiovascular biomarkers.
- Conditions
- Cardiovascular Disease, Obstructive Sleep Apnea, Coronary Artery Disease
- Trial name
- HeartBEAT (NCT01086800)
- Testing
- Healthy Lifestyles and Sleep Education plus PAP, Healthy Lifestyles and Sleep Education plus Supplemental Oxygen, Healthy Lifestyles and Sleep Education
- Where
- 4 sites in United States
- Volunteers
- 318 people
- Sponsor
- Brigham and Women's Hospital
TAVI(Transcatheter Aortic Valve Implantation), Conduction Disorder
Biomarkers of Inflammation and Fibrosis in Conduction Disorders After TAVI
Prediction of conduction disorders (CDs) in patients with severe aortic stenosis (AS) undergoing transcatheter aortic valve implantation (TAVI) is an important and complex process with a significant impact on patient outcomes.
- Conditions
- TAVI(Transcatheter Aortic Valve Implantation), Conduction Disorder, Aortic Stenosis, Permanent Pacemaker Implantation
- Trial name
- NCT07201363
- Testing
- Biomarkers of inflammation and fibrosis in pre-procedural serum blood samples, Transthoracic echocardiography with myocardial deformation analysis and staging according to the extent of cardiac damage related to AS
- Where
- Croatia
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Oxidative Stress, Inflammation
Effect of Dietary Supplemental Fish Oil in Alleviating Health Hazards Associated With Air Pollution
This study aims to evaluate whether dietary supplementation with fish oil can protect against the cardiopulmonary alterations linked to air pollution
- Conditions
- Oxidative Stress, Inflammation, Blood Pressure, Vasoconstriction
- Trial name
- NCT03255187
- Testing
- Fish oil supplementation, Sunflower seed oil supplementation
- Where
- China
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Fudan University
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