Clinical trials: Cardiovascular Complications
Diffuse Diabetic Macular Edema
Safety Study of iCo-007 Intravitreal Injection to Treat Diabetic Macular Edema
The goal of the study is to evaluate the safety and tolerability of 4 different doses of iCo-007 Intravitreal Injection in patients with diffuse diabetic macular edema.
- Trial name
- NCT00886808
- Testing
- iCo-007 Intravitreal Injection
- Where
- 4 sites in United States
- Volunteers
- 15 people
- Sponsor
- iCo Therapeutics Inc.
Lung Transplant Failure
Lung PGD Biomarkers in Organ Donors
PGD is a syndrome characterized by alveolocapillary barrier structural and functional alterations with surfactant inactivation and vascular permeability increase, which cause lung edema, parenchymal infiltrate and progressive…
- Trial name
- NCT03089489
- Testing
- lung biomarkers in organ donor for PGD in lung recipient
- Volunteers
- 50 people
- Sponsor
- University Hospital of Mont-Godinne
Cerebral Palsy, Intraventricular Hemorrhage
Beneficial Effects of Antenatal Magnesium Sulfate (BEAM Trial)
As many more premature infants survive, the numbers of these infants with health problems increases. The rate of cerebral palsy (CP) in extremely premature infants is approximately 20%.
- Conditions
- Cerebral Palsy, Intraventricular Hemorrhage, Periventricular Leukomalacia, Pulmonary Edema
- Trial name
- BEAM (NCT00014989)
- Testing
- magnesium sulfate
- Where
- 17 sites in United States
- Volunteers
- 2,136 people
- Sponsor
- The George Washington University Biostatistics Center
Morbid Obesity, Thromboembolism
Prophylaxis of Venous Thromboembolism After Bariatric Surgery
This study is a prospective evaluation of the relationship between lean body weight and anti-Xa activity and 5700 International Units (IU) nadroparin 4 hours after subcutaneous administration in morbidly obese patients after…
- Conditions
- Morbid Obesity, Thromboembolism, Bypass Complications
- Trial name
- NCT02295150
- Testing
- Nadroparin
- Where
- Netherlands
- Volunteers
- 50 people
- Sponsor
- Rijnstate Hospital
Shortness of Breath, Chest Pain
Checklists Resuscitation Emergency Department
The study will systematically evaluate how an emergency manual-a collection of checklists and fact sheets-affects the performance of resuscitation teams during the management of priority one patients in an emergency department.
- Conditions
- Shortness of Breath, Chest Pain, Abdominal Pain, Altered Mental Status
- Trial name
- NCT05649891
- Testing
- Emergency Manual
- Volunteers
- 2,000 people
- Sponsor
- Region Skane
Wound Heal, Diabetic Foot Ulcer
EDX110 Randomized Control Trial for Treatment of DFUs
Prospective, multi-centered, observer blinded, pre-market study, 1:1 randomized control trial, to determine if addition of EDX110 dressing system to standard of care leads to an improvement in diabetic foot ulcers healing…
- Trial name
- NCT07209358
- Testing
- EDX110
- Where
- 10 sites in United States, Puerto Rico
- Volunteers
- 300 people
- Sponsor
- ConvaTec Inc.
Age-related Macular Degeneration, Diabetic Retinopathy
Village-Integrated Eye Worker Trial II
The vast majority of blindness is avoidable. The World Health Organization (WHO) estimates that 80% of cases of visual impairment could be prevented or reversed with early diagnosis and treatment.
- Conditions
- Age-related Macular Degeneration, Diabetic Retinopathy, Glaucoma
- Trial name
- VIEW II (NCT03752840)
- Testing
- Visual acuity (presenting and pinhole), Optical coherence tomography (OCT), Intraocular pressure
- Where
- United States
- Volunteers
- 60,200 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Embolic Stroke, Postoperative Cognitive Dysfunction
Perfusion Pressure Cerebral Infarction Trial (PPCI)
STUDY HYPOTHESIS In cardiac surgery the volume of perioperative cerebral infarctions can be reduced by increasing mean arterial pressure (MAP) during the cardiopulmonary bypass procedure.
- Trial name
- PPCI (NCT02185885)
- Testing
- Increased bloodpressure during CPB.
- Where
- Denmark
- Volunteers
- 197 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Diabetic Foot Ulcer, Diabetic Foot
Adapting Lifestyle Offloading for DFUs
The goal of this pilot clinical trial is to develop and test a tailored occupational therapist-led lifestyle-focused intervention to aid patients in improving diabetic foot ulcer care.
- Trial name
- NCT06278935
- Testing
- Lifestyle-based intervention by an occupational therapist
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Southern California
Liver Injury
Liver Ischemia-reperfusion Injury and Clinical Data Analysis
Searching for new targets for the diagnosis and treatment of liver ischemia-reperfusion injury.
- Trial name
- NCT06080308
- Testing
- No intervention
- Where
- China
- Volunteers
- 270 people
- Sponsor
- Qin Zhang
Acute Myocardial Infarction
Sodium Nitrite in Acute Myocardial Infarction
The purpose of this study is to determine whether the intravenous infusion of sodium nitrite safely prevents ischemia-reperfusion injury in subjects with acute myocardial infarction resulting in improved left ventricular function.
- Trial name
- NCT00924118
- Testing
- Sodium Nitrite
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Diastolic Dysfunction
Pre-operative Focused Transthoracic Echocardiography for Prediction of Post-operative Cardiac Complications
The extent focused transthoracic echocardiography when done pre-operatively to patients admitted for elective surgery and suspected to be at risk of cardiac disease specially the geriatric population can affect perioperative…
- Trial name
- NCT04114474
- Testing
- TRANSTHORACIC ECHOCARDIOGRAPY
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- South Egypt Cancer Institute
Preterm Birth, Cardiovascular Diseases
Preterm Birth and Biomarkers for Cardiovascular Disease
Preterm birth is associated with maternal increased risk of cardiovascular disease later in life. In an observational case- control study, investigators want to evaluate whether women with preterm birth have increased levels of…
- Trial name
- BIO-PRETERM (NCT05693285)
- Testing
- No intervention
- Where
- Sweden
- Volunteers
- 65 people
- Sponsor
- Uppsala University
Hypertension, Diabetes Mellitus, Type 2
INV-144 Versus Losartan in Hypertension and Type 2 Diabetes Mellitus Patients With Macroalbuminuria
A randomized, double-blind, active control trial to determine the safety, efficacy and pharmacokinetics of INV-144 versus losartan potassium plus placebo in subjects with hypertension and Type 2 diabetes mellitus with nephropathy…
- Trial name
- NCT01398423
- Testing
- Active Control, INV-144
- Where
- 19 sites in United States
- Volunteers
- 88 people
- Sponsor
- InVasc Therapeutics, Inc.
Arterio-Venous Fistula, ESRD
VasQ External Support for Arteriovenous Fistula
This is a prospective clinical study of the VasQ external support for arteriovenous fistulas. The device is designed to improve fistula outcomes by optimizing the geometrical configuration of the fistula, influencing…
- Conditions
- Arterio-Venous Fistula, ESRD, Steal Syndrome, Aneurysm
- Trial name
- NCT03242343
- Testing
- VasQ
- Where
- 15 sites in United States
- Volunteers
- 144 people
- Sponsor
- Laminate Medical Technologies
Macular Degeneration, Retinal Vein Occlusion
Intravitreal v. Sub-tenon Injections of Triamcinolone Acetonide for Macular Edema in Retinal Disorders
The use of intravitreal injections of corticosteroid (triamcinolone acetonide) appears to be a promising treatment for a variety of ocular diseases associated with inflammation.
- Conditions
- Macular Degeneration, Retinal Vein Occlusion, Diabetic Retinopathy
- Trial name
- NCT00101764
- Testing
- Triamcinolone Acetonide
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- National Eye Institute (NEI)
Diabetic Foot Ulcers
Safety Evaluation of the KLOX BioPhotonic System in Diabetic Foot Ulcers
The primary objective of these case series is to evaluate the safety and tolerability of the KLOX BioPhotonic System as adjunctive therapy to Standard Of Care (SOC) in patients with diabetic foot ulcers.
- Trial name
- NCT02222506
- Testing
- KLOX BioPhotonic System
- Where
- 3 sites in Canada
- Volunteers
- 10 people
- Sponsor
- KLOX Technologies Inc.
Sleep Apnea, Obstructive, Pre-Eclampsia
Screening and Treatment of Obstructive Sleep Apnea in High-risk Pregnancy
This is an open-label multicenter randomized-controlled trial in 3 tertiary care hospitals including Ramathibodi Hospital, Phramongkutklao Hospital and Rajavithi Hospital.
- Conditions
- Sleep Apnea, Obstructive, Pre-Eclampsia, Hypertension, Pregnancy-Induced
- Trial name
- NCT03356106
- Testing
- Continuous positive airway pressure (CPAP)
- Where
- 3 sites in Thailand
- Volunteers
- 340 people
- Sponsor
- Ramathibodi Hospital
Inflammation, Veins
The Role of Pyroptosis in Chronic Venous Disease
Enrollment criteria and clinical data collection: following the principles of medical ethics, the development of inclusion and exclusion criteria.
- Conditions
- Inflammation, Veins, Complication, Varicose Veins
- Trial name
- PYROCVD (NCT03744858)
- Testing
- Peripheral blood draw
- Where
- Italy
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Catanzaro
Ovarian Cancer, Renal Cancer
Phase 1b/2 Study of Carfilzomib in Relapsed Solid Tumors, Multiple Myeloma, or Lymphoma
The primary objectives of this Phase 1b/2 study were as follows: Phase 1b (Bolus and Infusion): To evaluate the safety and tolerability of carfilzomib in patients with relapsed solid tumors and in patients with relapsed and/or…
- Conditions
- Ovarian Cancer, Renal Cancer, Non-small Cell Lung Cancer, Small Cell Lung Cancer
- Trial name
- NCT00531284
- Testing
- Carfilzomib, Dexamethasone
- Where
- 7 sites in United States
- Volunteers
- 184 people
- Sponsor
- Amgen
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