Clinical trials: Cardiovascular Complications
Mechanical Heart Valve Recipients
Very Low Dose Oral Anticoagulation and Thromboembolic and Bleeding Complications
We aim to investiagte whether very low dose self management of oral anticoagulation is superior to low dose oral anticoagulation in order to prevent bleeding events in patients undergoing mechanuical heart valve replacement.
- Trial name
- ESCAT III (NCT00528671)
- Testing
- phenprocoumon
- Where
- Germany
- Volunteers
- 1,571 people
- Sponsor
- Heart and Diabetes Center North-Rhine Westfalia
Bleeding Disorder, Ischemic Stroke
XIENCE 28 USA Study
The XIENCE 28 USA Study is prospective, single arm, multi-center, open label, non-randomized trial to evaluate safety of 1-month (as short as 28 days) dual antiplatelet therapy (DAPT) in subjects at high risk of bleeding (HBR)…
- Conditions
- Bleeding Disorder, Ischemic Stroke, Hemorrhagic Stroke, Hematological Diseases
- Trial name
- NCT03815175
- Testing
- XIENCE, DAPT (aspirin and/or P2Y12 receptor inhibitor)
- Where
- 111 sites in United States, Austria and 13 more
- Volunteers
- 1,605 people
- Sponsor
- Abbott Medical Devices
Analgesia, Obstetrical, Coagulation Defect; Postpartum
IV Ketorolac on Platelet Function Post-Cesarean Delivery
Cesarean delivery has become the most common surgical procedure in the US. Non-steroidal anti-inflammatory drugs (NSAIDs) have been shown to improve the quality of post-cesarean analgesia and markedly reduce opioid consumption.
- Conditions
- Analgesia, Obstetrical, Coagulation Defect; Postpartum, Nonsteroidals (NSAIDs)Toxicity, Postpartum Hemorrhage
- Trial name
- KetoPltAgg (NCT03805607)
- Testing
- Ketorolac Tromethamine 30 MG/ML
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
Cancer
Itraconazole Compared With Fluconazole to Prevent Infections in Patients Undergoing Peripheral Stem Cell or Bone Marrow Transplantation
RATIONALE: Giving itraconazole or fluconazole may be effective in preventing infections in patients undergoing peripheral stem cell or bone marrow transplantation.
- Trial name
- NCT00003883
- Testing
- fluconazole, itraconazole
- Where
- 2 sites in United States
- Volunteers
- 578 people
- Sponsor
- Fred Hutchinson Cancer Center
Peripheral Arterial Disease, Peripheral Artery Disease
Implementation of Telemedicine for Patient With Lower Extremity Wounds
The objective of this study is to determine if patients with lower extremity wounds in rural communities who undergo specialty referral through telemedicine have expedited care compared to patients who are treated through…
- Conditions
- Peripheral Arterial Disease, Peripheral Artery Disease, Peripheral Vascular Diseases, Diabetic Foot
- Trial name
- NCT04440839
- Testing
- Telemedicine specialty consultation
- Where
- United States
- Volunteers
- 116 people
- Sponsor
- University of California, Davis
Healthy, Cancer
Archival of Human Biological Samples in CU-Med Biobank
CU-Med Biobank collaborates with different researchers for collecting and distributing human biospecimens and clinical data for assisting scientific research.
- Conditions
- Healthy, Cancer, Heart Diseases, Neurological Diseases or Conditions
- Trial name
- NCT04706481
- Testing
- Specimen Collection
- Where
- Hong Kong
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Heart Failure Acute, Heart Failure; With Decompensation
Diuretic and Natriuretic Effect of High-dose Spironolactone in Patients With Acute Heart Failure
This is a prospective, single-center, open-label and randomized trial for evaluation of the effect of a 5-day administration of high doses of spironolactone (≥100mg daily) on diuresis, natriuresis, weight loss and levels of…
- Trial name
- DANAUS-AHF (NCT04618601)
- Testing
- Spironolactone
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- Laikο General Hospital, Athens
Multiple Myeloma
Lymphodepleting Total Body Irradiation (TBI) Plus Cyclophosphamide Prior to Ciltacabtagene Autoleucel (Carvykti; Cilta-cel) for Multiple Myeloma (MM) Patients With Impaired Renal Function
Treatment for relapsed/refractory multiple myeloma continues to evolve with the approval of highly effective anti-BCMA CAR T therapies in recent years.
- Trial name
- NCT06623630
- Testing
- Cyclophosphamide, Ciltacabtagene Autoleucel, Total body irradiation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Washington University School of Medicine
Septic Shock
Discontinuation Order of Vasopressors in Septic Shock
The purpose of this study is to evaluate the incidence of hypotension based on the discontinuation order of norepinephrine and vasopressin in patients receiving concomitant norepinephrine and vasopressin infusions for the…
- Trial name
- DOVSS (NCT01493102)
- Testing
- Vasopressin, Norepinephrine
- Where
- South Korea
- Volunteers
- 78 people
- Sponsor
- Samsung Medical Center
Cardiovascular Autonomic Neuropathy, Type 2 Diabetes
Finerenone Treatment for Diabetic Cardiovascular Autonomic Neuropathy: the FibroCAN Study
Diabetic neuropathy is a serious and common complication of diabetes that currently has no cure. One form of this condition is cardiovascular autonomic neuropathy (CAN), which affects about 20% of people with diabetes-an…
- Conditions
- Cardiovascular Autonomic Neuropathy, Type 2 Diabetes, Diabetic Neuropathies
- Trial name
- FibroCAN (NCT06906081)
- Testing
- Kerendia (Finerenone, BAY94-8862)
- Where
- 2 sites in Denmark
- Volunteers
- 100 people
- Sponsor
- Peter Rossing
Postoperative Pain, Renal Insufficiency
Pain Management After Cardiac Surgery - Opioids or NSAID
The aim of this randomized controlled study is to shed light on the analgesic properties and side-effect profile of an opiod-based regimen as opposed to an Ibuprofene based regimen.
- Conditions
- Postoperative Pain, Renal Insufficiency, Myocardial Infarction
- Trial name
- NCT02479165
- Testing
- Ibuprofene, Oxycodone
- Volunteers
- 182 people
- Sponsor
- Aalborg University Hospital
Diabetes, Diabetic Retinopathy
Genetic Association of Diabetic Retinopathy-1
The primary purpose of the study is to investigate allele frequencies of candidate genes in Chinese diabetic patients with or without known diabetic retinopathy.
- Trial name
- DMR-1 (NCT01298245)
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Infant, Premature, Ductus Arteriosus, Patent
Plasma B-Type Natriuretic Peptide Concentrations in Preterm Infants < 28 Weeks
The aim of the study was to evaluate BNP in preterm infants < 28 weeks on the second day of life, when it is still unknown, if a patent ductus arteriosus is hemodynamic significant or not.
- Conditions
- Infant, Premature, Ductus Arteriosus, Patent, Natriuretic Peptide Brain
- Trial name
- NCT00528736
- Where
- Germany
- Volunteers
- 82 people
- Sponsor
- Charite University, Berlin, Germany
Diabetic Retinopathy
Evaluation of RC28-E Injection in Diabetic Retinopathy
This is a randomized, open-label, multicenter study of the efficacy and safety of RC28-E injection (a chimric decoy receptor trap fusion protein by dual blockage of VEGF and FGF-2) in the treatment of patients with moderately…
- Trial name
- NCT04782128
- Testing
- RC28-E injection
- Where
- China
- Volunteers
- 120 people
- Sponsor
- RemeGen Co., Ltd.
Cardiovascular Disease, Surgical Site Infection
Innovative Sternal Closure Techniques: Evaluating STRATAFIX™ and DERMABOND™ for Reduced Complications in CABG Patients
The goal of this clinical trial is to learn if a new method of closing the breastbone after heart bypass surgery can improve healing and reduce complications in adults undergoing coronary artery bypass graft (CABG) surgery.
- Conditions
- Cardiovascular Disease, Surgical Site Infection, Superficial Sternal Wound Infection, Mediastinitis
- Trial name
- NCT07507409
- Testing
- Knotless Barbed Sutures, Mesh-based Topical Skin Adhesive
- Volunteers
- 401 people
- Sponsor
- Unity Health Toronto
Diabetes, Diabetic Foot Ulcer
The Mount Sinai Diabetic Foot Ulcer Prospective Trial
The purpose of this study is to evaluate whether placing stent(s) for a blockage in a leg vein will help improve the healing of diabetic foot ulcers (DFU).
- Conditions
- Diabetes, Diabetic Foot Ulcer, Edema
- Trial name
- NCT03404895
- Testing
- Conventional Therapy, Venous Stent(s)
- Where
- United States
- Sponsor
- Windsor Ting
Multiple Myeloma, End Stage Renal Disease
Combined Bone Marrow Transplantation (BMT) and Renal Transplant for Multiple Myeloma (MM) With End Stage Renal Disease (ESRD)
The primary objective is to cure multiple myeloma with less toxic allogeneic bone marrow transplantation while inducing renal allograft tolerance through mixed chimerism in patients with end stage renal failure and multiple…
- Trial name
- NCT00854139
- Testing
- Cyclophosphamide, anti-thymocyte globulin, Kidney transplant, Thymic irradiation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Massachusetts General Hospital
Hypertension, Preeclampsia
A Randomized Feasibility Trial Comparing Drospirenone and Norethindrone for Postpartum Hypertension Management in Preeclampsia
This is an open-label, randomized feasibility trial in which patients admitted to Oregon Health \& Science University (OHSU) after a pregnancy complicated by preeclampsia who are considering a progestin-only pill contraception…
- Trial name
- NCT07293728
- Testing
- Norethindrone 0.35 MG, Drospirenone
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Oregon Health and Science University
Postoperative Cardiovascular Complications
Preoperative BNP as Biomarker of Postoperative Cardiovascular Complications
BNP is a hormone that predicts preoperatively the occurrence of postoperative cardiovascular complications. In practice, the problem is that the practitioner don't know the most opportune moment for the preoperative sample or…
- Trial name
- BNP (NCT02570607)
- Testing
- BNP dosage
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Diabetic Foot Ulcer
Amnio-Maxx in Patients With Diabetic Foot Ulcers Unresponsive to Standard of Care Treatment Alone
This randomized controlled study evaluates the adjuvant use of Amnio-Maxx in patients with diabetic foot ulcers
- Trial name
- NCT06572839
- Testing
- Amnio-Maxx
- Where
- 12 sites in United States
- Volunteers
- 74 people
- Sponsor
- Capsicure, LLC
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